Homo sapiens

0 known processes

KPNA4

karyopherin alpha 4 (importin alpha 3)

(Aliases: MGC12217,MGC26703,QIP1,SRP3,IPOA3)

KPNA4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.456
Worm
modification dependent protein catabolic process GO:0019941 209 0.273
determination of adult lifespan GO:0008340 2 0.250
segmentation GO:0035282 4 0.219
protein modification by small protein conjugation GO:0032446 342 0.209
regulation of nucleocytoplasmic transport GO:0046822 98 0.179
Fly
nls bearing protein import into nucleus GO:0006607 2 0.168
Human
covalent chromatin modification GO:0016569 254 0.136
ubiquitin dependent protein catabolic process GO:0006511 206 0.119
negative regulation of proteolysis GO:0045861 132 0.119
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.117
protein catabolic process GO:0030163 325 0.117
amine metabolic process GO:0009308 44 0.116
positive regulation of cytoplasmic transport GO:1903651 82 0.115
Fly
multicellular organismal aging GO:0010259 3 0.113
cytoplasmic transport GO:0016482 379 0.112
Human Mouse Worm Fly
regulation of protein maturation GO:1903317 150 0.104
protein ubiquitination GO:0016567 314 0.104
regulation of cytoplasmic transport GO:1903649 149 0.103
Fly
cellular component morphogenesis GO:0032989 314 0.096
female gamete generation GO:0007292 2 0.094
Worm
positive regulation of sequestering of triglyceride GO:0010890 3 0.093
negative regulation of protein processing GO:0010955 142 0.092
actin filament organization GO:0007015 128 0.092
cell morphogenesis GO:0000902 296 0.089
histone modification GO:0016570 251 0.089
negative regulation of mitotic cell cycle GO:0045930 102 0.089
Fly
dna geometric change GO:0032392 32 0.087
protein deubiquitination GO:0016579 79 0.081
actin cytoskeleton organization GO:0030036 207 0.079
nuclear transport GO:0051169 179 0.079
Human Mouse Worm Fly
cell development GO:0048468 328 0.076
Worm
purine ribonucleoside metabolic process GO:0046128 437 0.076
regulation of protein processing GO:0070613 150 0.075
somitogenesis GO:0001756 2 0.075
positive regulation of transport GO:0051050 336 0.074
Fly
protein modification by small protein removal GO:0070646 92 0.072
regulation of kinase activity GO:0043549 314 0.072
single organism cellular localization GO:1902580 332 0.069
Human Mouse Worm Fly
protein import GO:0017038 130 0.069
Human Mouse Worm Fly
regulation of cell morphogenesis GO:0022604 153 0.067
wnt signaling pathway GO:0016055 156 0.067
regulation of cellular response to stress GO:0080135 244 0.066
protein acylation GO:0043543 138 0.066
dna conformation change GO:0071103 113 0.065
protein localization to organelle GO:0033365 280 0.060
Human Mouse Worm Fly
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.060
embryo development GO:0009790 123 0.059
Worm
protein localization to nucleus GO:0034504 136 0.059
Human Mouse Worm Fly
chordate embryonic development GO:0043009 34 0.058
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.057
Fly
cellular protein catabolic process GO:0044257 261 0.057
cellular macromolecule catabolic process GO:0044265 380 0.056
regulation of cellular ketone metabolic process GO:0010565 50 0.056
positive regulation of catabolic process GO:0009896 310 0.056
vesicle mediated transport GO:0016192 371 0.054
establishment of protein localization to organelle GO:0072594 172 0.054
Human Mouse Worm Fly
negative regulation of programmed cell death GO:0043069 321 0.054
gtp metabolic process GO:0046039 239 0.053
ribonucleoside triphosphate metabolic process GO:0009199 412 0.053
endosome to lysosome transport GO:0008333 21 0.052
small gtpase mediated signal transduction GO:0007264 78 0.052
g2 dna damage checkpoint GO:0031572 26 0.050
Fly
cellular ketone metabolic process GO:0042180 80 0.050
microtubule based process GO:0007017 210 0.050
protein maturation GO:0051604 233 0.050
modification dependent macromolecule catabolic process GO:0043632 212 0.049
anatomical structure formation involved in morphogenesis GO:0048646 284 0.048
histone h4 acetylation GO:0043967 47 0.046
cellular macromolecular complex assembly GO:0034622 324 0.046
regulation of anatomical structure morphogenesis GO:0022603 286 0.045
regulation of cellular component size GO:0032535 82 0.045
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.044
negative regulation of protein metabolic process GO:0051248 391 0.044
protein processing GO:0016485 226 0.041
organelle assembly GO:0070925 176 0.041
oocyte differentiation GO:0009994 2 0.041
neural tube formation GO:0001841 3 0.041
nucleocytoplasmic transport GO:0006913 176 0.040
Human Mouse Worm Fly
chromatin modification GO:0016568 298 0.040
endocytosis GO:0006897 159 0.040
regulation of peptidase activity GO:0052547 180 0.040
cell projection organization GO:0030030 252 0.040
rho protein signal transduction GO:0007266 26 0.039
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.039
canonical wnt signaling pathway GO:0060070 116 0.039
secretion GO:0046903 254 0.039
negative regulation of cellular component organization GO:0051129 235 0.037
secretion by cell GO:0032940 226 0.037
growth GO:0040007 202 0.037
dna damage checkpoint GO:0000077 68 0.037
Fly
proteasomal protein catabolic process GO:0010498 176 0.036
regulation of response to external stimulus GO:0032101 222 0.036
regulation of cellular component biogenesis GO:0044087 281 0.036
negative regulation of catalytic activity GO:0043086 335 0.034
anterior posterior axis specification embryo GO:0008595 2 0.034
single organism nuclear import GO:1902593 104 0.034
Human Mouse Worm Fly
oocyte development GO:0048599 1 0.033
lysosomal transport GO:0007041 33 0.033
negative regulation of hydrolase activity GO:0051346 182 0.032
regulation of anatomical structure size GO:0090066 101 0.032
regulation of proteolysis GO:0030162 293 0.032
tube morphogenesis GO:0035239 95 0.032
positive regulation of protein kinase activity GO:0045860 190 0.032
negative regulation of cellular protein metabolic process GO:0032269 353 0.031
locomotory behavior GO:0007626 1 0.031
cell cycle checkpoint GO:0000075 117 0.031
Fly
maintenance of cell polarity GO:0030011 2 0.031
regulation of cell motility GO:2000145 299 0.031
negative regulation of peptidase activity GO:0010466 91 0.030
negative regulation of protein maturation GO:1903318 142 0.030
regulation of cell cycle GO:0051726 393 0.030
Fly
nervous system development GO:0007399 293 0.030
regulation of cell projection organization GO:0031344 107 0.030
positive regulation of protein transport GO:0051222 135 0.030
Fly
actin filament based process GO:0030029 224 0.029
cilium morphogenesis GO:0060271 75 0.029
cellular amino acid metabolic process GO:0006520 116 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
chromatin organization GO:0006325 351 0.028
exocytosis GO:0006887 71 0.028
response to abiotic stimulus GO:0009628 336 0.028
Fly
posttranscriptional regulation of gene expression GO:0010608 213 0.028
Worm
regulation of establishment of protein localization GO:0070201 242 0.028
Fly
regulation of purine nucleotide metabolic process GO:1900542 264 0.027
regulation of receptor mediated endocytosis GO:0048259 32 0.027
regulation of intracellular transport GO:0032386 195 0.027
Fly
dephosphorylation GO:0016311 209 0.027
sister chromatid segregation GO:0000819 54 0.026
neuron differentiation GO:0030182 138 0.026
mitotic cell cycle GO:0000278 326 0.026
Fly
positive regulation of cellular component organization GO:0051130 376 0.026
meiosis i GO:0007127 4 0.025
Worm
positive regulation of protein phosphorylation GO:0001934 313 0.025
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.025
single organism reproductive process GO:0044702 98 0.025
Worm
regulation of cellular protein catabolic process GO:1903362 96 0.024
regulation of protein import into nucleus GO:0042306 78 0.024
Fly
organelle localization GO:0051640 84 0.024
vacuolar transport GO:0007034 34 0.024
protein acetylation GO:0006473 116 0.024
neurotransmitter secretion GO:0007269 4 0.023
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.023
regulation of protein kinase activity GO:0045859 289 0.023
internal peptidyl lysine acetylation GO:0018393 97 0.023
regulation of locomotion GO:0040012 329 0.023
regulation of mitotic cell cycle phase transition GO:1901990 118 0.023
Fly
regulation of neurotransmitter secretion GO:0046928 3 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.023
positive regulation of phosphorylation GO:0042327 394 0.023
positive regulation of transferase activity GO:0051347 227 0.022
blastoderm segmentation GO:0007350 2 0.022
gtp catabolic process GO:0006184 237 0.022
positive regulation of intracellular transport GO:0032388 104 0.022
Fly
negative regulation of apoptotic process GO:0043066 316 0.022
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.021
negative regulation of cell growth GO:0030308 83 0.021
nucleoside triphosphate metabolic process GO:0009141 422 0.021
peptidyl lysine acetylation GO:0018394 101 0.021
associative learning GO:0008306 1 0.021
positive regulation of proteolysis GO:0045862 142 0.021
positive regulation of smoothened signaling pathway GO:0045880 4 0.020
regulation of synaptic vesicle transport GO:1902803 3 0.020
positive regulation of protein localization to nucleus GO:1900182 48 0.020
Fly
organelle fission GO:0048285 149 0.020
Worm
translation GO:0006412 132 0.020
immune response GO:0006955 307 0.020
dna integrity checkpoint GO:0031570 71 0.020
Fly
regulation of stress activated mapk cascade GO:0032872 84 0.020
regulation of protein localization to nucleus GO:1900180 85 0.020
Fly
organic hydroxy compound transport GO:0015850 63 0.020
regulation of jnk cascade GO:0046328 73 0.020
cell adhesion GO:0007155 325 0.019
ribonucleoprotein complex subunit organization GO:0071826 81 0.019
positive regulation of nfat protein import into nucleus GO:0051533 3 0.019
Fly
neurogenesis GO:0022008 169 0.019
negative regulation of endopeptidase activity GO:0010951 84 0.019
positive regulation of apoptotic process GO:0043065 246 0.019
regulation of secretion by cell GO:1903530 177 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
digestive tract morphogenesis GO:0048546 56 0.019
myoblast fusion GO:0007520 1 0.019
regulation of small gtpase mediated signal transduction GO:0051056 156 0.019
embryonic morphogenesis GO:0048598 85 0.019
positive regulation of wnt signaling pathway GO:0030177 54 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
glycosyl compound catabolic process GO:1901658 413 0.018
regulation of cellular amino acid metabolic process GO:0006521 6 0.018
negative regulation of phosphorylation GO:0042326 174 0.018
syncytium formation by plasma membrane fusion GO:0000768 2 0.018
protein targeting GO:0006605 187 0.018
Human Mouse Worm Fly
histone acetylation GO:0016573 93 0.018
positive regulation of programmed cell death GO:0043068 249 0.018
regulation of cell growth GO:0001558 135 0.017
mitotic nuclear division GO:0007067 119 0.017
positive regulation of kinase activity GO:0033674 204 0.017
chemical homeostasis GO:0048878 306 0.017
blood vessel development GO:0001568 172 0.017
ras protein signal transduction GO:0007265 73 0.017
apoptotic signaling pathway GO:0097190 268 0.017
regulation of protein transport GO:0051223 213 0.017
Fly
ribonucleoprotein complex assembly GO:0022618 78 0.017
sister chromatid cohesion GO:0007062 24 0.017
positive regulation of hydrolase activity GO:0051345 331 0.017
protein targeting to nucleus GO:0044744 104 0.017
Human Mouse Worm Fly
regulation of cellular amine metabolic process GO:0033238 11 0.017
regulation of growth GO:0040008 165 0.017
regulation of protein targeting GO:1903533 91 0.017
Fly
unidimensional cell growth GO:0009826 1 0.017
protein k48 linked ubiquitination GO:0070936 38 0.017
oogenesis GO:0048477 2 0.017
Worm
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.017
regulation of ras protein signal transduction GO:0046578 155 0.017
regulation of intracellular protein transport GO:0033157 123 0.017
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.016
chemotaxis GO:0006935 157 0.016
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
regionalization GO:0003002 29 0.016
negative regulation of catabolic process GO:0009895 104 0.016
regulation of protein catabolic process GO:0042176 155 0.016
ribonucleoside triphosphate catabolic process GO:0009203 391 0.016
regeneration GO:0031099 4 0.016
generation of neurons GO:0048699 152 0.016
reproductive system development GO:0061458 56 0.016
methylation GO:0032259 106 0.016
convergent extension GO:0060026 1 0.016
negative regulation of cell death GO:0060548 345 0.016
neuron development GO:0048666 113 0.015
biological adhesion GO:0022610 331 0.015
embryonic epithelial tube formation GO:0001838 4 0.015
purine nucleoside triphosphate catabolic process GO:0009146 392 0.015
purine ribonucleoside catabolic process GO:0046130 398 0.015
regulation of translation GO:0006417 89 0.015
extrinsic apoptotic signaling pathway GO:0097191 119 0.015
negative regulation of growth GO:0045926 97 0.015
chromosome segregation GO:0007059 114 0.015
cell fate determination GO:0001709 3 0.015
single organismal cell cell adhesion GO:0016337 148 0.015
cell growth GO:0016049 160 0.015
vasculature development GO:0001944 181 0.015
peptidyl lysine modification GO:0018205 144 0.015
receptor internalization involved in canonical wnt signaling pathway GO:2000286 3 0.015
regulation of cell cycle phase transition GO:1901987 126 0.015
Fly
regulation of neuron differentiation GO:0045664 70 0.015
nuclear import GO:0051170 106 0.014
Human Mouse Worm Fly
system process GO:0003008 349 0.014
peptidyl serine phosphorylation GO:0018105 101 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.014
Worm
sex differentiation GO:0007548 45 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
synaptic vesicle recycling GO:0036465 3 0.014
anterior posterior axis specification GO:0009948 2 0.014
regulation of chromosome organization GO:0033044 103 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.014
cilium assembly GO:0042384 63 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
negative regulation of apoptotic signaling pathway GO:2001234 97 0.014
dna repair GO:0006281 198 0.014
protein polyubiquitination GO:0000209 110 0.014
lipid metabolic process GO:0006629 381 0.014
purine containing compound catabolic process GO:0072523 411 0.013
positive regulation of protein import into nucleus GO:0042307 46 0.013
Fly
mapk cascade GO:0000165 288 0.013
establishment of organelle localization GO:0051656 59 0.013
intracellular mrna localization GO:0008298 1 0.013
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.013
regulation of protein localization GO:0032880 296 0.013
Fly
nuclear export GO:0051168 69 0.013
mitotic sister chromatid cohesion GO:0007064 12 0.013
cellular amine metabolic process GO:0044106 41 0.013
positive regulation of cell death GO:0010942 263 0.013
regulation of neuron projection development GO:0010975 57 0.013
receptor mediated endocytosis GO:0006898 84 0.013
early endosome to late endosome transport GO:0045022 21 0.013
morphogenesis of embryonic epithelium GO:0016331 4 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.012
positive regulation of growth GO:0045927 58 0.012
monovalent inorganic cation transport GO:0015672 128 0.012
nucleosome organization GO:0034728 66 0.012
reproductive structure development GO:0048608 55 0.012
internal protein amino acid acetylation GO:0006475 101 0.012
regulation of cell cycle process GO:0010564 266 0.012
Fly
ameboidal type cell migration GO:0001667 135 0.012
actomyosin structure organization GO:0031032 59 0.012
response to other organism GO:0051707 261 0.012
protein autophosphorylation GO:0046777 123 0.012
regulation of actin filament based process GO:0032970 141 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
developmental process involved in reproduction GO:0003006 66 0.012
Worm
protein localization to plasma membrane GO:0072659 93 0.012
cell projection morphogenesis GO:0048858 129 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
somatic muscle development GO:0007525 1 0.012
regulation of cell adhesion GO:0030155 166 0.012
morphogenesis of an epithelium GO:0002009 60 0.012
vesicle targeting rough er to cis golgi GO:0048207 2 0.012
ion homeostasis GO:0050801 230 0.012
mitotic sister chromatid segregation GO:0000070 53 0.012
regulation of protein stability GO:0031647 87 0.012
autophagy GO:0006914 88 0.012
cell type specific apoptotic process GO:0097285 125 0.012
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.011
Fly
organophosphate catabolic process GO:0046434 430 0.011
regulation of secretion GO:0051046 194 0.011
regulation of transferase activity GO:0051338 355 0.011
tube development GO:0035295 125 0.011
regulation of nucleotide metabolic process GO:0006140 269 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.011
cardiovascular system development GO:0072358 262 0.011
angiogenesis GO:0001525 147 0.011
regulation of nervous system development GO:0051960 88 0.011
reproduction GO:0000003 63 0.011
Worm
memory GO:0007613 3 0.011
cytokinesis GO:0000910 96 0.011
response to nitrogen compound GO:1901698 184 0.011
negative regulation of cell cycle GO:0045786 193 0.011
Fly
negative regulation of cell migration GO:0030336 102 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
neuromuscular junction development GO:0007528 3 0.011
stress activated mapk cascade GO:0051403 93 0.011
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.011
positive regulation of receptor mediated endocytosis GO:0048260 21 0.011
regulation of defense response GO:0031347 154 0.011
defense response GO:0006952 315 0.011
tissue regeneration GO:0042246 3 0.011
positive regulation of endocytosis GO:0045807 42 0.011
protein localization to membrane GO:0072657 160 0.011
steroid metabolic process GO:0008202 94 0.011
regulation of cell development GO:0060284 161 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
kinetochore organization GO:0051383 8 0.011
neurological system process GO:0050877 163 0.010
rhythmic behavior GO:0007622 2 0.010
positive regulation of organelle organization GO:0010638 195 0.010
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.010
epithelial cell proliferation GO:0050673 128 0.010
positive regulation of cellular amine metabolic process GO:0033240 7 0.010
purine nucleotide catabolic process GO:0006195 405 0.010
nitrogen compound transport GO:0071705 191 0.010
synaptic vesicle exocytosis GO:0016079 3 0.010
tissue morphogenesis GO:0048729 96 0.010
aging GO:0007568 66 0.010
regulation of synaptic vesicle exocytosis GO:2000300 2 0.010
cell division GO:0051301 168 0.010
myosin filament organization GO:0031033 2 0.010
membrane organization GO:0061024 292 0.010
positive regulation of cellular protein catabolic process GO:1903364 37 0.010
regulation of cytoskeleton organization GO:0051493 177 0.010
response to external biotic stimulus GO:0043207 261 0.010
mitochondrion organization GO:0007005 156 0.010

KPNA4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.039
cancer DOID:162 167 0.025
organ system cancer DOID:0050686 164 0.025
musculoskeletal system disease DOID:17 223 0.023
gastrointestinal system cancer DOID:3119 52 0.011
sensory system disease DOID:0050155 203 0.011
nervous system disease DOID:863 431 0.011