Homo sapiens

186 known processes

GBA

glucosidase, beta, acid

(Aliases: GBA1,GCB,GLUC)

GBA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
natural killer cell activation involved in immune response GO:0002323 2 0.878
golgi to vacuole transport GO:0006896 3 0.799
positive regulation of natural killer cell activation GO:0032816 8 0.659
natural killer cell mediated immunity GO:0002228 23 0.481
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 11 0.472
regulation of natural killer cell activation GO:0032814 9 0.465
positive regulation of exocytosis GO:0045921 35 0.433
post golgi vesicle mediated transport GO:0006892 36 0.425
lysosomal transport GO:0007041 33 0.413
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.408
cytoplasmic transport GO:0016482 379 0.386
positive regulation of secretion by cell GO:1903532 108 0.386
regulation of microtubule based process GO:0032886 74 0.384
cytoskeleton dependent intracellular transport GO:0030705 21 0.354
regulation of immune response GO:0050776 201 0.330
positive regulation of leukocyte activation GO:0002696 80 0.305
innate immune response GO:0045087 178 0.305
golgi vesicle transport GO:0048193 80 0.304
positive regulation of immune system process GO:0002684 283 0.303
positive regulation of secretion GO:0051047 116 0.287
vacuolar transport GO:0007034 34 0.269
regulation of exocytosis GO:0017157 46 0.263
cell activation GO:0001775 213 0.239
regulation of lymphocyte mediated immunity GO:0002706 33 0.238
positive regulation of leukocyte degranulation GO:0043302 3 0.238
defense response GO:0006952 315 0.231
regulation of leukocyte mediated immunity GO:0002703 38 0.229
positive regulation of innate immune response GO:0045089 79 0.223
regulation of immune effector process GO:0002697 91 0.217
natural killer cell mediated cytotoxicity GO:0042267 23 0.216
regulation of defense response GO:0031347 154 0.213
exocytosis GO:0006887 71 0.211
protein stabilization GO:0050821 64 0.211
positive regulation of defense response GO:0031349 87 0.209
immune effector process GO:0002252 159 0.208
secretion GO:0046903 254 0.207
cell killing GO:0001906 34 0.204
lymphocyte mediated immunity GO:0002449 48 0.203
microtubule based movement GO:0007018 32 0.202
regulation of innate immune response GO:0045088 97 0.193
positive regulation of immune response GO:0050778 159 0.192
regulation of secretion by cell GO:1903530 177 0.190
immune response GO:0006955 307 0.188
regulated secretory pathway GO:0045055 20 0.185
apoptotic signaling pathway GO:0097190 268 0.181
secretion by cell GO:0032940 226 0.180
regulation of cellular component movement GO:0051270 334 0.178
positive regulation of transport GO:0051050 336 0.173
regulation of regulated secretory pathway GO:1903305 10 0.172
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.169
regulation of secretion GO:0051046 194 0.169
positive regulation of leukocyte mediated immunity GO:0002705 24 0.165
regulation of leukocyte activation GO:0002694 115 0.160
establishment of protein localization to organelle GO:0072594 172 0.156
regulation of cell killing GO:0031341 22 0.155
regulation of intracellular transport GO:0032386 195 0.151
positive regulation of regulated secretory pathway GO:1903307 8 0.145
regulation of protein stability GO:0031647 87 0.145
posttranscriptional regulation of gene expression GO:0010608 213 0.143
natural killer cell degranulation GO:0043320 2 0.141
leukocyte mediated immunity GO:0002443 59 0.138
regulation of vesicle mediated transport GO:0060627 130 0.124
regulation of cell activation GO:0050865 125 0.122
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.121
positive regulation of cell killing GO:0031343 19 0.111
regulation of natural killer cell mediated immunity GO:0002715 16 0.111
protein localization to organelle GO:0033365 280 0.109
lymphocyte activation GO:0046649 133 0.107
microtubule based process GO:0007017 210 0.103
regulation of lymphocyte activation GO:0051249 103 0.103
positive regulation of leukocyte mediated cytotoxicity GO:0001912 16 0.102
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.100
positive regulation of cell activation GO:0050867 81 0.099
positive regulation of lymphocyte activation GO:0051251 73 0.098
leukocyte activation GO:0045321 164 0.097
granzyme mediated apoptotic signaling pathway GO:0008626 4 0.089
cell activation involved in immune response GO:0002263 30 0.085
regulation of organelle transport along microtubule GO:1902513 2 0.084
positive regulation of immune effector process GO:0002699 40 0.079
leukocyte activation involved in immune response GO:0002366 30 0.077
post embryonic development GO:0009791 2 0.064
microtubule based transport GO:0010970 21 0.061
cellular lipid metabolic process GO:0044255 303 0.060
regulation of microtubule based movement GO:0060632 6 0.058
regulation of cellular amino acid metabolic process GO:0006521 6 0.057
cellular amino acid metabolic process GO:0006520 116 0.050
female gamete generation GO:0007292 2 0.049
cellular ketone metabolic process GO:0042180 80 0.049
vesicle mediated transport GO:0016192 371 0.045
lipid metabolic process GO:0006629 381 0.043
amine metabolic process GO:0009308 44 0.043
locomotory behavior GO:0007626 1 0.041
leukocyte degranulation GO:0043299 11 0.041
regulation of cellular amine metabolic process GO:0033238 11 0.035
lymphocyte activation involved in immune response GO:0002285 20 0.035
maintenance of location GO:0051235 112 0.034
regulation of cellular ketone metabolic process GO:0010565 50 0.034
carbohydrate metabolic process GO:0005975 207 0.033
inorganic ion transmembrane transport GO:0098660 231 0.033
multicellular organismal aging GO:0010259 3 0.032
negative regulation of catalytic activity GO:0043086 335 0.031
single organism membrane organization GO:0044802 268 0.031
membrane lipid metabolic process GO:0006643 53 0.031
cellular amine metabolic process GO:0044106 41 0.030
cellular macromolecule catabolic process GO:0044265 380 0.030
ion homeostasis GO:0050801 230 0.030
nucleoside catabolic process GO:0009164 408 0.030
cellular amide metabolic process GO:0043603 69 0.029
purine nucleotide catabolic process GO:0006195 405 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.028
organophosphate catabolic process GO:0046434 430 0.028
ribonucleoside triphosphate catabolic process GO:0009203 391 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.028
ribonucleotide catabolic process GO:0009261 405 0.028
golgi to lysosome transport GO:0090160 3 0.027
purine nucleoside triphosphate metabolic process GO:0009144 412 0.027
purine ribonucleotide catabolic process GO:0009154 404 0.026
peripheral nervous system development GO:0007422 2 0.026
ribonucleoside triphosphate metabolic process GO:0009199 412 0.025
rho protein signal transduction GO:0007266 26 0.025
purine ribonucleoside metabolic process GO:0046128 437 0.025
positive regulation of cellular component organization GO:0051130 376 0.025
regulation of leukocyte degranulation GO:0043300 6 0.025
membrane organization GO:0061024 292 0.025
nucleoside triphosphate metabolic process GO:0009141 422 0.025
positive regulation of cellular amine metabolic process GO:0033240 7 0.024
ribonucleoside catabolic process GO:0042454 406 0.024
cellular macromolecular complex assembly GO:0034622 324 0.024
glycosyl compound catabolic process GO:1901658 413 0.024
nucleotide catabolic process GO:0009166 408 0.024
purine containing compound catabolic process GO:0072523 411 0.023
ion transmembrane transport GO:0034220 338 0.023
cellular protein catabolic process GO:0044257 261 0.023
cellular ion homeostasis GO:0006873 168 0.023
transmembrane transport GO:0055085 399 0.022
adult locomotory behavior GO:0008344 1 0.022
neuromuscular junction development GO:0007528 3 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.022
organonitrogen compound biosynthetic process GO:1901566 200 0.022
protein maturation GO:0051604 233 0.022
purine ribonucleoside catabolic process GO:0046130 398 0.021
cation transport GO:0006812 331 0.021
cellular homeostasis GO:0019725 196 0.021
lipid localization GO:0010876 106 0.021
phospholipid metabolic process GO:0006644 99 0.021
purine nucleoside monophosphate metabolic process GO:0009126 186 0.021
ribonucleoside monophosphate metabolic process GO:0009161 187 0.021
circulatory system development GO:0072359 262 0.021
response to abiotic stimulus GO:0009628 336 0.021
negative regulation of protein metabolic process GO:0051248 391 0.020
purine nucleoside catabolic process GO:0006152 398 0.020
purine nucleoside triphosphate catabolic process GO:0009146 392 0.020
nucleoside monophosphate metabolic process GO:0009123 191 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
regulation of transferase activity GO:0051338 355 0.020
regulation of natural killer cell degranulation GO:0043321 2 0.020
oogenesis GO:0048477 2 0.020
single organism carbohydrate metabolic process GO:0044723 193 0.020
regulation of cellular response to stress GO:0080135 244 0.020
nervous system development GO:0007399 293 0.019
metal ion homeostasis GO:0055065 169 0.019
lipid catabolic process GO:0016042 84 0.019
lipid biosynthetic process GO:0008610 177 0.019
mating GO:0007618 1 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
nucleoside triphosphate catabolic process GO:0009143 394 0.019
cellular chemical homeostasis GO:0055082 180 0.019
dephosphorylation GO:0016311 209 0.018
positive regulation of cellular catabolic process GO:0031331 284 0.018
regulation of protein kinase activity GO:0045859 289 0.018
negative regulation of cell death GO:0060548 345 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
negative regulation of multicellular organismal process GO:0051241 317 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
response to external biotic stimulus GO:0043207 261 0.018
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
cation transmembrane transport GO:0098655 238 0.017
regulation of peptidase activity GO:0052547 180 0.017
epithelial cell proliferation GO:0050673 128 0.017
endomembrane system organization GO:0010256 196 0.017
cation homeostasis GO:0055080 189 0.017
cellular protein complex assembly GO:0043623 188 0.017
negative regulation of protein modification process GO:0031400 200 0.017
spermatid differentiation GO:0048515 4 0.017
regulation of proteolysis GO:0030162 293 0.017
positive regulation of catabolic process GO:0009896 310 0.016
regulation of anatomical structure morphogenesis GO:0022603 286 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
ras protein signal transduction GO:0007265 73 0.016
organic hydroxy compound metabolic process GO:1901615 147 0.016
atp metabolic process GO:0046034 176 0.016
neurological system process GO:0050877 163 0.016
cellular component morphogenesis GO:0032989 314 0.016
blastocyst development GO:0001824 3 0.016
cellular cation homeostasis GO:0030003 163 0.016
glycerolipid metabolic process GO:0046486 107 0.016
determination of adult lifespan GO:0008340 2 0.016
regulation of cytoskeleton organization GO:0051493 177 0.015
oocyte development GO:0048599 1 0.015
regulation of nucleotide metabolic process GO:0006140 269 0.015
anion transport GO:0006820 161 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
sulfur compound metabolic process GO:0006790 101 0.015
vacuole organization GO:0007033 44 0.015
gtp metabolic process GO:0046039 239 0.015
cellular lipid catabolic process GO:0044242 65 0.015
protein catabolic process GO:0030163 325 0.015
small molecule biosynthetic process GO:0044283 157 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
negative regulation of cellular component organization GO:0051129 235 0.015
single organism cellular localization GO:1902580 332 0.015
oocyte differentiation GO:0009994 2 0.015
spermatid development GO:0007286 4 0.015
cellular response to dna damage stimulus GO:0006974 379 0.015
monocarboxylic acid metabolic process GO:0032787 185 0.015
negative regulation of hydrolase activity GO:0051346 182 0.014
alcohol metabolic process GO:0006066 114 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
organophosphate biosynthetic process GO:0090407 163 0.014
metal ion transport GO:0030001 272 0.014
negative regulation of apoptotic process GO:0043066 316 0.014
response to oxygen containing compound GO:1901700 369 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
protein acylation GO:0043543 138 0.014
positive regulation of organelle organization GO:0010638 195 0.014
glycoprotein metabolic process GO:0009100 110 0.014
oxidation reduction process GO:0055114 396 0.013
nitrogen compound transport GO:0071705 191 0.013
monovalent inorganic cation transport GO:0015672 128 0.013
calcium ion homeostasis GO:0055074 122 0.013
mitotic cell cycle GO:0000278 326 0.013
regulation of mapk cascade GO:0043408 262 0.013
regulation of protein processing GO:0070613 150 0.013
rna processing GO:0006396 255 0.013
regulation of locomotion GO:0040012 329 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
positive regulation of phosphorylation GO:0042327 394 0.013
regulation of cell migration GO:0030334 289 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
response to biotic stimulus GO:0009607 276 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
protein processing GO:0016485 226 0.013
cellular divalent inorganic cation homeostasis GO:0072503 128 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
sequestering of metal ion GO:0051238 24 0.013
negative regulation of synaptic transmission GO:0050805 2 0.013
regulation of cell differentiation GO:0045595 393 0.013
endocytosis GO:0006897 159 0.013
hindbrain development GO:0030902 3 0.013
positive regulation of proteolysis GO:0045862 142 0.013
regulation of cell cycle GO:0051726 393 0.013
positive regulation of nucleotide metabolic process GO:0045981 230 0.013
regeneration GO:0031099 4 0.013
regulation of ion transport GO:0043269 189 0.013
glycerophospholipid metabolic process GO:0006650 84 0.012
biological adhesion GO:0022610 331 0.012
mitotic cell cycle process GO:1903047 286 0.012
liposaccharide metabolic process GO:1903509 27 0.012
regulation of protein maturation GO:1903317 150 0.012
epithelium development GO:0060429 227 0.012
cell projection organization GO:0030030 252 0.012
inorganic cation transmembrane transport GO:0098662 194 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
endosomal transport GO:0016197 129 0.012
actin cytoskeleton organization GO:0030036 207 0.012
microtubule cytoskeleton organization GO:0000226 176 0.012
signal transduction by phosphorylation GO:0023014 297 0.012
regulation of multi organism process GO:0043900 157 0.012
cell part morphogenesis GO:0032990 137 0.012
organic anion transport GO:0015711 103 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
guanosine containing compound metabolic process GO:1901068 244 0.012
chromatin organization GO:0006325 351 0.012
chromatin modification GO:0016568 298 0.012
system process GO:0003008 349 0.012
fatty acid metabolic process GO:0006631 115 0.012
wnt signaling pathway GO:0016055 156 0.012
response to oxidative stress GO:0006979 121 0.012
regulation of protein localization GO:0032880 296 0.012
defense response to other organism GO:0098542 129 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
regulation of kinase activity GO:0043549 314 0.012
mitochondrion organization GO:0007005 156 0.012
regulation of nucleotide catabolic process GO:0030811 205 0.012
covalent chromatin modification GO:0016569 254 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
neuron differentiation GO:0030182 138 0.011
intracellular protein transport GO:0006886 270 0.011
mapk cascade GO:0000165 288 0.011
sensory perception of pain GO:0019233 4 0.011
regulation of cell cycle process GO:0010564 266 0.011
memory GO:0007613 3 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
regulation of cytokine production GO:0001817 232 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
histone modification GO:0016570 251 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
embryo development GO:0009790 123 0.011
morphogenesis of embryonic epithelium GO:0016331 4 0.011
cell projection assembly GO:0030031 126 0.011
actin filament based process GO:0030029 224 0.011
generation of neurons GO:0048699 152 0.011
cell growth GO:0016049 160 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
regulation of protein transport GO:0051223 213 0.011
protein targeting GO:0006605 187 0.011
regulation of growth GO:0040008 165 0.011
blastoderm segmentation GO:0007350 2 0.011
tissue homeostasis GO:0001894 63 0.011
cytokine production GO:0001816 247 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
atp catabolic process GO:0006200 157 0.011
regulation of gtp catabolic process GO:0033124 180 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
protein ubiquitination GO:0016567 314 0.011
coenzyme metabolic process GO:0006732 65 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
nerve development GO:0021675 4 0.011
glycoprotein biosynthetic process GO:0009101 91 0.011
negative regulation of locomotion GO:0040013 118 0.011
regulation of cell motility GO:2000145 299 0.011
neuron development GO:0048666 113 0.011
response to metal ion GO:0010038 84 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
divalent inorganic cation transport GO:0072511 158 0.010
dna repair GO:0006281 198 0.010
regulation of response to external stimulus GO:0032101 222 0.010
reproductive process GO:0022414 106 0.010
regulation of protein complex assembly GO:0043254 147 0.010
response to virus GO:0009615 126 0.010
response to other organism GO:0051707 261 0.010
segmentation GO:0035282 4 0.010
negative regulation of organelle organization GO:0010639 126 0.010
cofactor metabolic process GO:0051186 87 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010
calcium ion transport GO:0006816 147 0.010
negative regulation of developmental process GO:0051093 247 0.010
cell adhesion GO:0007155 325 0.010
response to cytokine GO:0034097 232 0.010
negative regulation of transferase activity GO:0051348 124 0.010
reactive nitrogen species metabolic process GO:2001057 3 0.010
cell projection morphogenesis GO:0048858 129 0.010

GBA disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.303
inherited metabolic disorder DOID:655 242 0.303
lysosomal storage disease DOID:3211 47 0.112
central nervous system disease DOID:331 186 0.048
nervous system disease DOID:863 431 0.048
lipid storage disease DOID:9455 28 0.023
immune system disease DOID:2914 155 0.015
brain disease DOID:936 73 0.014
disease of cellular proliferation DOID:14566 174 0.014
sensory system disease DOID:0050155 203 0.014
eye and adnexa disease DOID:1492 150 0.013
eye disease DOID:5614 149 0.013
cancer DOID:162 167 0.013
organ system cancer DOID:0050686 164 0.012
musculoskeletal system disease DOID:17 223 0.011
neurodegenerative disease DOID:1289 102 0.010
disease of mental health DOID:150 70 0.006
cognitive disorder DOID:1561 29 0.003
synucleinopathy DOID:0050890 22 0.002
parkinson s disease DOID:14330 18 0.002
dementia DOID:1307 19 0.001
sphingolipidosis DOID:1927 14 0.000
lewy body dementia DOID:12217 3 0.000