Homo sapiens

45 known processes

PALB2

partner and localizer of BRCA2

(Aliases: PNCA3,DKFZp686E1054,FLJ21816,DKFZp667I166,FANCN)

PALB2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via homologous recombination GO:0000724 50 0.952
recombinational repair GO:0000725 50 0.881
specification of axis polarity GO:0065001 1 0.830
dna recombination GO:0006310 77 0.788
male meiosis GO:0007140 1 0.729
cellular response to dna damage stimulus GO:0006974 379 0.710
oogenesis GO:0048477 2 0.673
anterior posterior axis specification GO:0009948 2 0.621
double strand break repair GO:0006302 101 0.595
dna repair GO:0006281 198 0.494
oocyte maturation GO:0001556 1 0.462
regulation of double strand break repair via homologous recombination GO:0010569 11 0.451
regulation of double strand break repair GO:2000779 22 0.404
female gamete generation GO:0007292 2 0.391
intracellular mrna localization GO:0008298 1 0.281
meiotic chromosome segregation GO:0045132 4 0.252
response to radiation GO:0009314 151 0.196
chromatin modification GO:0016568 298 0.157
double strand break repair via single strand annealing GO:0045002 4 0.146
microtubule organizing center organization GO:0031023 62 0.141
cellular macromolecule catabolic process GO:0044265 380 0.117
reciprocal dna recombination GO:0035825 4 0.113
organelle fission GO:0048285 149 0.113
negative regulation of programmed cell death GO:0043069 321 0.100
microtubule cytoskeleton organization GO:0000226 176 0.097
regulation of dna metabolic process GO:0051052 153 0.091
response to ionizing radiation GO:0010212 65 0.089
telomere maintenance via recombination GO:0000722 4 0.079
protein homooligomerization GO:0051260 100 0.079
dna replication GO:0006260 116 0.078
glycosyl compound catabolic process GO:1901658 413 0.073
internal protein amino acid acetylation GO:0006475 101 0.072
oocyte development GO:0048599 1 0.071
cell development GO:0048468 328 0.071
sister chromatid segregation GO:0000819 54 0.071
post embryonic development GO:0009791 2 0.071
negative regulation of apoptotic process GO:0043066 316 0.067
histone modification GO:0016570 251 0.065
cellular amino acid metabolic process GO:0006520 116 0.061
reciprocal meiotic recombination GO:0007131 4 0.060
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.059
histone acetylation GO:0016573 93 0.058
nuclear division GO:0000280 128 0.058
response to nitrogen compound GO:1901698 184 0.056
meiosis i GO:0007127 4 0.054
regulation of cell cycle GO:0051726 393 0.053
immune system development GO:0002520 195 0.050
ribonucleoside monophosphate metabolic process GO:0009161 187 0.050
rna localization GO:0006403 41 0.047
dna duplex unwinding GO:0032508 30 0.047
single organism reproductive process GO:0044702 98 0.046
reproductive process GO:0022414 106 0.046
pattern specification process GO:0007389 43 0.044
nucleotide catabolic process GO:0009166 408 0.044
negative regulation of cell death GO:0060548 345 0.043
purine ribonucleoside catabolic process GO:0046130 398 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.043
small gtpase mediated signal transduction GO:0007264 78 0.043
response to abiotic stimulus GO:0009628 336 0.042
cytokinesis GO:0000910 96 0.041
positive regulation of cellular amine metabolic process GO:0033240 7 0.040
negative regulation of multicellular organismal process GO:0051241 317 0.040
spermatid development GO:0007286 4 0.040
dna damage induced protein phosphorylation GO:0006975 5 0.039
microtubule based process GO:0007017 210 0.038
growth GO:0040007 202 0.037
intrinsic apoptotic signaling pathway GO:0097193 127 0.036
ras protein signal transduction GO:0007265 73 0.036
oocyte differentiation GO:0009994 2 0.036
purine nucleoside triphosphate catabolic process GO:0009146 392 0.035
negative regulation of protein maturation GO:1903318 142 0.035
ribonucleotide catabolic process GO:0009261 405 0.035
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.033
regulation of establishment of protein localization GO:0070201 242 0.033
cytokine production GO:0001816 247 0.032
cellular response to abiotic stimulus GO:0071214 117 0.032
purine nucleotide catabolic process GO:0006195 405 0.032
negative regulation of developmental process GO:0051093 247 0.032
cell morphogenesis GO:0000902 296 0.030
response to light stimulus GO:0009416 87 0.030
regulation of mitotic cell cycle GO:0007346 189 0.030
cellular macromolecular complex assembly GO:0034622 324 0.030
covalent chromatin modification GO:0016569 254 0.029
dna dependent dna replication GO:0006261 44 0.029
mitotic sister chromatid segregation GO:0000070 53 0.029
chromatin organization GO:0006325 351 0.029
amine metabolic process GO:0009308 44 0.029
regulation of dna repair GO:0006282 47 0.029
lipid metabolic process GO:0006629 381 0.028
response to inorganic substance GO:0010035 127 0.028
negative regulation of protein modification process GO:0031400 200 0.028
histone h3 acetylation GO:0043966 45 0.027
determination of adult lifespan GO:0008340 2 0.027
hematopoietic or lymphoid organ development GO:0048534 186 0.027
ribonucleoside catabolic process GO:0042454 406 0.027
negative regulation of protein metabolic process GO:0051248 391 0.027
purine nucleoside monophosphate metabolic process GO:0009126 186 0.025
apoptotic signaling pathway GO:0097190 268 0.025
negative regulation of cell proliferation GO:0008285 228 0.025
negative regulation of protein processing GO:0010955 142 0.024
chromosome segregation GO:0007059 114 0.024
regulation of protein processing GO:0070613 150 0.024
nucleoside triphosphate catabolic process GO:0009143 394 0.024
response to caffeine GO:0031000 3 0.024
dna catabolic process endonucleolytic GO:0000737 37 0.024
regulation of endopeptidase activity GO:0052548 170 0.024
cellular ketone metabolic process GO:0042180 80 0.024
positive regulation of cytokine production GO:0001819 167 0.024
vesicle mediated transport GO:0016192 371 0.024
protein maturation GO:0051604 233 0.024
regulation of cytokine production GO:0001817 232 0.024
centrosome organization GO:0051297 58 0.023
nucleoside monophosphate catabolic process GO:0009125 159 0.023
nucleoside triphosphate metabolic process GO:0009141 422 0.023
cellular response to ionizing radiation GO:0071479 32 0.023
regulation of protein maturation GO:1903317 150 0.023
response to cytokine GO:0034097 232 0.022
response to organic cyclic compound GO:0014070 204 0.022
negative regulation of cellular component organization GO:0051129 235 0.022
regionalization GO:0003002 29 0.022
hemopoiesis GO:0030097 180 0.021
mitotic cell cycle phase transition GO:0044772 162 0.021
nucleoside phosphate catabolic process GO:1901292 412 0.021
ncrna processing GO:0034470 83 0.021
regulation of response to external stimulus GO:0032101 222 0.020
cellular amine metabolic process GO:0044106 41 0.020
epithelium development GO:0060429 227 0.020
response to oxygen containing compound GO:1901700 369 0.020
regulation of cell cycle g2 m phase transition GO:1902749 22 0.020
protein acylation GO:0043543 138 0.020
peptidyl lysine modification GO:0018205 144 0.020
g2 dna damage checkpoint GO:0031572 26 0.019
regulation of cellular component movement GO:0051270 334 0.019
regulation of cellular ketone metabolic process GO:0010565 50 0.019
regulation of dna recombination GO:0000018 23 0.019
internal peptidyl lysine acetylation GO:0018393 97 0.019
cellular response to radiation GO:0071478 65 0.019
defense response GO:0006952 315 0.019
intracellular protein transport GO:0006886 270 0.019
mitotic cell cycle process GO:1903047 286 0.019
protein localization to organelle GO:0033365 280 0.018
negative regulation of hydrolase activity GO:0051346 182 0.018
cell division GO:0051301 168 0.018
ribonucleoside monophosphate catabolic process GO:0009158 158 0.018
endocytosis GO:0006897 159 0.018
nervous system development GO:0007399 293 0.017
negative regulation of cell cycle GO:0045786 193 0.017
blastocyst development GO:0001824 3 0.017
multicellular organism reproduction GO:0032504 42 0.017
regulation of protein stability GO:0031647 87 0.017
regulation of cellular amine metabolic process GO:0033238 11 0.017
purine ribonucleotide catabolic process GO:0009154 404 0.017
positive regulation of developmental process GO:0051094 314 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
gland development GO:0048732 48 0.016
response to metal ion GO:0010038 84 0.016
cell growth GO:0016049 160 0.016
regulation of intracellular transport GO:0032386 195 0.016
positive regulation of cell cycle GO:0045787 140 0.016
cellular response to nitrogen compound GO:1901699 144 0.016
sister chromatid cohesion GO:0007062 24 0.016
dna packaging GO:0006323 77 0.016
regulation of cell growth GO:0001558 135 0.015
multi organism reproductive process GO:0044703 54 0.015
purine containing compound catabolic process GO:0072523 411 0.015
positive regulation of transport GO:0051050 336 0.015
response to uv GO:0009411 73 0.015
cell cycle checkpoint GO:0000075 117 0.015
chemical homeostasis GO:0048878 306 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.015
actin mediated cell contraction GO:0070252 12 0.015
cellular response to cytokine stimulus GO:0071345 181 0.014
axis specification GO:0009798 12 0.014
innate immune response GO:0045087 178 0.014
lens development in camera type eye GO:0002088 2 0.014
compound eye development GO:0048749 1 0.014
multicellular organismal reproductive process GO:0048609 40 0.014
oxidation reduction process GO:0055114 396 0.014
rna processing GO:0006396 255 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
dna geometric change GO:0032392 32 0.014
meiotic cell cycle GO:0051321 13 0.014
dna damage checkpoint GO:0000077 68 0.013
positive regulation of cellular component organization GO:0051130 376 0.013
atp catabolic process GO:0006200 157 0.013
immune response GO:0006955 307 0.013
head development GO:0060322 108 0.013
positive regulation of cell death GO:0010942 263 0.013
rna catabolic process GO:0006401 71 0.013
reproduction GO:0000003 63 0.013
regulation of protein kinase activity GO:0045859 289 0.013
regulation of dna replication GO:0006275 68 0.013
regulation of protein transport GO:0051223 213 0.013
dna integrity checkpoint GO:0031570 71 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
purine ribonucleoside metabolic process GO:0046128 437 0.013
cellular component morphogenesis GO:0032989 314 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
negative regulation of catalytic activity GO:0043086 335 0.013
response to purine containing compound GO:0014074 40 0.013
protein oligomerization GO:0051259 173 0.013
negative regulation of cellular catabolic process GO:0031330 83 0.013
regulation of locomotion GO:0040012 329 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
regulation of protein catabolic process GO:0042176 155 0.013
regulation of mammary gland epithelial cell proliferation GO:0033599 6 0.012
negative regulation of proteolysis GO:0045861 132 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
negative regulation of dna metabolic process GO:0051053 57 0.012
organophosphate catabolic process GO:0046434 430 0.012
regulation of growth GO:0040008 165 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
gtp catabolic process GO:0006184 237 0.012
hindbrain development GO:0030902 3 0.012
chromosome separation GO:0051304 23 0.012
cellular protein complex assembly GO:0043623 188 0.012
ncrna metabolic process GO:0034660 108 0.012
positive regulation of cellular component biogenesis GO:0044089 158 0.012
protein processing GO:0016485 226 0.012
regulation of immune response GO:0050776 201 0.012
dna double strand break processing GO:0000729 10 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
response to gamma radiation GO:0010332 14 0.012
regulation of leukocyte activation GO:0002694 115 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
g2 m transition of mitotic cell cycle GO:0000086 41 0.012
dorsal ventral pattern formation GO:0009953 15 0.012
protein glycosylation GO:0006486 62 0.012
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.012
protein ubiquitination GO:0016567 314 0.012
multicellular organismal aging GO:0010259 3 0.011
negative regulation of cellular protein metabolic process GO:0032269 353 0.011
positive regulation of catabolic process GO:0009896 310 0.011
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
cell projection organization GO:0030030 252 0.011
negative regulation of cellular protein catabolic process GO:1903363 38 0.011
regulation of mitosis GO:0007088 63 0.011
purine nucleoside monophosphate catabolic process GO:0009128 158 0.011
signal transduction by p53 class mediator GO:0072331 72 0.011
mitochondrion organization GO:0007005 156 0.011
regulation of proteasomal protein catabolic process GO:0061136 87 0.011
single organism cellular localization GO:1902580 332 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
regulation of proteolysis GO:0030162 293 0.011
spermatid differentiation GO:0048515 4 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
tube closure GO:0060606 3 0.011
regulation of protein localization GO:0032880 296 0.011
regulation of cytoskeleton organization GO:0051493 177 0.010
cardiac muscle cell contraction GO:0086003 4 0.010
positive regulation of cell motility GO:2000147 177 0.010
regulation of microtubule cytoskeleton organization GO:0070507 61 0.010
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.010
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.010
tube morphogenesis GO:0035239 95 0.010
regulation of kinase activity GO:0043549 314 0.010
maintenance of location GO:0051235 112 0.010
regulation of cell development GO:0060284 161 0.010
positive regulation of hydrolase activity GO:0051345 331 0.010

PALB2 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.367
disease of cellular proliferation DOID:14566 174 0.367
endocrine gland cancer DOID:170 26 0.243
organ system cancer DOID:0050686 164 0.243
immune system disease DOID:2914 155 0.185
anemia DOID:2355 55 0.185
hematopoietic system disease DOID:74 100 0.185
aplastic anemia DOID:12449 30 0.086
bone marrow disease DOID:4961 31 0.086
breast cancer DOID:1612 21 0.078
thoracic cancer DOID:5093 21 0.078
kidney cancer DOID:263 11 0.073
urinary system cancer DOID:3996 15 0.073
central nervous system disease DOID:331 186 0.027
nervous system disease DOID:863 431 0.027
reproductive organ cancer DOID:193 23 0.022
congenital hypoplastic anemia DOID:1342 26 0.019
fanconi s anemia DOID:13636 16 0.019
prostate cancer DOID:10283 13 0.018
male reproductive organ cancer DOID:3856 16 0.018
neurodegenerative disease DOID:1289 102 0.012
pancreatic cancer DOID:1793 8 0.006