Homo sapiens

86 known processes

OPA1

optic atrophy 1 (autosomal dominant)

(Aliases: NPG,largeG,FLJ12460,MGM1,KIAA0567,NTG)

OPA1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.556
Worm
female gamete generation GO:0007292 2 0.486
multicellular organismal aging GO:0010259 3 0.342
atp metabolic process GO:0046034 176 0.308
oogenesis GO:0048477 2 0.308
ribonucleoside triphosphate metabolic process GO:0009199 412 0.290
organophosphate catabolic process GO:0046434 430 0.248
positive regulation of cellular component organization GO:0051130 376 0.237
nucleoside triphosphate metabolic process GO:0009141 422 0.200
cellular component morphogenesis GO:0032989 314 0.195
nucleoside triphosphate catabolic process GO:0009143 394 0.182
organelle fission GO:0048285 149 0.176
cellular macromolecule catabolic process GO:0044265 380 0.138
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.138
purine ribonucleoside metabolic process GO:0046128 437 0.135
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.135
lipid metabolic process GO:0006629 381 0.133
cell development GO:0048468 328 0.132
ribonucleoside monophosphate catabolic process GO:0009158 158 0.131
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.131
purine ribonucleoside catabolic process GO:0046130 398 0.124
determination of adult lifespan GO:0008340 2 0.124
purine nucleoside triphosphate metabolic process GO:0009144 412 0.122
response to abiotic stimulus GO:0009628 336 0.121
purine nucleoside triphosphate catabolic process GO:0009146 392 0.118
establishment of organelle localization GO:0051656 59 0.116
cellular homeostasis GO:0019725 196 0.115
cellular lipid metabolic process GO:0044255 303 0.109
apoptotic mitochondrial changes GO:0008637 57 0.108
protein catabolic process GO:0030163 325 0.104
Worm
reactive oxygen species metabolic process GO:0072593 75 0.104
mitochondrion organization GO:0007005 156 0.104
cell morphogenesis GO:0000902 296 0.103
nucleoside catabolic process GO:0009164 408 0.102
apoptotic signaling pathway GO:0097190 268 0.102
single organism membrane organization GO:0044802 268 0.095
vesicle mediated transport GO:0016192 371 0.095
defense response to other organism GO:0098542 129 0.093
defense response GO:0006952 315 0.093
ribonucleoside monophosphate metabolic process GO:0009161 187 0.091
ribonucleoside catabolic process GO:0042454 406 0.091
purine ribonucleotide catabolic process GO:0009154 404 0.090
response to external biotic stimulus GO:0043207 261 0.088
response to virus GO:0009615 126 0.088
organelle fusion GO:0048284 36 0.088
purine nucleotide catabolic process GO:0006195 405 0.084
purine containing compound catabolic process GO:0072523 411 0.082
mitotic cell cycle process GO:1903047 286 0.081
microtubule based process GO:0007017 210 0.081
microtubule cytoskeleton organization GO:0000226 176 0.080
cellular protein catabolic process GO:0044257 261 0.080
single organism membrane fusion GO:0044801 37 0.079
positive regulation of programmed cell death GO:0043068 249 0.079
membrane organization GO:0061024 292 0.079
purine nucleoside catabolic process GO:0006152 398 0.078
regulation of membrane potential GO:0042391 95 0.076
ribonucleoside triphosphate catabolic process GO:0009203 391 0.075
nucleoside monophosphate metabolic process GO:0009123 191 0.075
cell projection organization GO:0030030 252 0.074
response to biotic stimulus GO:0009607 276 0.074
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.072
cellular macromolecular complex assembly GO:0034622 324 0.071
mitotic cell cycle GO:0000278 326 0.070
meiotic chromosome segregation GO:0045132 4 0.069
cytoplasmic transport GO:0016482 379 0.069
oocyte development GO:0048599 1 0.067
negative regulation of apoptotic process GO:0043066 316 0.066
nuclear division GO:0000280 128 0.066
cellular component disassembly GO:0022411 92 0.066
growth GO:0040007 202 0.065
Worm
alcohol metabolic process GO:0006066 114 0.064
cell morphogenesis involved in differentiation GO:0000904 144 0.063
mitotic nuclear division GO:0007067 119 0.063
chemical homeostasis GO:0048878 306 0.062
single organism cellular localization GO:1902580 332 0.061
modification dependent macromolecule catabolic process GO:0043632 212 0.061
intrinsic apoptotic signaling pathway GO:0097193 127 0.060
oocyte differentiation GO:0009994 2 0.060
organelle localization GO:0051640 84 0.060
chromosome segregation GO:0007059 114 0.059
glycosyl compound catabolic process GO:1901658 413 0.059
ion transmembrane transport GO:0034220 338 0.056
inorganic ion transmembrane transport GO:0098660 231 0.056
regulation of apoptotic signaling pathway GO:2001233 175 0.056
tube morphogenesis GO:0035239 95 0.054
Mouse
nucleotide catabolic process GO:0009166 408 0.053
sulfur compound metabolic process GO:0006790 101 0.053
negative regulation of programmed cell death GO:0043069 321 0.053
purine nucleoside monophosphate catabolic process GO:0009128 158 0.052
negative regulation of cell death GO:0060548 345 0.052
embryo development GO:0009790 123 0.051
Mouse Worm
ubiquitin dependent protein catabolic process GO:0006511 206 0.050
cell part morphogenesis GO:0032990 137 0.050
response to organic cyclic compound GO:0014070 204 0.048
response to inorganic substance GO:0010035 127 0.048
Worm
regulation of system process GO:0044057 101 0.048
regulation of cell cycle GO:0051726 393 0.047
taxis GO:0042330 157 0.046
small gtpase mediated signal transduction GO:0007264 78 0.044
regulation of kinase activity GO:0043549 314 0.044
negative regulation of catalytic activity GO:0043086 335 0.043
regulation of protein localization GO:0032880 296 0.043
ribonucleotide catabolic process GO:0009261 405 0.043
negative regulation of protein metabolic process GO:0051248 391 0.043
dephosphorylation GO:0016311 209 0.041
nucleoside phosphate catabolic process GO:1901292 412 0.041
spindle organization GO:0007051 53 0.040
positive regulation of mitochondrial fission GO:0090141 7 0.040
response to metal ion GO:0010038 84 0.039
protein ubiquitination GO:0016567 314 0.039
regulation of homeostatic process GO:0032844 121 0.039
spermatid differentiation GO:0048515 4 0.039
lipid modification GO:0030258 84 0.039
single organism carbohydrate metabolic process GO:0044723 193 0.039
cation transmembrane transport GO:0098655 238 0.038
nervous system development GO:0007399 293 0.038
Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.038
regulation of cellular amine metabolic process GO:0033238 11 0.037
positive regulation of catabolic process GO:0009896 310 0.037
regulation of growth GO:0040008 165 0.037
Worm
positive regulation of cell death GO:0010942 263 0.037
metal ion transport GO:0030001 272 0.036
cellular amino acid metabolic process GO:0006520 116 0.036
transmembrane transport GO:0055085 399 0.036
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.036
cellular response to growth factor stimulus GO:0071363 197 0.036
inorganic cation transmembrane transport GO:0098662 194 0.035
system process GO:0003008 349 0.034
nucleoside monophosphate catabolic process GO:0009125 159 0.034
protein modification by small protein conjugation GO:0032446 342 0.034
neuron projection development GO:0031175 106 0.034
protein complex disassembly GO:0043241 52 0.034
neuron differentiation GO:0030182 138 0.033
digestion GO:0007586 22 0.033
negative regulation of intracellular signal transduction GO:1902532 183 0.033
metaphase plate congression GO:0051310 18 0.033
cell projection morphogenesis GO:0048858 129 0.032
regulation of viral process GO:0050792 103 0.032
positive regulation of cellular amine metabolic process GO:0033240 7 0.032
carbohydrate metabolic process GO:0005975 207 0.032
dna repair GO:0006281 198 0.032
positive regulation of apoptotic process GO:0043065 246 0.031
regulation of anatomical structure morphogenesis GO:0022603 286 0.031
positive regulation of apoptotic signaling pathway GO:2001235 70 0.031
nuclear import GO:0051170 106 0.031
chromosome separation GO:0051304 23 0.031
establishment of cell polarity GO:0030010 22 0.030
response to nitrogen compound GO:1901698 184 0.030
oxidation reduction process GO:0055114 396 0.029
negative regulation of organelle organization GO:0010639 126 0.029
cell growth GO:0016049 160 0.029
ras protein signal transduction GO:0007265 73 0.029
neurogenesis GO:0022008 169 0.029
neuromuscular junction development GO:0007528 3 0.029
cellular response to dna damage stimulus GO:0006974 379 0.029
fatty acid metabolic process GO:0006631 115 0.028
spermatid development GO:0007286 4 0.028
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.028
proteasomal protein catabolic process GO:0010498 176 0.028
monovalent inorganic cation transport GO:0015672 128 0.027
regulation of meiotic cell cycle GO:0051445 4 0.027
intracellular protein transport GO:0006886 270 0.027
cell division GO:0051301 168 0.026
positive regulation of organelle organization GO:0010638 195 0.026
organic hydroxy compound metabolic process GO:1901615 147 0.026
mitochondrial fragmentation involved in apoptotic process GO:0043653 7 0.026
amine metabolic process GO:0009308 44 0.026
regulation of response to dna damage stimulus GO:2001020 94 0.025
reproduction GO:0000003 63 0.025
Worm
behavior GO:0007610 112 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.024
single organism reproductive process GO:0044702 98 0.024
chemotaxis GO:0006935 157 0.024
peptidyl serine modification GO:0018209 106 0.024
regulation of mitochondrial fission GO:0090140 8 0.024
cellular response to abiotic stimulus GO:0071214 117 0.023
sister chromatid segregation GO:0000819 54 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
cellular protein complex assembly GO:0043623 188 0.023
defense response to virus GO:0051607 71 0.023
mitochondrial membrane organization GO:0007006 40 0.023
meiosis i GO:0007127 4 0.022
protein localization to organelle GO:0033365 280 0.022
mitotic spindle organization GO:0007052 27 0.022
macromolecular complex disassembly GO:0032984 60 0.022
protein targeting GO:0006605 187 0.022
glycerolipid metabolic process GO:0046486 107 0.022
modification dependent protein catabolic process GO:0019941 209 0.022
mitotic spindle elongation GO:0000022 4 0.022
immune effector process GO:0002252 159 0.021
protein autophosphorylation GO:0046777 123 0.021
regulation of multi organism process GO:0043900 157 0.021
protein processing GO:0016485 226 0.021
enzyme linked receptor protein signaling pathway GO:0007167 303 0.021
single organism nuclear import GO:1902593 104 0.021
organ morphogenesis GO:0009887 147 0.021
metal ion homeostasis GO:0055065 169 0.021
neuron development GO:0048666 113 0.020
reproductive process GO:0022414 106 0.020
mitotic sister chromatid segregation GO:0000070 53 0.020
positive regulation of intracellular transport GO:0032388 104 0.020
spindle elongation GO:0051231 4 0.020
monocarboxylic acid metabolic process GO:0032787 185 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
regulation of translation GO:0006417 89 0.020
signal transduction by phosphorylation GO:0023014 297 0.019
response to radiation GO:0009314 151 0.019
establishment of protein localization to organelle GO:0072594 172 0.019
protein polymerization GO:0051258 71 0.019
negative regulation of developmental process GO:0051093 247 0.019
positive regulation of dna metabolic process GO:0051054 73 0.019
granzyme mediated apoptotic signaling pathway GO:0008626 4 0.019
viral life cycle GO:0019058 132 0.019
digestive tract morphogenesis GO:0048546 56 0.019
regulation of cytoskeleton organization GO:0051493 177 0.019
ion homeostasis GO:0050801 230 0.018
response to uv GO:0009411 73 0.018
response to light stimulus GO:0009416 87 0.018
actin filament based movement GO:0030048 17 0.018
regulation of protein kinase activity GO:0045859 289 0.018
aging GO:0007568 66 0.018
calcium ion homeostasis GO:0055074 122 0.017
positive regulation of meiotic cell cycle GO:0051446 2 0.017
developmental growth GO:0048589 48 0.017
Worm
positive regulation of protein transport GO:0051222 135 0.017
establishment of protein localization to membrane GO:0090150 121 0.017
regulation of protein maturation GO:1903317 150 0.017
multi organism cellular process GO:0044764 156 0.017
positive regulation of protein complex disassembly GO:0043243 8 0.017
regulation of proteolysis GO:0030162 293 0.017
organonitrogen compound biosynthetic process GO:1901566 200 0.017
regulation of protein catabolic process GO:0042176 155 0.017
regulation of cell morphogenesis GO:0022604 153 0.017
protein oligomerization GO:0051259 173 0.017
response to growth factor GO:0070848 205 0.017
viral process GO:0016032 146 0.017
response to other organism GO:0051707 261 0.016
cofactor metabolic process GO:0051186 87 0.016
fat cell differentiation GO:0045444 32 0.016
regulation of mitosis GO:0007088 63 0.016
cellular ketone metabolic process GO:0042180 80 0.016
axon development GO:0061564 34 0.016
regeneration GO:0031099 4 0.016
positive regulation of proteolysis GO:0045862 142 0.016
hindbrain development GO:0030902 3 0.016
glycerophospholipid metabolic process GO:0006650 84 0.016
phospholipid metabolic process GO:0006644 99 0.016
actin filament based process GO:0030029 224 0.016
regulation of locomotion GO:0040012 329 0.016
regulation of cell growth GO:0001558 135 0.016
multicellular organismal reproductive process GO:0048609 40 0.015
establishment of mitotic spindle localization GO:0040001 8 0.015
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.015
regulation of protein processing GO:0070613 150 0.015
positive regulation of protein kinase activity GO:0045860 190 0.015
nuclear export GO:0051168 69 0.015
regulation of cellular component biogenesis GO:0044087 281 0.015
atp catabolic process GO:0006200 157 0.015
regulation of nuclear division GO:0051783 65 0.015
nucleocytoplasmic transport GO:0006913 176 0.015
cell type specific apoptotic process GO:0097285 125 0.015
neuron projection morphogenesis GO:0048812 50 0.015
regulation of vesicle mediated transport GO:0060627 130 0.015
negative regulation of cellular component organization GO:0051129 235 0.015
regulation of transferase activity GO:0051338 355 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.014
Mouse Worm
rna processing GO:0006396 255 0.014
positive regulation of transferase activity GO:0051347 227 0.014
response to oxygen containing compound GO:1901700 369 0.014
Worm
nucleus localization GO:0051647 1 0.014
lipid transport GO:0006869 90 0.014
negative regulation of proteolysis GO:0045861 132 0.014
positive regulation of protein complex assembly GO:0031334 86 0.014
regulation of mitotic cell cycle phase transition GO:1901990 118 0.014
regulation of cell division GO:0051302 116 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
cellular amine metabolic process GO:0044106 41 0.014
endocytosis GO:0006897 159 0.014
cell adhesion GO:0007155 325 0.014
cellular response to endogenous stimulus GO:0071495 336 0.014
cell cycle phase transition GO:0044770 173 0.014
cellular response to hormone stimulus GO:0032870 125 0.013
membrane fusion GO:0061025 43 0.013
biological adhesion GO:0022610 331 0.013
regulation of mapk cascade GO:0043408 262 0.013
multi organism reproductive process GO:0044703 54 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
rna interference GO:0016246 4 0.013
response to oxidative stress GO:0006979 121 0.013
Worm
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
segmentation GO:0035282 4 0.013
mitotic sister chromatid separation GO:0051306 18 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
regulation of mitotic cell cycle GO:0007346 189 0.012
protein maturation GO:0051604 233 0.012
wnt signaling pathway GO:0016055 156 0.012
tissue morphogenesis GO:0048729 96 0.012
Mouse
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
nuclear transport GO:0051169 179 0.012
secretion GO:0046903 254 0.012
defense response to bacterium GO:0042742 63 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
ribonucleoprotein complex biogenesis GO:0022613 116 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
tripartite regional subdivision GO:0007351 2 0.012
compound eye development GO:0048749 1 0.012
regulation of cellular amino acid metabolic process GO:0006521 6 0.012
regulation of cellular component movement GO:0051270 334 0.012
divalent inorganic cation transport GO:0072511 158 0.012
positive regulation of cellular component biogenesis GO:0044089 158 0.011
nuclear migration GO:0007097 1 0.011
cation transport GO:0006812 331 0.011
developmental process involved in reproduction GO:0003006 66 0.011
generation of neurons GO:0048699 152 0.011
positive regulation of intracellular protein transport GO:0090316 76 0.011
endosomal transport GO:0016197 129 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
establishment of nucleus localization GO:0040023 1 0.011
protein dephosphorylation GO:0006470 81 0.011
cellular response to nitrogen compound GO:1901699 144 0.011
protein import GO:0017038 130 0.011
epithelium development GO:0060429 227 0.011
Mouse
regulation of cell migration GO:0030334 289 0.011
organic acid transport GO:0015849 65 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
regulation of response to external stimulus GO:0032101 222 0.011
double strand break repair GO:0006302 101 0.011
organophosphate biosynthetic process GO:0090407 163 0.010
regulation of protein ubiquitination GO:0031396 95 0.010
mitochondrial transport GO:0006839 60 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.010
regulation of cell cycle process GO:0010564 266 0.010
regulation of dephosphorylation GO:0035303 96 0.010
somitogenesis GO:0001756 2 0.010
regulation of meiosis GO:0040020 3 0.010
mrna metabolic process GO:0016071 175 0.010
negative regulation of small gtpase mediated signal transduction GO:0051058 12 0.010
positive regulation of kinase activity GO:0033674 204 0.010
regulation of developmental growth GO:0048638 30 0.010
Worm

OPA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.019
disease of cellular proliferation DOID:14566 174 0.015
skin disease DOID:37 33 0.015
integumentary system disease DOID:16 43 0.015
cancer DOID:162 167 0.013
organ system cancer DOID:0050686 164 0.013