Homo sapiens

51 known processes

PNKP

polynucleotide kinase 3'-phosphatase

(Aliases: PNK,MCSZ,EIEE10)

PNKP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna ligation involved in dna repair GO:0051103 4 0.971
dna repair GO:0006281 198 0.874
cellular response to dna damage stimulus GO:0006974 379 0.627
double strand break repair GO:0006302 101 0.405
dna recombination GO:0006310 77 0.311
pro b cell differentiation GO:0002328 1 0.257
nucleotide excision repair GO:0006289 31 0.227
base excision repair GO:0006284 21 0.202
dna ligation GO:0006266 10 0.144
non recombinational repair GO:0000726 14 0.142
response to abiotic stimulus GO:0009628 336 0.141
regulation of dna metabolic process GO:0051052 153 0.129
limbic system development GO:0021761 3 0.103
central nervous system development GO:0007417 123 0.080
glycosyl compound catabolic process GO:1901658 413 0.073
negative regulation of dna metabolic process GO:0051053 57 0.063
mitochondrion organization GO:0007005 156 0.062
response to inorganic substance GO:0010035 127 0.060
hemopoiesis GO:0030097 180 0.057
single strand break repair GO:0000012 6 0.056
negative regulation of cell death GO:0060548 345 0.054
cellular macromolecule catabolic process GO:0044265 380 0.052
v d j recombination GO:0033151 3 0.052
negative regulation of programmed cell death GO:0043069 321 0.050
response to hypoxia GO:0001666 96 0.049
establishment of protein localization to organelle GO:0072594 172 0.047
ribonucleotide catabolic process GO:0009261 405 0.047
dna catabolic process GO:0006308 49 0.047
enzyme linked receptor protein signaling pathway GO:0007167 303 0.046
negative regulation of apoptotic process GO:0043066 316 0.045
response to drug GO:0042493 81 0.041
hippocampus development GO:0021766 1 0.040
regulation of cellular amino acid metabolic process GO:0006521 6 0.039
response to oxygen containing compound GO:1901700 369 0.039
t cell differentiation in thymus GO:0033077 4 0.038
double strand break repair via nonhomologous end joining GO:0006303 10 0.038
cytoplasmic transport GO:0016482 379 0.035
negative regulation of dna recombination GO:0045910 6 0.035
cell projection organization GO:0030030 252 0.035
immune effector process GO:0002252 159 0.035
immune response GO:0006955 307 0.034
brain development GO:0007420 97 0.034
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.034
peptidyl tyrosine modification GO:0018212 170 0.033
regulation of fibroblast proliferation GO:0048145 32 0.030
purine nucleoside triphosphate catabolic process GO:0009146 392 0.028
ras protein signal transduction GO:0007265 73 0.027
nucleotide excision repair dna incision GO:0033683 7 0.027
response to radiation GO:0009314 151 0.027
neurogenesis GO:0022008 169 0.026
organophosphate catabolic process GO:0046434 430 0.025
cellular macromolecular complex assembly GO:0034622 324 0.025
regulation of cellular ketone metabolic process GO:0010565 50 0.025
regulation of cellular amine metabolic process GO:0033238 11 0.024
response to decreased oxygen levels GO:0036293 96 0.023
positive regulation of developmental process GO:0051094 314 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
protein import GO:0017038 130 0.022
endosomal transport GO:0016197 129 0.022
regulation of cell differentiation GO:0045595 393 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
regulation of locomotion GO:0040012 329 0.021
base excision repair dna ligation GO:0006288 2 0.021
gtp catabolic process GO:0006184 237 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
nervous system development GO:0007399 293 0.020
regulation of response to external stimulus GO:0032101 222 0.019
protein targeting to nucleus GO:0044744 104 0.019
positive regulation of cellular amine metabolic process GO:0033240 7 0.019
positive regulation of cytoskeleton organization GO:0051495 83 0.019
regulation of peptidase activity GO:0052547 180 0.018
head development GO:0060322 108 0.018
protein targeting GO:0006605 187 0.018
hematopoietic or lymphoid organ development GO:0048534 186 0.018
fibroblast proliferation GO:0048144 33 0.017
neuron differentiation GO:0030182 138 0.017
positive regulation of cell development GO:0010720 92 0.017
cellular ketone metabolic process GO:0042180 80 0.016
regulation of secretion by cell GO:1903530 177 0.016
somatic muscle development GO:0007525 1 0.016
response to cytokine GO:0034097 232 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
immune system development GO:0002520 195 0.015
cellular amino acid metabolic process GO:0006520 116 0.015
regulation of protein localization GO:0032880 296 0.015
positive regulation of protein phosphorylation GO:0001934 313 0.015
compound eye development GO:0048749 1 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
protein autophosphorylation GO:0046777 123 0.015
regulation of protein complex assembly GO:0043254 147 0.015
purine containing compound catabolic process GO:0072523 411 0.015
positive regulation of nervous system development GO:0051962 54 0.015
chemical homeostasis GO:0048878 306 0.015
intracellular protein transport GO:0006886 270 0.015
generation of neurons GO:0048699 152 0.015
regulation of neurogenesis GO:0050767 82 0.015
defense response to other organism GO:0098542 129 0.014
protein localization to nucleus GO:0034504 136 0.014
nucleoside catabolic process GO:0009164 408 0.014
protein catabolic process GO:0030163 325 0.014
amine metabolic process GO:0009308 44 0.014
positive regulation of neurogenesis GO:0050769 49 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
cellular response to cytokine stimulus GO:0071345 181 0.014
negative regulation of transport GO:0051051 176 0.014
regulation of cell development GO:0060284 161 0.014
protein localization to organelle GO:0033365 280 0.014
single organism cellular localization GO:1902580 332 0.014
ribonucleoside triphosphate catabolic process GO:0009203 391 0.014
secretion by cell GO:0032940 226 0.014
purine nucleoside triphosphate metabolic process GO:0009144 412 0.013
regulation of dna recombination GO:0000018 23 0.013
chromosome segregation GO:0007059 114 0.013
peptidyl tyrosine phosphorylation GO:0018108 170 0.013
protein import into nucleus GO:0006606 104 0.013
forebrain development GO:0030900 26 0.013
lymphocyte differentiation GO:0030098 35 0.013
response to reactive oxygen species GO:0000302 61 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
cell activation GO:0001775 213 0.013
guanosine containing compound catabolic process GO:1901069 239 0.013
response to growth factor GO:0070848 205 0.012
cellular homeostasis GO:0019725 196 0.012
regulation of proteolysis GO:0030162 293 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
positive regulation of locomotion GO:0040017 186 0.012
carbohydrate metabolic process GO:0005975 207 0.012
regulation of nervous system development GO:0051960 88 0.012
cell morphogenesis GO:0000902 296 0.012
negative regulation of catalytic activity GO:0043086 335 0.012
regulation of homeostatic process GO:0032844 121 0.012
positive regulation of cellular component organization GO:0051130 376 0.011
ribonucleoside catabolic process GO:0042454 406 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
regulation of growth GO:0040008 165 0.011
nucleotide catabolic process GO:0009166 408 0.011
protein modification by small protein conjugation GO:0032446 342 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.011
microtubule cytoskeleton organization GO:0000226 176 0.011
protein ubiquitination GO:0016567 314 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
single organism nuclear import GO:1902593 104 0.011
response to oxidative stress GO:0006979 121 0.011
post embryonic development GO:0009791 2 0.011
nuclear import GO:0051170 106 0.011
defense response to virus GO:0051607 71 0.011
gtp metabolic process GO:0046039 239 0.011
rho protein signal transduction GO:0007266 26 0.011
regulation of cell growth GO:0001558 135 0.011
lymphoid progenitor cell differentiation GO:0002320 3 0.011
nuclear transport GO:0051169 179 0.011
mapk cascade GO:0000165 288 0.011
locomotory behavior GO:0007626 1 0.011
regulation of secretion GO:0051046 194 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.011
rna processing GO:0006396 255 0.011
defense response GO:0006952 315 0.011
dna catabolic process exonucleolytic GO:0000738 17 0.011
microtubule based process GO:0007017 210 0.010
adaptive immune response GO:0002250 49 0.010
protein processing GO:0016485 226 0.010
guanosine containing compound metabolic process GO:1901068 244 0.010
leukocyte activation GO:0045321 164 0.010
cell growth GO:0016049 160 0.010
meiotic chromosome segregation GO:0045132 4 0.010
nucleoside phosphate catabolic process GO:1901292 412 0.010
lymphocyte activation GO:0046649 133 0.010

PNKP disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.149
disease of cellular proliferation DOID:14566 174 0.149
organ system cancer DOID:0050686 164 0.149
immune system disease DOID:2914 155 0.042
primary ciliary dyskinesia DOID:9562 27 0.035
nervous system disease DOID:863 431 0.005
central nervous system disease DOID:331 186 0.005
brain disease DOID:936 73 0.002
idiopathic generalized epilepsy DOID:1827 21 0.001
epilepsy syndrome DOID:1826 41 0.001
electroclinical syndrome DOID:0050701 32 0.001
neonatal period electroclinical syndrome DOID:0050702 19 0.001
ohtahara syndrome DOID:0050709 17 0.001
infantile epileptic encephalopathy DOID:2481 12 0.001