Homo sapiens

268 known processes

CD40

CD40 molecule, TNF receptor superfamily member 5

(Aliases: TNFRSF5,Bp50,MGC9013,p50,CDW40)

CD40 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
osteoclast differentiation GO:0030316 21 0.985
Human
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.983
Mouse Rat
adaptive immune response GO:0002250 49 0.955
Human Mouse Rat
hematopoietic or lymphoid organ development GO:0048534 186 0.943
Human
cytokine mediated signaling pathway GO:0019221 109 0.943
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.935
t cell cytokine production GO:0002369 12 0.931
immune system development GO:0002520 195 0.920
Human Mouse Rat
leukocyte differentiation GO:0002521 98 0.902
Human
regulation of cytokine production involved in immune response GO:0002718 22 0.896
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.874
i kappab kinase nf kappab signaling GO:0007249 166 0.864
lymphocyte mediated immunity GO:0002449 48 0.857
Mouse Rat
hemopoiesis GO:0030097 180 0.846
Human
response to cytokine GO:0034097 232 0.836
Human
regulation of leukocyte differentiation GO:1902105 61 0.821
cytokine production involved in immune response GO:0002367 27 0.803
cellular response to biotic stimulus GO:0071216 71 0.798
Human Rat
cellular response to molecule of bacterial origin GO:0071219 62 0.786
Human Rat
signal transduction by phosphorylation GO:0023014 297 0.781
positive regulation of jnk cascade GO:0046330 52 0.780
Human
positive regulation of osteoclast differentiation GO:0045672 9 0.764
positive regulation of map kinase activity GO:0043406 80 0.764
interleukin 2 production GO:0032623 20 0.763
positive regulation of mapk cascade GO:0043410 190 0.757
response to biotic stimulus GO:0009607 276 0.741
Human Mouse Rat
positive regulation of cytokine production GO:0001819 167 0.738
Mouse Rat
positive regulation of immune response GO:0050778 159 0.734
Mouse Rat
defense response GO:0006952 315 0.721
Mouse Rat
regulation of osteoclast differentiation GO:0045670 18 0.715
leukocyte mediated immunity GO:0002443 59 0.671
Mouse Rat
immune response GO:0006955 307 0.654
Human Mouse Rat
myeloid cell differentiation GO:0030099 117 0.653
Human
positive regulation of protein phosphorylation GO:0001934 313 0.639
positive regulation of cell activation GO:0050867 81 0.639
Mouse Rat
positive regulation of stress activated mapk cascade GO:0032874 60 0.639
Human
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.628
Human
regulation of myeloid leukocyte differentiation GO:0002761 39 0.625
positive regulation of protein kinase activity GO:0045860 190 0.619
regulation of lymphocyte mediated immunity GO:0002706 33 0.596
Mouse Rat
regulation of map kinase activity GO:0043405 108 0.578
activation of immune response GO:0002253 114 0.572
activation of nf kappab inducing kinase activity GO:0007250 9 0.564
response to tumor necrosis factor GO:0034612 76 0.562
Human
cellular ketone metabolic process GO:0042180 80 0.558
cellular homeostasis GO:0019725 196 0.555
response to interleukin 1 GO:0070555 47 0.545
cellular response to tumor necrosis factor GO:0071356 63 0.538
Human
immune effector process GO:0002252 159 0.538
Mouse Rat
positive regulation of jun kinase activity GO:0043507 23 0.527
Human
regulation of t cell cytokine production GO:0002724 10 0.526
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.521
Mouse Rat
regulation of mapk cascade GO:0043408 262 0.518
cytokine production GO:0001816 247 0.518
Mouse Rat
positive regulation of t cell cytokine production GO:0002726 4 0.510
positive regulation of interleukin 2 production GO:0032743 11 0.504
positive regulation of leukocyte differentiation GO:1902107 37 0.502
immune response activating signal transduction GO:0002757 90 0.500
positive regulation of transcription regulatory region dna binding GO:2000679 8 0.499
small gtpase mediated signal transduction GO:0007264 78 0.499
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.496
Mouse Rat
extrinsic apoptotic signaling pathway GO:0097191 119 0.496
Human
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.492
regulation of mononuclear cell proliferation GO:0032944 65 0.482
Mouse Rat
regulation of cell differentiation GO:0045595 393 0.476
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.474
Mouse Rat
regulation of leukocyte mediated immunity GO:0002703 38 0.462
Mouse Rat
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.461
Mouse Rat
regulation of myeloid cell differentiation GO:0045637 81 0.449
response to bacterium GO:0009617 144 0.446
Human Rat
regulation of adaptive immune response GO:0002819 33 0.429
Mouse Rat
cellular response to lipid GO:0071396 127 0.428
Human Rat
cell activation GO:0001775 213 0.426
Mouse Rat
cellular response to oxygen containing compound GO:1901701 276 0.425
Human Rat
regulation of immune response GO:0050776 201 0.425
Mouse Rat
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.422
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.412
positive regulation of kinase activity GO:0033674 204 0.407
regulation of jnk cascade GO:0046328 73 0.402
Human
regulation of transferase activity GO:0051338 355 0.402
positive regulation of t cell proliferation GO:0042102 33 0.398
cellular response to lipopolysaccharide GO:0071222 57 0.392
Human Rat
regulation of cellular amino acid metabolic process GO:0006521 6 0.391
regulation of protein serine threonine kinase activity GO:0071900 179 0.386
positive regulation of cellular amine metabolic process GO:0033240 7 0.383
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.383
positive regulation of cell death GO:0010942 263 0.377
positive regulation of developmental process GO:0051094 314 0.375
Mouse Rat
positive regulation of adaptive immune response GO:0002821 21 0.372
Mouse Rat
lymphocyte activation GO:0046649 133 0.372
Mouse Rat
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.372
mapk cascade GO:0000165 288 0.361
regulation of protein kinase activity GO:0045859 289 0.359
regulation of cytokine production GO:0001817 232 0.353
Mouse Rat
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.351
Human
regulation of protein homodimerization activity GO:0043496 9 0.340
cellular response to cytokine stimulus GO:0071345 181 0.339
Human
t cell mediated immunity GO:0002456 25 0.333
regulation of stress activated mapk cascade GO:0032872 84 0.325
Human
activation of protein kinase activity GO:0032147 90 0.324
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.324
Human
positive regulation of immune system process GO:0002684 283 0.323
Mouse Rat
positive regulation of transferase activity GO:0051347 227 0.322
cellular response to mechanical stimulus GO:0071260 39 0.321
positive regulation of cell differentiation GO:0045597 211 0.318
erk1 and erk2 cascade GO:0070371 104 0.315
Human
jnk cascade GO:0007254 80 0.315
Human
positive regulation of apoptotic process GO:0043065 246 0.313
cellular amino acid metabolic process GO:0006520 116 0.306
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.301
myeloid leukocyte differentiation GO:0002573 60 0.300
Human
positive regulation of cell proliferation GO:0008284 301 0.294
Mouse Rat
regulation of kinase activity GO:0043549 314 0.293
response to lipid GO:0033993 206 0.291
Human Rat
response to other organism GO:0051707 261 0.289
Human Mouse Rat
negative regulation of apoptotic process GO:0043066 316 0.286
regulation of production of molecular mediator of immune response GO:0002700 25 0.282
Mouse Rat
t cell receptor signaling pathway GO:0050852 21 0.281
antigen receptor mediated signaling pathway GO:0050851 38 0.281
negative regulation of multicellular organismal process GO:0051241 317 0.273
Human
protein oligomerization GO:0051259 173 0.269
stress activated protein kinase signaling cascade GO:0031098 94 0.267
Human
regulation of apoptotic signaling pathway GO:2001233 175 0.261
Human
response to external biotic stimulus GO:0043207 261 0.258
Human Mouse Rat
regulation of protein binding GO:0043393 66 0.255
protein homotrimerization GO:0070207 9 0.254
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.250
positive regulation of programmed cell death GO:0043068 249 0.249
regulation of rho gtpase activity GO:0032319 66 0.249
rho protein signal transduction GO:0007266 26 0.246
apoptotic signaling pathway GO:0097190 268 0.244
Human
positive regulation of leukocyte mediated immunity GO:0002705 24 0.241
Mouse Rat
regulation of response to external stimulus GO:0032101 222 0.241
regulation of jun kinase activity GO:0043506 27 0.240
Human
regulation of defense response GO:0031347 154 0.236
regulation of interleukin 2 production GO:0032663 19 0.231
positive regulation of lymphocyte activation GO:0051251 73 0.222
Mouse Rat
response to oxygen containing compound GO:1901700 369 0.219
Human Rat
response to lipopolysaccharide GO:0032496 70 0.219
Human Rat
cellular response to external stimulus GO:0071496 111 0.212
protein kinase c signaling GO:0070528 17 0.207
cellular cation homeostasis GO:0030003 163 0.204
cellular amine metabolic process GO:0044106 41 0.196
calcium ion homeostasis GO:0055074 122 0.196
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.195
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.195
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.191
Mouse Rat
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.188
stress activated mapk cascade GO:0051403 93 0.188
Human
regulation of t cell mediated immunity GO:0002709 18 0.184
positive regulation of t helper cell differentiation GO:0045624 2 0.181
ion transmembrane transport GO:0034220 338 0.180
ribonucleoside triphosphate metabolic process GO:0009199 412 0.180
regulation of cellular response to stress GO:0080135 244 0.179
Human
leukocyte activation GO:0045321 164 0.179
Mouse Rat
response to mechanical stimulus GO:0009612 51 0.177
mature natural killer cell chemotaxis GO:0035782 1 0.175
negative regulation of c c chemokine binding GO:2001264 1 0.175
cell type specific apoptotic process GO:0097285 125 0.171
regulation of granzyme a production GO:2000511 1 0.168
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.167
negative regulation of cell proliferation GO:0008285 228 0.165
positive regulation of leukocyte activation GO:0002696 80 0.165
Mouse Rat
regulation of ras protein signal transduction GO:0046578 155 0.164
guanosine containing compound catabolic process GO:1901069 239 0.163
protein homooligomerization GO:0051260 100 0.162
positive regulation of leukocyte proliferation GO:0070665 48 0.160
Mouse Rat
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.160
immune response regulating signaling pathway GO:0002764 97 0.158
Mouse Rat
lipid metabolic process GO:0006629 381 0.157
positive regulation of phosphorylation GO:0042327 394 0.155
ribonucleoside triphosphate catabolic process GO:0009203 391 0.154
positive regulation of t cell mediated immunity GO:0002711 12 0.153
regulation of lymphocyte activation GO:0051249 103 0.149
Mouse Rat
regulation of t cell activation GO:0050863 77 0.148
myeloid dendritic cell chemotaxis GO:0002408 3 0.145
positive regulation of cd8 positive alpha beta t cell proliferation GO:2000566 1 0.139
regulation of protein transport GO:0051223 213 0.138
Mouse Rat
regulation of leukocyte proliferation GO:0070663 67 0.137
Mouse Rat
negative regulation of neurological system process GO:0031645 2 0.135
Human
positive regulation of nik nf kappab signaling GO:1901224 10 0.135
regulation of establishment of protein localization GO:0070201 242 0.135
Mouse Rat
nik nf kappab signaling GO:0038061 12 0.135
positive regulation of immune effector process GO:0002699 40 0.135
Mouse Rat
immunoglobulin secretion GO:0048305 1 0.134
Mouse Rat
negative regulation of alpha beta t cell proliferation GO:0046642 1 0.133
positive regulation of rho gtpase activity GO:0032321 56 0.132
negative regulation of alpha beta t cell activation GO:0046636 3 0.132
positive regulation of myeloid cell differentiation GO:0045639 39 0.130
negative regulation of apoptotic signaling pathway GO:2001234 97 0.129
protein secretion GO:0009306 98 0.127
Mouse Rat
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.127
positive regulation of t cell activation GO:0050870 54 0.125
cellular divalent inorganic cation homeostasis GO:0072503 128 0.125
positive regulation of protein binding GO:0032092 24 0.124
regulation of nik nf kappab signaling GO:1901222 11 0.124
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.124
secretion by cell GO:0032940 226 0.124
Mouse Rat
production of molecular mediator of immune response GO:0002440 37 0.123
Mouse Rat
dendritic cell antigen processing and presentation GO:0002468 1 0.123
lymphocyte proliferation GO:0046651 70 0.123
Mouse Rat
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.122
response to nitric oxide GO:0071731 4 0.121
nitrogen compound transport GO:0071705 191 0.119
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.118
regulation of leukocyte activation GO:0002694 115 0.118
Mouse Rat
positive regulation of apoptotic signaling pathway GO:2001235 70 0.118
Human
regulation of binding GO:0051098 111 0.118
response to virus GO:0009615 126 0.117
Mouse Rat
regulation of gtp catabolic process GO:0033124 180 0.115
positive regulation of defense response GO:0031349 87 0.114
peptidyl tyrosine phosphorylation GO:0018108 170 0.113
nucleotide catabolic process GO:0009166 408 0.111
innate immune response GO:0045087 178 0.109
positive regulation of transport GO:0051050 336 0.108
regulation of purine nucleotide metabolic process GO:1900542 264 0.108
secretion GO:0046903 254 0.108
Mouse Rat
nucleoside triphosphate metabolic process GO:0009141 422 0.107
regulation of ras gtpase activity GO:0032318 128 0.106
cdc42 protein signal transduction GO:0032488 4 0.106
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.106
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.104
regulation of cellular component biogenesis GO:0044087 281 0.103
protein polyubiquitination GO:0000209 110 0.103
response to molecule of bacterial origin GO:0002237 82 0.102
Human Rat
positive regulation of secretion GO:0051047 116 0.101
positive regulation of gtpase activity GO:0043547 166 0.100
regulation of erk1 and erk2 cascade GO:0070372 99 0.100
Human
nucleoside triphosphate catabolic process GO:0009143 394 0.100
regulation of immune effector process GO:0002697 91 0.099
Mouse Rat
protein k63 linked ubiquitination GO:0070534 31 0.099
mononuclear cell proliferation GO:0032943 71 0.099
Mouse Rat
positive regulation of rac gtpase activity GO:0032855 31 0.098
peptidyl serine autophosphorylation GO:0036289 2 0.096
metal ion homeostasis GO:0055065 169 0.095
protein autoubiquitination GO:0051865 37 0.091
negative regulation of t cell cytokine production GO:0002725 4 0.087
regulation of secretion GO:0051046 194 0.086
Mouse Rat
positive regulation of nucleoside metabolic process GO:0045979 186 0.086
tyrosine phosphorylation of stat protein GO:0007260 33 0.086
divalent inorganic cation homeostasis GO:0072507 136 0.085
regulation of purine nucleotide catabolic process GO:0033121 205 0.084
defense response to other organism GO:0098542 129 0.083
Mouse Rat
ras protein signal transduction GO:0007265 73 0.083
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 3 0.082
regulation of lymphocyte proliferation GO:0050670 64 0.082
Mouse Rat
protein ubiquitination GO:0016567 314 0.082
toll like receptor 2 signaling pathway GO:0034134 4 0.081
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.080
ribonucleotide catabolic process GO:0009261 405 0.080
regulation of nucleotide catabolic process GO:0030811 205 0.080
regulation of multi organism process GO:0043900 157 0.080
positive regulation of cellular component movement GO:0051272 181 0.079
biological adhesion GO:0022610 331 0.079
amine metabolic process GO:0009308 44 0.079
regulation of cytokine biosynthetic process GO:0042035 35 0.079
positive regulation of protein kinase c signaling GO:0090037 5 0.079
regulation of sensory perception GO:0051931 3 0.078
cellular macromolecular complex assembly GO:0034622 324 0.077
negative regulation of cd4 positive alpha beta t cell proliferation GO:2000562 1 0.077
nucleoside catabolic process GO:0009164 408 0.076
purine containing compound catabolic process GO:0072523 411 0.076
positive regulation of lymphocyte proliferation GO:0050671 46 0.075
Mouse Rat
positive regulation of protein homodimerization activity GO:0090073 5 0.075
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.075
eosinophil activation involved in immune response GO:0002278 2 0.075
purine nucleotide catabolic process GO:0006195 405 0.075
cellular ion homeostasis GO:0006873 168 0.074
ion homeostasis GO:0050801 230 0.074
positive regulation of mononuclear cell proliferation GO:0032946 47 0.072
Mouse Rat
tumor necrosis factor mediated signaling pathway GO:0033209 27 0.071
Human
positive regulation of ras gtpase activity GO:0032320 117 0.071
positive regulation of cytokine biosynthetic process GO:0042108 25 0.070
regulation of dna binding GO:0051101 37 0.069
regulation of small gtpase mediated signal transduction GO:0051056 156 0.068
regulation of gtpase activity GO:0043087 180 0.068
regulation of interleukin 12 production GO:0032655 15 0.068
Mouse Rat
negative regulation of programmed cell death GO:0043069 321 0.066
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.066
lymphocyte apoptotic process GO:0070227 20 0.065
positive regulation of cellular catabolic process GO:0031331 284 0.064
negative regulation of t cell apoptotic process GO:0070233 4 0.064
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.064
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.063
intracellular protein transport GO:0006886 270 0.062
jak stat cascade GO:0007259 46 0.062
t cell proliferation GO:0042098 45 0.062
positive regulation of cell motility GO:2000147 177 0.062
cation homeostasis GO:0055080 189 0.062
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.061
regulation of protein complex assembly GO:0043254 147 0.061
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 1 0.061
negative regulation of natural killer cell chemotaxis GO:2000502 1 0.061
purine ribonucleotide catabolic process GO:0009154 404 0.061
positive regulation of binding GO:0051099 45 0.060
response to oxidative stress GO:0006979 121 0.060
system process GO:0003008 349 0.060
Human
positive regulation of catabolic process GO:0009896 310 0.060
t helper 1 type immune response GO:0042088 8 0.059
myeloid dendritic cell differentiation GO:0043011 3 0.058
regulation of proteolysis GO:0030162 293 0.058
Human
negative regulation of phosphorus metabolic process GO:0010563 267 0.058
regulation of anatomical structure morphogenesis GO:0022603 286 0.058
regulation of response to wounding GO:1903034 101 0.058
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.057
transmission of nerve impulse GO:0019226 11 0.057
cellular lipid metabolic process GO:0044255 303 0.056
t helper 1 cell differentiation GO:0045063 1 0.056
purine ribonucleoside catabolic process GO:0046130 398 0.056
gtp catabolic process GO:0006184 237 0.055
negative regulation of leukocyte differentiation GO:1902106 24 0.054
response to fungus GO:0009620 4 0.054
cellular chemical homeostasis GO:0055082 180 0.054
regulation of cell motility GO:2000145 299 0.054
positive regulation of alpha beta t cell differentiation GO:0046638 4 0.054
negative regulation of cell differentiation GO:0045596 171 0.053
protein modification by small protein conjugation GO:0032446 342 0.053
multi organism cellular process GO:0044764 156 0.052
cellular protein complex assembly GO:0043623 188 0.051
myeloid leukocyte activation GO:0002274 34 0.050
positive regulation of gtp catabolic process GO:0033126 166 0.050
regulation of wnt signaling pathway GO:0030111 123 0.050
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.050
Human
membrane protein ectodomain proteolysis GO:0006509 33 0.049
Human
granzyme b production GO:0071613 1 0.049
response to reactive oxygen species GO:0000302 61 0.049
cellular response to abiotic stimulus GO:0071214 117 0.049
response to nitrogen compound GO:1901698 184 0.049
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.048
regulation of transcription regulatory region dna binding GO:2000677 15 0.048
positive regulation of cellular component organization GO:0051130 376 0.048
chemical homeostasis GO:0048878 306 0.047
nucleoside phosphate catabolic process GO:1901292 412 0.047
positive regulation of cell migration GO:0030335 172 0.047
regulation of actin filament based process GO:0032970 141 0.046
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.046
protein trimerization GO:0070206 20 0.046
regulation of cell migration GO:0030334 289 0.046
negative regulation of catalytic activity GO:0043086 335 0.045
negative regulation of cellular protein metabolic process GO:0032269 353 0.045
glycosyl compound catabolic process GO:1901658 413 0.045
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.045
negative regulation of cell death GO:0060548 345 0.045
divalent metal ion transport GO:0070838 152 0.044
cell cell signaling GO:0007267 155 0.044
t cell activation GO:0042110 99 0.044
regulation of cellular component movement GO:0051270 334 0.044
regulation of alpha beta t cell activation GO:0046634 13 0.044
positive regulation of cytokine production involved in immune response GO:0002720 6 0.043
positive regulation of interleukin 8 production GO:0032757 36 0.043
female gamete generation GO:0007292 2 0.043
leukocyte activation involved in immune response GO:0002366 30 0.043
Mouse Rat
regulation of rho protein signal transduction GO:0035023 79 0.042
negative regulation of phosphorylation GO:0042326 174 0.042
ossification GO:0001503 121 0.042
regulation of cytokine secretion GO:0050707 57 0.041
positive regulation of leukocyte migration GO:0002687 46 0.041
positive regulation of dna binding GO:0043388 17 0.040
positive regulation of lymphocyte differentiation GO:0045621 13 0.040
positive regulation of response to external stimulus GO:0032103 88 0.040
cd8 positive alpha beta t cell activation GO:0036037 3 0.039
regulation of cellular amine metabolic process GO:0033238 11 0.039
negative regulation of t helper 1 cell activation GO:2000518 1 0.039
astrocyte cell migration GO:0043615 1 0.039
response to growth factor GO:0070848 205 0.039
regulation of endothelial cell apoptotic process GO:2000351 24 0.038
negative regulation of cytokine production GO:0001818 82 0.038
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.037
regulation of secretion by cell GO:1903530 177 0.037
Mouse Rat
sequestering of metal ion GO:0051238 24 0.037
cation transport GO:0006812 331 0.037
regulation of leukocyte apoptotic process GO:2000106 25 0.037
positive regulation of alpha beta t cell activation GO:0046635 10 0.037
transmembrane transport GO:0055085 399 0.037
myoblast fusion GO:0007520 1 0.037
negative regulation of lymphocyte migration GO:2000402 4 0.036
regulation of granzyme b production GO:0071661 1 0.036
glial cell migration GO:0008347 4 0.036
establishment of lymphocyte polarity GO:0001767 2 0.036
regulation of cell adhesion GO:0030155 166 0.036
regulation of regulatory t cell differentiation GO:0045589 4 0.036
neuronal action potential GO:0019228 9 0.036
pattern recognition receptor signaling pathway GO:0002221 48 0.035
regulation of nucleotide metabolic process GO:0006140 269 0.035
reactive oxygen species metabolic process GO:0072593 75 0.035
negative regulation of cellular component organization GO:0051129 235 0.035
oogenesis GO:0048477 2 0.034
guanosine containing compound metabolic process GO:1901068 244 0.034
negative regulation of lymphocyte chemotaxis GO:1901624 2 0.034
cellular calcium ion homeostasis GO:0006874 117 0.034
dendritic cell differentiation GO:0097028 13 0.034
regulation of interferon gamma production GO:0032649 36 0.034
positive regulation of locomotion GO:0040017 186 0.034
t helper cell differentiation GO:0042093 4 0.033
gtp metabolic process GO:0046039 239 0.033
purine ribonucleoside metabolic process GO:0046128 437 0.033
regulation of protein processing GO:0070613 150 0.033
negative regulation of immune response GO:0050777 40 0.033
viral process GO:0016032 146 0.033
positive regulation of t cell apoptotic process GO:0070234 4 0.033
alpha beta t cell activation GO:0046631 15 0.033
purine nucleoside triphosphate metabolic process GO:0009144 412 0.033
myeloid dendritic cell activation GO:0001773 4 0.032
dephosphorylation GO:0016311 209 0.032
negative regulation of t cell activation GO:0050868 18 0.032
regulation of protein localization GO:0032880 296 0.032
Mouse Rat
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.032
Mouse Rat
regulation of t cell proliferation GO:0042129 42 0.031
regulation of leukocyte migration GO:0002685 63 0.031
regulation of peptidase activity GO:0052547 180 0.031
interleukin 12 secretion GO:0072610 1 0.031
regulation of immunoglobulin production GO:0002637 4 0.031
Mouse Rat
organophosphate catabolic process GO:0046434 430 0.031
regulation of interleukin 10 secretion GO:2001179 4 0.031
response to organonitrogen compound GO:0010243 156 0.031
regulation of t helper cell differentiation GO:0045622 3 0.030
carbohydrate derivative biosynthetic process GO:1901137 207 0.030
post embryonic development GO:0009791 2 0.030
response to inorganic substance GO:0010035 127 0.030
negative regulation of leukocyte apoptotic process GO:2000107 16 0.030
regulation of immunoglobulin secretion GO:0051023 1 0.030
Mouse Rat
regulation of nucleoside metabolic process GO:0009118 209 0.030
actin filament based process GO:0030029 224 0.030
activation of innate immune response GO:0002218 55 0.029
regulation of cd8 positive alpha beta t cell activation GO:2001185 2 0.029
positive regulation of nucleotide metabolic process GO:0045981 230 0.029
response to wounding GO:0009611 168 0.029
cellular response to growth factor stimulus GO:0071363 197 0.029
peptide secretion GO:0002790 51 0.029
purine nucleoside triphosphate catabolic process GO:0009146 392 0.028
negative regulation of multi organism process GO:0043901 92 0.028
establishment of protein localization to organelle GO:0072594 172 0.028
carbohydrate derivative transport GO:1901264 20 0.028
nuclear transport GO:0051169 179 0.028
negative regulation of protein metabolic process GO:0051248 391 0.028
divalent inorganic cation transport GO:0072511 158 0.028
negative regulation of peptidase activity GO:0010466 91 0.027
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.027
eosinophil mediated immunity GO:0002447 2 0.027
calcium ion transport GO:0006816 147 0.027
positive regulation of innate immune response GO:0045089 79 0.027
blastoderm segmentation GO:0007350 2 0.027
metal ion transport GO:0030001 272 0.027
positive regulation of nucleotide catabolic process GO:0030813 185 0.026
vesicle mediated transport GO:0016192 371 0.026
positive regulation of cytokine secretion involved in immune response GO:0002741 2 0.026
regulation of cell activation GO:0050865 125 0.026
Mouse Rat
establishment of t cell polarity GO:0001768 2 0.026
interleukin 12 production GO:0032615 15 0.026
Mouse Rat
positive regulation of ion transport GO:0043270 87 0.026
positive regulation of proteolysis GO:0045862 142 0.026
Human
regulation of cell morphogenesis GO:0022604 153 0.026
phospholipid metabolic process GO:0006644 99 0.026
purine nucleoside catabolic process GO:0006152 398 0.026
cell activation involved in immune response GO:0002263 30 0.026
Mouse Rat
hormone secretion GO:0046879 65 0.025
regulation of cd4 positive alpha beta t cell activation GO:2000514 5 0.025
cell morphogenesis involved in differentiation GO:0000904 144 0.025
antigen processing and presentation GO:0019882 33 0.025
peptide transport GO:0015833 74 0.024
positive regulation of cellular component biogenesis GO:0044089 158 0.024
positive regulation of chemotaxis GO:0050921 57 0.024
positive regulation of intracellular transport GO:0032388 104 0.024
cellular metal ion homeostasis GO:0006875 146 0.024
regulation of ion transmembrane transport GO:0034765 132 0.024
lymphocyte differentiation GO:0030098 35 0.024
single organism cellular localization GO:1902580 332 0.024
syncytium formation by plasma membrane fusion GO:0000768 2 0.024
regulation of type i interferon production GO:0032479 26 0.024
positive regulation of protein catabolic process GO:0045732 75 0.024
Human
response to abiotic stimulus GO:0009628 336 0.024
regulation of protein secretion GO:0050708 86 0.024
Mouse Rat
interspecies interaction between organisms GO:0044419 156 0.023
regulation of c c chemokine binding GO:2001263 1 0.023
positive regulation of immunoglobulin production GO:0002639 4 0.023
Mouse Rat
regulation of chemokine production GO:0032642 31 0.023
endothelial cell apoptotic process GO:0072577 26 0.023
ribonucleoside catabolic process GO:0042454 406 0.023
regulation of lipid kinase activity GO:0043550 19 0.023
negative regulation of developmental process GO:0051093 247 0.023
Human
nervous system development GO:0007399 293 0.023
Human
hormone transport GO:0009914 68 0.023
negative regulation of phosphate metabolic process GO:0045936 267 0.023
cellular component morphogenesis GO:0032989 314 0.023
neurogenesis GO:0022008 169 0.023

CD40 disease predictions

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 36 0.225
immune system disease DOID:2914 155 0.225
hematopoietic system disease DOID:74 100 0.083
musculoskeletal system disease DOID:17 223 0.053
Human
blood protein disease DOID:620 16 0.037
agammaglobulinemia DOID:2583 16 0.037
b cell deficiency DOID:2115 17 0.037
disease by infectious agent DOID:0050117 34 0.036
organ system cancer DOID:0050686 164 0.032
cancer DOID:162 167 0.032
disease of cellular proliferation DOID:14566 174 0.032
connective tissue disease DOID:65 109 0.029
Human
common variable immunodeficiency DOID:12177 10 0.028