Homo sapiens

2 known processes

PPA1

pyrophosphatase (inorganic) 1

(Aliases: IOPPP,PP,MGC111556,PP1,SID6-8061)

PPA1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cytoplasmic transport GO:0016482 379 0.444
negative regulation of cell death GO:0060548 345 0.341
cellular chemical homeostasis GO:0055082 180 0.246
organophosphate catabolic process GO:0046434 430 0.229
cellular amine metabolic process GO:0044106 41 0.216
oxidation reduction process GO:0055114 396 0.209
response to tumor cell GO:0002347 10 0.206
secretion GO:0046903 254 0.197
negative regulation of apoptotic process GO:0043066 316 0.193
regulation of defense response GO:0031347 154 0.186
negative regulation of programmed cell death GO:0043069 321 0.182
cellular amino acid metabolic process GO:0006520 116 0.172
amine metabolic process GO:0009308 44 0.163
mitochondrion organization GO:0007005 156 0.160
regulation of nucleotide metabolic process GO:0006140 269 0.138
purine containing compound catabolic process GO:0072523 411 0.136
cellular response to oxidative stress GO:0034599 85 0.116
response to other organism GO:0051707 261 0.115
purine ribonucleotide catabolic process GO:0009154 404 0.111
purine nucleotide catabolic process GO:0006195 405 0.108
regulation of peptidase activity GO:0052547 180 0.105
regulation of transferase activity GO:0051338 355 0.103
sulfur compound metabolic process GO:0006790 101 0.100
intracellular protein transport GO:0006886 270 0.098
apoptotic signaling pathway GO:0097190 268 0.098
regulation of intracellular transport GO:0032386 195 0.096
cellular homeostasis GO:0019725 196 0.096
purine ribonucleoside metabolic process GO:0046128 437 0.094
purine containing compound salvage GO:0043101 2 0.091
guanosine containing compound metabolic process GO:1901068 244 0.089
positive regulation of apoptotic process GO:0043065 246 0.084
response to biotic stimulus GO:0009607 276 0.084
nucleotide catabolic process GO:0009166 408 0.084
negative regulation of protein metabolic process GO:0051248 391 0.083
nucleotide biosynthetic process GO:0009165 109 0.083
cellular metabolic compound salvage GO:0043094 7 0.082
nucleoside phosphate catabolic process GO:1901292 412 0.080
protein processing GO:0016485 226 0.077
positive regulation of programmed cell death GO:0043068 249 0.077
purine ribonucleoside catabolic process GO:0046130 398 0.077
positive regulation of cellular amine metabolic process GO:0033240 7 0.076
response to external biotic stimulus GO:0043207 261 0.073
establishment of protein localization to organelle GO:0072594 172 0.072
protein maturation GO:0051604 233 0.072
purine nucleoside triphosphate metabolic process GO:0009144 412 0.071
positive regulation of developmental process GO:0051094 314 0.071
secretion by cell GO:0032940 226 0.070
protein import GO:0017038 130 0.070
innate immune response GO:0045087 178 0.070
Worm
positive regulation of cytokine production GO:0001819 167 0.069
post embryonic development GO:0009791 2 0.069
Worm
cellular modified amino acid metabolic process GO:0006575 64 0.069
regulation of ion transport GO:0043269 189 0.064
regulation of kinase activity GO:0043549 314 0.064
protein targeting GO:0006605 187 0.063
organonitrogen compound biosynthetic process GO:1901566 200 0.063
regulation of response to external stimulus GO:0032101 222 0.063
nitrogen compound transport GO:0071705 191 0.063
regulation of cellular amine metabolic process GO:0033238 11 0.062
positive regulation of cell death GO:0010942 263 0.062
purine ribonucleoside biosynthetic process GO:0046129 23 0.059
regulation of protein localization GO:0032880 296 0.058
response to inorganic substance GO:0010035 127 0.058
negative regulation of cellular protein metabolic process GO:0032269 353 0.058
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.057
regulation of response to wounding GO:1903034 101 0.056
cell type specific apoptotic process GO:0097285 125 0.055
regulation of proteolysis GO:0030162 293 0.055
response to oxidative stress GO:0006979 121 0.055
cellular response to cytokine stimulus GO:0071345 181 0.054
nucleoside triphosphate catabolic process GO:0009143 394 0.053
response to organonitrogen compound GO:0010243 156 0.052
transmembrane transport GO:0055085 399 0.052
regulation of cytokine production GO:0001817 232 0.052
apoptotic mitochondrial changes GO:0008637 57 0.051
regulation of purine nucleotide biosynthetic process GO:1900371 50 0.051
nuclear transport GO:0051169 179 0.051
regulation of apoptotic signaling pathway GO:2001233 175 0.050
response to organic cyclic compound GO:0014070 204 0.050
metal ion homeostasis GO:0055065 169 0.049
locomotory behavior GO:0007626 1 0.049
purine ribonucleotide biosynthetic process GO:0009152 79 0.049
response to oxygen containing compound GO:1901700 369 0.047
positive regulation of transport GO:0051050 336 0.046
nucleoside phosphate biosynthetic process GO:1901293 109 0.043
ribonucleoside catabolic process GO:0042454 406 0.043
regulation of cell cycle GO:0051726 393 0.043
membrane organization GO:0061024 292 0.043
regulation of protein transport GO:0051223 213 0.042
protein import into nucleus GO:0006606 104 0.040
hindbrain development GO:0030902 3 0.040
single organism cellular localization GO:1902580 332 0.040
vesicle mediated transport GO:0016192 371 0.039
organic acid biosynthetic process GO:0016053 97 0.039
regulation of intracellular protein transport GO:0033157 123 0.038
positive regulation of cell proliferation GO:0008284 301 0.038
negative regulation of phosphate metabolic process GO:0045936 267 0.038
nucleocytoplasmic transport GO:0006913 176 0.038
response to abiotic stimulus GO:0009628 336 0.038
negative regulation of transport GO:0051051 176 0.037
response to wounding GO:0009611 168 0.037
defense response GO:0006952 315 0.036
Worm
ribonucleoside triphosphate catabolic process GO:0009203 391 0.036
immune response activating signal transduction GO:0002757 90 0.036
alcohol metabolic process GO:0006066 114 0.036
purine containing compound biosynthetic process GO:0072522 88 0.036
epithelial cell differentiation GO:0030855 141 0.036
single organism membrane organization GO:0044802 268 0.035
purine nucleoside triphosphate catabolic process GO:0009146 392 0.035
response to nitrogen compound GO:1901698 184 0.035
regulation of cellular response to stress GO:0080135 244 0.035
hemopoiesis GO:0030097 180 0.035
gtp metabolic process GO:0046039 239 0.035
nucleoside triphosphate metabolic process GO:0009141 422 0.034
rna transport GO:0050658 39 0.034
negative regulation of binding GO:0051100 57 0.034
purine nucleotide biosynthetic process GO:0006164 84 0.034
protein secretion GO:0009306 98 0.034
epithelium development GO:0060429 227 0.033
cation homeostasis GO:0055080 189 0.033
glycosyl compound catabolic process GO:1901658 413 0.033
regulation of cellular amino acid metabolic process GO:0006521 6 0.033
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.033
immune response GO:0006955 307 0.033
Worm
immune system development GO:0002520 195 0.033
cellular ketone metabolic process GO:0042180 80 0.033
regeneration GO:0031099 4 0.033
regulation of cell differentiation GO:0045595 393 0.032
positive regulation of proteolysis GO:0045862 142 0.032
cellular response to oxygen containing compound GO:1901701 276 0.032
cytokine production GO:0001816 247 0.032
tissue regeneration GO:0042246 3 0.032
regulation of endopeptidase activity GO:0052548 170 0.032
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.031
negative regulation of immune system process GO:0002683 136 0.031
nucleoside catabolic process GO:0009164 408 0.031
regulation of neuron death GO:1901214 56 0.030
inflammatory response GO:0006954 79 0.030
ion homeostasis GO:0050801 230 0.029
protein localization to organelle GO:0033365 280 0.029
regulation of ion transmembrane transport GO:0034765 132 0.029
single organism nuclear import GO:1902593 104 0.029
protein autophosphorylation GO:0046777 123 0.029
immune effector process GO:0002252 159 0.029
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.029
signal transduction by phosphorylation GO:0023014 297 0.029
negative regulation of catalytic activity GO:0043086 335 0.028
system process GO:0003008 349 0.028
nuclear export GO:0051168 69 0.027
protein targeting to nucleus GO:0044744 104 0.027
receptor mediated endocytosis GO:0006898 84 0.027
regulation of protein kinase activity GO:0045859 289 0.027
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.027
regulation of establishment of protein localization GO:0070201 242 0.027
gmp metabolic process GO:0046037 4 0.027
nervous system development GO:0007399 293 0.027
multi organism cellular process GO:0044764 156 0.027
negative regulation of protein processing GO:0010955 142 0.027
protein localization to nucleus GO:0034504 136 0.027
small molecule biosynthetic process GO:0044283 157 0.026
cell activation GO:0001775 213 0.026
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.026
ribonucleoside triphosphate metabolic process GO:0009199 412 0.026
mitotic cell cycle GO:0000278 326 0.026
regulation of cysteine type endopeptidase activity GO:2000116 127 0.026
regulation of cellular component movement GO:0051270 334 0.026
cell development GO:0048468 328 0.026
negative regulation of neuron apoptotic process GO:0043524 23 0.026
positive regulation of cell differentiation GO:0045597 211 0.025
nuclear import GO:0051170 106 0.025
de novo protein folding GO:0006458 2 0.025
cellular cation homeostasis GO:0030003 163 0.025
regulation of neuron apoptotic process GO:0043523 35 0.025
spermatid differentiation GO:0048515 4 0.025
single organism cell adhesion GO:0098602 179 0.024
cofactor metabolic process GO:0051186 87 0.024
positive regulation of hydrolase activity GO:0051345 331 0.024
negative regulation of phosphorus metabolic process GO:0010563 267 0.024
regulation of transporter activity GO:0032409 82 0.024
positive regulation of peptidase activity GO:0010952 88 0.024
nucleic acid transport GO:0050657 39 0.024
regulation of inflammatory response GO:0050727 46 0.024
positive regulation of immune system process GO:0002684 283 0.024
ncrna metabolic process GO:0034660 108 0.023
response to cytokine GO:0034097 232 0.023
endocytosis GO:0006897 159 0.023
gtp catabolic process GO:0006184 237 0.023
positive regulation of cellular component movement GO:0051272 181 0.023
nuclear division GO:0000280 128 0.023
response to virus GO:0009615 126 0.023
guanosine containing compound catabolic process GO:1901069 239 0.023
positive regulation of innate immune response GO:0045089 79 0.022
leukocyte proliferation GO:0070661 74 0.022
positive regulation of immune response GO:0050778 159 0.022
positive regulation of defense response GO:0031349 87 0.022
regulation of immune response GO:0050776 201 0.022
regulation of binding GO:0051098 111 0.022
reactive oxygen species metabolic process GO:0072593 75 0.022
response to hormone GO:0009725 175 0.022
regulation of translational initiation in response to stress GO:0043558 1 0.022
regulation of innate immune response GO:0045088 97 0.022
cellular ion homeostasis GO:0006873 168 0.022
cellular metal ion homeostasis GO:0006875 146 0.022
regulation of protein targeting GO:1903533 91 0.021
regulation of cell cycle process GO:0010564 266 0.021
purine nucleoside monophosphate metabolic process GO:0009126 186 0.021
regulation of cell motility GO:2000145 299 0.021
purine nucleoside catabolic process GO:0006152 398 0.021
regulation of transmembrane transport GO:0034762 139 0.021
regulation of protein maturation GO:1903317 150 0.021
embryo development GO:0009790 123 0.021
Worm
cellular macromolecular complex assembly GO:0034622 324 0.021
purine nucleoside monophosphate catabolic process GO:0009128 158 0.021
ribonucleoside monophosphate metabolic process GO:0009161 187 0.021
nucleobase containing compound transport GO:0015931 51 0.020
regulation of nucleotide biosynthetic process GO:0030808 50 0.020
sex differentiation GO:0007548 45 0.020
mononuclear cell proliferation GO:0032943 71 0.020
rab protein signal transduction GO:0032482 4 0.020
calcium ion homeostasis GO:0055074 122 0.020
negative regulation of endopeptidase activity GO:0010951 84 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.020
cellular response to nitrogen compound GO:1901699 144 0.020
negative regulation of proteolysis GO:0045861 132 0.020
protein catabolic process GO:0030163 325 0.020
positive regulation of nucleotide metabolic process GO:0045981 230 0.019
negative regulation of protein maturation GO:1903318 142 0.019
regulation of ion transmembrane transporter activity GO:0032412 72 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.019
immune response regulating signaling pathway GO:0002764 97 0.019
spindle assembly involved in mitosis GO:0090307 12 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
mapk cascade GO:0000165 288 0.019
response to lipid GO:0033993 206 0.019
heart process GO:0003015 62 0.018
neuron death GO:0070997 65 0.018
cation transport GO:0006812 331 0.018
cation transmembrane transport GO:0098655 238 0.018
spermatid development GO:0007286 4 0.018
ras protein signal transduction GO:0007265 73 0.018
reproductive process GO:0022414 106 0.018
sulfur compound biosynthetic process GO:0044272 38 0.018
regulation of cytoplasmic transport GO:1903649 149 0.018
positive regulation of ion transport GO:0043270 87 0.018
glial cell migration GO:0008347 4 0.018
rna processing GO:0006396 255 0.018
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.018
midbrain development GO:0030901 45 0.018
blood circulation GO:0008015 113 0.018
chemical homeostasis GO:0048878 306 0.018
response to hyperoxia GO:0055093 4 0.017
cellular respiration GO:0045333 21 0.017
cellular divalent inorganic cation homeostasis GO:0072503 128 0.017
activation of immune response GO:0002253 114 0.017
determination of adult lifespan GO:0008340 2 0.017
positive regulation of endopeptidase activity GO:0010950 84 0.017
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.017
multicellular organismal aging GO:0010259 3 0.017
regulation of cellular ketone metabolic process GO:0010565 50 0.017
negative regulation of intracellular transport GO:0032387 60 0.017
establishment of protein localization to membrane GO:0090150 121 0.017
positive regulation of apoptotic signaling pathway GO:2001235 70 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.016
organophosphate biosynthetic process GO:0090407 163 0.016
hydrogen peroxide metabolic process GO:0042743 20 0.016
regulation of secretion by cell GO:1903530 177 0.016
regulation of dna metabolic process GO:0051052 153 0.016
neuron apoptotic process GO:0051402 39 0.016
lipid biosynthetic process GO:0008610 177 0.016
regulation of protein localization to nucleus GO:1900180 85 0.016
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.016
inorganic cation transmembrane transport GO:0098662 194 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
negative regulation of organelle organization GO:0010639 126 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
monosaccharide metabolic process GO:0005996 74 0.016
regulation of cell migration GO:0030334 289 0.016
positive regulation of protein transport GO:0051222 135 0.015
hematopoietic or lymphoid organ development GO:0048534 186 0.015
lymphocyte activation GO:0046649 133 0.015
single organism reproductive process GO:0044702 98 0.015
positive regulation of protein phosphorylation GO:0001934 313 0.015
activation of innate immune response GO:0002218 55 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
negative regulation of cell cycle GO:0045786 193 0.015
monocarboxylic acid biosynthetic process GO:0072330 67 0.015
cranial nerve development GO:0021545 4 0.015
cell growth GO:0016049 160 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.015
negative regulation of neuron death GO:1901215 32 0.015
coenzyme metabolic process GO:0006732 65 0.015
protein modification by small protein removal GO:0070646 92 0.015
regulation of locomotion GO:0040012 329 0.015
response to oxygen levels GO:0070482 100 0.014
ribonucleoprotein complex assembly GO:0022618 78 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.014
peptidyl serine phosphorylation GO:0018105 101 0.014
regulation of multi organism process GO:0043900 157 0.014
reproductive system development GO:0061458 56 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.014
endomembrane system organization GO:0010256 196 0.014
regulation of growth GO:0040008 165 0.014
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.014
lymphocyte proliferation GO:0046651 70 0.014
negative regulation of multi organism process GO:0043901 92 0.014
detection of stimulus GO:0051606 85 0.014
regulation of protein processing GO:0070613 150 0.014
purine deoxyribonucleoside triphosphate metabolic process GO:0009215 4 0.014
cellular calcium ion homeostasis GO:0006874 117 0.014
positive regulation of response to external stimulus GO:0032103 88 0.014
regulation of transmembrane transporter activity GO:0022898 74 0.014
protein oxidation GO:0018158 5 0.014
reproductive structure development GO:0048608 55 0.014
activation of cysteine type endopeptidase activity GO:0097202 57 0.013
regulation of lymphocyte activation GO:0051249 103 0.013
negative regulation of cellular component organization GO:0051129 235 0.013
response to cocaine GO:0042220 1 0.013
protein folding GO:0006457 38 0.013
cell part morphogenesis GO:0032990 137 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.013
neuron differentiation GO:0030182 138 0.013
regulation of protein import into nucleus GO:0042306 78 0.013
hydrogen peroxide catabolic process GO:0042744 13 0.013
cellular component morphogenesis GO:0032989 314 0.013
regulation of protein secretion GO:0050708 86 0.013
detection of chemical stimulus GO:0009593 55 0.013
zymogen activation GO:0031638 70 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
negative regulation of protein modification process GO:0031400 200 0.013
maintenance of location GO:0051235 112 0.013
negative regulation of protein transport GO:0051224 75 0.013
organic hydroxy compound metabolic process GO:1901615 147 0.013
stress activated mapk cascade GO:0051403 93 0.012
central nervous system development GO:0007417 123 0.012
regulation of cell development GO:0060284 161 0.012
ion transmembrane transport GO:0034220 338 0.012
negative regulation of transferase activity GO:0051348 124 0.012
cellular amide metabolic process GO:0043603 69 0.012
protein homooligomerization GO:0051260 100 0.012
pattern recognition receptor signaling pathway GO:0002221 48 0.012
organelle fission GO:0048285 149 0.012
positive regulation of intracellular transport GO:0032388 104 0.012
response to bacterium GO:0009617 144 0.012
leukocyte differentiation GO:0002521 98 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
metal ion transport GO:0030001 272 0.012
response to drug GO:0042493 81 0.012
glycosyl compound biosynthetic process GO:1901659 27 0.012
response to acid chemical GO:0001101 66 0.012
substantia nigra development GO:0021762 45 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
regulation of proteasomal protein catabolic process GO:0061136 87 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.012
ribose phosphate biosynthetic process GO:0046390 82 0.012
mitotic cell cycle process GO:1903047 286 0.012
protein oligomerization GO:0051259 173 0.012
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.012
ribonucleotide biosynthetic process GO:0009260 81 0.012
heart contraction GO:0060047 62 0.012
ameboidal type cell migration GO:0001667 135 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
calcium ion transport GO:0006816 147 0.012
cell substrate adhesion GO:0031589 132 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
negative regulation of kinase activity GO:0033673 106 0.012
nerve development GO:0021675 4 0.012
cellular protein complex assembly GO:0043623 188 0.011
establishment of organelle localization GO:0051656 59 0.011
dna catabolic process GO:0006308 49 0.011
divalent inorganic cation transport GO:0072511 158 0.011
regulation of immune response to tumor cell GO:0002837 8 0.011
cellular amino acid biosynthetic process GO:0008652 30 0.011
cell projection organization GO:0030030 252 0.011
organelle assembly GO:0070925 176 0.011
carbohydrate metabolic process GO:0005975 207 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.011
negative regulation of response to external stimulus GO:0032102 83 0.011
positive regulation of cell migration GO:0030335 172 0.011
divalent inorganic cation homeostasis GO:0072507 136 0.011
innate immune response activating signal transduction GO:0002758 48 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
positive regulation of cellular catabolic process GO:0031331 284 0.011
adult locomotory behavior GO:0008344 1 0.011
neuromuscular junction development GO:0007528 3 0.011
rho protein signal transduction GO:0007266 26 0.011
negative regulation of defense response GO:0031348 47 0.011
cofactor biosynthetic process GO:0051188 31 0.011
neuron development GO:0048666 113 0.011
growth GO:0040007 202 0.011
regulation of cell substrate adhesion GO:0010810 68 0.011
myeloid cell differentiation GO:0030099 117 0.011
male sex differentiation GO:0046661 25 0.011
regulation of membrane potential GO:0042391 95 0.011
response to reactive oxygen species GO:0000302 61 0.011
regulation of mitosis GO:0007088 63 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
regulation of protein catabolic process GO:0042176 155 0.010
regulation of dna binding GO:0051101 37 0.010
biological adhesion GO:0022610 331 0.010
positive regulation of ras gtpase activity GO:0032320 117 0.010
cell morphogenesis GO:0000902 296 0.010
cell chemotaxis GO:0060326 112 0.010
regulation of protein stability GO:0031647 87 0.010
regulation of ras gtpase activity GO:0032318 128 0.010
behavior GO:0007610 112 0.010
regulation of cellular response to growth factor stimulus GO:0090287 76 0.010
intrinsic apoptotic signaling pathway GO:0097193 127 0.010
positive regulation of cell motility GO:2000147 177 0.010
reproduction GO:0000003 63 0.010
Worm
regulation of mitochondrion organization GO:0010821 54 0.010

PPA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.346
amino acid metabolic disorder DOID:9252 50 0.346
inherited metabolic disorder DOID:655 242 0.346
immune system disease DOID:2914 155 0.117
central nervous system disease DOID:331 186 0.054
nervous system disease DOID:863 431 0.054
cancer DOID:162 167 0.039
disease of cellular proliferation DOID:14566 174 0.039
organ system cancer DOID:0050686 164 0.039
hematopoietic system disease DOID:74 100 0.013