Homo sapiens

71 known processes

KLHL12

kelch-like 12 (Drosophila)

(Aliases: DKIR,C3IP1,FLJ27152)

KLHL12 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
renal sodium ion absorption GO:0070294 2 0.942
Human
sodium ion transport GO:0006814 61 0.875
Human
protein k33 linked ubiquitination GO:1990390 1 0.872
Human
chromosome passenger complex localization to spindle midzone GO:0035853 1 0.854
Human
nephron epithelium morphogenesis GO:0072088 15 0.832
Human
vesicle targeting rough er to cis golgi GO:0048207 2 0.829
copii vesicle coating GO:0048208 2 0.749
modification dependent macromolecule catabolic process GO:0043632 212 0.749
Human
distal tubule development GO:0072017 4 0.717
Human
nephron morphogenesis GO:0072028 15 0.637
Human
protein monoubiquitination GO:0006513 39 0.627
nephron tubule morphogenesis GO:0072078 13 0.624
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.618
Human
kidney development GO:0001822 53 0.608
Human
ubiquitin dependent protein catabolic process GO:0006511 206 0.592
Human
regulation of cell cycle GO:0051726 393 0.586
Human
cellular macromolecule catabolic process GO:0044265 380 0.540
Human
protein k48 linked ubiquitination GO:0070936 38 0.535
Human
protein modification by small protein conjugation GO:0032446 342 0.501
kidney morphogenesis GO:0060993 19 0.481
Human
monovalent inorganic cation transport GO:0015672 128 0.435
Human
protein polyubiquitination GO:0000209 110 0.401
Human
vesicle targeting to from or within golgi GO:0048199 6 0.390
modification dependent protein catabolic process GO:0019941 209 0.356
Human
proteasomal protein catabolic process GO:0010498 176 0.354
Human
protein ubiquitination GO:0016567 314 0.352
membrane organization GO:0061024 292 0.313
tube morphogenesis GO:0035239 95 0.304
Human
distal tubule morphogenesis GO:0072156 3 0.301
Human
protein catabolic process GO:0030163 325 0.289
Human
regulation of cell differentiation GO:0045595 393 0.278
actin filament based process GO:0030029 224 0.243
posttranscriptional regulation of gene expression GO:0010608 213 0.209
Human
nephron epithelium development GO:0072009 23 0.208
Human
cation transport GO:0006812 331 0.191
Human
translation GO:0006412 132 0.190
Human
anatomical structure formation involved in morphogenesis GO:0048646 284 0.190
tissue morphogenesis GO:0048729 96 0.184
Human Zebrafish
epithelium development GO:0060429 227 0.182
Human Zebrafish
post golgi vesicle mediated transport GO:0006892 36 0.179
Human
female gamete generation GO:0007292 2 0.177
ion homeostasis GO:0050801 230 0.173
Human
translational initiation GO:0006413 48 0.170
Human
chemical homeostasis GO:0048878 306 0.145
Human
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.145
metal ion transport GO:0030001 272 0.139
Human
negative regulation of programmed cell death GO:0043069 321 0.138
Human
tube development GO:0035295 125 0.137
Human
renal tubule morphogenesis GO:0061333 14 0.135
Human
blastoderm segmentation GO:0007350 2 0.133
endodermal cell fate commitment GO:0001711 4 0.132
kidney epithelium development GO:0072073 25 0.131
Human
regulation of cell division GO:0051302 116 0.128
Human
renal system process GO:0003014 25 0.126
Human
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.125
regulation of translation GO:0006417 89 0.123
Human
vesicle mediated transport GO:0016192 371 0.114
protein localization to organelle GO:0033365 280 0.108
Human
negative regulation of protein metabolic process GO:0051248 391 0.105
Human
nephron development GO:0072006 30 0.099
Human
regulation of transferase activity GO:0051338 355 0.094
negative regulation of cellular protein metabolic process GO:0032269 353 0.094
Human
nephron tubule development GO:0072080 17 0.093
Human
cellular protein catabolic process GO:0044257 261 0.090
Human
actin cytoskeleton organization GO:0030036 207 0.089
lipid localization GO:0010876 106 0.089
golgi vesicle transport GO:0048193 80 0.088
oogenesis GO:0048477 2 0.087
maintenance of location GO:0051235 112 0.086
regulation of cytokinesis GO:0032465 45 0.085
Human
cellular protein complex localization GO:0034629 8 0.083
Human
endodermal cell fate specification GO:0001714 4 0.083
regulation of cell development GO:0060284 161 0.083
regulation of protein catabolic process GO:0042176 155 0.081
vesicle coating GO:0006901 9 0.081
lipid biosynthetic process GO:0008610 177 0.080
cell development GO:0048468 328 0.080
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.079
single organism membrane organization GO:0044802 268 0.078
somatic stem cell maintenance GO:0035019 4 0.075
cellular lipid metabolic process GO:0044255 303 0.073
anterior posterior axis specification GO:0009948 2 0.071
regulation of cellular ketone metabolic process GO:0010565 50 0.070
regulation of translational initiation GO:0006446 24 0.067
Human
vesicle organization GO:0016050 62 0.067
cellular amino acid metabolic process GO:0006520 116 0.064
cellular ketone metabolic process GO:0042180 80 0.062
cytoplasmic transport GO:0016482 379 0.059
system process GO:0003008 349 0.058
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.056
negative regulation of apoptotic process GO:0043066 316 0.055
Human
regulation of cell cycle process GO:0010564 266 0.055
Human
single organism cellular localization GO:1902580 332 0.054
cellular amine metabolic process GO:0044106 41 0.053
regulation of protein kinase activity GO:0045859 289 0.052
protein oligomerization GO:0051259 173 0.052
response to inorganic substance GO:0010035 127 0.051
organ morphogenesis GO:0009887 147 0.049
Human
nervous system development GO:0007399 293 0.048
er to golgi vesicle mediated transport GO:0006888 19 0.048
generation of neurons GO:0048699 152 0.046
regulation of proteasomal protein catabolic process GO:0061136 87 0.046
segmentation GO:0035282 4 0.046
positive regulation of protein phosphorylation GO:0001934 313 0.045
heart field specification GO:0003128 2 0.045
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.045
positive regulation of cell differentiation GO:0045597 211 0.045
long term memory GO:0007616 2 0.045
protein complex localization GO:0031503 31 0.045
Human
photoreceptor cell differentiation GO:0046530 2 0.044
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.044
Human
mapk cascade GO:0000165 288 0.043
monocarboxylic acid metabolic process GO:0032787 185 0.043
neurogenesis GO:0022008 169 0.042
regulation of nervous system development GO:0051960 88 0.042
post embryonic development GO:0009791 2 0.041
regulation of cytoskeleton organization GO:0051493 177 0.039
memory GO:0007613 3 0.039
associative learning GO:0008306 1 0.039
positive regulation of phosphorylation GO:0042327 394 0.038
regulation of actin filament based process GO:0032970 141 0.037
amine metabolic process GO:0009308 44 0.037
cell projection organization GO:0030030 252 0.036
negative regulation of cell death GO:0060548 345 0.036
Human
negative regulation of translation GO:0017148 37 0.035
Human
organelle localization GO:0051640 84 0.035
regulation of cellular amino acid metabolic process GO:0006521 6 0.034
cell fate commitment involved in pattern specification GO:0060581 1 0.033
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.033
phototransduction visible light GO:0007603 2 0.033
small molecule biosynthetic process GO:0044283 157 0.033
single organism reproductive process GO:0044702 98 0.033
regulation of apoptotic signaling pathway GO:2001233 175 0.033
organ formation GO:0048645 3 0.033
negative regulation of kinase activity GO:0033673 106 0.032
regulation of cellular component biogenesis GO:0044087 281 0.032
negative regulation of cell proliferation GO:0008285 228 0.032
rna polyadenylation GO:0043631 14 0.032
negative regulation of response to external stimulus GO:0032102 83 0.032
positive regulation of cellular component organization GO:0051130 376 0.032
formation of primary germ layer GO:0001704 42 0.032
actin filament bundle organization GO:0061572 54 0.031
regulation of kinase activity GO:0043549 314 0.031
response to other organism GO:0051707 261 0.031
cell division GO:0051301 168 0.031
Human
negative regulation of cellular component organization GO:0051129 235 0.031
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.030
neuromuscular junction development GO:0007528 3 0.030
regulation of receptor mediated endocytosis GO:0048259 32 0.030
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.030
regulation of cellular amine metabolic process GO:0033238 11 0.030
receptor internalization GO:0031623 43 0.030
specification of organ identity GO:0010092 3 0.030
viral process GO:0016032 146 0.030
regulation of neurogenesis GO:0050767 82 0.029
negative regulation of cell fate commitment GO:0010454 3 0.029
positive regulation of protein catabolic process GO:0045732 75 0.029
outflow tract septum morphogenesis GO:0003148 4 0.028
muscle cell fate commitment GO:0042693 4 0.028
lipid metabolic process GO:0006629 381 0.028
enzyme linked receptor protein signaling pathway GO:0007167 303 0.028
apoptotic signaling pathway GO:0097190 268 0.028
cytokinesis GO:0000910 96 0.028
Human
determination of adult lifespan GO:0008340 2 0.027
regulation of protein binding GO:0043393 66 0.027
regulation of heart morphogenesis GO:2000826 4 0.027
regulation of actin cytoskeleton organization GO:0032956 116 0.027
regulation of endocytosis GO:0030100 72 0.027
lipid storage GO:0019915 28 0.027
regulation of protein localization GO:0032880 296 0.026
non canonical wnt signaling pathway via jnk cascade GO:0038031 3 0.026
negative regulation of intracellular signal transduction GO:1902532 183 0.026
neural tube formation GO:0001841 3 0.026
negative regulation of phosphorylation GO:0042326 174 0.026
nitrogen compound transport GO:0071705 191 0.025
multicellular organismal aging GO:0010259 3 0.025
vesicle localization GO:0051648 26 0.024
regulation of vesicle mediated transport GO:0060627 130 0.024
receptor metabolic process GO:0043112 81 0.024
positive regulation of cellular amine metabolic process GO:0033240 7 0.024
tripartite regional subdivision GO:0007351 2 0.024
negative regulation of protein modification process GO:0031400 200 0.024
cell fate determination GO:0001709 3 0.024
regulation of heart induction GO:0090381 2 0.024
inner ear morphogenesis GO:0042472 4 0.023
cochlea development GO:0090102 1 0.023
ribonucleoside triphosphate catabolic process GO:0009203 391 0.023
digestive system development GO:0055123 75 0.023
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.023
Human
rna export from nucleus GO:0006405 33 0.022
transmembrane transport GO:0055085 399 0.022
negative regulation of transport GO:0051051 176 0.022
organic acid biosynthetic process GO:0016053 97 0.022
limbic system development GO:0021761 3 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
negative regulation of catalytic activity GO:0043086 335 0.022
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.021
cell projection morphogenesis GO:0048858 129 0.021
positive regulation of developmental process GO:0051094 314 0.021
anterior posterior axis specification embryo GO:0008595 2 0.021
endosomal transport GO:0016197 129 0.021
Human
mitotic cell cycle GO:0000278 326 0.020
establishment of planar polarity GO:0001736 3 0.020
positive regulation of proteolysis GO:0045862 142 0.020
embryonic epithelial tube formation GO:0001838 4 0.020
protein secretion GO:0009306 98 0.020
negative regulation of phosphate metabolic process GO:0045936 267 0.020
reproductive process GO:0022414 106 0.020
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.020
neuron differentiation GO:0030182 138 0.020
localization within membrane GO:0051668 14 0.020
positive regulation of neurogenesis GO:0050769 49 0.019
dephosphorylation GO:0016311 209 0.019
regulation of cellular protein catabolic process GO:1903362 96 0.019
positive regulation of transferase activity GO:0051347 227 0.019
actin filament bundle assembly GO:0051017 54 0.019
regulation of meiosis GO:0040020 3 0.019
multi organism reproductive process GO:0044703 54 0.019
regulation of response to external stimulus GO:0032101 222 0.019
heart development GO:0007507 95 0.018
organ induction GO:0001759 4 0.018
salivary gland morphogenesis GO:0007435 4 0.018
regulation of proteolysis GO:0030162 293 0.018
primary neural tube formation GO:0014020 3 0.018
retinal ganglion cell axon guidance GO:0031290 2 0.018
regulation of homeostatic process GO:0032844 121 0.018
establishment of apical basal cell polarity GO:0035089 1 0.018
negative regulation of apoptotic signaling pathway GO:2001234 97 0.018
positive regulation of catabolic process GO:0009896 310 0.018
regulation of wnt signaling pathway GO:0030111 123 0.018
response to uv GO:0009411 73 0.017
response to radiation GO:0009314 151 0.017
response to abiotic stimulus GO:0009628 336 0.017
cell morphogenesis GO:0000902 296 0.017
rna interference GO:0016246 4 0.017
heart formation GO:0060914 2 0.017
regulation of ion homeostasis GO:2000021 73 0.017
digestive tract development GO:0048565 75 0.017
negative regulation of cell fate specification GO:0009996 3 0.017
cell fate specification GO:0001708 8 0.017
nucleobase containing compound transport GO:0015931 51 0.017
response to external biotic stimulus GO:0043207 261 0.017
positive regulation of kinase activity GO:0033674 204 0.017
ras protein signal transduction GO:0007265 73 0.017
protein autophosphorylation GO:0046777 123 0.017
mitochondrion organization GO:0007005 156 0.016
negative regulation of multi organism process GO:0043901 92 0.016
cellular response to metal ion GO:0071248 43 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
rna processing GO:0006396 255 0.016
spermatid development GO:0007286 4 0.016
rna transport GO:0050658 39 0.016
purine ribonucleoside catabolic process GO:0046130 398 0.016
rho protein signal transduction GO:0007266 26 0.016
muscle structure development GO:0061061 98 0.016
actin filament organization GO:0007015 128 0.016
positive regulation of cellular protein catabolic process GO:1903364 37 0.016
response to oxygen containing compound GO:1901700 369 0.016
tor signaling GO:0031929 39 0.016
viral life cycle GO:0019058 132 0.015
axis elongation GO:0003401 4 0.015
Zebrafish
negative regulation of cell differentiation GO:0045596 171 0.015
gastrulation GO:0007369 51 0.015
protein autoubiquitination GO:0051865 37 0.015
organelle fission GO:0048285 149 0.015
regulation of organ formation GO:0003156 4 0.015
motor neuron axon guidance GO:0008045 2 0.015
neuron development GO:0048666 113 0.015
positive regulation of nervous system development GO:0051962 54 0.015
cellular response to dna damage stimulus GO:0006974 379 0.015
spermatid differentiation GO:0048515 4 0.015
digestive tract morphogenesis GO:0048546 56 0.015
regulation of isoprenoid metabolic process GO:0019747 1 0.015
mrna polyadenylation GO:0006378 12 0.015
multicellular organismal reproductive process GO:0048609 40 0.015
tube closure GO:0060606 3 0.015
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.015
organophosphate biosynthetic process GO:0090407 163 0.014
multi organism cellular process GO:0044764 156 0.014
protein localization to nucleus GO:0034504 136 0.014
neural tube closure GO:0001843 3 0.014
sexual reproduction GO:0019953 37 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
protein targeting GO:0006605 187 0.014
response to fungus GO:0009620 4 0.014
regulation of meiotic cell cycle GO:0051445 4 0.014
cardiovascular system development GO:0072358 262 0.014
positive regulation of wnt signaling pathway GO:0030177 54 0.014
neurotransmitter secretion GO:0007269 4 0.014
negative regulation of immune system process GO:0002683 136 0.014
lens development in camera type eye GO:0002088 2 0.014
compound eye development GO:0048749 1 0.014
regulation of neural precursor cell proliferation GO:2000177 4 0.014
postsynaptic membrane organization GO:0001941 2 0.014
negative regulation of transferase activity GO:0051348 124 0.014
actomyosin structure organization GO:0031032 59 0.014
embryo development GO:0009790 123 0.014
gtp metabolic process GO:0046039 239 0.014
regulation of defense response GO:0031347 154 0.014
morphogenesis of embryonic epithelium GO:0016331 4 0.013
ribonucleoside catabolic process GO:0042454 406 0.013
regulation of cellular response to stress GO:0080135 244 0.013
defense response to other organism GO:0098542 129 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
nucleotide catabolic process GO:0009166 408 0.013
phototransduction GO:0007602 3 0.013
cell growth GO:0016049 160 0.013
stress fiber assembly GO:0043149 40 0.013
forebrain regionalization GO:0021871 3 0.013
forebrain generation of neurons GO:0021872 3 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
regulation of cardioblast differentiation GO:0051890 4 0.013
establishment of protein localization to organelle GO:0072594 172 0.013
cardiac muscle cell contraction GO:0086003 4 0.013
regulation of notch signaling pathway GO:0008593 18 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
developmental process involved in reproduction GO:0003006 66 0.013
establishment or maintenance of monopolar cell polarity GO:0061339 1 0.013
interspecies interaction between organisms GO:0044419 156 0.013
positive regulation of dendrite morphogenesis GO:0050775 3 0.013
regulation of membrane potential GO:0042391 95 0.013
oxidation reduction process GO:0055114 396 0.013
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.012
regulation of cell adhesion GO:0030155 166 0.012
regulation of multi organism process GO:0043900 157 0.012
late endosome to vacuole transport GO:0045324 2 0.012
secretion GO:0046903 254 0.012
regulation of binding GO:0051098 111 0.012
sodium ion transmembrane transport GO:0035725 59 0.012
defense response GO:0006952 315 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.012
rna splicing GO:0008380 131 0.012
ribonucleoprotein complex biogenesis GO:0022613 116 0.012
nuclear transport GO:0051169 179 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
visual learning GO:0008542 1 0.012
wnt signaling pathway GO:0016055 156 0.012
ribonucleoside triphosphate metabolic process GO:0009199 412 0.012
cellular cation homeostasis GO:0030003 163 0.012
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.012
circulatory system development GO:0072359 262 0.012
ribonucleoprotein complex subunit organization GO:0071826 81 0.012
type b pancreatic cell development GO:0003323 4 0.012
positive regulation of neuron differentiation GO:0045666 40 0.012
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.012
cellular response to oxygen containing compound GO:1901701 276 0.012
multicellular organism reproduction GO:0032504 42 0.012
macroautophagy GO:0016236 39 0.012
protein localization to membrane GO:0072657 160 0.012
negative regulation of protein kinase activity GO:0006469 98 0.012
plasma membrane organization GO:0007009 115 0.012
negative regulation of catabolic process GO:0009895 104 0.012
mrna 3 end processing GO:0031124 24 0.012
locomotory behavior GO:0007626 1 0.012
inorganic ion transmembrane transport GO:0098660 231 0.011
monocarboxylic acid biosynthetic process GO:0072330 67 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
reproduction GO:0000003 63 0.011
regulation of rna splicing GO:0043484 62 0.011
growth GO:0040007 202 0.011
Zebrafish
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.011
dendritic spine morphogenesis GO:0060997 3 0.011
establishment of tissue polarity GO:0007164 3 0.011
urogenital system development GO:0001655 65 0.011
Human
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
regulation of intracellular transport GO:0032386 195 0.011
notch signaling pathway GO:0007219 31 0.011
regulation of cardioblast cell fate specification GO:0042686 1 0.011
regulation of ossification GO:0030278 58 0.011
negative regulation of protein processing GO:0010955 142 0.011
cation homeostasis GO:0055080 189 0.011
hippocampus development GO:0021766 1 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.011
nucleoside catabolic process GO:0009164 408 0.011
mrna metabolic process GO:0016071 175 0.011
mrna splicing via spliceosome GO:0000398 89 0.011
nucleic acid transport GO:0050657 39 0.011
cardioblast cell fate commitment GO:0042684 1 0.011
coenzyme metabolic process GO:0006732 65 0.010
regulation of membrane depolarization GO:0003254 19 0.010
protein acylation GO:0043543 138 0.010
response to metal ion GO:0010038 84 0.010
convergent extension GO:0060026 1 0.010
Zebrafish
regulation of ion transport GO:0043269 189 0.010
response to nutrient levels GO:0031667 81 0.010
regulation of stress activated mapk cascade GO:0032872 84 0.010
response to cytokine GO:0034097 232 0.010
regulation of actin filament bundle assembly GO:0032231 36 0.010
fatty acid biosynthetic process GO:0006633 46 0.010
ncrna metabolic process GO:0034660 108 0.010
cardioblast cell fate specification GO:0042685 1 0.010
eye photoreceptor cell differentiation GO:0001754 2 0.010
myosin filament assembly GO:0031034 2 0.010
regulation of growth GO:0040008 165 0.010
neuron projection development GO:0031175 106 0.010
cellular chemical homeostasis GO:0055082 180 0.010
cellular response to radiation GO:0071478 65 0.010
adult locomotory behavior GO:0008344 1 0.010
visual behavior GO:0007632 2 0.010
heart induction GO:0003129 4 0.010
organonitrogen compound biosynthetic process GO:1901566 200 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010

KLHL12 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.022
eye and adnexa disease DOID:1492 150 0.022
nervous system disease DOID:863 431 0.022
eye disease DOID:5614 149 0.022
myopathy DOID:423 104 0.015
muscular disease DOID:0080000 114 0.015
musculoskeletal system disease DOID:17 223 0.015
muscle tissue disease DOID:66 113 0.015
cancer DOID:162 167 0.014
disease of cellular proliferation DOID:14566 174 0.014
organ system cancer DOID:0050686 164 0.014
disease of metabolism DOID:0014667 295 0.012