Homo sapiens

0 known processes

PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

(Aliases: p55,Rpn5,MGC75406)

PSMD12 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
protein deubiquitination GO:0016579 79 0.973
modification dependent protein catabolic process GO:0019941 209 0.939
cellular macromolecule catabolic process GO:0044265 380 0.917
modification dependent macromolecule catabolic process GO:0043632 212 0.909
ubiquitin dependent protein catabolic process GO:0006511 206 0.905
regulation of proteasomal protein catabolic process GO:0061136 87 0.870
multicellular organismal aging GO:0010259 3 0.865
post embryonic development GO:0009791 2 0.858
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.845
cellular protein catabolic process GO:0044257 261 0.802
protein catabolic process GO:0030163 325 0.794
proteasomal protein catabolic process GO:0010498 176 0.770
protein ubiquitination GO:0016567 314 0.738
protein modification by small protein removal GO:0070646 92 0.683
Yeast
determination of adult lifespan GO:0008340 2 0.677
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.650
cellular response to dna damage stimulus GO:0006974 379 0.542
proteasome regulatory particle assembly GO:0070682 2 0.504
embryo development GO:0009790 123 0.481
Worm
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.473
chromosome segregation GO:0007059 114 0.411
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.396
purine ribonucleoside metabolic process GO:0046128 437 0.367
cellular macromolecular complex assembly GO:0034622 324 0.284
protein modification by small protein conjugation GO:0032446 342 0.263
oogenesis GO:0048477 2 0.239
blastocyst development GO:0001824 3 0.219
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.191
negative regulation of cell death GO:0060548 345 0.186
regulation of cellular protein catabolic process GO:1903362 96 0.175
aging GO:0007568 66 0.153
embryo development ending in birth or egg hatching GO:0009792 34 0.146
Worm
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.135
purine ribonucleoside catabolic process GO:0046130 398 0.134
dna repair GO:0006281 198 0.122
positive regulation of peptidase activity GO:0010952 88 0.112
negative regulation of apoptotic process GO:0043066 316 0.109
regulation of kinase activity GO:0043549 314 0.107
regulation of proteolysis GO:0030162 293 0.103
nucleoside triphosphate catabolic process GO:0009143 394 0.101
nucleoside phosphate catabolic process GO:1901292 412 0.099
negative regulation of protein metabolic process GO:0051248 391 0.097
proteasome assembly GO:0043248 7 0.091
nuclear division GO:0000280 128 0.089
negative regulation of proteolysis GO:0045861 132 0.084
regulation of response to external stimulus GO:0032101 222 0.084
regulation of protein catabolic process GO:0042176 155 0.082
secretion by cell GO:0032940 226 0.075
signal transduction by phosphorylation GO:0023014 297 0.074
purine ribonucleotide catabolic process GO:0009154 404 0.073
cellular protein complex assembly GO:0043623 188 0.068
negative regulation of cellular protein catabolic process GO:1903363 38 0.065
nucleotide catabolic process GO:0009166 408 0.064
purine nucleoside monophosphate catabolic process GO:0009128 158 0.062
glycosyl compound catabolic process GO:1901658 413 0.061
regulation of protein ubiquitination GO:0031396 95 0.061
ribonucleotide catabolic process GO:0009261 405 0.058
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.056
protein k63 linked deubiquitination GO:0070536 21 0.053
multicellular organism reproduction GO:0032504 42 0.051
locomotory behavior GO:0007626 1 0.051
regulation of peptidase activity GO:0052547 180 0.050
reproduction GO:0000003 63 0.050
Worm
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.050
purine nucleoside catabolic process GO:0006152 398 0.048
regulation of transferase activity GO:0051338 355 0.046
regulation of mitotic cell cycle GO:0007346 189 0.045
female gamete generation GO:0007292 2 0.045
regulation of cellular response to stress GO:0080135 244 0.042
negative regulation of cellular protein metabolic process GO:0032269 353 0.042
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.041
negative regulation of phosphorylation GO:0042326 174 0.040
organophosphate catabolic process GO:0046434 430 0.039
negative regulation of catalytic activity GO:0043086 335 0.039
positive regulation of protein catabolic process GO:0045732 75 0.038
microtubule based process GO:0007017 210 0.038
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.038
rna interference GO:0016246 4 0.036
positive regulation of phosphorylation GO:0042327 394 0.036
positive regulation of protein complex assembly GO:0031334 86 0.036
ribonucleoside catabolic process GO:0042454 406 0.036
regulation of protein maturation GO:1903317 150 0.036
chordate embryonic development GO:0043009 34 0.036
secretion GO:0046903 254 0.035
purine nucleotide catabolic process GO:0006195 405 0.035
regulation of cell cycle GO:0051726 393 0.035
negative regulation of protein processing GO:0010955 142 0.035
chromatin organization GO:0006325 351 0.035
regulation of protein processing GO:0070613 150 0.034
defense response GO:0006952 315 0.033
cell morphogenesis involved in differentiation GO:0000904 144 0.032
mitotic spindle organization GO:0007052 27 0.031
regulation of protein serine threonine kinase activity GO:0071900 179 0.031
ribonucleoside triphosphate catabolic process GO:0009203 391 0.031
nucleoside catabolic process GO:0009164 408 0.031
ossification GO:0001503 121 0.030
meiotic chromosome segregation GO:0045132 4 0.029
purine nucleoside triphosphate catabolic process GO:0009146 392 0.029
non recombinational repair GO:0000726 14 0.028
negative regulation of peptidase activity GO:0010466 91 0.027
double strand break repair GO:0006302 101 0.027
negative regulation of protein maturation GO:1903318 142 0.027
positive regulation of cellular catabolic process GO:0031331 284 0.026
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 3 0.026
regulation of protein kinase activity GO:0045859 289 0.026
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.025
spermatid differentiation GO:0048515 4 0.025
chromatin modification GO:0016568 298 0.025
nervous system development GO:0007399 293 0.024
positive regulation of protein ubiquitination GO:0031398 53 0.024
purine containing compound catabolic process GO:0072523 411 0.024
apoptotic signaling pathway GO:0097190 268 0.023
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.023
monoubiquitinated histone deubiquitination GO:0035521 3 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.023
mitotic spindle elongation GO:0000022 4 0.022
mitotic cell cycle process GO:1903047 286 0.022
microtubule cytoskeleton organization GO:0000226 176 0.021
ribonucleoside triphosphate metabolic process GO:0009199 412 0.021
vesicle mediated transport GO:0016192 371 0.021
nucleoside triphosphate metabolic process GO:0009141 422 0.021
protein processing GO:0016485 226 0.021
dna templated transcription initiation GO:0006352 35 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.020
double strand break repair via homologous recombination GO:0000724 50 0.020
apoptotic mitochondrial changes GO:0008637 57 0.020
organelle assembly GO:0070925 176 0.020
mitotic cell cycle GO:0000278 326 0.020
ribonucleoside monophosphate metabolic process GO:0009161 187 0.019
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.019
cellular amine metabolic process GO:0044106 41 0.019
negative regulation of endopeptidase activity GO:0010951 84 0.019
receptor mediated endocytosis GO:0006898 84 0.018
metaphase anaphase transition of cell cycle GO:0044784 21 0.018
chromosome separation GO:0051304 23 0.017
behavior GO:0007610 112 0.017
protein maturation GO:0051604 233 0.017
organelle fission GO:0048285 149 0.017
regulation of protein complex assembly GO:0043254 147 0.017
positive regulation of cellular component biogenesis GO:0044089 158 0.017
regulation of apoptotic signaling pathway GO:2001233 175 0.016
response to biotic stimulus GO:0009607 276 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
nitrogen compound transport GO:0071705 191 0.015
protein targeting GO:0006605 187 0.015
mitochondrion organization GO:0007005 156 0.015
molting cycle GO:0042303 28 0.015
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.015
positive regulation of endopeptidase activity GO:0010950 84 0.015
response to other organism GO:0051707 261 0.015
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.014
chemical homeostasis GO:0048878 306 0.014
recombinational repair GO:0000725 50 0.014
regulation of dna damage response signal transduction by p53 class mediator GO:0043516 20 0.014
protein polyubiquitination GO:0000209 110 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
positive regulation of cell cycle GO:0045787 140 0.014
regulation of locomotion GO:0040012 329 0.014
spindle elongation GO:0051231 4 0.013
protein secretion GO:0009306 98 0.013
system process GO:0003008 349 0.013
anatomical structure homeostasis GO:0060249 100 0.013
positive regulation of kinase activity GO:0033674 204 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
sister chromatid segregation GO:0000819 54 0.012
nucleoside monophosphate metabolic process GO:0009123 191 0.012
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.012
regulation of response to dna damage stimulus GO:2001020 94 0.012
amine metabolic process GO:0009308 44 0.012
neurogenesis GO:0022008 169 0.012
mitotic sister chromatid segregation GO:0000070 53 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
regulation of chromosome organization GO:0033044 103 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.012
negative regulation of programmed cell death GO:0043069 321 0.011
regulation of cellular amino acid metabolic process GO:0006521 6 0.011
protein dna complex subunit organization GO:0071824 80 0.011
covalent chromatin modification GO:0016569 254 0.011
positive regulation of catabolic process GO:0009896 310 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.011
positive regulation of proteolysis GO:0045862 142 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
internal peptidyl lysine acetylation GO:0018393 97 0.011
regulation of signal transduction by p53 class mediator GO:1901796 26 0.011
atp catabolic process GO:0006200 157 0.010
regulation of protein import into nucleus GO:0042306 78 0.010

PSMD12 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.010
nervous system disease DOID:863 431 0.010