Homo sapiens

143 known processes

EIF2B1

eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa

(Aliases: MGC117409,MGC125869,EIF2B,MGC125868,EIF2BA)

EIF2B1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.433
nucleoside phosphate catabolic process GO:1901292 412 0.309
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.280
purine nucleotide catabolic process GO:0006195 405 0.266
nucleoside catabolic process GO:0009164 408 0.260
translation GO:0006412 132 0.229
glycosyl compound catabolic process GO:1901658 413 0.220
purine nucleoside triphosphate catabolic process GO:0009146 392 0.211
ribonucleoside triphosphate catabolic process GO:0009203 391 0.191
vesicle mediated transport GO:0016192 371 0.172
ribonucleotide catabolic process GO:0009261 405 0.149
nucleotide catabolic process GO:0009166 408 0.137
guanosine containing compound catabolic process GO:1901069 239 0.126
purine ribonucleoside metabolic process GO:0046128 437 0.118
nervous system development GO:0007399 293 0.106
oligodendrocyte development GO:0014003 6 0.104
purine nucleoside triphosphate metabolic process GO:0009144 412 0.097
organophosphate catabolic process GO:0046434 430 0.097
nucleoside triphosphate catabolic process GO:0009143 394 0.095
ribonucleoside catabolic process GO:0042454 406 0.093
purine ribonucleoside catabolic process GO:0046130 398 0.090
purine containing compound catabolic process GO:0072523 411 0.089
posttranscriptional regulation of gene expression GO:0010608 213 0.077
Yeast
positive regulation of hydrolase activity GO:0051345 331 0.077
guanosine containing compound metabolic process GO:1901068 244 0.077
ncrna metabolic process GO:0034660 108 0.073
regulation of purine nucleotide metabolic process GO:1900542 264 0.064
gtp catabolic process GO:0006184 237 0.062
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.059
gtp metabolic process GO:0046039 239 0.058
endocytosis GO:0006897 159 0.057
nucleoside triphosphate metabolic process GO:0009141 422 0.054
rna processing GO:0006396 255 0.053
regulation of nucleoside metabolic process GO:0009118 209 0.053
rna interference GO:0016246 4 0.051
anterior posterior axis specification GO:0009948 2 0.048
purine nucleoside catabolic process GO:0006152 398 0.048
positive regulation of nucleoside metabolic process GO:0045979 186 0.048
cellular amino acid metabolic process GO:0006520 116 0.046
regulation of gtp catabolic process GO:0033124 180 0.045
regulation of purine nucleotide catabolic process GO:0033121 205 0.042
determination of adult lifespan GO:0008340 2 0.042
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.041
segmentation GO:0035282 4 0.040
negative regulation of protein metabolic process GO:0051248 391 0.039
neurogenesis GO:0022008 169 0.037
negative regulation of catalytic activity GO:0043086 335 0.037
growth GO:0040007 202 0.036
ribonucleoside triphosphate metabolic process GO:0009199 412 0.035
regulation of gtpase activity GO:0043087 180 0.035
translational initiation GO:0006413 48 0.035
regulation of nucleotide catabolic process GO:0030811 205 0.035
positive regulation of gtpase activity GO:0043547 166 0.035
positive regulation of cellular catabolic process GO:0031331 284 0.034
single organism reproductive process GO:0044702 98 0.033
female gamete generation GO:0007292 2 0.033
cytoplasmic transport GO:0016482 379 0.033
regulation of translation GO:0006417 89 0.032
Yeast
positive regulation of nucleotide catabolic process GO:0030813 185 0.032
response to abiotic stimulus GO:0009628 336 0.030
system process GO:0003008 349 0.030
oogenesis GO:0048477 2 0.030
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.030
receptor mediated endocytosis GO:0006898 84 0.030
methylation GO:0032259 106 0.030
oligodendrocyte differentiation GO:0048709 7 0.029
positive regulation of gtp catabolic process GO:0033126 166 0.029
cellular component morphogenesis GO:0032989 314 0.029
positive regulation of nucleotide metabolic process GO:0045981 230 0.029
trna processing GO:0008033 23 0.028
multicellular organismal aging GO:0010259 3 0.027
regulation of cellular amino acid metabolic process GO:0006521 6 0.027
cellular macromolecular complex assembly GO:0034622 324 0.026
tripartite regional subdivision GO:0007351 2 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
mitotic cell cycle phase transition GO:0044772 162 0.025
regulation of cellular amine metabolic process GO:0033238 11 0.024
regulation of protein kinase activity GO:0045859 289 0.024
negative regulation of cell death GO:0060548 345 0.024
purine ribonucleotide catabolic process GO:0009154 404 0.024
negative regulation of apoptotic process GO:0043066 316 0.024
regulation of growth GO:0040008 165 0.023
carbohydrate derivative biosynthetic process GO:1901137 207 0.023
reproductive process GO:0022414 106 0.023
negative regulation of phosphate metabolic process GO:0045936 267 0.023
negative regulation of intracellular signal transduction GO:1902532 183 0.023
adult locomotory behavior GO:0008344 1 0.023
cellular response to cytokine stimulus GO:0071345 181 0.023
posttranscriptional gene silencing GO:0016441 25 0.022
negative regulation of programmed cell death GO:0043069 321 0.022
locomotory behavior GO:0007626 1 0.022
protein modification by small protein conjugation GO:0032446 342 0.022
regulation of cellular response to stress GO:0080135 244 0.022
peptidyl lysine modification GO:0018205 144 0.021
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
trna metabolic process GO:0006399 35 0.021
nucleoside monophosphate catabolic process GO:0009125 159 0.021
macromolecule methylation GO:0043414 97 0.021
embryo development GO:0009790 123 0.021
rna modification GO:0009451 27 0.021
cellular response to dna damage stimulus GO:0006974 379 0.021
cellular amine metabolic process GO:0044106 41 0.020
response to cytokine GO:0034097 232 0.020
internal protein amino acid acetylation GO:0006475 101 0.020
oocyte development GO:0048599 1 0.020
single organism membrane organization GO:0044802 268 0.020
amine metabolic process GO:0009308 44 0.020
carbohydrate metabolic process GO:0005975 207 0.019
cell division GO:0051301 168 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
regulation of peptidase activity GO:0052547 180 0.019
ribosome biogenesis GO:0042254 48 0.019
regulation of kinase activity GO:0043549 314 0.018
establishment of ribosome localization GO:0033753 4 0.018
regulation of proteolysis GO:0030162 293 0.018
posttranscriptional gene silencing by rna GO:0035194 25 0.018
protein maturation GO:0051604 233 0.018
regulation of transferase activity GO:0051338 355 0.018
positive regulation of apoptotic process GO:0043065 246 0.018
negative regulation of protein processing GO:0010955 142 0.018
nucleoside monophosphate metabolic process GO:0009123 191 0.018
positive regulation of catabolic process GO:0009896 310 0.017
dna replication GO:0006260 116 0.017
histone modification GO:0016570 251 0.017
protein acylation GO:0043543 138 0.017
cell development GO:0048468 328 0.017
regulation of gene expression epigenetic GO:0040029 73 0.017
regulation of cell cycle GO:0051726 393 0.017
biological adhesion GO:0022610 331 0.017
negative regulation of hydrolase activity GO:0051346 182 0.016
nuclear export GO:0051168 69 0.016
gene silencing by rna GO:0031047 26 0.016
ribonucleoprotein complex biogenesis GO:0022613 116 0.016
chromatin organization GO:0006325 351 0.016
regulation of cytokine production GO:0001817 232 0.016
cellular macromolecule catabolic process GO:0044265 380 0.016
protein catabolic process GO:0030163 325 0.016
regulation of mitotic cell cycle phase transition GO:1901990 118 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
reproduction GO:0000003 63 0.016
central nervous system development GO:0007417 123 0.015
rna splicing GO:0008380 131 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
ribonucleoprotein complex assembly GO:0022618 78 0.015
mitotic cell cycle process GO:1903047 286 0.015
small gtpase mediated signal transduction GO:0007264 78 0.015
ras protein signal transduction GO:0007265 73 0.015
cell cell signaling GO:0007267 155 0.015
positive regulation of developmental process GO:0051094 314 0.015
regulation of mapk cascade GO:0043408 262 0.014
regulation of protein stability GO:0031647 87 0.014
protein ubiquitination GO:0016567 314 0.014
actin filament based process GO:0030029 224 0.014
metal ion homeostasis GO:0055065 169 0.014
endosomal transport GO:0016197 129 0.014
reproductive structure development GO:0048608 55 0.014
histone acetylation GO:0016573 93 0.014
response to hypoxia GO:0001666 96 0.014
protein alkylation GO:0008213 74 0.014
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
cellular ketone metabolic process GO:0042180 80 0.013
regulation of response to dna damage stimulus GO:2001020 94 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
positive regulation of cell death GO:0010942 263 0.013
generation of neurons GO:0048699 152 0.013
cation transport GO:0006812 331 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
regulation of cell cycle process GO:0010564 266 0.013
organelle localization GO:0051640 84 0.013
nitrogen compound transport GO:0071705 191 0.013
blastoderm segmentation GO:0007350 2 0.013
regulation of locomotion GO:0040012 329 0.013
endomembrane system organization GO:0010256 196 0.013
protein acetylation GO:0006473 116 0.013
small molecule biosynthetic process GO:0044283 157 0.013
ribosome localization GO:0033750 4 0.013
regulation of endopeptidase activity GO:0052548 170 0.013
i kappab kinase nf kappab signaling GO:0007249 166 0.013
neurological system process GO:0050877 163 0.013
ion homeostasis GO:0050801 230 0.012
negative regulation of protein modification process GO:0031400 200 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
maintenance of location GO:0051235 112 0.012
developmental process involved in reproduction GO:0003006 66 0.012
response to nitrogen compound GO:1901698 184 0.012
metal ion transport GO:0030001 272 0.012
dna geometric change GO:0032392 32 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
immune system development GO:0002520 195 0.012
multi organism cellular process GO:0044764 156 0.012
regulation of membrane potential GO:0042391 95 0.012
cellular ion homeostasis GO:0006873 168 0.012
purine nucleoside monophosphate catabolic process GO:0009128 158 0.012
dephosphorylation GO:0016311 209 0.012
regulation of dna metabolic process GO:0051052 153 0.012
cellular protein catabolic process GO:0044257 261 0.011
protein stabilization GO:0050821 64 0.011
peptidyl lysine acetylation GO:0018394 101 0.011
mapk cascade GO:0000165 288 0.011
negative regulation of growth GO:0045926 97 0.011
protein modification by small protein removal GO:0070646 92 0.011
cell morphogenesis GO:0000902 296 0.011
response to oxygen containing compound GO:1901700 369 0.011
protein localization to organelle GO:0033365 280 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
hematopoietic stem cell differentiation GO:0060218 4 0.011
gene silencing GO:0016458 49 0.011
signal transduction by phosphorylation GO:0023014 297 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
mrna metabolic process GO:0016071 175 0.011
histone methylation GO:0016571 60 0.011
cell cycle checkpoint GO:0000075 117 0.011
negative regulation of kinase activity GO:0033673 106 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.010
secretion GO:0046903 254 0.010
nuclear transport GO:0051169 179 0.010
regulation of ion transport GO:0043269 189 0.010
regulation of protein processing GO:0070613 150 0.010
organic acid biosynthetic process GO:0016053 97 0.010
regulation of protein maturation GO:1903317 150 0.010
negative regulation of cell cycle GO:0045786 193 0.010
atp catabolic process GO:0006200 157 0.010
development of primary sexual characteristics GO:0045137 35 0.010
anatomical structure formation involved in morphogenesis GO:0048646 284 0.010
epithelium development GO:0060429 227 0.010

EIF2B1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.031
inherited metabolic disorder DOID:655 242 0.027
primary ciliary dyskinesia DOID:9562 27 0.017
congenital disorder of glycosylation type i DOID:0050570 16 0.012
carbohydrate metabolic disorder DOID:2978 55 0.012
congenital disorder of glycosylation DOID:5212 26 0.012
central nervous system disease DOID:331 186 0.011
nervous system disease DOID:863 431 0.011