Homo sapiens

80 known processes

HIST4H4

histone cluster 4, H4

(Aliases: HIST1H4C,HIST1H4B,HIST1H4A,HIST1H4F,HIST1H4E,HIST1H4D,HIST1H4K,HIST1H4J,HIST1H4I,HIST1H4H,HIST1H4L,H4/p,MGC24116,HIST2H4B,HIST2H4A)

HIST4H4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna replication dependent nucleosome assembly GO:0006335 32 0.962
chromatin assembly or disassembly GO:0006333 78 0.846
chromatin organization GO:0006325 351 0.775
chromatin assembly GO:0031497 61 0.764
nucleosome assembly GO:0006334 50 0.700
dna conformation change GO:0071103 113 0.609
dna replication independent nucleosome assembly GO:0006336 27 0.596
covalent chromatin modification GO:0016569 254 0.553
Yeast
protein dna complex assembly GO:0065004 64 0.516
dna packaging GO:0006323 77 0.469
nucleosome organization GO:0034728 66 0.465
dna replication dependent nucleosome organization GO:0034723 32 0.391
dna replication independent nucleosome organization GO:0034724 27 0.374
histone modification GO:0016570 251 0.369
Yeast
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.266
Yeast
chromatin modification GO:0016568 298 0.221
Yeast
protein dna complex subunit organization GO:0071824 80 0.217
cellular macromolecular complex assembly GO:0034622 324 0.201
post embryonic development GO:0009791 2 0.137
regulation of cellular amine metabolic process GO:0033238 11 0.123
cellular amino acid metabolic process GO:0006520 116 0.114
histone methylation GO:0016571 60 0.109
Yeast
peptidyl lysine modification GO:0018205 144 0.105
methylation GO:0032259 106 0.098
Yeast
cellular ketone metabolic process GO:0042180 80 0.094
amine metabolic process GO:0009308 44 0.091
regulation of cellular ketone metabolic process GO:0010565 50 0.090
macromolecule methylation GO:0043414 97 0.089
Yeast
cellular response to dna damage stimulus GO:0006974 379 0.086
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.079
protein ubiquitination GO:0016567 314 0.077
internal protein amino acid acetylation GO:0006475 101 0.077
protein modification by small protein conjugation GO:0032446 342 0.076
oogenesis GO:0048477 2 0.076
positive regulation of cellular amine metabolic process GO:0033240 7 0.074
multicellular organismal aging GO:0010259 3 0.067
histone acetylation GO:0016573 93 0.063
female gamete generation GO:0007292 2 0.062
gene silencing GO:0016458 49 0.060
Yeast
regulation of cell cycle GO:0051726 393 0.055
protein alkylation GO:0008213 74 0.054
Yeast
cellular amine metabolic process GO:0044106 41 0.051
internal peptidyl lysine acetylation GO:0018393 97 0.050
protein catabolic process GO:0030163 325 0.049
regulation of cell growth GO:0001558 135 0.049
negative regulation of developmental process GO:0051093 247 0.048
segmentation GO:0035282 4 0.048
protein acylation GO:0043543 138 0.048
negative regulation of multicellular organismal process GO:0051241 317 0.048
determination of adult lifespan GO:0008340 2 0.046
peptidyl lysine acetylation GO:0018394 101 0.044
regulation of cellular amino acid metabolic process GO:0006521 6 0.044
mitotic cell cycle GO:0000278 326 0.044
protein processing GO:0016485 226 0.044
nervous system development GO:0007399 293 0.042
dna repair GO:0006281 198 0.042
positive regulation of organelle organization GO:0010638 195 0.042
growth GO:0040007 202 0.041
negative regulation of cellular protein metabolic process GO:0032269 353 0.041
cellular macromolecule catabolic process GO:0044265 380 0.041
negative regulation of protein maturation GO:1903318 142 0.039
regulation of cell differentiation GO:0045595 393 0.038
anatomical structure formation involved in morphogenesis GO:0048646 284 0.038
Yeast
negative regulation of protein metabolic process GO:0051248 391 0.038
negative regulation of cell differentiation GO:0045596 171 0.037
regulation of growth GO:0040008 165 0.036
cell morphogenesis GO:0000902 296 0.036
regulation of protein maturation GO:1903317 150 0.036
protein maturation GO:0051604 233 0.035
histone lysine methylation GO:0034968 50 0.033
Yeast
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.032
protein acetylation GO:0006473 116 0.032
ubiquitin dependent protein catabolic process GO:0006511 206 0.032
intracellular protein transport GO:0006886 270 0.031
positive regulation of cellular component organization GO:0051130 376 0.031
response to abiotic stimulus GO:0009628 336 0.031
cell growth GO:0016049 160 0.031
regulation of proteolysis GO:0030162 293 0.031
cytoplasmic transport GO:0016482 379 0.030
cell projection organization GO:0030030 252 0.030
regulation of protein processing GO:0070613 150 0.030
negative regulation of catalytic activity GO:0043086 335 0.030
negative regulation of cell death GO:0060548 345 0.030
rna processing GO:0006396 255 0.029
cellular component morphogenesis GO:0032989 314 0.029
mitotic cell cycle process GO:1903047 286 0.029
regulation of cell cycle process GO:0010564 266 0.029
modification dependent protein catabolic process GO:0019941 209 0.028
single organism cellular localization GO:1902580 332 0.028
purine ribonucleoside metabolic process GO:0046128 437 0.028
modification dependent macromolecule catabolic process GO:0043632 212 0.028
protein methylation GO:0006479 74 0.028
Yeast
muscle structure development GO:0061061 98 0.027
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.027
immune response GO:0006955 307 0.027
chromosome segregation GO:0007059 114 0.027
ras protein signal transduction GO:0007265 73 0.027
hematopoietic or lymphoid organ development GO:0048534 186 0.027
immune system development GO:0002520 195 0.027
positive regulation of phosphorylation GO:0042327 394 0.027
neurogenesis GO:0022008 169 0.027
organophosphate catabolic process GO:0046434 430 0.026
regulation of chromosome organization GO:0033044 103 0.025
protein localization to organelle GO:0033365 280 0.025
ribonucleoside triphosphate catabolic process GO:0009203 391 0.025
negative regulation of protein processing GO:0010955 142 0.025
negative regulation of programmed cell death GO:0043069 321 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.025
negative regulation of apoptotic process GO:0043066 316 0.025
cellular response to endogenous stimulus GO:0071495 336 0.025
positive regulation of apoptotic process GO:0043065 246 0.024
apoptotic signaling pathway GO:0097190 268 0.024
cell development GO:0048468 328 0.024
nucleoside phosphate catabolic process GO:1901292 412 0.024
mrna metabolic process GO:0016071 175 0.024
positive regulation of hydrolase activity GO:0051345 331 0.024
regulation of cellular response to stress GO:0080135 244 0.023
negative regulation of phosphorus metabolic process GO:0010563 267 0.023
purine nucleoside triphosphate metabolic process GO:0009144 412 0.023
cellular protein catabolic process GO:0044257 261 0.023
negative regulation of proteolysis GO:0045861 132 0.023
cellular response to oxygen containing compound GO:1901701 276 0.022
chemical homeostasis GO:0048878 306 0.022
negative regulation of cellular component organization GO:0051129 235 0.022
proteasomal protein catabolic process GO:0010498 176 0.022
regulation of transferase activity GO:0051338 355 0.022
regulation of peptidase activity GO:0052547 180 0.022
glycosyl compound catabolic process GO:1901658 413 0.022
mitotic cell cycle phase transition GO:0044772 162 0.022
blastoderm segmentation GO:0007350 2 0.022
negative regulation of cell cycle GO:0045786 193 0.021
nucleoside triphosphate catabolic process GO:0009143 394 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.021
nucleoside triphosphate metabolic process GO:0009141 422 0.021
regulation of protein kinase activity GO:0045859 289 0.021
generation of neurons GO:0048699 152 0.021
regulation of anatomical structure morphogenesis GO:0022603 286 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
positive regulation of programmed cell death GO:0043068 249 0.021
regulation of chromatin organization GO:1902275 56 0.021
cell adhesion GO:0007155 325 0.020
regeneration GO:0031099 4 0.020
cell cycle phase transition GO:0044770 173 0.020
ribonucleoside triphosphate metabolic process GO:0009199 412 0.020
dna replication GO:0006260 116 0.020
regulation of protein localization GO:0032880 296 0.020
regulation of protein catabolic process GO:0042176 155 0.020
myeloid cell differentiation GO:0030099 117 0.020
anterior posterior axis specification GO:0009948 2 0.020
membrane organization GO:0061024 292 0.020
regulation of mitotic cell cycle GO:0007346 189 0.020
regulation of establishment of protein localization GO:0070201 242 0.020
posttranscriptional regulation of gene expression GO:0010608 213 0.020
negative regulation of chromosome organization GO:2001251 48 0.019
metencephalon development GO:0022037 2 0.019
positive regulation of cell death GO:0010942 263 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
regulation of kinase activity GO:0043549 314 0.019
ribonucleoside catabolic process GO:0042454 406 0.019
neuromuscular junction development GO:0007528 3 0.019
cell part morphogenesis GO:0032990 137 0.019
locomotory behavior GO:0007626 1 0.019
cell division GO:0051301 168 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.019
regulation of apoptotic signaling pathway GO:2001233 175 0.019
cellular component disassembly GO:0022411 92 0.018
carbohydrate derivative biosynthetic process GO:1901137 207 0.018
regulation of cell morphogenesis GO:0022604 153 0.018
biological adhesion GO:0022610 331 0.018
small gtpase mediated signal transduction GO:0007264 78 0.018
regulation of endopeptidase activity GO:0052548 170 0.018
regulation of cellular protein catabolic process GO:1903362 96 0.018
mrna processing GO:0006397 133 0.018
response to hormone GO:0009725 175 0.018
positive regulation of transport GO:0051050 336 0.018
nucleoside catabolic process GO:0009164 408 0.018
system process GO:0003008 349 0.018
regulation of cell division GO:0051302 116 0.018
single organism carbohydrate metabolic process GO:0044723 193 0.018
positive regulation of catabolic process GO:0009896 310 0.017
negative regulation of catabolic process GO:0009895 104 0.017
ribonucleotide catabolic process GO:0009261 405 0.017
negative regulation of organelle organization GO:0010639 126 0.017
purine nucleoside catabolic process GO:0006152 398 0.017
regulation of response to dna damage stimulus GO:2001020 94 0.017
cation transport GO:0006812 331 0.017
regulation of gene silencing GO:0060968 24 0.017
single organism membrane organization GO:0044802 268 0.017
regulation of mitotic cell cycle phase transition GO:1901990 118 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
cell projection morphogenesis GO:0048858 129 0.016
purine nucleoside triphosphate catabolic process GO:0009146 392 0.016
cell morphogenesis involved in differentiation GO:0000904 144 0.016
positive regulation of developmental process GO:0051094 314 0.016
nucleotide catabolic process GO:0009166 408 0.016
neuron projection development GO:0031175 106 0.016
dephosphorylation GO:0016311 209 0.016
positive regulation of protein phosphorylation GO:0001934 313 0.016
response to decreased oxygen levels GO:0036293 96 0.016
purine ribonucleoside catabolic process GO:0046130 398 0.016
cell type specific apoptotic process GO:0097285 125 0.016
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.016
cranial nerve development GO:0021545 4 0.016
negative regulation of cell proliferation GO:0008285 228 0.016
cellular response to abiotic stimulus GO:0071214 117 0.016
carbohydrate metabolic process GO:0005975 207 0.016
response to radiation GO:0009314 151 0.016
regulation of gene expression epigenetic GO:0040029 73 0.015
Yeast
negative regulation of cellular catabolic process GO:0031330 83 0.015
reproductive process GO:0022414 106 0.015
Yeast
tripartite regional subdivision GO:0007351 2 0.015
regulation of cellular component biogenesis GO:0044087 281 0.015
regulation of chromatin modification GO:1903308 51 0.015
oocyte development GO:0048599 1 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.015
regulation of proteasomal protein catabolic process GO:0061136 87 0.015
negative regulation of cell cycle process GO:0010948 121 0.015
purine containing compound catabolic process GO:0072523 411 0.015
actin filament based process GO:0030029 224 0.015
positive regulation of kinase activity GO:0033674 204 0.015
intracellular receptor signaling pathway GO:0030522 104 0.015
organelle fission GO:0048285 149 0.015
positive regulation of transferase activity GO:0051347 227 0.015
rna splicing GO:0008380 131 0.015
muscle organ development GO:0007517 56 0.015
nitrogen compound transport GO:0071705 191 0.015
response to external biotic stimulus GO:0043207 261 0.014
anterior posterior axis specification embryo GO:0008595 2 0.014
response to oxygen containing compound GO:1901700 369 0.014
positive regulation of protein transport GO:0051222 135 0.014
cellular lipid metabolic process GO:0044255 303 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
cellular homeostasis GO:0019725 196 0.014
cellular response to cytokine stimulus GO:0071345 181 0.014
protein targeting GO:0006605 187 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
response to other organism GO:0051707 261 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
negative regulation of megakaryocyte differentiation GO:0045653 16 0.014
neuron differentiation GO:0030182 138 0.014
negative regulation of protein modification process GO:0031400 200 0.014
response to organic cyclic compound GO:0014070 204 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
metal ion transport GO:0030001 272 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.014
single organism reproductive process GO:0044702 98 0.014
Yeast
response to wounding GO:0009611 168 0.014
regulation of binding GO:0051098 111 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.014
maintenance of location GO:0051235 112 0.014
epithelium development GO:0060429 227 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
response to nitrogen compound GO:1901698 184 0.014
positive regulation of cellular catabolic process GO:0031331 284 0.014
metal ion homeostasis GO:0055065 169 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
negative regulation of protein catabolic process GO:0042177 59 0.013
vesicle mediated transport GO:0016192 371 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
spermatid differentiation GO:0048515 4 0.013
ion homeostasis GO:0050801 230 0.013
embryo development GO:0009790 123 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
regulation of cell development GO:0060284 161 0.013
blastocyst development GO:0001824 3 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
regulation of secretion GO:0051046 194 0.013
regulation of nuclear division GO:0051783 65 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
cellular protein complex assembly GO:0043623 188 0.013
atp metabolic process GO:0046034 176 0.013
neural crest cell development GO:0014032 3 0.013
mitotic nuclear division GO:0007067 119 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
limbic system development GO:0021761 3 0.013
signal transduction by p53 class mediator GO:0072331 72 0.013
negative regulation of cell cycle phase transition GO:1901988 89 0.013
protein oligomerization GO:0051259 173 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
thymus development GO:0048538 3 0.013
nuclear transport GO:0051169 179 0.013
regulation of locomotion GO:0040012 329 0.013
cation homeostasis GO:0055080 189 0.013
peptidyl tyrosine modification GO:0018212 170 0.013
regulation of cytokine production GO:0001817 232 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
glial cell migration GO:0008347 4 0.013
neurological system process GO:0050877 163 0.012
negative regulation of myeloid cell differentiation GO:0045638 42 0.012
positive regulation of chromosome organization GO:2001252 41 0.012
dna damage checkpoint GO:0000077 68 0.012
negative regulation of growth GO:0045926 97 0.012
negative regulation of immune system process GO:0002683 136 0.012
endomembrane system organization GO:0010256 196 0.012
oocyte differentiation GO:0009994 2 0.012
innate immune response GO:0045087 178 0.012
response to oxygen levels GO:0070482 100 0.012
secretion by cell GO:0032940 226 0.012
peripheral nervous system development GO:0007422 2 0.012
oxidation reduction process GO:0055114 396 0.012
spermatid development GO:0007286 4 0.012
memory GO:0007613 3 0.012
tissue regeneration GO:0042246 3 0.012
regulation of cell migration GO:0030334 289 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
regulation of multi organism process GO:0043900 157 0.012
response to organonitrogen compound GO:0010243 156 0.012
regulation of mitosis GO:0007088 63 0.012
regulation of cellular component movement GO:0051270 334 0.012
adult locomotory behavior GO:0008344 1 0.012
cardiovascular system development GO:0072358 262 0.012
response to hypoxia GO:0001666 96 0.012
ameboidal type cell migration GO:0001667 135 0.012
response to growth factor GO:0070848 205 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
negative regulation of cell growth GO:0030308 83 0.012
negative regulation of cellular protein catabolic process GO:1903363 38 0.012
protein localization to membrane GO:0072657 160 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
negative regulation of cell migration GO:0030336 102 0.012
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.012
protein complex disassembly GO:0043241 52 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
developmental process involved in reproduction GO:0003006 66 0.012
Yeast
mapk cascade GO:0000165 288 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
gtp catabolic process GO:0006184 237 0.012
cell cycle checkpoint GO:0000075 117 0.012
regulation of megakaryocyte differentiation GO:0045652 22 0.012
hindbrain development GO:0030902 3 0.012
defense response GO:0006952 315 0.012
dna integrity checkpoint GO:0031570 71 0.012
response to lipid GO:0033993 206 0.012
interspecies interaction between organisms GO:0044419 156 0.012
cellular response to hormone stimulus GO:0032870 125 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
head development GO:0060322 108 0.012
cerebellum development GO:0021549 2 0.011
multi organism cellular process GO:0044764 156 0.011
regulation of ion transport GO:0043269 189 0.011
ossification GO:0001503 121 0.011
transmembrane transport GO:0055085 399 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
mitotic cell cycle checkpoint GO:0007093 68 0.011
hemopoiesis GO:0030097 180 0.011
signal transduction in response to dna damage GO:0042770 57 0.011
regulation of intracellular transport GO:0032386 195 0.011
histone h4 acetylation GO:0043967 47 0.011
regulation of dna metabolic process GO:0051052 153 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
positive regulation of cell growth GO:0030307 48 0.011
tube development GO:0035295 125 0.011
negative regulation of apoptotic signaling pathway GO:2001234 97 0.011
regulation of protein transport GO:0051223 213 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
circulatory system development GO:0072359 262 0.011
cellular response to radiation GO:0071478 65 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.011
wnt signaling pathway GO:0016055 156 0.011
protein localization to nucleus GO:0034504 136 0.011
negative regulation of gene expression epigenetic GO:0045814 19 0.011
Yeast
epithelial cell differentiation GO:0030855 141 0.011
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.011
response to inorganic substance GO:0010035 127 0.011
protein import GO:0017038 130 0.011
regulation of nucleotide catabolic process GO:0030811 205 0.011
neuron development GO:0048666 113 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
macromolecular complex disassembly GO:0032984 60 0.011
gtp metabolic process GO:0046039 239 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
positive regulation of cell cycle process GO:0090068 106 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
glycoprotein metabolic process GO:0009100 110 0.011
primary neural tube formation GO:0014020 3 0.010
cellular ion homeostasis GO:0006873 168 0.010
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.010
regulation of response to external stimulus GO:0032101 222 0.010
response to metal ion GO:0010038 84 0.010
cellular response to oxidative stress GO:0034599 85 0.010
positive regulation of cell cycle GO:0045787 140 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.010
regulation of reactive oxygen species metabolic process GO:2000377 41 0.010
negative regulation of protein phosphorylation GO:0001933 140 0.010
response to ionizing radiation GO:0010212 65 0.010
negative regulation of kinase activity GO:0033673 106 0.010
positive regulation of peptidase activity GO:0010952 88 0.010
vasculature development GO:0001944 181 0.010
mitotic sister chromatid separation GO:0051306 18 0.010
chemotaxis GO:0006935 157 0.010
sensory perception of pain GO:0019233 4 0.010
divalent inorganic cation transport GO:0072511 158 0.010
regulation of defense response GO:0031347 154 0.010
regulation of small gtpase mediated signal transduction GO:0051056 156 0.010

HIST4H4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.024
disease of cellular proliferation DOID:14566 174 0.019
immune system disease DOID:2914 155 0.018
cancer DOID:162 167 0.018
organ system cancer DOID:0050686 164 0.017
musculoskeletal system disease DOID:17 223 0.017
central nervous system disease DOID:331 186 0.015
nervous system disease DOID:863 431 0.015
sensory system disease DOID:0050155 203 0.014
inherited metabolic disorder DOID:655 242 0.012
eye and adnexa disease DOID:1492 150 0.011
connective tissue disease DOID:65 109 0.011
eye disease DOID:5614 149 0.010
neurodegenerative disease DOID:1289 102 0.010