Homo sapiens

87 known processes

HAND2

heart and neural crest derivatives expressed 2

(Aliases: Thing2,DHAND2,FLJ16260,bHLHa26,Hed,MGC125303,dHand,MGC125304)

HAND2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cardiac right ventricle morphogenesis GO:0003215 3 0.794
Human Mouse
cranial nerve development GO:0021545 4 0.661
Human
organ morphogenesis GO:0009887 147 0.418
Human Zebrafish Mouse
positive regulation of cell proliferation GO:0008284 301 0.371
cardiovascular system development GO:0072358 262 0.361
cellular ketone metabolic process GO:0042180 80 0.353
Human
nerve development GO:0021675 4 0.289
Human
skeletal system development GO:0001501 79 0.269
Human Zebrafish Mouse
regulation of anatomical structure morphogenesis GO:0022603 286 0.268
Human Mouse
circulatory system development GO:0072359 262 0.264
cardiac cell fate determination GO:0060913 3 0.262
negative regulation of multicellular organismal process GO:0051241 317 0.232
Human Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.222
Human
anatomical structure formation involved in morphogenesis GO:0048646 284 0.216
Human Zebrafish Mouse
system process GO:0003008 349 0.215
Zebrafish
organ formation GO:0048645 3 0.201
Mouse
cell differentiation in spinal cord GO:0021515 1 0.193
regulation of secretion GO:0051046 194 0.183
Human
amine metabolic process GO:0009308 44 0.178
regulation of locomotion GO:0040012 329 0.167
Human
vasculature development GO:0001944 181 0.167
Human Mouse
secretion GO:0046903 254 0.162
Human
regulation of secretion by cell GO:1903530 177 0.156
Human
cell cell signaling GO:0007267 155 0.155
Human
cellular amine metabolic process GO:0044106 41 0.155
regulation of cell differentiation GO:0045595 393 0.154
Human Mouse
regulation of cellular amino acid metabolic process GO:0006521 6 0.149
regulation of interleukin 5 secretion GO:2000662 2 0.149
cell development GO:0048468 328 0.148
Human Mouse Fly
hematopoietic or lymphoid organ development GO:0048534 186 0.143
Human Mouse Fly
regulation of cellular component movement GO:0051270 334 0.137
Human
nervous system development GO:0007399 293 0.134
Human Mouse Fly
positive regulation of cellular amine metabolic process GO:0033240 7 0.131
eosinophil differentiation GO:0030222 2 0.125
hindbrain development GO:0030902 3 0.124
Human
cell morphogenesis GO:0000902 296 0.119
Human Fly
cellular amino acid metabolic process GO:0006520 116 0.114
epithelium development GO:0060429 227 0.112
Zebrafish Mouse Fly
neuron fate commitment GO:0048663 2 0.112
regulation of cellular ketone metabolic process GO:0010565 50 0.111
Human
positive regulation of cell differentiation GO:0045597 211 0.111
Human
positive regulation of cardioblast differentiation GO:0051891 2 0.110
metencephalon development GO:0022037 2 0.104
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.103
cardiac muscle cell contraction GO:0086003 4 0.102
positive regulation of locomotion GO:0040017 186 0.102
Human
regulation of cellular amine metabolic process GO:0033238 11 0.102
regulation of hormone levels GO:0010817 125 0.100
Human
cell fate determination GO:0001709 3 0.098
response to oxygen containing compound GO:1901700 369 0.098
Human
blood vessel morphogenesis GO:0048514 162 0.096
Mouse
interleukin 13 secretion GO:0072611 2 0.095
head development GO:0060322 108 0.094
Human
cellular response to endogenous stimulus GO:0071495 336 0.094
post embryonic development GO:0009791 2 0.092
Worm Fly
extraocular skeletal muscle development GO:0002074 1 0.091
enzyme linked receptor protein signaling pathway GO:0007167 303 0.088
regulation of cell migration GO:0030334 289 0.088
angiogenesis GO:0001525 147 0.088
positive regulation of erythrocyte differentiation GO:0045648 11 0.088
Human
positive regulation of cell motility GO:2000147 177 0.088
Human
secretion by cell GO:0032940 226 0.086
Human
regulation of establishment of protein localization GO:0070201 242 0.085
Human
regulation of stem cell differentiation GO:2000736 56 0.085
Human
cellular component morphogenesis GO:0032989 314 0.085
Human Fly
spinal cord development GO:0021510 4 0.084
negative regulation of programmed cell death GO:0043069 321 0.082
Mouse Fly
stem cell differentiation GO:0048863 93 0.082
Human Zebrafish Mouse
positive regulation of phosphorylation GO:0042327 394 0.082
neuron differentiation GO:0030182 138 0.081
Mouse Fly
specification of organ identity GO:0010092 3 0.080
mesenchyme development GO:0060485 59 0.080
Human Zebrafish Mouse
regulation of cell cycle GO:0051726 393 0.078
Human
neuron projection development GO:0031175 106 0.078
Fly
regulation of protein localization GO:0032880 296 0.077
Human
ventral spinal cord development GO:0021517 1 0.076
positive regulation of transport GO:0051050 336 0.076
Human
positive regulation of protein phosphorylation GO:0001934 313 0.075
menstrual cycle phase GO:0022601 2 0.074
urogenital system development GO:0001655 65 0.073
positive regulation of developmental process GO:0051094 314 0.072
Human Mouse
negative regulation of cell proliferation GO:0008285 228 0.072
heart development GO:0007507 95 0.070
regulation of cytokine production GO:0001817 232 0.070
Human
canonical wnt signaling pathway GO:0060070 116 0.070
cytokine production GO:0001816 247 0.070
Human
actin filament based movement GO:0030048 17 0.070
regulation of protein secretion GO:0050708 86 0.069
Human
regeneration GO:0031099 4 0.069
regulation of myeloid cell differentiation GO:0045637 81 0.068
Human
segmentation GO:0035282 4 0.068
cardiac ventricle formation GO:0003211 2 0.068
Human Mouse
tissue morphogenesis GO:0048729 96 0.068
Human Zebrafish Mouse
actin filament based process GO:0030029 224 0.066
cellular response to dna damage stimulus GO:0006974 379 0.065
Human
negative regulation of developmental process GO:0051093 247 0.064
Human Mouse
neurogenesis GO:0022008 169 0.064
Mouse Fly
positive regulation of immune system process GO:0002684 283 0.064
Human
trophectodermal cell differentiation GO:0001829 3 0.064
Human
chemical homeostasis GO:0048878 306 0.064
atrioventricular valve development GO:0003171 3 0.063
tube morphogenesis GO:0035239 95 0.063
Zebrafish Mouse
generation of neurons GO:0048699 152 0.062
Mouse Fly
cell morphogenesis involved in differentiation GO:0000904 144 0.061
Human Fly
regulation of cellular response to stress GO:0080135 244 0.061
Human
regulation of cell motility GO:2000145 299 0.060
Human
aortic valve development GO:0003176 3 0.060
Human
forebrain regionalization GO:0021871 3 0.058
negative regulation of cell death GO:0060548 345 0.058
Mouse Fly
immune response GO:0006955 307 0.057
growth GO:0040007 202 0.057
hormone secretion GO:0046879 65 0.057
Human
blastoderm segmentation GO:0007350 2 0.056
negative regulation of apoptotic process GO:0043066 316 0.056
Mouse Fly
muscle tissue development GO:0060537 62 0.056
Human
negative regulation of phosphate metabolic process GO:0045936 267 0.055
Human
epithelial cell differentiation GO:0030855 141 0.054
Zebrafish
heart morphogenesis GO:0003007 48 0.054
Human Zebrafish Mouse
forebrain dorsal ventral pattern formation GO:0021798 1 0.054
regulation of protein transport GO:0051223 213 0.054
Human
regulation of body fluid levels GO:0050878 99 0.054
negative regulation of cellular component organization GO:0051129 235 0.053
Human
biological adhesion GO:0022610 331 0.053
cell adhesion GO:0007155 325 0.053
tube development GO:0035295 125 0.052
Zebrafish Mouse Fly
blood vessel development GO:0001568 172 0.051
Human Mouse
cardiac right ventricle formation GO:0003219 1 0.051
Human Mouse
circulatory system process GO:0003013 113 0.051
Zebrafish
response to organic cyclic compound GO:0014070 204 0.050
organonitrogen compound biosynthetic process GO:1901566 200 0.050
Mouse
cellular response to cytokine stimulus GO:0071345 181 0.050
negative regulation of protein metabolic process GO:0051248 391 0.050
Human
kidney development GO:0001822 53 0.050
immune system development GO:0002520 195 0.050
Human Mouse Fly
carbohydrate derivative biosynthetic process GO:1901137 207 0.050
regulation of cardiac muscle tissue growth GO:0055021 4 0.049
cytoplasmic transport GO:0016482 379 0.049
apoptotic signaling pathway GO:0097190 268 0.049
striated muscle tissue development GO:0014706 59 0.049
Human
regulation of cell development GO:0060284 161 0.048
Human
regulation of system process GO:0044057 101 0.048
mesenchymal cell differentiation GO:0048762 52 0.048
Human Mouse
cellular chemical homeostasis GO:0055082 180 0.048
positive regulation of cell death GO:0010942 263 0.048
regulation of cardioblast differentiation GO:0051890 4 0.048
response to lipid GO:0033993 206 0.048
peptidyl tyrosine phosphorylation GO:0018108 170 0.048
positive regulation of catabolic process GO:0009896 310 0.047
Human
regulation of apoptotic signaling pathway GO:2001233 175 0.047
epithelial cell proliferation GO:0050673 128 0.047
response to abiotic stimulus GO:0009628 336 0.046
Human
regulation of protein kinase activity GO:0045859 289 0.046
positive regulation of cellular component organization GO:0051130 376 0.046
Human
central nervous system development GO:0007417 123 0.046
Human
negative regulation of catalytic activity GO:0043086 335 0.046
regulation of blood circulation GO:1903522 59 0.046
signal transduction by phosphorylation GO:0023014 297 0.046
regulation of epithelial cell proliferation GO:0050678 113 0.045
positive regulation of cytokine production GO:0001819 167 0.045
Human
lipid metabolic process GO:0006629 381 0.044
Human
coagulation GO:0050817 78 0.044
response to cytokine GO:0034097 232 0.044
positive regulation of stem cell differentiation GO:2000738 29 0.044
Human
positive regulation of apoptotic process GO:0043065 246 0.044
cardiac muscle contraction GO:0060048 34 0.043
regulation of cardiac muscle cell proliferation GO:0060043 4 0.043
mitotic cell cycle GO:0000278 326 0.043
Human
response to wounding GO:0009611 168 0.043
heart contraction GO:0060047 62 0.043
Zebrafish
regulation of transferase activity GO:0051338 355 0.042
regulation of heart growth GO:0060420 4 0.042
negative regulation of cellular component movement GO:0051271 106 0.042
hemostasis GO:0007599 76 0.042
cellular response to oxygen containing compound GO:1901701 276 0.042
cardiac chamber development GO:0003205 30 0.042
Human Mouse
striated muscle contraction GO:0006941 52 0.042
regulation of response to external stimulus GO:0032101 222 0.041
locomotory behavior GO:0007626 1 0.041
determination of adult lifespan GO:0008340 2 0.041
negative regulation of locomotion GO:0040013 118 0.041
embryonic forelimb morphogenesis GO:0035115 4 0.040
defense response GO:0006952 315 0.040
prostate gland morphogenesis GO:0060512 1 0.040
negative regulation of cell differentiation GO:0045596 171 0.040
Human Mouse
enteric nervous system development GO:0048484 1 0.040
female gamete generation GO:0007292 2 0.039
peptidyl tyrosine modification GO:0018212 170 0.039
cellular lipid metabolic process GO:0044255 303 0.039
Human
response to biotic stimulus GO:0009607 276 0.038
embryonic camera type eye formation GO:0060900 2 0.038
Human
behavior GO:0007610 112 0.038
Mouse
positive regulation of secretion by cell GO:1903532 108 0.038
Human
multicellular organismal aging GO:0010259 3 0.038
heart formation GO:0060914 2 0.038
Mouse
regulation of growth GO:0040008 165 0.038
positive regulation of secretion GO:0051047 116 0.038
Human
response to other organism GO:0051707 261 0.038
regulation of nervous system development GO:0051960 88 0.038
stem cell development GO:0048864 69 0.037
Human Mouse
renal system development GO:0072001 63 0.037
cellular homeostasis GO:0019725 196 0.037
oxidation reduction process GO:0055114 396 0.037
Human
positive regulation of protein transport GO:0051222 135 0.037
Human
hormone metabolic process GO:0042445 61 0.037
transmembrane transport GO:0055085 399 0.036
negative regulation of cell cycle GO:0045786 193 0.036
regulation of kinase activity GO:0043549 314 0.036
digestive system development GO:0055123 75 0.036
Zebrafish
forelimb morphogenesis GO:0035136 4 0.036
blood coagulation GO:0007596 76 0.035
ion homeostasis GO:0050801 230 0.035
positive regulation of monocyte chemotactic protein 1 production GO:0071639 3 0.035
Human
neuron development GO:0048666 113 0.035
Mouse Fly
wnt signaling pathway GO:0016055 156 0.035
copulation GO:0007620 1 0.035
pattern specification process GO:0007389 43 0.035
Zebrafish Mouse
regulation of vasculature development GO:1901342 97 0.035
cellular response to hormone stimulus GO:0032870 125 0.035
negative regulation of intracellular signal transduction GO:1902532 183 0.035
Human
positive regulation of organelle organization GO:0010638 195 0.034
Human
negative regulation of cell migration GO:0030336 102 0.034
endocardial cushion development GO:0003197 3 0.034
single organism cellular localization GO:1902580 332 0.034
positive regulation of cellular component movement GO:0051272 181 0.034
Human
regulation of cell cycle process GO:0010564 266 0.034
regulation of neural precursor cell proliferation GO:2000177 4 0.034
cardiac muscle tissue development GO:0048738 39 0.034
Human
wound healing GO:0042060 115 0.034
regulation of homeostatic process GO:0032844 121 0.034
Human
leukocyte migration GO:0050900 107 0.034
associative learning GO:0008306 1 0.033
cell proliferation involved in heart valve development GO:2000793 1 0.033
Human
mapk cascade GO:0000165 288 0.033
neuromuscular junction development GO:0007528 3 0.033
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.033
Human Mouse
blastocyst formation GO:0001825 3 0.033
Human
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.033
Human
positive regulation of cell migration GO:0030335 172 0.033
morphogenesis of a polarized epithelium GO:0001738 3 0.033
Zebrafish
striated muscle adaptation GO:0014888 4 0.033
cell type specific apoptotic process GO:0097285 125 0.033
Mouse
muscle contraction GO:0006936 73 0.033
regulation of response to wounding GO:1903034 101 0.032
muscle system process GO:0003012 81 0.032
mesenchymal cell development GO:0014031 50 0.032
Human Mouse
blood circulation GO:0008015 113 0.032
Zebrafish
male genitalia development GO:0030539 1 0.032
regulation of mapk cascade GO:0043408 262 0.032
cardiac ventricle morphogenesis GO:0003208 20 0.032
Human Mouse
regulation of protein complex assembly GO:0043254 147 0.032
Human
histone modification GO:0016570 251 0.032
Human
positive regulation of cell cycle GO:0045787 140 0.031
Human
negative regulation of phosphorus metabolic process GO:0010563 267 0.031
Human
small gtpase mediated signal transduction GO:0007264 78 0.031
oogenesis GO:0048477 2 0.031
regulation of actin filament based process GO:0032970 141 0.031
positive regulation of cellular catabolic process GO:0031331 284 0.031
Human
myeloid leukocyte differentiation GO:0002573 60 0.031
Human
megakaryocyte differentiation GO:0030219 25 0.031
Human
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.031
muscle organ morphogenesis GO:0048644 19 0.031
Human
positive regulation of programmed cell death GO:0043068 249 0.031
dna repair GO:0006281 198 0.031
Human
regulation of mitotic cell cycle GO:0007346 189 0.031
Human
cardiac chamber formation GO:0003207 2 0.031
Human Mouse
blastocyst development GO:0001824 3 0.031
Human
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.030
second messenger mediated signaling GO:0019932 78 0.030
Human
forebrain generation of neurons GO:0021872 3 0.030
protein localization to organelle GO:0033365 280 0.030
cell division GO:0051301 168 0.030
Human
negative regulation of phosphorylation GO:0042326 174 0.030
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.030
Human
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.030
chromatin organization GO:0006325 351 0.030
Human
regulation of cell growth GO:0001558 135 0.029
response to hormone GO:0009725 175 0.029
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.029
Human
tissue regeneration GO:0042246 3 0.029
reactive oxygen species metabolic process GO:0072593 75 0.029
response to external biotic stimulus GO:0043207 261 0.029
regulation of interleukin 13 secretion GO:2000665 2 0.029
embryonic organ development GO:0048568 36 0.029
Human Zebrafish Mouse Fly
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 1 0.029
chemotaxis GO:0006935 157 0.029
regulation of protein serine threonine kinase activity GO:0071900 179 0.029
ameboidal type cell migration GO:0001667 135 0.029
Mouse
cardioblast cell fate commitment GO:0042684 1 0.029
cerebellum development GO:0021549 2 0.028
Human
cell part morphogenesis GO:0032990 137 0.028
Fly
regulation of angiogenesis GO:0045765 92 0.028
response to hypoxia GO:0001666 96 0.028
Human
single organism cell adhesion GO:0098602 179 0.028
regulation of bone mineralization GO:0030500 29 0.028
Human
nitrogen compound transport GO:0071705 191 0.028
Human
muscle structure development GO:0061061 98 0.027
Human
adult locomotory behavior GO:0008344 1 0.027
regulation of dna metabolic process GO:0051052 153 0.027
Human
hemopoiesis GO:0030097 180 0.027
Human Fly
organic hydroxy compound metabolic process GO:1901615 147 0.027
Mouse
immune effector process GO:0002252 159 0.027
response to virus GO:0009615 126 0.027
muscle hypertrophy in response to stress GO:0003299 4 0.027
positive regulation of kinase activity GO:0033674 204 0.027
muscle organ development GO:0007517 56 0.027
Human
regulation of membrane potential GO:0042391 95 0.027
heart valve formation GO:0003188 2 0.027
g protein coupled receptor signaling pathway GO:0007186 207 0.027
glycoprotein metabolic process GO:0009100 110 0.027
cell growth GO:0016049 160 0.027
limbic system development GO:0021761 3 0.027
negative regulation of protein phosphorylation GO:0001933 140 0.027
Human
single organism reproductive process GO:0044702 98 0.026
Worm
epithelial cell fate commitment GO:0072148 3 0.026
chromatin modification GO:0016568 298 0.026
Human
developmental growth GO:0048589 48 0.026
taxis GO:0042330 157 0.026
cell activation GO:0001775 213 0.026
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.026
cell projection morphogenesis GO:0048858 129 0.026
Fly
vesicle mediated transport GO:0016192 371 0.026
axis elongation GO:0003401 4 0.026
negative regulation of cell motility GO:2000146 104 0.026
regionalization GO:0003002 29 0.026
cardiac ventricle development GO:0003231 23 0.025
Human Mouse
embryo development GO:0009790 123 0.025
Human Zebrafish Mouse Worm Fly
aortic valve morphogenesis GO:0003180 3 0.025
Human
cellular macromolecular complex assembly GO:0034622 324 0.025
negative regulation of immune system process GO:0002683 136 0.025
morphogenesis of embryonic epithelium GO:0016331 4 0.025
Zebrafish
mitotic cell cycle process GO:1903047 286 0.025
response to decreased oxygen levels GO:0036293 96 0.025
Human
regulation of muscle contraction GO:0006937 45 0.025
septum secundum development GO:0003285 2 0.025
regulation of multi organism process GO:0043900 157 0.025
cation transmembrane transport GO:0098655 238 0.025
extrinsic apoptotic signaling pathway GO:0097191 119 0.025
organophosphate catabolic process GO:0046434 430 0.025
positive regulation of protein kinase activity GO:0045860 190 0.025
regulation of heart contraction GO:0008016 50 0.025
reactive oxygen species biosynthetic process GO:1903409 4 0.025
cell substrate adhesion GO:0031589 132 0.025
hematopoietic progenitor cell differentiation GO:0002244 38 0.025
Human
bmp signaling pathway GO:0030509 49 0.025
cellular macromolecule catabolic process GO:0044265 380 0.025
embryonic morphogenesis GO:0048598 85 0.025
Human Zebrafish Mouse
response to radiation GO:0009314 151 0.025
response to nitrogen compound GO:1901698 184 0.025
cellular response to abiotic stimulus GO:0071214 117 0.025
ras protein signal transduction GO:0007265 73 0.025
brain development GO:0007420 97 0.025
Human
cellular response to decreased oxygen levels GO:0036294 51 0.024
Human
regulation of binding GO:0051098 111 0.024
noradrenergic neuron differentiation GO:0003357 1 0.024
cytokine secretion GO:0050663 64 0.024
Human
protein catabolic process GO:0030163 325 0.024
prostate gland development GO:0030850 3 0.024
bmp signaling pathway involved in heart development GO:0061312 3 0.024
muscle cell proliferation GO:0033002 35 0.024
cardiac muscle adaptation GO:0014887 4 0.024
mating GO:0007618 1 0.024
digestive tract development GO:0048565 75 0.024
Zebrafish
cardiac left ventricle formation GO:0003218 1 0.024
Human
somitogenesis GO:0001756 2 0.024
regulation of nucleotide metabolic process GO:0006140 269 0.024
tissue migration GO:0090130 119 0.024
fatty acid metabolic process GO:0006631 115 0.024
Human
forebrain neuron differentiation GO:0021879 3 0.024
inner ear morphogenesis GO:0042472 4 0.024
positive regulation of transferase activity GO:0051347 227 0.024
nucleoside phosphate catabolic process GO:1901292 412 0.024
glycoprotein biosynthetic process GO:0009101 91 0.024
membrane organization GO:0061024 292 0.023
response to oxygen levels GO:0070482 100 0.023
Human
memory GO:0007613 3 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
regulation of reactive oxygen species metabolic process GO:2000377 41 0.023
cellular response to gonadotropin stimulus GO:0071371 4 0.023
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.023
cellular response to oxygen levels GO:0071453 55 0.023
Human
regulation of cell morphogenesis GO:0022604 153 0.023
Human
actin mediated cell contraction GO:0070252 12 0.023
cellular lipid catabolic process GO:0044242 65 0.023
Human
positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 3 0.023
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.023
embryonic camera type eye development GO:0031076 2 0.023
Human
hormone transport GO:0009914 68 0.023
Human
positive regulation of organ growth GO:0046622 2 0.023
negative regulation of transport GO:0051051 176 0.023
embryonic skeletal system development GO:0048706 13 0.023
Human Zebrafish
regulation of striated muscle contraction GO:0006942 37 0.023
interleukin 5 secretion GO:0072603 2 0.023
peripheral nervous system development GO:0007422 2 0.022
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 97 0.022
cellular response to hypoxia GO:0071456 51 0.022
Human
regulation of cytoskeleton organization GO:0051493 177 0.022
compound eye development GO:0048749 1 0.022
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.022
Human
negative regulation of cell development GO:0010721 48 0.022
regulation of defense response GO:0031347 154 0.022
cranial nerve morphogenesis GO:0021602 1 0.022
regulation of anatomical structure size GO:0090066 101 0.022
epithelial cell migration GO:0010631 119 0.022
regulation of methylation dependent chromatin silencing GO:0090308 3 0.022
cardiocyte differentiation GO:0035051 23 0.022
Zebrafish Mouse
purine containing compound catabolic process GO:0072523 411 0.022
convergent extension GO:0060026 1 0.022
ribose phosphate biosynthetic process GO:0046390 82 0.021
negative regulation of response to wounding GO:1903035 47 0.021
actin cytoskeleton organization GO:0030036 207 0.021
neuroendocrine cell differentiation GO:0061101 2 0.021
cellular cation homeostasis GO:0030003 163 0.021
positive regulation of protein complex assembly GO:0031334 86 0.021
Human
circadian behavior GO:0048512 2 0.021
negative regulation of protein modification process GO:0031400 200 0.021
Human
cellular response to tumor necrosis factor GO:0071356 63 0.021
single organismal cell cell adhesion GO:0016337 148 0.021
negative regulation of organelle organization GO:0010639 126 0.021
Human
response to growth factor GO:0070848 205 0.021
signal release GO:0023061 70 0.021
Human
cellular response to prostaglandin stimulus GO:0071379 4 0.021
heart process GO:0003015 62 0.021
Zebrafish
regulation of immune response GO:0050776 201 0.021
positive regulation of dna binding GO:0043388 17 0.021
regulation of cellular component biogenesis GO:0044087 281 0.020
Human
positive regulation of lipid metabolic process GO:0045834 50 0.020
Human
ion transmembrane transport GO:0034220 338 0.020
myeloid cell differentiation GO:0030099 117 0.020
Human
positive regulation of mapk cascade GO:0043410 190 0.020
purine nucleoside triphosphate metabolic process GO:0009144 412 0.020
epithelium migration GO:0090132 119 0.020
morphogenesis of an epithelium GO:0002009 60 0.020
Zebrafish Mouse
syncytium formation by plasma membrane fusion GO:0000768 2 0.020
regulation of cell division GO:0051302 116 0.020
Human
protein maturation GO:0051604 233 0.020
nucleocytoplasmic transport GO:0006913 176 0.020
negative regulation of cellular amine metabolic process GO:0033239 3 0.020
single organism membrane organization GO:0044802 268 0.020
rhythmic behavior GO:0007622 2 0.020
regulation of intracellular transport GO:0032386 195 0.020
positive regulation of cell development GO:0010720 92 0.020
Human
glycosyl compound catabolic process GO:1901658 413 0.020
carboxylic acid catabolic process GO:0046395 71 0.020
Human
cellular protein catabolic process GO:0044257 261 0.020
ribonucleoside catabolic process GO:0042454 406 0.020
positive regulation of odontogenesis GO:0042482 3 0.020
positive regulation of cell division GO:0051781 59 0.020
Human
epithelial tube morphogenesis GO:0060562 38 0.020
Zebrafish Mouse
cellular response to oxidative stress GO:0034599 85 0.020
organophosphate biosynthetic process GO:0090407 163 0.020
regulation of muscle organ development GO:0048634 27 0.020
hindlimb morphogenesis GO:0035137 2 0.020
anion transport GO:0006820 161 0.020
protein localization to nucleus GO:0034504 136 0.020
embryonic epithelial tube formation GO:0001838 4 0.020
Zebrafish
nuclear transport GO:0051169 179 0.020
endocrine system development GO:0035270 26 0.020
Zebrafish
cell projection organization GO:0030030 252 0.019
Fly
cell cycle phase transition GO:0044770 173 0.019
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.019
nucleoside triphosphate metabolic process GO:0009141 422 0.019
purine ribonucleoside catabolic process GO:0046130 398 0.019
sensory organ development GO:0007423 52 0.019
Human Mouse
negative regulation of response to external stimulus GO:0032102 83 0.019
regulation of ossification GO:0030278 58 0.019
Human Mouse
receptor guanylyl cyclase signaling pathway GO:0007168 5 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
positive regulation of protein secretion GO:0050714 60 0.019
Human
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
myeloid cell homeostasis GO:0002262 34 0.019
Human
covalent chromatin modification GO:0016569 254 0.019
Human
negative regulation of epithelial cell proliferation GO:0050680 48 0.019
nucleotide biosynthetic process GO:0009165 109 0.019
ribonucleotide catabolic process GO:0009261 405 0.019
purine nucleoside triphosphate catabolic process GO:0009146 392 0.019
regulation of wnt signaling pathway GO:0030111 123 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.019
ribonucleoside triphosphate catabolic process GO:0009203 391 0.019
regulation of proteolysis GO:0030162 293 0.019
myoblast fusion GO:0007520 1 0.019
intracellular protein transport GO:0006886 270 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.019
lipid catabolic process GO:0016042 84 0.019
Human
reactive nitrogen species metabolic process GO:2001057 3 0.019
regulation of ion transmembrane transport GO:0034765 132 0.019

HAND2 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.059
Human
congenital heart disease DOID:1682 16 0.040
tetralogy of fallot DOID:6419 7 0.040
heart disease DOID:114 68 0.040
cardiovascular system disease DOID:1287 106 0.040
heart septal defect DOID:1681 14 0.033
disease of metabolism DOID:0014667 295 0.031
Human
bone disease DOID:0080001 88 0.027
Human
connective tissue disease DOID:65 109 0.027
Human
atrial heart septal defect DOID:1882 8 0.021