Homo sapiens

120 known processes

SPAST

spastin

(Aliases: ADPSP,SPG4,KIAA1083,FSP2)

SPAST biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell cycle GO:0051726 393 0.102
growth GO:0040007 202 0.092
Zebrafish Fly
macromolecule methylation GO:0043414 97 0.081
methylation GO:0032259 106 0.080
purine containing compound catabolic process GO:0072523 411 0.068
cell morphogenesis GO:0000902 296 0.063
Zebrafish Fly
nucleoside catabolic process GO:0009164 408 0.060
ribonucleoside monophosphate catabolic process GO:0009158 158 0.059
carbohydrate metabolic process GO:0005975 207 0.057
atp catabolic process GO:0006200 157 0.052
female gamete generation GO:0007292 2 0.051
regulation of growth GO:0040008 165 0.050
Zebrafish Fly
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.047
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.045
negative regulation of cell death GO:0060548 345 0.044
Zebrafish
negative regulation of cellular protein metabolic process GO:0032269 353 0.042
microtubule based process GO:0007017 210 0.041
nucleoside phosphate catabolic process GO:1901292 412 0.041
nucleoside triphosphate catabolic process GO:0009143 394 0.041
ribonucleoside triphosphate metabolic process GO:0009199 412 0.039
secretion by cell GO:0032940 226 0.038
tissue migration GO:0090130 119 0.038
regulation of anatomical structure morphogenesis GO:0022603 286 0.037
Zebrafish Fly
purine nucleoside monophosphate metabolic process GO:0009126 186 0.036
mitotic cell cycle process GO:1903047 286 0.035
Fly
locomotory behavior GO:0007626 1 0.035
Fly
ribonucleotide catabolic process GO:0009261 405 0.035
nucleoside monophosphate catabolic process GO:0009125 159 0.035
protein modification by small protein conjugation GO:0032446 342 0.034
cellular component morphogenesis GO:0032989 314 0.034
Zebrafish Fly
purine nucleoside triphosphate metabolic process GO:0009144 412 0.033
cellular macromolecular complex assembly GO:0034622 324 0.033
ameboidal type cell migration GO:0001667 135 0.033
multi organism cellular process GO:0044764 156 0.032
oocyte development GO:0048599 1 0.032
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.031
mitotic cell cycle GO:0000278 326 0.031
Fly
regulation of transferase activity GO:0051338 355 0.031
regulation of multi organism process GO:0043900 157 0.031
response to oxygen containing compound GO:1901700 369 0.031
regulation of developmental growth GO:0048638 30 0.031
Zebrafish Fly
cellular response to growth factor stimulus GO:0071363 197 0.031
oogenesis GO:0048477 2 0.030
response to growth factor GO:0070848 205 0.029
enzyme linked receptor protein signaling pathway GO:0007167 303 0.029
developmental growth GO:0048589 48 0.028
Zebrafish Fly
neuromuscular junction development GO:0007528 3 0.028
Fly
chemical homeostasis GO:0048878 306 0.028
regulation of cell cycle process GO:0010564 266 0.028
microtubule cytoskeleton organization GO:0000226 176 0.027
nucleotide catabolic process GO:0009166 408 0.027
dephosphorylation GO:0016311 209 0.026
cellular homeostasis GO:0019725 196 0.026
ribonucleoside catabolic process GO:0042454 406 0.026
viral process GO:0016032 146 0.026
positive regulation of transport GO:0051050 336 0.026
vesicle mediated transport GO:0016192 371 0.025
regulation of cellular component biogenesis GO:0044087 281 0.025
Fly
ribonucleoside monophosphate metabolic process GO:0009161 187 0.025
organophosphate catabolic process GO:0046434 430 0.024
cell part morphogenesis GO:0032990 137 0.024
Zebrafish Fly
endocytosis GO:0006897 159 0.024
negative regulation of phosphate metabolic process GO:0045936 267 0.024
rna processing GO:0006396 255 0.024
nucleoside monophosphate metabolic process GO:0009123 191 0.023
cell projection organization GO:0030030 252 0.023
Zebrafish Fly
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.023
purine nucleoside triphosphate catabolic process GO:0009146 392 0.023
negative regulation of protein metabolic process GO:0051248 391 0.023
dna repair GO:0006281 198 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
cellular protein complex assembly GO:0043623 188 0.022
negative regulation of catalytic activity GO:0043086 335 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
negative regulation of multicellular organismal process GO:0051241 317 0.022
Fly
defense response GO:0006952 315 0.021
interspecies interaction between organisms GO:0044419 156 0.020
amine metabolic process GO:0009308 44 0.020
positive regulation of developmental process GO:0051094 314 0.020
Zebrafish Fly
response to other organism GO:0051707 261 0.020
purine ribonucleotide catabolic process GO:0009154 404 0.020
regulation of kinase activity GO:0043549 314 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
cellular amino acid metabolic process GO:0006520 116 0.019
regulation of viral process GO:0050792 103 0.019
regulation of protein kinase activity GO:0045859 289 0.019
regulation of mapk cascade GO:0043408 262 0.018
positive regulation of developmental growth GO:0048639 16 0.018
Zebrafish Fly
purine ribonucleoside catabolic process GO:0046130 398 0.018
response to abiotic stimulus GO:0009628 336 0.018
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.018
nucleoside triphosphate metabolic process GO:0009141 422 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
negative regulation of phosphorylation GO:0042326 174 0.017
segmentation GO:0035282 4 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
regulation of cell differentiation GO:0045595 393 0.017
Zebrafish Fly
regulation of cell morphogenesis GO:0022604 153 0.017
Zebrafish Fly
cellular response to dna damage stimulus GO:0006974 379 0.016
protein catabolic process GO:0030163 325 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
oocyte differentiation GO:0009994 2 0.016
positive regulation of cell proliferation GO:0008284 301 0.016
protein localization to organelle GO:0033365 280 0.016
endosomal transport GO:0016197 129 0.016
spermatid development GO:0007286 4 0.016
positive regulation of immune system process GO:0002684 283 0.016
negative regulation of protein modification process GO:0031400 200 0.016
cytoplasmic transport GO:0016482 379 0.016
response to radiation GO:0009314 151 0.015
negative regulation of programmed cell death GO:0043069 321 0.015
Zebrafish
purine ribonucleoside metabolic process GO:0046128 437 0.015
membrane organization GO:0061024 292 0.015
regulation of cellular component size GO:0032535 82 0.015
Zebrafish
positive regulation of cell differentiation GO:0045597 211 0.015
Zebrafish Fly
epithelium migration GO:0090132 119 0.015
negative regulation of protein phosphorylation GO:0001933 140 0.015
regulation of cell development GO:0060284 161 0.015
Zebrafish Fly
ribonucleoside triphosphate catabolic process GO:0009203 391 0.015
response to external biotic stimulus GO:0043207 261 0.014
purine nucleoside monophosphate catabolic process GO:0009128 158 0.014
cytokine production GO:0001816 247 0.014
protein dephosphorylation GO:0006470 81 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
positive regulation of locomotion GO:0040017 186 0.014
cellular amine metabolic process GO:0044106 41 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.014
spermatid differentiation GO:0048515 4 0.014
negative regulation of transferase activity GO:0051348 124 0.014
post embryonic development GO:0009791 2 0.014
neuron projection morphogenesis GO:0048812 50 0.014
Zebrafish Fly
embryo development GO:0009790 123 0.013
Fly
mrna metabolic process GO:0016071 175 0.013
neuron projection development GO:0031175 106 0.013
Zebrafish Fly
regulation of dna metabolic process GO:0051052 153 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.013
regulation of cell motility GO:2000145 299 0.013
organelle localization GO:0051640 84 0.013
meiotic chromosome segregation GO:0045132 4 0.013
regulation of cell migration GO:0030334 289 0.013
cellular ketone metabolic process GO:0042180 80 0.013
protein ubiquitination GO:0016567 314 0.013
long term memory GO:0007616 2 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
response to hormone GO:0009725 175 0.012
cellular protein catabolic process GO:0044257 261 0.012
regulation of cellular amine metabolic process GO:0033238 11 0.012
chromatin modification GO:0016568 298 0.012
chromatin organization GO:0006325 351 0.012
rna interference GO:0016246 4 0.012
covalent chromatin modification GO:0016569 254 0.012
organelle assembly GO:0070925 176 0.012
cell development GO:0048468 328 0.012
Zebrafish Fly
cell morphogenesis involved in differentiation GO:0000904 144 0.012
Zebrafish Fly
response to virus GO:0009615 126 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
Zebrafish Fly
cellular macromolecule catabolic process GO:0044265 380 0.012
regulation of cell division GO:0051302 116 0.012
regulation of gene expression epigenetic GO:0040029 73 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
Zebrafish
immune response GO:0006955 307 0.012
peptidyl lysine acetylation GO:0018394 101 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
positive regulation of cell migration GO:0030335 172 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.012
Zebrafish Fly
negative regulation of immune system process GO:0002683 136 0.011
transmembrane transport GO:0055085 399 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
positive regulation of cellular component organization GO:0051130 376 0.011
Zebrafish Fly
single organism cellular localization GO:1902580 332 0.011
glycoprotein metabolic process GO:0009100 110 0.011
positive regulation of proteolysis GO:0045862 142 0.011
multicellular organismal aging GO:0010259 3 0.011
protein glycosylation GO:0006486 62 0.011
reproductive process GO:0022414 106 0.011
cell adhesion GO:0007155 325 0.011
positive regulation of transferase activity GO:0051347 227 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
atp metabolic process GO:0046034 176 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
Fly
generation of neurons GO:0048699 152 0.011
Zebrafish Fly
mapk cascade GO:0000165 288 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
taxis GO:0042330 157 0.011
determination of adult lifespan GO:0008340 2 0.011
negative regulation of kinase activity GO:0033673 106 0.011
modification dependent macromolecule catabolic process GO:0043632 212 0.010
protein methylation GO:0006479 74 0.010
centrosome organization GO:0051297 58 0.010
regulation of small gtpase mediated signal transduction GO:0051056 156 0.010
cell growth GO:0016049 160 0.010
Zebrafish
protein targeting GO:0006605 187 0.010
alcohol metabolic process GO:0006066 114 0.010
cell cycle checkpoint GO:0000075 117 0.010
negative regulation of cell cycle GO:0045786 193 0.010

SPAST disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.019
nervous system disease DOID:863 431 0.019
central nervous system disease DOID:331 186 0.017
bone disease DOID:0080001 88 0.014
musculoskeletal system disease DOID:17 223 0.014
connective tissue disease DOID:65 109 0.014
disease of metabolism DOID:0014667 295 0.013
paraplegia DOID:607 19 0.001
hereditary spastic paraplegia DOID:2476 19 0.001