Homo sapiens

0 known processes

CIC

capicua homolog (Drosophila)

(Aliases: KIAA0306)

CIC biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ribonucleotide catabolic process GO:0009261 405 0.447
small gtpase mediated signal transduction GO:0007264 78 0.411
rho protein signal transduction GO:0007266 26 0.355
ribonucleoside triphosphate metabolic process GO:0009199 412 0.355
purine ribonucleoside catabolic process GO:0046130 398 0.340
purine nucleotide catabolic process GO:0006195 405 0.332
purine nucleoside catabolic process GO:0006152 398 0.296
nucleoside catabolic process GO:0009164 408 0.288
ras protein signal transduction GO:0007265 73 0.283
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.276
purine ribonucleotide catabolic process GO:0009154 404 0.244
guanosine containing compound catabolic process GO:1901069 239 0.239
purine nucleoside triphosphate catabolic process GO:0009146 392 0.235
regulation of gtpase activity GO:0043087 180 0.224
nucleoside phosphate catabolic process GO:1901292 412 0.223
nucleotide catabolic process GO:0009166 408 0.219
organophosphate catabolic process GO:0046434 430 0.218
nervous system development GO:0007399 293 0.218
gtp catabolic process GO:0006184 237 0.215
glycosyl compound catabolic process GO:1901658 413 0.213
cell development GO:0048468 328 0.210
regulation of ras protein signal transduction GO:0046578 155 0.197
covalent chromatin modification GO:0016569 254 0.196
purine containing compound catabolic process GO:0072523 411 0.183
cell projection organization GO:0030030 252 0.182
ribonucleoside catabolic process GO:0042454 406 0.180
nucleoside triphosphate catabolic process GO:0009143 394 0.175
positive regulation of gtpase activity GO:0043547 166 0.171
ribonucleoside triphosphate catabolic process GO:0009203 391 0.170
regulation of purine nucleotide catabolic process GO:0033121 205 0.168
neurogenesis GO:0022008 169 0.161
purine nucleoside triphosphate metabolic process GO:0009144 412 0.159
regulation of nucleotide catabolic process GO:0030811 205 0.157
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.153
guanosine containing compound metabolic process GO:1901068 244 0.143
regulation of cell differentiation GO:0045595 393 0.139
regulation of small gtpase mediated signal transduction GO:0051056 156 0.135
positive regulation of cellular catabolic process GO:0031331 284 0.135
positive regulation of cellular component organization GO:0051130 376 0.130
regulation of nucleotide metabolic process GO:0006140 269 0.129
positive regulation of catabolic process GO:0009896 310 0.122
nucleoside triphosphate metabolic process GO:0009141 422 0.121
chromatin organization GO:0006325 351 0.121
post embryonic development GO:0009791 2 0.120
purine ribonucleoside metabolic process GO:0046128 437 0.116
chromatin modification GO:0016568 298 0.115
histone modification GO:0016570 251 0.115
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.114
regulation of purine nucleotide metabolic process GO:1900542 264 0.112
regulation of nucleoside metabolic process GO:0009118 209 0.110
regulation of gtp catabolic process GO:0033124 180 0.109
actin filament based process GO:0030029 224 0.105
positive regulation of ras gtpase activity GO:0032320 117 0.105
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.102
positive regulation of gtp catabolic process GO:0033126 166 0.097
anatomical structure formation involved in morphogenesis GO:0048646 284 0.093
gtp metabolic process GO:0046039 239 0.090
signal transduction by phosphorylation GO:0023014 297 0.089
positive regulation of hydrolase activity GO:0051345 331 0.088
mapk cascade GO:0000165 288 0.088
cellular component morphogenesis GO:0032989 314 0.088
positive regulation of nucleoside metabolic process GO:0045979 186 0.086
positive regulation of rab gtpase activity GO:0032851 39 0.082
cell fate determination GO:0001709 3 0.082
morphogenesis of embryonic epithelium GO:0016331 4 0.081
positive regulation of nucleotide catabolic process GO:0030813 185 0.081
actin cytoskeleton organization GO:0030036 207 0.081
regulation of cell cycle GO:0051726 393 0.078
positive regulation of nucleotide metabolic process GO:0045981 230 0.078
regulation of cellular component biogenesis GO:0044087 281 0.075
protein localization to membrane GO:0072657 160 0.074
multicellular organismal aging GO:0010259 3 0.072
regulation of ras gtpase activity GO:0032318 128 0.071
cell morphogenesis GO:0000902 296 0.069
regulation of rho gtpase activity GO:0032319 66 0.067
g protein coupled receptor signaling pathway GO:0007186 207 0.066
regulation of cell development GO:0060284 161 0.065
taxis GO:0042330 157 0.064
neuron differentiation GO:0030182 138 0.064
regulation of cytoskeleton organization GO:0051493 177 0.064
nitrogen compound transport GO:0071705 191 0.062
negative regulation of cellular component organization GO:0051129 235 0.061
membrane organization GO:0061024 292 0.061
regulation of rho protein signal transduction GO:0035023 79 0.060
positive regulation of cellular component biogenesis GO:0044089 158 0.058
regulation of neuron differentiation GO:0045664 70 0.056
rab protein signal transduction GO:0032482 4 0.056
positive regulation of organelle organization GO:0010638 195 0.055
cell projection morphogenesis GO:0048858 129 0.055
cell part morphogenesis GO:0032990 137 0.055
cellular macromolecular complex assembly GO:0034622 324 0.055
neuromuscular junction development GO:0007528 3 0.054
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.053
determination of adult lifespan GO:0008340 2 0.052
actin filament organization GO:0007015 128 0.050
vesicle mediated transport GO:0016192 371 0.050
regulation of nervous system development GO:0051960 88 0.049
cellular response to oxygen containing compound GO:1901701 276 0.048
response to abiotic stimulus GO:0009628 336 0.048
negative regulation of cell death GO:0060548 345 0.048
positive regulation of rho gtpase activity GO:0032321 56 0.048
ion transmembrane transport GO:0034220 338 0.047
histone acetylation GO:0016573 93 0.047
single organism membrane organization GO:0044802 268 0.046
generation of neurons GO:0048699 152 0.046
memory GO:0007613 3 0.046
microtubule cytoskeleton organization GO:0000226 176 0.044
regulation of cell projection organization GO:0031344 107 0.044
regulation of transferase activity GO:0051338 355 0.044
regulation of kinase activity GO:0043549 314 0.044
intracellular protein transport GO:0006886 270 0.043
regulation of anatomical structure morphogenesis GO:0022603 286 0.043
cell morphogenesis involved in differentiation GO:0000904 144 0.043
regulation of cellular amino acid metabolic process GO:0006521 6 0.043
protein ubiquitination GO:0016567 314 0.042
microtubule based process GO:0007017 210 0.041
ribonucleoside monophosphate metabolic process GO:0009161 187 0.040
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.040
response to oxygen containing compound GO:1901700 369 0.039
positive regulation of protein phosphorylation GO:0001934 313 0.039
regulation of synaptic plasticity GO:0048167 3 0.038
regulation of cellular response to stress GO:0080135 244 0.038
biological adhesion GO:0022610 331 0.038
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 2 0.037
female gamete generation GO:0007292 2 0.037
regulation of rab gtpase activity GO:0032313 39 0.037
cellular protein complex assembly GO:0043623 188 0.037
positive regulation of protein complex assembly GO:0031334 86 0.037
oogenesis GO:0048477 2 0.037
regulation of cell cycle process GO:0010564 266 0.037
protein autophosphorylation GO:0046777 123 0.036
histone lysine methylation GO:0034968 50 0.036
mitotic cell cycle GO:0000278 326 0.036
segmentation GO:0035282 4 0.035
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.035
cellular amino acid metabolic process GO:0006520 116 0.035
regulation of protein localization GO:0032880 296 0.035
negative regulation of catalytic activity GO:0043086 335 0.034
protein targeting GO:0006605 187 0.034
neuron projection development GO:0031175 106 0.034
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.034
cellular response to dna damage stimulus GO:0006974 379 0.034
peptidyl lysine modification GO:0018205 144 0.034
single organism cellular localization GO:1902580 332 0.033
purine nucleoside monophosphate metabolic process GO:0009126 186 0.033
regulation of response to external stimulus GO:0032101 222 0.033
regulation of microtubule cytoskeleton organization GO:0070507 61 0.033
peptidyl serine phosphorylation GO:0018105 101 0.032
positive regulation of developmental process GO:0051094 314 0.032
atp catabolic process GO:0006200 157 0.032
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.032
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
central nervous system development GO:0007417 123 0.032
regulation of microtubule based process GO:0032886 74 0.031
cellular response to starvation GO:0009267 58 0.031
chemotaxis GO:0006935 157 0.031
regulation of axon guidance GO:1902667 3 0.031
regulation of neurogenesis GO:0050767 82 0.031
negative regulation of phosphate metabolic process GO:0045936 267 0.030
cellular ketone metabolic process GO:0042180 80 0.030
protein localization to organelle GO:0033365 280 0.030
cytoplasmic transport GO:0016482 379 0.029
cellular lipid metabolic process GO:0044255 303 0.029
internal protein amino acid acetylation GO:0006475 101 0.029
nucleoside monophosphate catabolic process GO:0009125 159 0.028
endomembrane system organization GO:0010256 196 0.028
endosomal transport GO:0016197 129 0.028
purine nucleoside monophosphate catabolic process GO:0009128 158 0.028
inorganic ion transmembrane transport GO:0098660 231 0.027
cell adhesion GO:0007155 325 0.027
somatic stem cell maintenance GO:0035019 4 0.027
regulation of cell adhesion GO:0030155 166 0.027
positive regulation of cell cycle GO:0045787 140 0.027
neurological system process GO:0050877 163 0.025
sensory perception GO:0007600 103 0.025
growth GO:0040007 202 0.025
protein acylation GO:0043543 138 0.025
peptidyl lysine acetylation GO:0018394 101 0.025
regulation of locomotion GO:0040012 329 0.025
regulation of protein complex assembly GO:0043254 147 0.025
cellular response to nutrient levels GO:0031669 69 0.025
apoptotic signaling pathway GO:0097190 268 0.025
embryonic placenta development GO:0001892 1 0.024
amine metabolic process GO:0009308 44 0.024
regulation of cellular ketone metabolic process GO:0010565 50 0.024
regulation of cellular component size GO:0032535 82 0.024
maintenance of location GO:0051235 112 0.024
embryo development GO:0009790 123 0.024
positive regulation of phosphorylation GO:0042327 394 0.024
atp metabolic process GO:0046034 176 0.024
negative regulation of organelle organization GO:0010639 126 0.024
regulation of cell morphogenesis GO:0022604 153 0.024
nucleoside monophosphate metabolic process GO:0009123 191 0.024
peptidyl serine modification GO:0018209 106 0.023
glycerolipid metabolic process GO:0046486 107 0.023
cellular macromolecule catabolic process GO:0044265 380 0.023
system process GO:0003008 349 0.023
epithelium development GO:0060429 227 0.023
plasma membrane organization GO:0007009 115 0.023
brain development GO:0007420 97 0.023
internal peptidyl lysine acetylation GO:0018393 97 0.022
positive regulation of transferase activity GO:0051347 227 0.022
protein modification by small protein conjugation GO:0032446 342 0.022
neural tube formation GO:0001841 3 0.021
cardiovascular system development GO:0072358 262 0.021
negative regulation of developmental process GO:0051093 247 0.021
neural tube closure GO:0001843 3 0.021
nuclear transport GO:0051169 179 0.021
neuron development GO:0048666 113 0.021
cellular chemical homeostasis GO:0055082 180 0.021
regulation of protein kinase activity GO:0045859 289 0.021
neuroblast proliferation GO:0007405 4 0.021
mesonephric duct development GO:0072177 3 0.021
neuron projection morphogenesis GO:0048812 50 0.021
regulation of protein polymerization GO:0032271 63 0.021
protein catabolic process GO:0030163 325 0.021
associative learning GO:0008306 1 0.021
regulation of anatomical structure size GO:0090066 101 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
response to extracellular stimulus GO:0009991 85 0.020
mitotic cell cycle process GO:1903047 286 0.020
regulation of establishment of protein localization GO:0070201 242 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
circulatory system development GO:0072359 262 0.020
regulation of intracellular transport GO:0032386 195 0.020
regulation of neuron projection development GO:0010975 57 0.020
anterior posterior axis specification GO:0009948 2 0.020
embryonic morphogenesis GO:0048598 85 0.019
nucleocytoplasmic transport GO:0006913 176 0.019
cell cycle phase transition GO:0044770 173 0.019
positive regulation of cellular amine metabolic process GO:0033240 7 0.019
circadian behavior GO:0048512 2 0.019
regulation of actin cytoskeleton organization GO:0032956 116 0.019
regulation of actin filament based process GO:0032970 141 0.019
mrna metabolic process GO:0016071 175 0.019
negative regulation of cytoskeleton organization GO:0051494 45 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
positive regulation of cell development GO:0010720 92 0.019
negative regulation of cell cycle GO:0045786 193 0.019
receptor metabolic process GO:0043112 81 0.019
immune response GO:0006955 307 0.019
cell cell signaling GO:0007267 155 0.019
negative regulation of hydrolase activity GO:0051346 182 0.018
regulation of mapk cascade GO:0043408 262 0.018
regulation of cellular component movement GO:0051270 334 0.018
head development GO:0060322 108 0.018
cellular response to growth factor stimulus GO:0071363 197 0.018
spermatid differentiation GO:0048515 4 0.018
cell growth GO:0016049 160 0.018
establishment of protein localization to membrane GO:0090150 121 0.018
positive regulation of locomotion GO:0040017 186 0.018
protein polymerization GO:0051258 71 0.018
regulation of actin filament length GO:0030832 56 0.018
chemical homeostasis GO:0048878 306 0.018
negative regulation of programmed cell death GO:0043069 321 0.018
regulation of rab protein signal transduction GO:0032483 39 0.018
tube closure GO:0060606 3 0.018
compound eye development GO:0048749 1 0.017
histone h3 acetylation GO:0043966 45 0.017
embryonic epithelial tube formation GO:0001838 4 0.017
regulation of cellular amine metabolic process GO:0033238 11 0.017
dephosphorylation GO:0016311 209 0.017
regulation of chromosome organization GO:0033044 103 0.017
i kappab kinase nf kappab signaling GO:0007249 166 0.017
regulation of receptor mediated endocytosis GO:0048259 32 0.017
response to nutrient levels GO:0031667 81 0.017
endocytosis GO:0006897 159 0.017
positive regulation of cell cycle process GO:0090068 106 0.017
protein acetylation GO:0006473 116 0.017
skeletal system development GO:0001501 79 0.017
rna processing GO:0006396 255 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.017
locomotory behavior GO:0007626 1 0.016
regulation of cell motility GO:2000145 299 0.016
positive regulation of cell motility GO:2000147 177 0.016
positive regulation of cytoskeleton organization GO:0051495 83 0.016
blastoderm segmentation GO:0007350 2 0.016
axonogenesis GO:0007409 31 0.016
hindbrain development GO:0030902 3 0.016
macromolecule methylation GO:0043414 97 0.016
organophosphate biosynthetic process GO:0090407 163 0.016
nuclear export GO:0051168 69 0.016
cellular response to extracellular stimulus GO:0031668 72 0.016
negative regulation of protein metabolic process GO:0051248 391 0.016
single organism reproductive process GO:0044702 98 0.016
negative regulation of arp2 3 complex mediated actin nucleation GO:0034316 1 0.016
tissue morphogenesis GO:0048729 96 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.015
receptor internalization GO:0031623 43 0.015
mitotic cell cycle phase transition GO:0044772 162 0.015
cell chemotaxis GO:0060326 112 0.015
cellular homeostasis GO:0019725 196 0.015
viral process GO:0016032 146 0.015
pericardium development GO:0060039 2 0.015
cellular amine metabolic process GO:0044106 41 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
positive regulation of kinase activity GO:0033674 204 0.015
regulation of meiotic cell cycle GO:0051445 4 0.015
response to inorganic substance GO:0010035 127 0.015
regulation of actin filament polymerization GO:0030833 50 0.015
regulation of mitotic cell cycle GO:0007346 189 0.014
transmembrane transport GO:0055085 399 0.014
tube development GO:0035295 125 0.014
Mouse
positive regulation of transport GO:0051050 336 0.014
cell division GO:0051301 168 0.014
dna repair GO:0006281 198 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
negative regulation of multicellular organismal process GO:0051241 317 0.014
somatic stem cell division GO:0048103 1 0.014
long term memory GO:0007616 2 0.014
blood vessel morphogenesis GO:0048514 162 0.014
cell matrix adhesion GO:0007160 85 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
organelle assembly GO:0070925 176 0.014
myosin filament assembly GO:0031034 2 0.014
cellular response to external stimulus GO:0071496 111 0.014
regulation of nucleocytoplasmic transport GO:0046822 98 0.014
regulation of protein serine threonine kinase activity GO:0071900 179 0.014
cell substrate adhesion GO:0031589 132 0.014
regulation of body fluid levels GO:0050878 99 0.013
positive regulation of mapk cascade GO:0043410 190 0.013
metal ion transport GO:0030001 272 0.013
protein alkylation GO:0008213 74 0.013
heart development GO:0007507 95 0.013
regulation of dna metabolic process GO:0051052 153 0.013
primary neural tube formation GO:0014020 3 0.013
nucleosome organization GO:0034728 66 0.013
response to wounding GO:0009611 168 0.013
t cell differentiation in thymus GO:0033077 4 0.013
camp metabolic process GO:0046058 61 0.013
positive regulation of chromosome organization GO:2001252 41 0.013
response to starvation GO:0042594 59 0.013
lipid biosynthetic process GO:0008610 177 0.013
rhythmic behavior GO:0007622 2 0.013
enzyme linked receptor protein signaling pathway GO:0007167 303 0.013
negative regulation of cell differentiation GO:0045596 171 0.013
negative regulation of actin nucleation GO:0051126 3 0.013
mitotic nuclear division GO:0007067 119 0.013
regulation of gene expression epigenetic GO:0040029 73 0.013
regulation of peptidase activity GO:0052547 180 0.013
regulation of response to dna damage stimulus GO:2001020 94 0.013
carbohydrate metabolic process GO:0005975 207 0.013
methylation GO:0032259 106 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
protein targeting to nucleus GO:0044744 104 0.013
actin nucleation GO:0045010 21 0.013
regulation of proteolysis GO:0030162 293 0.013
response to oxygen levels GO:0070482 100 0.013
positive regulation of cell migration GO:0030335 172 0.013
regulation of growth GO:0040008 165 0.012
protein localization to nucleus GO:0034504 136 0.012
cell junction organization GO:0034330 79 0.012
regulation of meiosis GO:0040020 3 0.012
response to growth factor GO:0070848 205 0.012
cell projection assembly GO:0030031 126 0.012
protein processing GO:0016485 226 0.012
t cell selection GO:0045058 4 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
oocyte development GO:0048599 1 0.012
establishment of cell polarity GO:0030010 22 0.012
histone methylation GO:0016571 60 0.012
glycine transport GO:0015816 3 0.012
wnt signaling pathway GO:0016055 156 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
regulation of actin polymerization or depolymerization GO:0008064 56 0.012
regulation of protein catabolic process GO:0042176 155 0.012
somitogenesis GO:0001756 2 0.012
stem cell differentiation GO:0048863 93 0.012
dna templated transcription elongation GO:0006354 25 0.012
peripheral nervous system development GO:0007422 2 0.012
positive regulation of actin filament polymerization GO:0030838 38 0.012
protein dephosphorylation GO:0006470 81 0.012
lymphocyte activation GO:0046649 133 0.012
regulation of cell migration GO:0030334 289 0.011
oocyte differentiation GO:0009994 2 0.011
negative regulation of protein maturation GO:1903318 142 0.011
organ formation GO:0048645 3 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
cell activation GO:0001775 213 0.011
multicellular organismal response to stress GO:0033555 1 0.011
ion homeostasis GO:0050801 230 0.011
angiogenesis GO:0001525 147 0.011
reproductive process GO:0022414 106 0.011
secretion GO:0046903 254 0.011
developmental process involved in reproduction GO:0003006 66 0.011
protein dna complex subunit organization GO:0071824 80 0.011
nucleus localization GO:0051647 1 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.011
striated muscle myosin thick filament assembly GO:0071688 2 0.011
negative regulation of protein modification process GO:0031400 200 0.011
regeneration GO:0031099 4 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
negative regulation of protein processing GO:0010955 142 0.011
cdc42 protein signal transduction GO:0032488 4 0.011
nuclear migration GO:0007097 1 0.011
divalent metal ion transport GO:0070838 152 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
single organism carbohydrate metabolic process GO:0044723 193 0.011
regulation of phosphatase activity GO:0010921 81 0.011
meiotic chromosome segregation GO:0045132 4 0.011
mating GO:0007618 1 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.011
response to oxidative stress GO:0006979 121 0.011
epithelium migration GO:0090132 119 0.011
metencephalon development GO:0022037 2 0.011
regulation of cell growth GO:0001558 135 0.011
single organismal cell cell adhesion GO:0016337 148 0.011
midgut development GO:0007494 1 0.011
spindle organization GO:0007051 53 0.011
negative regulation of axonogenesis GO:0050771 4 0.010
regulation of protein transport GO:0051223 213 0.010
stem cell development GO:0048864 69 0.010
ossification GO:0001503 121 0.010
negative regulation of transport GO:0051051 176 0.010
regulation of cell cycle phase transition GO:1901987 126 0.010
cation transmembrane transport GO:0098655 238 0.010
toxin transport GO:1901998 4 0.010
protein import GO:0017038 130 0.010
retrograde transport endosome to golgi GO:0042147 45 0.010
spermatid development GO:0007286 4 0.010
metanephric nephron tubule morphogenesis GO:0072282 1 0.010
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.010
regulation of vesicle mediated transport GO:0060627 130 0.010
ribonucleoside monophosphate catabolic process GO:0009158 158 0.010
tripartite regional subdivision GO:0007351 2 0.010
reproductive system development GO:0061458 56 0.010
distal tubule development GO:0072017 4 0.010
protein maturation GO:0051604 233 0.010
regulation of secretion GO:0051046 194 0.010

CIC disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.029
nervous system disease DOID:863 431 0.029
immune system disease DOID:2914 155 0.022
musculoskeletal system disease DOID:17 223 0.015
neurodegenerative disease DOID:1289 102 0.012
muscular disease DOID:0080000 114 0.011
muscle tissue disease DOID:66 113 0.011
myopathy DOID:423 104 0.011
muscular dystrophy DOID:9884 51 0.010