Homo sapiens

15 known processes

PDHA2

pyruvate dehydrogenase (lipoamide) alpha 2

(Aliases: MGC149517,MGC149518,PDHAL)

PDHA2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cellular amine metabolic process GO:0033240 7 0.167
regulation of cellular amino acid metabolic process GO:0006521 6 0.101
cellular amine metabolic process GO:0044106 41 0.091
amine metabolic process GO:0009308 44 0.091
regulation of cellular amine metabolic process GO:0033238 11 0.090
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.081
cellular amino acid metabolic process GO:0006520 116 0.078
g protein coupled receptor signaling pathway GO:0007186 207 0.069
cation transport GO:0006812 331 0.066
regulation of cellular ketone metabolic process GO:0010565 50 0.063
cellular ketone metabolic process GO:0042180 80 0.056
cation transmembrane transport GO:0098655 238 0.053
immune response GO:0006955 307 0.049
post embryonic development GO:0009791 2 0.046
inorganic ion transmembrane transport GO:0098660 231 0.041
negative regulation of protein metabolic process GO:0051248 391 0.041
metal ion homeostasis GO:0055065 169 0.039
positive regulation of immune system process GO:0002684 283 0.039
response to other organism GO:0051707 261 0.038
regulation of cell cycle GO:0051726 393 0.038
negative regulation of cell migration GO:0030336 102 0.037
ion homeostasis GO:0050801 230 0.037
innate immune response GO:0045087 178 0.037
negative regulation of cellular protein metabolic process GO:0032269 353 0.036
response to abiotic stimulus GO:0009628 336 0.036
cytoplasmic transport GO:0016482 379 0.036
tissue migration GO:0090130 119 0.035
cellular homeostasis GO:0019725 196 0.035
system process GO:0003008 349 0.035
regulation of ion transport GO:0043269 189 0.035
metal ion transport GO:0030001 272 0.033
positive regulation of transport GO:0051050 336 0.033
negative regulation of catalytic activity GO:0043086 335 0.031
regulation of cell motility GO:2000145 299 0.031
negative regulation of cell death GO:0060548 345 0.031
response to biotic stimulus GO:0009607 276 0.030
cellular cation homeostasis GO:0030003 163 0.029
negative regulation of programmed cell death GO:0043069 321 0.029
ion transmembrane transport GO:0034220 338 0.029
chemical homeostasis GO:0048878 306 0.029
regulation of locomotion GO:0040012 329 0.029
negative regulation of apoptotic process GO:0043066 316 0.028
cellular calcium ion homeostasis GO:0006874 117 0.027
spermatid differentiation GO:0048515 4 0.027
actin filament based process GO:0030029 224 0.027
mating GO:0007618 1 0.027
response to external biotic stimulus GO:0043207 261 0.026
positive regulation of cytokine production GO:0001819 167 0.026
transmembrane transport GO:0055085 399 0.026
cation homeostasis GO:0055080 189 0.026
response to oxygen containing compound GO:1901700 369 0.026
female gamete generation GO:0007292 2 0.026
positive regulation of cell proliferation GO:0008284 301 0.026
calcium ion transport GO:0006816 147 0.026
cytosolic calcium ion homeostasis GO:0051480 89 0.026
circulatory system development GO:0072359 262 0.025
regulation of cell migration GO:0030334 289 0.025
cellular chemical homeostasis GO:0055082 180 0.024
protein processing GO:0016485 226 0.024
regulation of cell cycle process GO:0010564 266 0.024
oogenesis GO:0048477 2 0.024
monovalent inorganic cation transport GO:0015672 128 0.024
spermatid development GO:0007286 4 0.024
carbohydrate derivative biosynthetic process GO:1901137 207 0.024
cellular ion homeostasis GO:0006873 168 0.023
oxidation reduction process GO:0055114 396 0.023
divalent metal ion transport GO:0070838 152 0.023
reactive nitrogen species metabolic process GO:2001057 3 0.023
protein maturation GO:0051604 233 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
epithelium migration GO:0090132 119 0.022
regulation of ion transmembrane transport GO:0034765 132 0.022
regulation of transferase activity GO:0051338 355 0.022
copulation GO:0007620 1 0.022
determination of adult lifespan GO:0008340 2 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
response to lipid GO:0033993 206 0.022
opioid receptor signaling pathway GO:0038003 4 0.021
reactive oxygen species metabolic process GO:0072593 75 0.021
nucleotide biosynthetic process GO:0009165 109 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
regulation of metal ion transport GO:0010959 120 0.021
multicellular organismal aging GO:0010259 3 0.021
negative regulation of cell motility GO:2000146 104 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.021
cellular response to endogenous stimulus GO:0071495 336 0.021
inorganic cation transmembrane transport GO:0098662 194 0.021
divalent inorganic cation transport GO:0072511 158 0.020
negative regulation of protein modification process GO:0031400 200 0.020
signal transduction by phosphorylation GO:0023014 297 0.020
protein catabolic process GO:0030163 325 0.020
morphogenesis of embryonic epithelium GO:0016331 4 0.020
chromatin organization GO:0006325 351 0.020
response to growth factor GO:0070848 205 0.020
anatomical structure formation involved in morphogenesis GO:0048646 284 0.020
intracellular protein transport GO:0006886 270 0.020
ribonucleoside triphosphate catabolic process GO:0009203 391 0.020
epithelial cell migration GO:0010631 119 0.020
cellular protein catabolic process GO:0044257 261 0.020
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway GO:0035625 4 0.019
organophosphate biosynthetic process GO:0090407 163 0.019
cellular divalent inorganic cation homeostasis GO:0072503 128 0.019
secretion GO:0046903 254 0.019
divalent inorganic cation homeostasis GO:0072507 136 0.019
neurological system process GO:0050877 163 0.019
epidermis morphogenesis GO:0048730 3 0.019
neuromuscular junction development GO:0007528 3 0.019
single organism cellular localization GO:1902580 332 0.019
chromatin modification GO:0016568 298 0.019
protein modification by small protein conjugation GO:0032446 342 0.019
rhythmic behavior GO:0007622 2 0.019
cell activation GO:0001775 213 0.019
purine containing compound catabolic process GO:0072523 411 0.019
regulation of cellular component movement GO:0051270 334 0.019
purine nucleoside triphosphate catabolic process GO:0009146 392 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
vesicle mediated transport GO:0016192 371 0.019
defense response GO:0006952 315 0.018
cellular metal ion homeostasis GO:0006875 146 0.018
regulation of cell growth GO:0001558 135 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
ribonucleotide catabolic process GO:0009261 405 0.018
nucleoside phosphate biosynthetic process GO:1901293 109 0.018
neuropeptide signaling pathway GO:0007218 19 0.018
negative regulation of cellular component movement GO:0051271 106 0.018
purine ribonucleotide biosynthetic process GO:0009152 79 0.018
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
regulation of protein localization GO:0032880 296 0.018
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.018
ribose phosphate biosynthetic process GO:0046390 82 0.018
response to virus GO:0009615 126 0.018
regulation of keratinocyte migration GO:0051547 4 0.018
nucleoside monophosphate metabolic process GO:0009123 191 0.017
single organism membrane organization GO:0044802 268 0.017
calcium ion homeostasis GO:0055074 122 0.017
purine nucleotide biosynthetic process GO:0006164 84 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.017
ameboidal type cell migration GO:0001667 135 0.017
protein acetylation GO:0006473 116 0.017
secretion by cell GO:0032940 226 0.017
insemination GO:0007320 1 0.017
reproductive process GO:0022414 106 0.017
positive regulation of cell cycle GO:0045787 140 0.017
actin filament based movement GO:0030048 17 0.017
rna processing GO:0006396 255 0.017
cellular response to oxygen containing compound GO:1901701 276 0.017
ribonucleotide biosynthetic process GO:0009260 81 0.017
positive regulation of cellular component organization GO:0051130 376 0.017
regulation of immune response GO:0050776 201 0.017
positive regulation of locomotion GO:0040017 186 0.017
nitrogen compound transport GO:0071705 191 0.017
organonitrogen compound biosynthetic process GO:1901566 200 0.017
purine nucleoside monophosphate catabolic process GO:0009128 158 0.017
segmentation GO:0035282 4 0.017
purine nucleotide catabolic process GO:0006195 405 0.016
reactive oxygen species biosynthetic process GO:1903409 4 0.016
regulation of protein maturation GO:1903317 150 0.016
cell cycle phase transition GO:0044770 173 0.016
response to bacterium GO:0009617 144 0.016
regeneration GO:0031099 4 0.016
organelle assembly GO:0070925 176 0.016
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
mitotic cell cycle process GO:1903047 286 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
peptidyl tyrosine modification GO:0018212 170 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
negative regulation of cytosolic calcium ion concentration GO:0051481 1 0.016
cellular potassium ion transport GO:0071804 60 0.016
peptidyl tyrosine phosphorylation GO:0018108 170 0.016
actin mediated cell contraction GO:0070252 12 0.016
blastoderm segmentation GO:0007350 2 0.016
cell growth GO:0016049 160 0.016
nucleotide catabolic process GO:0009166 408 0.016
membrane organization GO:0061024 292 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
negative regulation of multicellular organismal process GO:0051241 317 0.016
nucleoside monophosphate catabolic process GO:0009125 159 0.016
regulation of circadian sleep wake cycle GO:0042749 2 0.016
actin cytoskeleton organization GO:0030036 207 0.016
regulation of protein kinase activity GO:0045859 289 0.016
purine nucleoside monophosphate metabolic process GO:0009126 186 0.016
negative regulation of locomotion GO:0040013 118 0.016
cellular macromolecular complex assembly GO:0034622 324 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
cyclic nucleotide metabolic process GO:0009187 82 0.015
cyclic nucleotide biosynthetic process GO:0009190 61 0.015
ribonucleoside catabolic process GO:0042454 406 0.015
sequestering of metal ion GO:0051238 24 0.015
regulation of transmembrane transport GO:0034762 139 0.015
serotonin transport GO:0006837 3 0.015
cellular lipid metabolic process GO:0044255 303 0.015
atp metabolic process GO:0046034 176 0.015
cell development GO:0048468 328 0.015
sleep GO:0030431 2 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
positive regulation of secretion by cell GO:1903532 108 0.015
ribonucleoside monophosphate metabolic process GO:0009161 187 0.015
negative regulation of transport GO:0051051 176 0.015
regulation of erk1 and erk2 cascade GO:0070372 99 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
mapk cascade GO:0000165 288 0.015
cell division GO:0051301 168 0.015
regulation of protein transport GO:0051223 213 0.015
response to nitrogen compound GO:1901698 184 0.015
regulation of intracellular transport GO:0032386 195 0.015
ribonucleoside triphosphate metabolic process GO:0009199 412 0.015
regulation of proteolysis GO:0030162 293 0.015
single organism reproductive process GO:0044702 98 0.015
anterior posterior axis specification GO:0009948 2 0.014
glycosyl compound catabolic process GO:1901658 413 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
epithelial cell differentiation GO:0030855 141 0.014
organophosphate catabolic process GO:0046434 430 0.014
maintenance of location GO:0051235 112 0.014
protein ubiquitination GO:0016567 314 0.014
sensory perception of pain GO:0019233 4 0.014
positive regulation of cell motility GO:2000147 177 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
nervous system development GO:0007399 293 0.014
response to hypoxia GO:0001666 96 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
cellular response to nitrogen compound GO:1901699 144 0.014
response to hormone GO:0009725 175 0.014
mitotic cell cycle GO:0000278 326 0.014
purine containing compound biosynthetic process GO:0072522 88 0.014
regulation of cytokine production GO:0001817 232 0.014
angiogenesis GO:0001525 147 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
regulation of secretion GO:0051046 194 0.014
cell morphogenesis GO:0000902 296 0.014
muscle contraction GO:0006936 73 0.014
memory GO:0007613 3 0.014
response to wounding GO:0009611 168 0.014
positive regulation of immune response GO:0050778 159 0.013
blood circulation GO:0008015 113 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.013
growth GO:0040007 202 0.013
ras protein signal transduction GO:0007265 73 0.013
negative regulation of wnt protein secretion GO:0061358 1 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
protein acylation GO:0043543 138 0.013
epithelium development GO:0060429 227 0.013
vasodilation GO:0042311 4 0.013
nucleoside catabolic process GO:0009164 408 0.013
oocyte development GO:0048599 1 0.013
purine ribonucleoside catabolic process GO:0046130 398 0.013
negative regulation of cellular component organization GO:0051129 235 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
sequestering of calcium ion GO:0051208 17 0.013
circadian behavior GO:0048512 2 0.013
protein oligomerization GO:0051259 173 0.013
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.013
cellular response to organic cyclic compound GO:0071407 127 0.013
enzyme linked receptor protein signaling pathway GO:0007167 303 0.013
central nervous system development GO:0007417 123 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.013
protein localization to organelle GO:0033365 280 0.013
regulation of cell division GO:0051302 116 0.013
regulation of protein processing GO:0070613 150 0.013
regulation of meiotic cell cycle GO:0051445 4 0.013
regulation of cellular response to stress GO:0080135 244 0.013
ribonucleoside monophosphate catabolic process GO:0009158 158 0.013
mitotic cell cycle phase transition GO:0044772 162 0.013
response to organic cyclic compound GO:0014070 204 0.013
organelle fission GO:0048285 149 0.013
immune system development GO:0002520 195 0.012
atp catabolic process GO:0006200 157 0.012
response to oxygen levels GO:0070482 100 0.012
biological adhesion GO:0022610 331 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
response to activity GO:0014823 0 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
cellular response to abiotic stimulus GO:0071214 117 0.012
associative learning GO:0008306 1 0.012
protein targeting GO:0006605 187 0.012
immune effector process GO:0002252 159 0.012
ureteric bud elongation GO:0060677 2 0.012
covalent chromatin modification GO:0016569 254 0.012
cellular component morphogenesis GO:0032989 314 0.012
muscle system process GO:0003012 81 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.012
oocyte differentiation GO:0009994 2 0.012
lipid metabolic process GO:0006629 381 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
adenylate cyclase inhibiting opioid receptor signaling pathway GO:0031635 1 0.012
cell projection organization GO:0030030 252 0.012
regulation of secretion by cell GO:1903530 177 0.012
lung alveolus development GO:0048286 4 0.012
cellular response to dna damage stimulus GO:0006974 379 0.012
embryonic epithelial tube formation GO:0001838 4 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
positive regulation of cellular component movement GO:0051272 181 0.012
regulation of reactive oxygen species metabolic process GO:2000377 41 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
regulation of growth GO:0040008 165 0.012
receptor transactivation GO:0035624 4 0.012
regulation of cell differentiation GO:0045595 393 0.012
axis elongation GO:0003401 4 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
regulation of kinase activity GO:0043549 314 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
carbohydrate metabolic process GO:0005975 207 0.012
positive regulation of synaptic transmission GO:0050806 4 0.012
regulation of cell adhesion GO:0030155 166 0.012
regulation of response to external stimulus GO:0032101 222 0.012
tripartite regional subdivision GO:0007351 2 0.012
nuclear transport GO:0051169 179 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
peptidyl serine modification GO:0018209 106 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
microtubule based process GO:0007017 210 0.012
apoptotic signaling pathway GO:0097190 268 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
negative regulation of growth GO:0045926 97 0.012
cell substrate adhesion GO:0031589 132 0.011
syncytium formation by plasma membrane fusion GO:0000768 2 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
response to axon injury GO:0048678 1 0.011
histone modification GO:0016570 251 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.011
response to lipopolysaccharide GO:0032496 70 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
cellular response to toxic substance GO:0097237 4 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
positive regulation of catabolic process GO:0009896 310 0.011
nucleoside phosphate catabolic process GO:1901292 412 0.011
regulation of lymphocyte activation GO:0051249 103 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
regulation of calcium ion transport GO:0051924 79 0.011
negative regulation of developmental process GO:0051093 247 0.011
dna repair GO:0006281 198 0.011
nuclear division GO:0000280 128 0.011
striated muscle contraction GO:0006941 52 0.011
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.011
cardiovascular system development GO:0072358 262 0.011
response to organonitrogen compound GO:0010243 156 0.011
regulation of mitotic cell cycle GO:0007346 189 0.011
regulation of mapk cascade GO:0043408 262 0.011
blood vessel development GO:0001568 172 0.011
meiosis i GO:0007127 4 0.011
sulfur compound metabolic process GO:0006790 101 0.011
vasculature development GO:0001944 181 0.011
regulation of system process GO:0044057 101 0.011
negative regulation of protein processing GO:0010955 142 0.011
regulation of protein secretion GO:0050708 86 0.011
modification dependent macromolecule catabolic process GO:0043632 212 0.011
regulation of protein complex assembly GO:0043254 147 0.011
negative regulation of transferase activity GO:0051348 124 0.011
negative regulation of synaptic transmission GO:0050805 2 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
anatomical structure homeostasis GO:0060249 100 0.011
response to disaccharide GO:0034285 1 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
locomotory behavior GO:0007626 1 0.011
cyclic purine nucleotide metabolic process GO:0052652 60 0.011
plasma membrane organization GO:0007009 115 0.011
cell adhesion GO:0007155 325 0.011
negative regulation of cell cycle GO:0045786 193 0.011
peripheral nervous system development GO:0007422 2 0.011
dephosphorylation GO:0016311 209 0.011
sensory perception of smell GO:0007608 2 0.010
positive regulation of cell migration GO:0030335 172 0.010
positive regulation of apoptotic process GO:0043065 246 0.010
lipid transport GO:0006869 90 0.010
positive regulation of transmembrane transport GO:0034764 41 0.010
cellular protein complex assembly GO:0043623 188 0.010
organ formation GO:0048645 3 0.010
tissue homeostasis GO:0001894 63 0.010
detection of chemical stimulus involved in sensory perception of smell GO:0050911 2 0.010
cytokine production GO:0001816 247 0.010
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.010
regulation of endopeptidase activity GO:0052548 170 0.010
single organism cell adhesion GO:0098602 179 0.010
endomembrane system organization GO:0010256 196 0.010
microtubule cytoskeleton organization GO:0000226 176 0.010

PDHA2 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.045
nervous system disease DOID:863 431 0.045
eye and adnexa disease DOID:1492 150 0.022
eye disease DOID:5614 149 0.022
musculoskeletal system disease DOID:17 223 0.021
retinal disease DOID:5679 118 0.020
cancer DOID:162 167 0.014
disease of cellular proliferation DOID:14566 174 0.014
organ system cancer DOID:0050686 164 0.014
disease of metabolism DOID:0014667 295 0.013
retinal degeneration DOID:8466 89 0.012
immune system disease DOID:2914 155 0.011
cardiovascular system disease DOID:1287 106 0.011
muscular disease DOID:0080000 114 0.011
muscle tissue disease DOID:66 113 0.011
myopathy DOID:423 104 0.011
central nervous system disease DOID:331 186 0.010