|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
1.000
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
1.000
|
|
|
|
ephrin receptor signaling pathway
|
GO:0048013 |
15 |
0.998
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.998
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.998
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.997
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.997
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.997
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.996
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.996
|
Fly |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.996
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.996
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.996
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.995
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.994
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.993
|
Fly |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.992
|
|
|
|
regulation of smooth muscle cell proliferation
|
GO:0048660 |
28 |
0.991
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.990
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.990
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.989
|
|
|
|
rap protein signal transduction
|
GO:0032486 |
7 |
0.988
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.988
|
|
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.988
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.987
|
|
|
|
regulation of phospholipase c activity
|
GO:1900274 |
14 |
0.986
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.986
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.986
|
Fly |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.985
|
|
|
|
positive regulation of rap gtpase activity
|
GO:0032854 |
8 |
0.984
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.983
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.982
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.981
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.980
|
|
|
|
muscle cell migration
|
GO:0014812 |
19 |
0.978
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.977
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.976
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.974
|
|
|
|
regulation of smooth muscle cell migration
|
GO:0014910 |
15 |
0.973
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.973
|
|
|
|
muscle cell proliferation
|
GO:0033002 |
35 |
0.970
|
|
|
|
regulation of interleukin 2 secretion
|
GO:1900040 |
2 |
0.970
|
|
|
|
regulation of cell junction assembly
|
GO:1901888 |
29 |
0.970
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.968
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.967
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.967
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
2 |
0.966
|
Worm |
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
42 |
0.964
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.959
|
Fly |
|
|
vegf activated platelet derived growth factor receptor signaling pathway
|
GO:0038086 |
3 |
0.959
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.959
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.958
|
|
|
|
positive regulation of cell proliferation by vegf activated platelet derived growth factor receptor signaling pathway
|
GO:0038091 |
3 |
0.956
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.953
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.952
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.951
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.950
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.949
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.949
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.946
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.942
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.942
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.937
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.936
|
Fly |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.934
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.930
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.927
|
Fly |
|
|
positive regulation of smooth muscle cell migration
|
GO:0014911 |
6 |
0.926
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.923
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.922
|
|
|
|
smooth muscle cell migration
|
GO:0014909 |
18 |
0.921
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.918
|
Fly |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.914
|
|
|
|
platelet derived growth factor receptor signaling pathway
|
GO:0048008 |
14 |
0.914
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.912
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.908
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.905
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.901
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.899
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.898
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.898
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.897
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.895
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.895
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.893
|
Fly |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.893
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.884
|
Fly |
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.882
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.877
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.875
|
Fly |
|
|
positive regulation of actin filament polymerization
|
GO:0030838 |
38 |
0.874
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.871
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.868
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.867
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.863
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.862
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.858
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.856
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.856
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.855
|
Fly |
|
|
circulatory system development
|
GO:0072359 |
262 |
0.852
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.851
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.848
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.845
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.843
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.838
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.836
|
Fly |
|
|
parathyroid gland development
|
GO:0060017 |
2 |
0.835
|
|
|
|
regulation of determination of dorsal identity
|
GO:2000015 |
2 |
0.834
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.833
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.830
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.829
|
Worm Fly |
|
|
platelet derived growth factor receptor beta signaling pathway
|
GO:0035791 |
4 |
0.825
|
|
|
|
central nervous system neuron axonogenesis
|
GO:0021955 |
3 |
0.824
|
|
|
|
adherens junction organization
|
GO:0034332 |
36 |
0.823
|
|
|
|
glial cell migration
|
GO:0008347 |
4 |
0.822
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.821
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.820
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.819
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.815
|
|
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.813
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.811
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.806
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.802
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.801
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.800
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.800
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.790
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.779
|
|
|
|
interleukin 2 secretion
|
GO:0070970 |
3 |
0.778
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.774
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.768
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.768
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.767
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.766
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.762
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.760
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.757
|
Zebrafish |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.744
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.743
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.741
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.739
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.732
|
|
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
32 |
0.732
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.729
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.728
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.726
|
|
|
|
apoptotic cell clearance
|
GO:0043277 |
12 |
0.722
|
Worm |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.721
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.721
|
|
|
|
cell junction assembly
|
GO:0034329 |
67 |
0.717
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.717
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.712
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.712
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.711
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.707
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.706
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.698
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.696
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.695
|
|
|
|
positive regulation of phospholipase activity
|
GO:0010518 |
22 |
0.689
|
|
|
|
vascular endothelial growth factor receptor signaling pathway
|
GO:0048010 |
19 |
0.687
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.687
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.682
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.681
|
|
|
|
nerve growth factor signaling pathway
|
GO:0038180 |
4 |
0.679
|
|
|
|
positive regulation of dna replication
|
GO:0045740 |
35 |
0.672
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.671
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.667
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.666
|
|
|
|
regulation of metanephric mesenchymal cell migration
|
GO:2000589 |
2 |
0.663
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.662
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
56 |
0.660
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.651
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.651
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.647
|
Fly |
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.638
|
|
|
|
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway
|
GO:1900238 |
2 |
0.637
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.635
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.632
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.632
|
|
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.624
|
Zebrafish |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.619
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.614
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.610
|
|
|
|
cellular response to acid chemical
|
GO:0071229 |
44 |
0.608
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.602
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.593
|
|
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
4 |
0.593
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.591
|
Zebrafish |
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.589
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.588
|
Fly |
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.583
|
|
|
|
growth
|
GO:0040007 |
202 |
0.582
|
|
|
|
regulation of phagocytosis engulfment
|
GO:0060099 |
2 |
0.581
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.576
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.576
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.574
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.573
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.571
|
|
|
|
regulation of adherens junction organization
|
GO:1903391 |
21 |
0.566
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.565
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.561
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.559
|
|
|
|
positive regulation of protein tyrosine kinase activity
|
GO:0061098 |
24 |
0.556
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.556
|
|
|
|
visual learning
|
GO:0008542 |
1 |
0.555
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.550
|
Rat |
|
|
secretion
|
GO:0046903 |
254 |
0.550
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.544
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.543
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.541
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.537
|
Rat |
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
55 |
0.536
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.531
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.528
|
|
|
|
phagocytosis engulfment
|
GO:0006911 |
7 |
0.528
|
Worm Fly |
|
|
dna replication
|
GO:0006260 |
116 |
0.527
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.526
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.522
|
|
|
|
cellular response to camp
|
GO:0071320 |
21 |
0.520
|
|
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.518
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.515
|
|
|
|
regulation of cell matrix adhesion
|
GO:0001952 |
42 |
0.514
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.511
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.510
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.508
|
|
|
|
astrocyte differentiation
|
GO:0048708 |
4 |
0.506
|
|
|
|
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway
|
GO:0035793 |
2 |
0.503
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.503
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.499
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.498
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.495
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.487
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.484
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.482
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.478
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.476
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.472
|
Fly |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.472
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.472
|
|
|
|
positive regulation of determination of dorsal identity
|
GO:2000017 |
1 |
0.471
|
|
|
|
axonogenesis
|
GO:0007409 |
31 |
0.470
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.468
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.465
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.465
|
Fly |
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.456
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.456
|
|
|
|
dendritic spine maintenance
|
GO:0097062 |
1 |
0.453
|
|
|
|
regulation of cardiac muscle cell proliferation
|
GO:0060043 |
4 |
0.452
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.450
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.450
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase activity
|
GO:0043552 |
12 |
0.439
|
|
|
|
regulation of blood coagulation
|
GO:0030193 |
42 |
0.437
|
|
|
|
regulation of natural killer cell proliferation
|
GO:0032817 |
4 |
0.436
|
|
|
|
vascular endothelial growth factor receptor 1 signaling pathway
|
GO:0036323 |
1 |
0.434
|
|
|
|
actin filament polymerization
|
GO:0030041 |
45 |
0.433
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.432
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.430
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.430
|
|
|
|
neurotrophin signaling pathway
|
GO:0038179 |
8 |
0.428
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.427
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.425
|
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
44 |
0.424
|
|
|
|
neuron migration
|
GO:0001764 |
11 |
0.423
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.422
|
Fly |
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.421
|
Fly |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.419
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.413
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.412
|
|
|
|
cell migration involved in kidney development
|
GO:0035787 |
2 |
0.405
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.403
|
|
|
|
salivary gland morphogenesis
|
GO:0007435 |
4 |
0.399
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.398
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.393
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.389
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.383
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.383
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.382
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.378
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.378
|
Zebrafish |
|
|
regulation of pro b cell differentiation
|
GO:2000973 |
1 |
0.377
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.375
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.373
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.367
|
Fly |
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.367
|
|
|
|
regulation of rap protein signal transduction
|
GO:0032487 |
9 |
0.367
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.365
|
|
|
|
regulation of cytokine secretion
|
GO:0050707 |
57 |
0.360
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.356
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.353
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.353
|
|
|
|
positive regulation of angiogenesis
|
GO:0045766 |
51 |
0.351
|
|
|
|
positive regulation of cytokine secretion
|
GO:0050715 |
42 |
0.350
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.348
|
|
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.346
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.345
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.344
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.341
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.337
|
|
|
|
positive regulation of metanephric mesenchymal cell migration
|
GO:2000591 |
2 |
0.336
|
|
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
23 |
0.335
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
54 |
0.334
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.332
|
|
|
|
negative regulation of wound healing
|
GO:0061045 |
25 |
0.330
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.328
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.326
|
|
|
|
negative regulation of endothelial cell apoptotic process
|
GO:2000352 |
16 |
0.324
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.322
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.322
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.321
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.318
|
|
|
|
cell migration involved in metanephros development
|
GO:0035788 |
2 |
0.316
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.315
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.310
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.309
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.309
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.307
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.306
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.305
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.305
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.305
|
|
|
|
metanephric mesenchymal cell migration
|
GO:0035789 |
2 |
0.304
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.297
|
Fly |
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.296
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.292
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.292
|
|
|
|
endocrine system development
|
GO:0035270 |
26 |
0.288
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.285
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.285
|
|
|
|
metencephalon development
|
GO:0022037 |
2 |
0.282
|
|
|
|
peptidyl tyrosine autophosphorylation
|
GO:0038083 |
5 |
0.282
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.280
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
19 |
0.279
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.278
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.274
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.274
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.273
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.272
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.271
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.270
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.269
|
|
|
|
platelet derived growth factor receptor alpha signaling pathway
|
GO:0035790 |
1 |
0.268
|
|
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
20 |
0.267
|
|
|
|
neurotrophin trk receptor signaling pathway
|
GO:0048011 |
4 |
0.265
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.265
|
|
|
|
regulation of glial cell proliferation
|
GO:0060251 |
4 |
0.264
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.263
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.262
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.262
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.261
|
|
|
|
regulation of non canonical wnt signaling pathway
|
GO:2000050 |
4 |
0.258
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.256
|
|
|
|
endodermal cell fate commitment
|
GO:0001711 |
4 |
0.256
|
|
|
|
visual behavior
|
GO:0007632 |
2 |
0.256
|
|
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.255
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.255
|
|
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.254
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.252
|
|
|
|
glycerophospholipid biosynthetic process
|
GO:0046474 |
40 |
0.248
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.248
|
|
|
|
cerebral cortex radially oriented cell migration
|
GO:0021799 |
1 |
0.246
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.243
|
|
|
|
cell substrate junction assembly
|
GO:0007044 |
35 |
0.242
|
|
|
|
regulation of focal adhesion assembly
|
GO:0051893 |
20 |
0.241
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.241
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.241
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.240
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.238
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.235
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.234
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.231
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.229
|
|
|
|
cerebral cortex cell migration
|
GO:0021795 |
3 |
0.228
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.225
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.223
|
|
|
|
smooth muscle cell proliferation
|
GO:0048659 |
28 |
0.223
|
|
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.223
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.223
|
Fly |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.222
|
|
|
|
endothelium development
|
GO:0003158 |
33 |
0.219
|
|
|
|
positive regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0045737 |
15 |
0.219
|
|
|
|
regulation of glomerulus development
|
GO:0090192 |
3 |
0.217
|
|
|
|
negative regulation of endocytosis
|
GO:0045806 |
19 |
0.214
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.214
|
|
|
|
negative regulation of jun kinase activity
|
GO:0043508 |
4 |
0.213
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.213
|
|
|
|
fibroblast proliferation
|
GO:0048144 |
33 |
0.212
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.212
|
|
|
|
positive regulation of focal adhesion assembly
|
GO:0051894 |
11 |
0.207
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.206
|
|
|
|
negative regulation of phospholipase activity
|
GO:0010519 |
3 |
0.205
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.204
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.201
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.200
|
|
|
|
endothelial cell development
|
GO:0001885 |
18 |
0.200
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.200
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.198
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.198
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.197
|
Fly |
|
|
positive regulation of cytokine mediated signaling pathway
|
GO:0001961 |
12 |
0.197
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.196
|
|
|
|
positive regulation of non canonical wnt signaling pathway
|
GO:2000052 |
3 |
0.196
|
|
|
|
negative regulation of phagocytosis engulfment
|
GO:0060101 |
1 |
0.195
|
|
|
|
response to insulin
|
GO:0032868 |
45 |
0.195
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.193
|
|
|
|
positive regulation of wnt signaling pathway planar cell polarity pathway
|
GO:2000096 |
2 |
0.192
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.191
|
|
|
|
positive regulation of nitric oxide synthase biosynthetic process
|
GO:0051770 |
3 |
0.190
|
|
|
|
focal adhesion assembly
|
GO:0048041 |
30 |
0.188
|
|
|
|
convergent extension involved in gastrulation
|
GO:0060027 |
1 |
0.188
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.188
|
|
|
|
metanephric glomerulus vasculature development
|
GO:0072239 |
1 |
0.188
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.187
|
|
|
|
gliogenesis
|
GO:0042063 |
21 |
0.187
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.186
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.186
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.182
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.181
|
|
|
|
positive regulation of peptidyl tyrosine autophosphorylation
|
GO:1900086 |
1 |
0.181
|
|
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.176
|
|
|
|
angiogenesis involved in wound healing
|
GO:0060055 |
4 |
0.176
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.176
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.175
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.173
|
|
|
|
hematopoietic progenitor cell differentiation
|
GO:0002244 |
38 |
0.172
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.172
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.171
|
|
|
|
regulation of nuclear division
|
GO:0051783 |
65 |
0.171
|
|
|
|
embryonic digestive tract morphogenesis
|
GO:0048557 |
2 |
0.171
|
|
|
|
establishment of endothelial barrier
|
GO:0061028 |
16 |
0.170
|
|
|
|
regulation of phagocytosis
|
GO:0050764 |
21 |
0.170
|
|
|
|
cell substrate adherens junction assembly
|
GO:0007045 |
30 |
0.169
|
|
|
|
regulation of dna replication
|
GO:0006275 |
68 |
0.169
|
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.169
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.168
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.167
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.166
|
|
|
|
male gonad development
|
GO:0008584 |
23 |
0.166
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.165
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.160
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.160
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.159
|
Fly |
|
|
endocytosis
|
GO:0006897 |
159 |
0.158
|
Worm Fly |
|
|
innate immune response
|
GO:0045087 |
178 |
0.157
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.157
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.157
|
|
|
|
myotube differentiation
|
GO:0014902 |
22 |
0.157
|
Zebrafish |
|
|
regulation of interferon gamma secretion
|
GO:1902713 |
2 |
0.155
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.154
|
|
|
|
positive regulation of canonical wnt signaling pathway
|
GO:0090263 |
33 |
0.153
|
|
|
|
actin filament bundle organization
|
GO:0061572 |
54 |
0.152
|
|
|
|
regulation of vascular endothelial growth factor receptor signaling pathway
|
GO:0030947 |
9 |
0.150
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.150
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.150
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
14 |
0.150
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.149
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.148
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.146
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.145
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.145
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.144
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.144
|
Worm Fly |
|
|
neuromuscular process controlling balance
|
GO:0050885 |
7 |
0.144
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.142
|
|
|
|
determination of dorsal ventral asymmetry
|
GO:0048262 |
4 |
0.142
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.141
|
|
|
|
negative regulation of small gtpase mediated signal transduction
|
GO:0051058 |
12 |
0.141
|
|
|
|
cerebellum development
|
GO:0021549 |
2 |
0.141
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.140
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.138
|
|
|
|
regulation of fibroblast proliferation
|
GO:0048145 |
32 |
0.137
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.135
|
|
|
|
morphogenesis of a branching epithelium
|
GO:0061138 |
20 |
0.135
|
|
|
|
endothelial cell differentiation
|
GO:0045446 |
26 |
0.133
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
13 |
0.133
|
|
|
|
negative regulation of protein homooligomerization
|
GO:0032463 |
4 |
0.133
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.132
|
|
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
53 |
0.132
|
|
|
|
regulation of organelle assembly
|
GO:1902115 |
40 |
0.132
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.130
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.130
|
|
|
|
pro b cell differentiation
|
GO:0002328 |
1 |
0.130
|
|
|
|
regulation of cell substrate junction assembly
|
GO:0090109 |
20 |
0.128
|
|
|
|
membrane invagination
|
GO:0010324 |
10 |
0.127
|
Worm Fly |
|
|
epithelial cell cell adhesion
|
GO:0090136 |
7 |
0.127
|
|
|
|
response to nerve growth factor
|
GO:1990089 |
6 |
0.127
|
|
|
|
glomerular mesangial cell proliferation
|
GO:0072110 |
3 |
0.127
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.124
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.123
|
|
|
|
vascular wound healing
|
GO:0061042 |
4 |
0.123
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.123
|
|
|
|
positive regulation of cell matrix adhesion
|
GO:0001954 |
23 |
0.122
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.122
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.122
|
|
