Homo sapiens

65 known processes

DIS3L2

DIS3 mitotic control homolog (S. cerevisiae)-like 2

(Aliases: FAM6A,MGC42174,FLJ36974)

DIS3L2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neurofilament bundle assembly GO:0033693 2 0.079
cellular response to growth factor stimulus GO:0071363 197 0.071
regulation of cellular amine metabolic process GO:0033238 11 0.070
astrocyte differentiation GO:0048708 4 0.061
cellular amino acid metabolic process GO:0006520 116 0.058
positive regulation of cellular amine metabolic process GO:0033240 7 0.055
protein modification by small protein conjugation GO:0032446 342 0.052
cellular amine metabolic process GO:0044106 41 0.050
regulation of cellular amino acid metabolic process GO:0006521 6 0.048
amine metabolic process GO:0009308 44 0.048
post embryonic development GO:0009791 2 0.047
segmentation GO:0035282 4 0.043
negative regulation of cell cycle GO:0045786 193 0.043
regulation of cellular component movement GO:0051270 334 0.043
posttranscriptional regulation of gene expression GO:0010608 213 0.038
positive regulation of developmental process GO:0051094 314 0.038
positive regulation of cellular component organization GO:0051130 376 0.037
cell development GO:0048468 328 0.036
Mouse
regulation of cell cycle GO:0051726 393 0.034
negative regulation of protein metabolic process GO:0051248 391 0.034
female gamete generation GO:0007292 2 0.034
negative regulation of cell proliferation GO:0008285 228 0.034
regulation of cell differentiation GO:0045595 393 0.033
Mouse
regulation of mapk cascade GO:0043408 262 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.033
regulation of cellular ketone metabolic process GO:0010565 50 0.033
cellular response to dna damage stimulus GO:0006974 379 0.033
determination of adult lifespan GO:0008340 2 0.032
glial cell migration GO:0008347 4 0.032
positive regulation of cell differentiation GO:0045597 211 0.032
glycosyl compound catabolic process GO:1901658 413 0.031
establishment of organelle localization GO:0051656 59 0.031
signal transduction by phosphorylation GO:0023014 297 0.030
negative regulation of synaptic transmission GO:0050805 2 0.029
neurogenesis GO:0022008 169 0.029
mitotic cell cycle GO:0000278 326 0.028
organelle localization GO:0051640 84 0.028
immune response GO:0006955 307 0.028
ras protein signal transduction GO:0007265 73 0.027
locomotory behavior GO:0007626 1 0.027
response to abiotic stimulus GO:0009628 336 0.026
positive regulation of transferase activity GO:0051347 227 0.026
response to oxygen containing compound GO:1901700 369 0.025
regulation of kinase activity GO:0043549 314 0.025
response to salt stress GO:0009651 3 0.025
negative regulation of cellular protein metabolic process GO:0032269 353 0.025
regulation of transferase activity GO:0051338 355 0.025
regulation of cell cycle process GO:0010564 266 0.025
response to other organism GO:0051707 261 0.025
positive regulation of cell development GO:0010720 92 0.025
positive regulation of immune system process GO:0002684 283 0.024
purine nucleotide catabolic process GO:0006195 405 0.024
neurotransmitter secretion GO:0007269 4 0.024
oogenesis GO:0048477 2 0.024
cell morphogenesis GO:0000902 296 0.024
protein catabolic process GO:0030163 325 0.023
nucleoside triphosphate metabolic process GO:0009141 422 0.023
modification dependent protein catabolic process GO:0019941 209 0.023
response to external biotic stimulus GO:0043207 261 0.023
cell adhesion GO:0007155 325 0.023
regulation of proteolysis GO:0030162 293 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
positive regulation of catabolic process GO:0009896 310 0.022
mapk cascade GO:0000165 288 0.022
lipid metabolic process GO:0006629 381 0.022
protein modification by small protein removal GO:0070646 92 0.021
regulation of small gtpase mediated signal transduction GO:0051056 156 0.021
cytokine production GO:0001816 247 0.021
positive regulation of phosphorylation GO:0042327 394 0.020
positive regulation of hydrolase activity GO:0051345 331 0.020
regulation of protein kinase activity GO:0045859 289 0.020
cellular protein catabolic process GO:0044257 261 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.020
cellular component morphogenesis GO:0032989 314 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
protein ubiquitination GO:0016567 314 0.020
negative regulation of developmental process GO:0051093 247 0.020
Mouse
lipid biosynthetic process GO:0008610 177 0.020
ubiquitin dependent protein catabolic process GO:0006511 206 0.020
leukocyte activation GO:0045321 164 0.020
cell cell signaling GO:0007267 155 0.019
protein processing GO:0016485 226 0.019
protein maturation GO:0051604 233 0.019
blastoderm segmentation GO:0007350 2 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
innate immune response GO:0045087 178 0.019
neuroblast proliferation GO:0007405 4 0.019
nucleoside phosphate catabolic process GO:1901292 412 0.019
response to lipid GO:0033993 206 0.019
regulation of cell morphogenesis GO:0022604 153 0.019
response to radiation GO:0009314 151 0.019
apoptotic signaling pathway GO:0097190 268 0.018
regulation of neural precursor cell proliferation GO:2000177 4 0.018
transmembrane transport GO:0055085 399 0.018
cellular response to cytokine stimulus GO:0071345 181 0.018
nucleotide catabolic process GO:0009166 408 0.018
positive regulation of protein phosphorylation GO:0001934 313 0.018
rhythmic behavior GO:0007622 2 0.018
positive regulation of nucleotide catabolic process GO:0030813 185 0.018
peptidyl tyrosine phosphorylation GO:0018108 170 0.018
cellular lipid metabolic process GO:0044255 303 0.018
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
guanosine containing compound catabolic process GO:1901069 239 0.017
response to growth factor GO:0070848 205 0.017
intrinsic apoptotic signaling pathway GO:0097193 127 0.017
cellular ketone metabolic process GO:0042180 80 0.017
mitotic cell cycle phase transition GO:0044772 162 0.017
regulation of mitotic cell cycle phase transition GO:1901990 118 0.017
negative regulation of protein modification process GO:0031400 200 0.017
histone modification GO:0016570 251 0.017
syncytium formation by plasma membrane fusion GO:0000768 2 0.017
positive regulation of cellular catabolic process GO:0031331 284 0.017
negative regulation of catalytic activity GO:0043086 335 0.017
regulation of secretion GO:0051046 194 0.017
positive regulation of protein kinase activity GO:0045860 190 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
protein localization to organelle GO:0033365 280 0.017
gtp catabolic process GO:0006184 237 0.017
purine containing compound catabolic process GO:0072523 411 0.017
positive regulation of kinase activity GO:0033674 204 0.016
regulation of secretion by cell GO:1903530 177 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.016
lung alveolus development GO:0048286 4 0.016
regulation of apoptotic signaling pathway GO:2001233 175 0.016
negative regulation of cell death GO:0060548 345 0.016
gtp metabolic process GO:0046039 239 0.016
response to cytokine GO:0034097 232 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
spermatid differentiation GO:0048515 4 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
neuromuscular junction development GO:0007528 3 0.016
endosomal transport GO:0016197 129 0.016
regulation of cellular response to stress GO:0080135 244 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.016
anterior posterior axis specification GO:0009948 2 0.016
negative regulation of programmed cell death GO:0043069 321 0.016
monocarboxylic acid metabolic process GO:0032787 185 0.016
actin filament based movement GO:0030048 17 0.016
actin mediated cell contraction GO:0070252 12 0.016
cell cycle phase transition GO:0044770 173 0.016
defense response GO:0006952 315 0.016
regulation of neurotransmitter secretion GO:0046928 3 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.016
vesicle organization GO:0016050 62 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
regulation of response to dna damage stimulus GO:2001020 94 0.015
regulation of protein catabolic process GO:0042176 155 0.015
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.015
negative regulation of cell cycle process GO:0010948 121 0.015
negative regulation of multicellular organismal process GO:0051241 317 0.015
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.015
rho protein signal transduction GO:0007266 26 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
tissue regeneration GO:0042246 3 0.015
membrane organization GO:0061024 292 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
dephosphorylation GO:0016311 209 0.015
response to biotic stimulus GO:0009607 276 0.015
secretion by cell GO:0032940 226 0.015
modification dependent macromolecule catabolic process GO:0043632 212 0.015
small molecule biosynthetic process GO:0044283 157 0.015
purine nucleoside catabolic process GO:0006152 398 0.015
cell activation GO:0001775 213 0.015
cytoplasmic transport GO:0016482 379 0.015
nucleoside catabolic process GO:0009164 408 0.014
organophosphate catabolic process GO:0046434 430 0.014
purine nucleoside triphosphate catabolic process GO:0009146 392 0.014
regulation of neurogenesis GO:0050767 82 0.014
regulation of ras protein signal transduction GO:0046578 155 0.014
neuron remodeling GO:0016322 2 0.014
nervous system development GO:0007399 293 0.014
cell cycle checkpoint GO:0000075 117 0.014
negative regulation of apoptotic process GO:0043066 316 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.014
regulation of synaptic plasticity GO:0048167 3 0.014
purine ribonucleoside metabolic process GO:0046128 437 0.014
carbohydrate metabolic process GO:0005975 207 0.014
purine nucleoside triphosphate metabolic process GO:0009144 412 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
ribonucleotide catabolic process GO:0009261 405 0.014
regulation of cell motility GO:2000145 299 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.014
cardiac muscle cell contraction GO:0086003 4 0.014
myoblast fusion GO:0007520 1 0.014
defense response to other organism GO:0098542 129 0.014
spermatid development GO:0007286 4 0.014
inner ear morphogenesis GO:0042472 4 0.014
actin filament based process GO:0030029 224 0.014
positive regulation of immune response GO:0050778 159 0.013
regeneration GO:0031099 4 0.013
cytokinesis GO:0000910 96 0.013
positive regulation of transport GO:0051050 336 0.013
biological adhesion GO:0022610 331 0.013
regulation of cytokine production GO:0001817 232 0.013
activation of protein kinase activity GO:0032147 90 0.013
response to bacterium GO:0009617 144 0.013
organic acid biosynthetic process GO:0016053 97 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
regulation of ras gtpase activity GO:0032318 128 0.013
spinal cord development GO:0021510 4 0.013
ribonucleoside triphosphate catabolic process GO:0009203 391 0.013
regulation of hormone levels GO:0010817 125 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
regulation of locomotion GO:0040012 329 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
peripheral nervous system development GO:0007422 2 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
regulation of defense response GO:0031347 154 0.013
epithelial cell differentiation GO:0030855 141 0.013
positive regulation of nervous system development GO:0051962 54 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
negative regulation of cellular component organization GO:0051129 235 0.013
regulation of gtpase activity GO:0043087 180 0.013
regulation of immune response GO:0050776 201 0.013
negative regulation of cell cycle phase transition GO:1901988 89 0.013
regulation of nervous system development GO:0051960 88 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
memory GO:0007613 3 0.013
positive regulation of mapk cascade GO:0043410 190 0.013
negative regulation of protein processing GO:0010955 142 0.013
rna interference GO:0016246 4 0.013
purine ribonucleotide catabolic process GO:0009154 404 0.013
vesicle mediated transport GO:0016192 371 0.013
positive regulation of leukocyte activation GO:0002696 80 0.013
cilium organization GO:0044782 68 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.013
oocyte development GO:0048599 1 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
oxidation reduction process GO:0055114 396 0.012
regulation of cellular protein catabolic process GO:1903362 96 0.012
peptidyl lysine modification GO:0018205 144 0.012
organelle assembly GO:0070925 176 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
cell differentiation in spinal cord GO:0021515 1 0.012
adult locomotory behavior GO:0008344 1 0.012
ventral spinal cord development GO:0021517 1 0.012
regulation of protein localization GO:0032880 296 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
translation GO:0006412 132 0.012
immune response regulating signaling pathway GO:0002764 97 0.012
response to inorganic substance GO:0010035 127 0.012
regulation of dephosphorylation GO:0035303 96 0.012
ribonucleoside monophosphate metabolic process GO:0009161 187 0.012
mrna metabolic process GO:0016071 175 0.012
organonitrogen compound biosynthetic process GO:1901566 200 0.012
regulation of cell adhesion GO:0030155 166 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
regulation of protein transport GO:0051223 213 0.012
regulation of growth GO:0040008 165 0.012
endothelial cell migration GO:0043542 86 0.012
dna damage checkpoint GO:0000077 68 0.012
monovalent inorganic cation transport GO:0015672 128 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
regulation of cell projection organization GO:0031344 107 0.012
negative regulation of transport GO:0051051 176 0.012
stress activated protein kinase signaling cascade GO:0031098 94 0.012
hindbrain development GO:0030902 3 0.012
autophagic cell death GO:0048102 3 0.012
peptidyl serine phosphorylation GO:0018105 101 0.012
nucleoside triphosphate catabolic process GO:0009143 394 0.012
neuron projection development GO:0031175 106 0.012
dna repair GO:0006281 198 0.012
response to extracellular stimulus GO:0009991 85 0.012
neuron differentiation GO:0030182 138 0.012
negative regulation of protein maturation GO:1903318 142 0.012
nitrogen compound transport GO:0071705 191 0.012
regulation of intracellular transport GO:0032386 195 0.012
positive regulation of proteolysis GO:0045862 142 0.012
regulation of neuroblast proliferation GO:1902692 3 0.012
response to ionizing radiation GO:0010212 65 0.012
response to metal ion GO:0010038 84 0.011
cation transport GO:0006812 331 0.011
multicellular organismal aging GO:0010259 3 0.011
response to wounding GO:0009611 168 0.011
negative regulation of multi organism process GO:0043901 92 0.011
response to molecule of bacterial origin GO:0002237 82 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
regulation of vesicle mediated transport GO:0060627 130 0.011
microtubule based process GO:0007017 210 0.011
response to fungus GO:0009620 4 0.011
generation of neurons GO:0048699 152 0.011
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.011
protein stabilization GO:0050821 64 0.011
negative regulation of phosphate metabolic process GO:0045936 267 0.011
cell division GO:0051301 168 0.011
fatty acid metabolic process GO:0006631 115 0.011
synaptic vesicle exocytosis GO:0016079 3 0.011
regulation of leukocyte activation GO:0002694 115 0.011
reproductive process GO:0022414 106 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
regulation of nucleotide catabolic process GO:0030811 205 0.011
negative regulation of transferase activity GO:0051348 124 0.011
protein polyubiquitination GO:0000209 110 0.011
compound eye development GO:0048749 1 0.011
regulation of lymphocyte activation GO:0051249 103 0.011
response to nutrient levels GO:0031667 81 0.011
neurofilament cytoskeleton organization GO:0060052 2 0.011
positive regulation of ras gtpase activity GO:0032320 117 0.011
negative regulation of secretion by cell GO:1903531 52 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
metencephalon development GO:0022037 2 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.010
activation of immune response GO:0002253 114 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.010
cilium morphogenesis GO:0060271 75 0.010
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.010
single organism membrane organization GO:0044802 268 0.010
response to organic cyclic compound GO:0014070 204 0.010
negative regulation of proteolysis GO:0045861 132 0.010
sensory perception of pain GO:0019233 4 0.010
negative regulation of secretion GO:0051048 58 0.010
nuclear transport GO:0051169 179 0.010
oocyte differentiation GO:0009994 2 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.010
immune effector process GO:0002252 159 0.010
protein localization to nucleus GO:0034504 136 0.010
regulation of synaptic vesicle exocytosis GO:2000300 2 0.010
cell projection organization GO:0030030 252 0.010
protein autophosphorylation GO:0046777 123 0.010
internal peptidyl lysine acetylation GO:0018393 97 0.010
protein homooligomerization GO:0051260 100 0.010
chromosome segregation GO:0007059 114 0.010
positive regulation of innate immune response GO:0045089 79 0.010
stress activated mapk cascade GO:0051403 93 0.010
motor neuron axon guidance GO:0008045 2 0.010

DIS3L2 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.047
sensory system disease DOID:0050155 203 0.028
nervous system disease DOID:863 431 0.028
disease of metabolism DOID:0014667 295 0.025
muscular disease DOID:0080000 114 0.023
muscle tissue disease DOID:66 113 0.022
central nervous system disease DOID:331 186 0.021
myopathy DOID:423 104 0.019
eye and adnexa disease DOID:1492 150 0.017
eye disease DOID:5614 149 0.017
muscular dystrophy DOID:9884 51 0.015
connective tissue disease DOID:65 109 0.014
bone disease DOID:0080001 88 0.012
cancer DOID:162 167 0.012
disease of cellular proliferation DOID:14566 174 0.012
neurodegenerative disease DOID:1289 102 0.012
inherited metabolic disorder DOID:655 242 0.011
organ system cancer DOID:0050686 164 0.011
brain disease DOID:936 73 0.011
retinal disease DOID:5679 118 0.011