Homo sapiens

65 known processes

LIG4

ligase IV, DNA, ATP-dependent

LIG4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna ligation GO:0006266 10 0.999
pro b cell differentiation GO:0002328 1 0.983
Mouse
dna ligation involved in dna repair GO:0051103 4 0.874
v d j recombination GO:0033151 3 0.869
single strand break repair GO:0000012 6 0.595
negative regulation of programmed cell death GO:0043069 321 0.332
Mouse
cellular macromolecule catabolic process GO:0044265 380 0.266
fibroblast proliferation GO:0048144 33 0.237
Mouse
negative regulation of cell death GO:0060548 345 0.230
Mouse
leukocyte differentiation GO:0002521 98 0.204
Mouse
negative regulation of apoptotic process GO:0043066 316 0.200
Mouse
response to radiation GO:0009314 151 0.198
t cell differentiation in thymus GO:0033077 4 0.191
Mouse
cell activation GO:0001775 213 0.187
Mouse
double strand break repair GO:0006302 101 0.186
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.171
Mouse
t cell activation GO:0042110 99 0.161
Mouse
regulation of cell differentiation GO:0045595 393 0.159
Mouse
leukocyte activation GO:0045321 164 0.152
Mouse
lymphocyte activation GO:0046649 133 0.146
Mouse
response to gamma radiation GO:0010332 14 0.140
Mouse
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.131
response to ionizing radiation GO:0010212 65 0.119
nervous system development GO:0007399 293 0.118
Mouse
positive regulation of dna metabolic process GO:0051054 73 0.117
cell development GO:0048468 328 0.115
Mouse
cellular response to dna damage stimulus GO:0006974 379 0.114
leukocyte mediated immunity GO:0002443 59 0.108
Mouse
post embryonic development GO:0009791 2 0.097
lymphocyte mediated immunity GO:0002449 48 0.086
Mouse
positive regulation of cell proliferation GO:0008284 301 0.085
Mouse
regulation of neuron apoptotic process GO:0043523 35 0.082
Mouse
adaptive immune response GO:0002250 49 0.081
Mouse
regulation of cell development GO:0060284 161 0.076
Mouse
positive regulation of cell development GO:0010720 92 0.075
Mouse
cell activation involved in immune response GO:0002263 30 0.071
Mouse
dna catabolic process endonucleolytic GO:0000737 37 0.064
neuron apoptotic process GO:0051402 39 0.064
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.060
Mouse
cellular amine metabolic process GO:0044106 41 0.058
dna repair GO:0006281 198 0.058
regulation of nervous system development GO:0051960 88 0.058
Mouse
response to oxidative stress GO:0006979 121 0.058
non recombinational repair GO:0000726 14 0.057
immune system development GO:0002520 195 0.056
response to abiotic stimulus GO:0009628 336 0.056
dephosphorylation GO:0016311 209 0.055
generation of neurons GO:0048699 152 0.055
Mouse
somatic diversification of immune receptors GO:0002200 8 0.053
regulation of fibroblast proliferation GO:0048145 32 0.051
Mouse
female gamete generation GO:0007292 2 0.049
leukocyte activation involved in immune response GO:0002366 30 0.048
Mouse
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.047
Mouse
hematopoietic or lymphoid organ development GO:0048534 186 0.044
Mouse
b cell activation GO:0042113 33 0.043
Mouse
lymphocyte differentiation GO:0030098 35 0.042
Mouse
response to oxygen containing compound GO:1901700 369 0.040
regulation of cellular amino acid metabolic process GO:0006521 6 0.040
protein catabolic process GO:0030163 325 0.039
lymphocyte activation involved in immune response GO:0002285 20 0.039
Mouse
dna damage response detection of dna damage GO:0042769 3 0.037
nucleoside triphosphate metabolic process GO:0009141 422 0.037
amine metabolic process GO:0009308 44 0.035
immune response GO:0006955 307 0.034
Mouse
carbohydrate metabolic process GO:0005975 207 0.034
positive regulation of nervous system development GO:0051962 54 0.033
Mouse
determination of adult lifespan GO:0008340 2 0.033
regulation of ligase activity GO:0051340 29 0.032
positive regulation of ligase activity GO:0051351 19 0.031
single organism carbohydrate metabolic process GO:0044723 193 0.031
regulation of cellular ketone metabolic process GO:0010565 50 0.029
regulation of dna metabolic process GO:0051052 153 0.028
production of molecular mediator of immune response GO:0002440 37 0.028
Mouse
lipid metabolic process GO:0006629 381 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
ubiquitin dependent protein catabolic process GO:0006511 206 0.025
positive regulation of cellular component organization GO:0051130 376 0.025
cellular ketone metabolic process GO:0042180 80 0.025
cellular amino acid metabolic process GO:0006520 116 0.024
negative regulation of cellular protein metabolic process GO:0032269 353 0.024
immune effector process GO:0002252 159 0.024
Mouse
regulation of cell cycle GO:0051726 393 0.024
regulation of proteolysis GO:0030162 293 0.024
oogenesis GO:0048477 2 0.023
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.023
Mouse
oxidation reduction process GO:0055114 396 0.023
protein maturation GO:0051604 233 0.023
organophosphate catabolic process GO:0046434 430 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.022
wnt signaling pathway GO:0016055 156 0.022
double strand break repair via nonhomologous end joining GO:0006303 10 0.022
cytoplasmic transport GO:0016482 379 0.021
macromolecule glycosylation GO:0043413 63 0.021
positive regulation of nucleoside metabolic process GO:0045979 186 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
receptor metabolic process GO:0043112 81 0.021
lipid biosynthetic process GO:0008610 177 0.021
cellular protein catabolic process GO:0044257 261 0.021
protein processing GO:0016485 226 0.020
rna processing GO:0006396 255 0.019
locomotory behavior GO:0007626 1 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
single organism cellular localization GO:1902580 332 0.019
modification dependent protein catabolic process GO:0019941 209 0.018
metal ion transport GO:0030001 272 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.018
purine nucleotide catabolic process GO:0006195 405 0.018
peptidyl serine phosphorylation GO:0018105 101 0.018
isotype switching GO:0045190 3 0.018
Mouse
protein localization to organelle GO:0033365 280 0.017
regulation of cellular amine metabolic process GO:0033238 11 0.017
posttranscriptional regulation of gene expression GO:0010608 213 0.017
canonical wnt signaling pathway GO:0060070 116 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
protein glycosylation GO:0006486 62 0.017
mitotic nuclear division GO:0007067 119 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
cellular lipid metabolic process GO:0044255 303 0.017
positive regulation of cell differentiation GO:0045597 211 0.016
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
nucleoside catabolic process GO:0009164 408 0.016
regulation of protein kinase activity GO:0045859 289 0.016
glycoprotein biosynthetic process GO:0009101 91 0.016
apoptotic signaling pathway GO:0097190 268 0.016
positive regulation of developmental process GO:0051094 314 0.015
Mouse
phospholipid metabolic process GO:0006644 99 0.015
maintenance of location GO:0051235 112 0.015
cation transport GO:0006812 331 0.015
memory GO:0007613 3 0.015
regulation of cell cycle process GO:0010564 266 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.015
positive regulation of transport GO:0051050 336 0.015
regulation of canonical wnt signaling pathway GO:0060828 88 0.015
ribonucleotide catabolic process GO:0009261 405 0.015
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.015
Mouse
regulation of purine nucleotide catabolic process GO:0033121 205 0.015
negative regulation of cellular component organization GO:0051129 235 0.015
protein ubiquitination GO:0016567 314 0.015
positive regulation of proteolysis GO:0045862 142 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.014
mitotic cell cycle process GO:1903047 286 0.014
purine containing compound catabolic process GO:0072523 411 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.014
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
negative regulation of neuron apoptotic process GO:0043524 23 0.014
Mouse
cell morphogenesis GO:0000902 296 0.014
glycosylation GO:0070085 71 0.014
negative regulation of catalytic activity GO:0043086 335 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
regulation of cell morphogenesis GO:0022604 153 0.014
i kappab kinase nf kappab signaling GO:0007249 166 0.014
protein polyubiquitination GO:0000209 110 0.014
blastoderm segmentation GO:0007350 2 0.014
meiotic chromosome segregation GO:0045132 4 0.013
positive regulation of phosphorylation GO:0042327 394 0.013
neurological system process GO:0050877 163 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
system process GO:0003008 349 0.013
atp catabolic process GO:0006200 157 0.013
chemical homeostasis GO:0048878 306 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
negative regulation of axonogenesis GO:0050771 4 0.013
regulation of endocytosis GO:0030100 72 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.013
regulation of wnt signaling pathway GO:0030111 123 0.013
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
regulation of protein processing GO:0070613 150 0.012
spermatid development GO:0007286 4 0.012
neuromuscular junction development GO:0007528 3 0.012
taxis GO:0042330 157 0.012
regulation of protein stability GO:0031647 87 0.012
nucleoside monophosphate catabolic process GO:0009125 159 0.012
regulation of protein catabolic process GO:0042176 155 0.012
response to inorganic substance GO:0010035 127 0.012
myeloid leukocyte differentiation GO:0002573 60 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
negative regulation of transport GO:0051051 176 0.012
rhythmic behavior GO:0007622 2 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
intracellular protein transport GO:0006886 270 0.012
ribonucleoside catabolic process GO:0042454 406 0.012
myeloid cell differentiation GO:0030099 117 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
regulation of protein localization GO:0032880 296 0.012
cellular component morphogenesis GO:0032989 314 0.012
compound eye development GO:0048749 1 0.011
cellular homeostasis GO:0019725 196 0.011
hemopoiesis GO:0030097 180 0.011
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
myoblast fusion GO:0007520 1 0.011
central nervous system development GO:0007417 123 0.011
Mouse
negative regulation of phosphate metabolic process GO:0045936 267 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
regulation of cellular response to stress GO:0080135 244 0.011
ras protein signal transduction GO:0007265 73 0.011
positive regulation of cell death GO:0010942 263 0.011
translation GO:0006412 132 0.011
single organism membrane organization GO:0044802 268 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
regulation of protein maturation GO:1903317 150 0.011
regulation of meiotic cell cycle GO:0051445 4 0.011
regulation of kinase activity GO:0043549 314 0.011
lysosomal transport GO:0007041 33 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
regulation of gene expression epigenetic GO:0040029 73 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.011
epithelial cell proliferation GO:0050673 128 0.011
spermatid differentiation GO:0048515 4 0.011
regulation of response to external stimulus GO:0032101 222 0.011
regulation of cytokine production GO:0001817 232 0.011
cell part morphogenesis GO:0032990 137 0.010
receptor internalization GO:0031623 43 0.010
nuclear transport GO:0051169 179 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.010
modification dependent macromolecule catabolic process GO:0043632 212 0.010
glycerophospholipid metabolic process GO:0006650 84 0.010
negative regulation of protein processing GO:0010955 142 0.010
nucleotide catabolic process GO:0009166 408 0.010
cellular response to oxidative stress GO:0034599 85 0.010
regulation of ras protein signal transduction GO:0046578 155 0.010
negative regulation of proteolysis GO:0045861 132 0.010
biological adhesion GO:0022610 331 0.010
reactive nitrogen species metabolic process GO:2001057 3 0.010
actin cytoskeleton organization GO:0030036 207 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
sequestering of metal ion GO:0051238 24 0.010
protein autophosphorylation GO:0046777 123 0.010

LIG4 disease predictions

Disease DO term ID Size Probability Func Analog Org
epilepsy syndrome DOID:1826 41 0.069
central nervous system disease DOID:331 186 0.069
brain disease DOID:936 73 0.069
electroclinical syndrome DOID:0050701 32 0.069
neonatal period electroclinical syndrome DOID:0050702 19 0.069
nervous system disease DOID:863 431 0.069
bone disease DOID:0080001 88 0.046
musculoskeletal system disease DOID:17 223 0.046
connective tissue disease DOID:65 109 0.046
disease of cellular proliferation DOID:14566 174 0.043
cancer DOID:162 167 0.027
sensory system disease DOID:0050155 203 0.017
organ system cancer DOID:0050686 164 0.014
disease of metabolism DOID:0014667 295 0.014
idiopathic generalized epilepsy DOID:1827 21 0.013
immune system disease DOID:2914 155 0.012
hematopoietic system disease DOID:74 100 0.012
bone remodeling disease DOID:0080005 26 0.011
retinal disease DOID:5679 118 0.011
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011
osteopetrosis DOID:13533 9 0.010
osteosclerosis DOID:4254 16 0.010
immune system cancer DOID:0060083 36 0.006
hematologic cancer DOID:2531 36 0.006
primary immunodeficiency disease DOID:612 36 0.003
bone marrow cancer DOID:4960 10 0.001
combined t cell and b cell immunodeficiency DOID:628 12 0.001
myeloma DOID:0070004 7 0.001