Homo sapiens

17 known processes

PPP6C

protein phosphatase 6, catalytic subunit

(Aliases: FLJ92648,PP6,MGC12249)

PPP6C biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of wnt signaling pathway GO:0030178 69 0.953
canonical wnt signaling pathway GO:0060070 116 0.770
post embryonic development GO:0009791 2 0.668
regulation of dephosphorylation GO:0035303 96 0.586
dephosphorylation GO:0016311 209 0.493
positive regulation of phosphorylation GO:0042327 394 0.455
endomembrane system organization GO:0010256 196 0.443
determination of adult lifespan GO:0008340 2 0.434
multicellular organismal aging GO:0010259 3 0.428
activation of jnkk activity GO:0007256 1 0.393
mapk cascade GO:0000165 288 0.355
signal transduction by phosphorylation GO:0023014 297 0.285
positive regulation of protein phosphorylation GO:0001934 313 0.283
regulation of phosphoprotein phosphatase activity GO:0043666 23 0.272
regulation of kinase activity GO:0043549 314 0.267
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.223
regulation of protein localization GO:0032880 296 0.220
protein maturation GO:0051604 233 0.217
peptidyl serine phosphorylation GO:0018105 101 0.205
regulation of phosphatase activity GO:0010921 81 0.199
protein autophosphorylation GO:0046777 123 0.192
embryonic epithelial tube formation GO:0001838 4 0.188
protein processing GO:0016485 226 0.179
mitotic cell cycle GO:0000278 326 0.172
Yeast Worm Fly
regulation of mapk cascade GO:0043408 262 0.147
negative regulation of mapk cascade GO:0043409 56 0.147
negative regulation of stress activated protein kinase signaling cascade GO:0070303 19 0.147
single organism membrane organization GO:0044802 268 0.143
apoptotic signaling pathway GO:0097190 268 0.133
regulation of microtubule based process GO:0032886 74 0.128
regulation of cellular component biogenesis GO:0044087 281 0.126
membrane organization GO:0061024 292 0.126
cellular macromolecule catabolic process GO:0044265 380 0.124
mitotic cell cycle process GO:1903047 286 0.123
Yeast Worm Fly
negative regulation of kinase activity GO:0033673 106 0.123
negative regulation of protein metabolic process GO:0051248 391 0.122
negative regulation of phosphate metabolic process GO:0045936 267 0.122
regulation of canonical wnt signaling pathway GO:0060828 88 0.121
negative regulation of phosphorus metabolic process GO:0010563 267 0.120
neural tube formation GO:0001841 3 0.112
compound eye development GO:0048749 1 0.110
peptidyl serine modification GO:0018209 106 0.109
protein localization to membrane GO:0072657 160 0.106
tor signaling GO:0031929 39 0.105
Yeast
wnt signaling pathway GO:0016055 156 0.105
protein localization to plasma membrane GO:0072659 93 0.104
organelle localization GO:0051640 84 0.104
Worm
negative regulation of phosphorylation GO:0042326 174 0.102
positive regulation of protein kinase activity GO:0045860 190 0.098
negative regulation of glial cell proliferation GO:0060253 2 0.095
negative regulation of protein modification process GO:0031400 200 0.094
single organism cellular localization GO:1902580 332 0.094
Worm
proteasomal protein catabolic process GO:0010498 176 0.093
hippo signaling GO:0035329 20 0.089
stress activated protein kinase signaling cascade GO:0031098 94 0.085
negative regulation of protein processing GO:0010955 142 0.085
positive regulation of transferase activity GO:0051347 227 0.082
negative regulation of stress activated mapk cascade GO:0032873 19 0.081
regulation of protein kinase activity GO:0045859 289 0.081
plasma membrane organization GO:0007009 115 0.080
microtubule based movement GO:0007018 32 0.078
modification dependent protein catabolic process GO:0019941 209 0.077
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.073
regulation of protein maturation GO:1903317 150 0.073
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.072
negative regulation of protein phosphorylation GO:0001933 140 0.072
negative regulation of protein transport GO:0051224 75 0.070
g1 s transition of mitotic cell cycle GO:0000082 78 0.069
Yeast Fly
morphogenesis of embryonic epithelium GO:0016331 4 0.069
regulation of cell differentiation GO:0045595 393 0.069
reproductive system development GO:0061458 56 0.067
meiotic chromosome segregation GO:0045132 4 0.066
intrinsic apoptotic signaling pathway GO:0097193 127 0.065
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.064
vesicle mediated transport GO:0016192 371 0.060
negative regulation of apoptotic process GO:0043066 316 0.059
regulation of stress activated mapk cascade GO:0032872 84 0.056
endocytosis GO:0006897 159 0.056
regulation of peptidase activity GO:0052547 180 0.055
negative regulation of intracellular signal transduction GO:1902532 183 0.055
protein localization to endoplasmic reticulum GO:0070972 19 0.055
stress activated mapk cascade GO:0051403 93 0.054
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.053
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.053
microtubule cytoskeleton organization GO:0000226 176 0.052
Worm
covalent chromatin modification GO:0016569 254 0.050
cortical actin cytoskeleton organization GO:0030866 9 0.048
Worm
nucleus localization GO:0051647 1 0.048
cytoplasmic transport GO:0016482 379 0.048
negative regulation of protein maturation GO:1903318 142 0.047
regulation of protein processing GO:0070613 150 0.047
ubiquitin dependent protein catabolic process GO:0006511 206 0.046
intracellular protein transport GO:0006886 270 0.045
ras protein signal transduction GO:0007265 73 0.044
nuclear migration GO:0007097 1 0.043
negative regulation of peptidase activity GO:0010466 91 0.043
cellular response to endogenous stimulus GO:0071495 336 0.043
regulation of cellular amino acid metabolic process GO:0006521 6 0.043
modification dependent macromolecule catabolic process GO:0043632 212 0.042
trachea development GO:0060438 1 0.042
negative regulation of cell proliferation GO:0008285 228 0.042
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.041
actin filament based process GO:0030029 224 0.040
Yeast Worm
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.040
microtubule based process GO:0007017 210 0.039
Worm
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.039
protein polyubiquitination GO:0000209 110 0.039
protein catabolic process GO:0030163 325 0.038
cell projection organization GO:0030030 252 0.038
rna interference GO:0016246 4 0.038
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.037
carbohydrate metabolic process GO:0005975 207 0.037
protein localization to organelle GO:0033365 280 0.036
regulation of wnt signaling pathway GO:0030111 123 0.036
cell development GO:0048468 328 0.036
tube development GO:0035295 125 0.035
negative regulation of endopeptidase activity GO:0010951 84 0.035
nucleoside triphosphate catabolic process GO:0009143 394 0.034
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.034
internal protein amino acid acetylation GO:0006475 101 0.034
embryo development GO:0009790 123 0.033
Worm
anatomical structure formation involved in morphogenesis GO:0048646 284 0.033
aging GO:0007568 66 0.033
Yeast
regulation of neurogenesis GO:0050767 82 0.033
negative regulation of hydrolase activity GO:0051346 182 0.033
female gamete generation GO:0007292 2 0.032
cellular response to dna damage stimulus GO:0006974 379 0.031
Yeast
negative regulation of protein kinase activity GO:0006469 98 0.031
positive regulation of cellular amine metabolic process GO:0033240 7 0.031
epidermal cell differentiation GO:0009913 45 0.031
negative regulation of catalytic activity GO:0043086 335 0.029
multi organism reproductive process GO:0044703 54 0.029
centrosome separation GO:0051299 3 0.029
positive regulation of kinase activity GO:0033674 204 0.029
negative regulation of programmed cell death GO:0043069 321 0.028
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.028
cellular protein catabolic process GO:0044257 261 0.028
negative regulation of cellular protein metabolic process GO:0032269 353 0.028
segmentation GO:0035282 4 0.028
nervous system development GO:0007399 293 0.027
cell morphogenesis GO:0000902 296 0.027
gtp catabolic process GO:0006184 237 0.027
meiosis i GO:0007127 4 0.027
programmed necrotic cell death GO:0097300 18 0.026
cell part morphogenesis GO:0032990 137 0.026
regulation of cell cycle process GO:0010564 266 0.026
enzyme linked receptor protein signaling pathway GO:0007167 303 0.025
guanosine containing compound metabolic process GO:1901068 244 0.025
reproductive process GO:0022414 106 0.025
regulation of cysteine type endopeptidase activity GO:2000116 127 0.025
regulation of cell cycle GO:0051726 393 0.025
anterior posterior axis specification GO:0009948 2 0.025
regulation of small gtpase mediated signal transduction GO:0051056 156 0.025
regulation of reactive oxygen species metabolic process GO:2000377 41 0.024
regulation of transferase activity GO:0051338 355 0.024
organ morphogenesis GO:0009887 147 0.024
pattern specification process GO:0007389 43 0.024
regulation of cellular ketone metabolic process GO:0010565 50 0.024
regulation of cell projection organization GO:0031344 107 0.023
reproduction GO:0000003 63 0.023
cell projection morphogenesis GO:0048858 129 0.023
axon cargo transport GO:0008088 2 0.023
cellular amine metabolic process GO:0044106 41 0.023
regulation of nervous system development GO:0051960 88 0.023
macromolecule glycosylation GO:0043413 63 0.023
regulation of protein complex assembly GO:0043254 147 0.022
phagocytosis GO:0006909 42 0.022
tissue homeostasis GO:0001894 63 0.022
cellular amide metabolic process GO:0043603 69 0.022
negative regulation of gliogenesis GO:0014014 3 0.022
cellular component assembly involved in morphogenesis GO:0010927 73 0.021
negative regulation of map kinase activity GO:0043407 27 0.021
heart development GO:0007507 95 0.021
negative regulation of proteolysis GO:0045861 132 0.021
signal transduction by p53 class mediator GO:0072331 72 0.021
cellular macromolecular complex assembly GO:0034622 324 0.020
cellular ketone metabolic process GO:0042180 80 0.020
regulation of cellular amine metabolic process GO:0033238 11 0.020
positive regulation of exocytosis GO:0045921 35 0.020
generation of neurons GO:0048699 152 0.020
anterior posterior axis specification embryo GO:0008595 2 0.020
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.019
endodermal cell fate specification GO:0001714 4 0.019
cardiovascular system development GO:0072358 262 0.019
blastoderm segmentation GO:0007350 2 0.019
cellular response to growth factor stimulus GO:0071363 197 0.019
negative regulation of protein localization to nucleus GO:1900181 34 0.019
dna damage checkpoint GO:0000077 68 0.019
protein complex disassembly GO:0043241 52 0.019
cellular component disassembly GO:0022411 92 0.019
response to external biotic stimulus GO:0043207 261 0.018
Zebrafish
negative regulation of cell differentiation GO:0045596 171 0.018
establishment or maintenance of cell polarity GO:0007163 31 0.018
neuromuscular junction development GO:0007528 3 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
response to cytokine GO:0034097 232 0.018
regulation of endopeptidase activity GO:0052548 170 0.018
embryo development ending in birth or egg hatching GO:0009792 34 0.018
rho protein signal transduction GO:0007266 26 0.018
carbohydrate derivative biosynthetic process GO:1901137 207 0.018
regulation of cell growth GO:0001558 135 0.018
positive regulation of multi organism process GO:0043902 56 0.017
protein acylation GO:0043543 138 0.017
regulation of cellular component movement GO:0051270 334 0.017
response to ionizing radiation GO:0010212 65 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.017
regulation of protein serine threonine kinase activity GO:0071900 179 0.017
amine metabolic process GO:0009308 44 0.017
cellular homeostasis GO:0019725 196 0.017
regulation of protein catabolic process GO:0042176 155 0.017
cell fate determination GO:0001709 3 0.017
cilium organization GO:0044782 68 0.017
regulation of protein transport GO:0051223 213 0.017
oocyte differentiation GO:0009994 2 0.017
protein targeting GO:0006605 187 0.017
neurogenesis GO:0022008 169 0.017
i kappab kinase nf kappab signaling GO:0007249 166 0.017
humoral immune response GO:0006959 49 0.017
fertilization GO:0009566 12 0.016
negative regulation of jun kinase activity GO:0043508 4 0.016
purine nucleoside triphosphate catabolic process GO:0009146 392 0.016
cellular protein complex assembly GO:0043623 188 0.016
embryonic morphogenesis GO:0048598 85 0.016
reproductive structure development GO:0048608 55 0.016
cellular response to gonadotropin stimulus GO:0071371 4 0.016
maintenance of protein location in cell GO:0032507 56 0.016
organonitrogen compound biosynthetic process GO:1901566 200 0.016
defense response to other organism GO:0098542 129 0.015
defense response to bacterium GO:0042742 63 0.015
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.015
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.015
regulation of protein polymerization GO:0032271 63 0.015
positive regulation of protein complex assembly GO:0031334 86 0.015
secretion GO:0046903 254 0.015
small gtpase mediated signal transduction GO:0007264 78 0.015
positive regulation of cell death GO:0010942 263 0.015
growth GO:0040007 202 0.015
regulation of transmembrane transporter activity GO:0022898 74 0.015
blood circulation GO:0008015 113 0.015
cell growth GO:0016049 160 0.014
cellular lipid metabolic process GO:0044255 303 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
regulation of heart contraction GO:0008016 50 0.014
regulation of cell development GO:0060284 161 0.014
negative regulation of transferase activity GO:0051348 124 0.014
antibacterial humoral response GO:0019731 24 0.014
nucleoside catabolic process GO:0009164 408 0.014
cellular amino acid metabolic process GO:0006520 116 0.014
cilium morphogenesis GO:0060271 75 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
oxidation reduction process GO:0055114 396 0.013
sister chromatid segregation GO:0000819 54 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
establishment of nucleus localization GO:0040023 1 0.013
endodermal cell fate commitment GO:0001711 4 0.013
system process GO:0003008 349 0.013
circulatory system development GO:0072359 262 0.013
single organism reproductive process GO:0044702 98 0.013
cell cycle arrest GO:0007050 71 0.013
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.013
maintenance of location GO:0051235 112 0.013
locomotory behavior GO:0007626 1 0.013
vesicle organization GO:0016050 62 0.013
maintenance of protein location GO:0045185 57 0.012
spermatid differentiation GO:0048515 4 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
adult locomotory behavior GO:0008344 1 0.012
response to hormone GO:0009725 175 0.012
purine containing compound catabolic process GO:0072523 411 0.012
regulation of immune effector process GO:0002697 91 0.012
negative regulation of jnk cascade GO:0046329 16 0.012
organelle fusion GO:0048284 36 0.012
developmental maturation GO:0021700 28 0.012
somitogenesis GO:0001756 2 0.012
nucleus organization GO:0006997 28 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
regeneration GO:0031099 4 0.012
response to virus GO:0009615 126 0.012
serine phosphorylation of stat protein GO:0042501 4 0.012
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.012
regulation of cellular response to stress GO:0080135 244 0.012
internal peptidyl lysine acetylation GO:0018393 97 0.012
organelle inheritance GO:0048308 2 0.011
mononuclear cell proliferation GO:0032943 71 0.011
neuron development GO:0048666 113 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
peptide metabolic process GO:0006518 51 0.011
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.011
oogenesis GO:0048477 2 0.011
response to tumor necrosis factor GO:0034612 76 0.011
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.011
chromatin organization GO:0006325 351 0.011
negative regulation of cell development GO:0010721 48 0.011
ribonucleoside triphosphate metabolic process GO:0009199 412 0.011
positive regulation of t cell cytokine production GO:0002726 4 0.011
regulation of dendrite morphogenesis GO:0048814 11 0.011
regulation of heart growth GO:0060420 4 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
protein depolymerization GO:0051261 30 0.011
developmental process involved in reproduction GO:0003006 66 0.011
central nervous system development GO:0007417 123 0.011
microtubule depolymerization GO:0007019 18 0.011
chromosome segregation GO:0007059 114 0.011
neuron death GO:0070997 65 0.011
negative regulation of cardiac muscle cell proliferation GO:0060044 2 0.011
eosinophil activation GO:0043307 3 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
positive regulation of cell cycle GO:0045787 140 0.010
hormone mediated signaling pathway GO:0009755 22 0.010
regulation of intracellular transport GO:0032386 195 0.010
tripartite regional subdivision GO:0007351 2 0.010
golgi vesicle transport GO:0048193 80 0.010
protein localization to mitochondrion GO:0070585 25 0.010
nucleoside triphosphate metabolic process GO:0009141 422 0.010
lipid transport GO:0006869 90 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.010
regulation of neuron differentiation GO:0045664 70 0.010
regulation of cytoskeleton organization GO:0051493 177 0.010
generation of precursor metabolites and energy GO:0006091 68 0.010
regulation of transmembrane transport GO:0034762 139 0.010

PPP6C disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.016
eye and adnexa disease DOID:1492 150 0.016
nervous system disease DOID:863 431 0.016
eye disease DOID:5614 149 0.016
disease of cellular proliferation DOID:14566 174 0.014
cancer DOID:162 167 0.012
organ system cancer DOID:0050686 164 0.012
disease of mental health DOID:150 70 0.011