Homo sapiens

31 known processes

POLR2B

polymerase (RNA) II (DNA directed) polypeptide B, 140kDa

(Aliases: hRPB140,hsRPB2,RPB2,POL2RB)

POLR2B biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.801
Worm
regulation of meiotic cell cycle GO:0051445 4 0.431
female gamete generation GO:0007292 2 0.353
regulation of meiosis GO:0040020 3 0.343
nuclear division GO:0000280 128 0.336
rna processing GO:0006396 255 0.326
organelle fission GO:0048285 149 0.261
purine nucleoside monophosphate catabolic process GO:0009128 158 0.247
atp catabolic process GO:0006200 157 0.238
response to biotic stimulus GO:0009607 276 0.226
response to other organism GO:0051707 261 0.217
macromolecule methylation GO:0043414 97 0.205
nucleoside monophosphate metabolic process GO:0009123 191 0.202
response to external biotic stimulus GO:0043207 261 0.201
purine ribonucleoside catabolic process GO:0046130 398 0.186
ribonucleoside monophosphate metabolic process GO:0009161 187 0.180
nucleoside monophosphate catabolic process GO:0009125 159 0.179
regulation of cell cycle process GO:0010564 266 0.172
cell development GO:0048468 328 0.169
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.156
oogenesis GO:0048477 2 0.154
atp metabolic process GO:0046034 176 0.152
vesicle mediated transport GO:0016192 371 0.145
cellular macromolecule catabolic process GO:0044265 380 0.144
cell cycle phase transition GO:0044770 173 0.140
positive regulation of cellular amine metabolic process GO:0033240 7 0.137
mrna metabolic process GO:0016071 175 0.133
rna splicing GO:0008380 131 0.129
purine nucleoside monophosphate metabolic process GO:0009126 186 0.122
nucleoside catabolic process GO:0009164 408 0.117
mitotic cell cycle process GO:1903047 286 0.113
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.112
embryo development GO:0009790 123 0.112
Worm
methylation GO:0032259 106 0.107
rna interference GO:0016246 4 0.107
gene silencing GO:0016458 49 0.103
cellular amine metabolic process GO:0044106 41 0.102
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.101
single organism reproductive process GO:0044702 98 0.100
Worm
organophosphate catabolic process GO:0046434 430 0.098
ribonucleoside catabolic process GO:0042454 406 0.096
determination of adult lifespan GO:0008340 2 0.093
ribonucleotide catabolic process GO:0009261 405 0.091
purine nucleoside triphosphate catabolic process GO:0009146 392 0.090
regulation of cell cycle GO:0051726 393 0.088
mitotic cell cycle GO:0000278 326 0.088
cellular ketone metabolic process GO:0042180 80 0.087
embryo development ending in birth or egg hatching GO:0009792 34 0.085
Worm
developmental growth GO:0048589 48 0.073
ncrna processing GO:0034470 83 0.070
cell division GO:0051301 168 0.069
protein catabolic process GO:0030163 325 0.069
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.068
mitotic nuclear division GO:0007067 119 0.068
regulation of mitotic cell cycle phase transition GO:1901990 118 0.068
posttranscriptional regulation of gene expression GO:0010608 213 0.066
endocytosis GO:0006897 159 0.065
cellular response to dna damage stimulus GO:0006974 379 0.064
nucleoside triphosphate catabolic process GO:0009143 394 0.064
negative regulation of cell death GO:0060548 345 0.062
regulation of cellular amine metabolic process GO:0033238 11 0.062
nucleotide catabolic process GO:0009166 408 0.062
regulation of growth GO:0040008 165 0.061
ribonucleoside monophosphate catabolic process GO:0009158 158 0.061
negative regulation of cell cycle process GO:0010948 121 0.060
defense response GO:0006952 315 0.059
protein modification by small protein conjugation GO:0032446 342 0.059
posttranscriptional gene silencing GO:0016441 25 0.057
system process GO:0003008 349 0.056
regulation of cellular amino acid metabolic process GO:0006521 6 0.055
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.054
developmental process involved in reproduction GO:0003006 66 0.054
Worm
embryonic morphogenesis GO:0048598 85 0.053
neurogenesis GO:0022008 169 0.052
negative regulation of apoptotic process GO:0043066 316 0.051
cellular amino acid metabolic process GO:0006520 116 0.051
rna phosphodiester bond hydrolysis GO:0090501 35 0.049
receptor mediated endocytosis GO:0006898 84 0.049
sister chromatid segregation GO:0000819 54 0.048
mrna splicing via spliceosome GO:0000398 89 0.048
purine ribonucleoside metabolic process GO:0046128 437 0.048
purine containing compound catabolic process GO:0072523 411 0.048
ribonucleoside triphosphate catabolic process GO:0009203 391 0.047
positive regulation of cellular component organization GO:0051130 376 0.047
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.047
purine nucleoside triphosphate metabolic process GO:0009144 412 0.046
glycosyl compound catabolic process GO:1901658 413 0.045
growth GO:0040007 202 0.042
purine nucleotide catabolic process GO:0006195 405 0.042
generation of neurons GO:0048699 152 0.042
spermatid development GO:0007286 4 0.041
response to bacterium GO:0009617 144 0.041
chromatin modification GO:0016568 298 0.040
protein methylation GO:0006479 74 0.040
reproductive structure development GO:0048608 55 0.039
Worm
negative regulation of cellular protein metabolic process GO:0032269 353 0.039
defense response to other organism GO:0098542 129 0.038
ncrna metabolic process GO:0034660 108 0.037
rna 3 end processing GO:0031123 35 0.037
regulation of nuclear division GO:0051783 65 0.037
segmentation GO:0035282 4 0.036
multicellular organismal aging GO:0010259 3 0.036
regulation of developmental growth GO:0048638 30 0.036
immune response GO:0006955 307 0.035
positive regulation of growth GO:0045927 58 0.035
regulation of cellular ketone metabolic process GO:0010565 50 0.035
negative regulation of cell cycle GO:0045786 193 0.035
dna conformation change GO:0071103 113 0.034
mitotic cell cycle phase transition GO:0044772 162 0.033
dna repair GO:0006281 198 0.033
reproduction GO:0000003 63 0.033
Worm
response to organic cyclic compound GO:0014070 204 0.032
spermatid differentiation GO:0048515 4 0.031
cellular macromolecular complex assembly GO:0034622 324 0.031
nucleoside phosphate catabolic process GO:1901292 412 0.031
purine nucleoside catabolic process GO:0006152 398 0.031
regulation of cellular component biogenesis GO:0044087 281 0.030
cytoplasmic transport GO:0016482 379 0.030
intrinsic apoptotic signaling pathway GO:0097193 127 0.030
meiotic chromosome segregation GO:0045132 4 0.030
apoptotic signaling pathway GO:0097190 268 0.029
chromatin organization GO:0006325 351 0.029
regulation of rna splicing GO:0043484 62 0.029
cellular response to organic cyclic compound GO:0071407 127 0.028
modification dependent macromolecule catabolic process GO:0043632 212 0.028
negative regulation of programmed cell death GO:0043069 321 0.028
microtubule based process GO:0007017 210 0.027
circulatory system development GO:0072359 262 0.027
cellular component morphogenesis GO:0032989 314 0.027
nucleoside triphosphate metabolic process GO:0009141 422 0.027
purine ribonucleotide catabolic process GO:0009154 404 0.026
blastocyst development GO:0001824 3 0.026
neuron development GO:0048666 113 0.026
reproductive process GO:0022414 106 0.025
Worm
rna splicing via transesterification reactions GO:0000375 90 0.025
multicellular organismal reproductive process GO:0048609 40 0.025
positive regulation of developmental process GO:0051094 314 0.025
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.025
amine metabolic process GO:0009308 44 0.024
cardiovascular system development GO:0072358 262 0.024
negative regulation of phosphate metabolic process GO:0045936 267 0.023
innate immune response GO:0045087 178 0.023
negative regulation of cell cycle phase transition GO:1901988 89 0.023
intracellular protein transport GO:0006886 270 0.023
mrna processing GO:0006397 133 0.022
cell morphogenesis GO:0000902 296 0.022
chromosome segregation GO:0007059 114 0.022
neuromuscular junction development GO:0007528 3 0.022
gene silencing by rna GO:0031047 26 0.021
regulation of dna metabolic process GO:0051052 153 0.021
regulation of cell cycle phase transition GO:1901987 126 0.021
reproductive system development GO:0061458 56 0.021
Worm
protein localization to organelle GO:0033365 280 0.020
mitotic sister chromatid segregation GO:0000070 53 0.020
nervous system development GO:0007399 293 0.020
meiotic nuclear division GO:0007126 10 0.019
positive regulation of catabolic process GO:0009896 310 0.019
protein ubiquitination GO:0016567 314 0.019
multicellular organism reproduction GO:0032504 42 0.019
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.019
response to radiation GO:0009314 151 0.018
regulation of gene expression epigenetic GO:0040029 73 0.018
mitotic dna replication checkpoint GO:0033314 2 0.018
signal transduction by p53 class mediator GO:0072331 72 0.018
negative regulation of cellular component organization GO:0051129 235 0.018
response to abiotic stimulus GO:0009628 336 0.018
covalent chromatin modification GO:0016569 254 0.017
positive regulation of cellular component biogenesis GO:0044089 158 0.017
defense response to bacterium GO:0042742 63 0.017
microtubule cytoskeleton organization GO:0000226 176 0.017
regulation of cell division GO:0051302 116 0.017
development of primary sexual characteristics GO:0045137 35 0.017
Worm
regulation of protein complex assembly GO:0043254 147 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
aging GO:0007568 66 0.017
single organism cellular localization GO:1902580 332 0.017
dna integrity checkpoint GO:0031570 71 0.017
response to growth factor GO:0070848 205 0.016
cellular protein catabolic process GO:0044257 261 0.016
nitrogen compound transport GO:0071705 191 0.016
ribonucleoprotein complex biogenesis GO:0022613 116 0.016
nucleus organization GO:0006997 28 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
neurological system process GO:0050877 163 0.016
cell type specific apoptotic process GO:0097285 125 0.015
response to lipid GO:0033993 206 0.015
response to nitrogen compound GO:1901698 184 0.015
multi organism reproductive process GO:0044703 54 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
positive regulation of protein complex assembly GO:0031334 86 0.015
nucleobase containing compound transport GO:0015931 51 0.015
negative regulation of developmental process GO:0051093 247 0.015
cellular protein complex assembly GO:0043623 188 0.015
cell morphogenesis involved in differentiation GO:0000904 144 0.015
response to oxygen containing compound GO:1901700 369 0.015
g2 dna damage checkpoint GO:0031572 26 0.013
blood vessel development GO:0001568 172 0.013
nucleosome organization GO:0034728 66 0.013
stem cell differentiation GO:0048863 93 0.013
cellular response to oxygen containing compound GO:1901701 276 0.013
establishment of protein localization to organelle GO:0072594 172 0.013
meiotic cell cycle GO:0051321 13 0.013
cell projection morphogenesis GO:0048858 129 0.013
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.013
neuron differentiation GO:0030182 138 0.013
lipid metabolic process GO:0006629 381 0.013
histone methylation GO:0016571 60 0.013
protein dna complex subunit organization GO:0071824 80 0.013
vasculature development GO:0001944 181 0.012
cell projection organization GO:0030030 252 0.012
regulation of immune response GO:0050776 201 0.012
cellular amide metabolic process GO:0043603 69 0.012
cell cycle checkpoint GO:0000075 117 0.012
negative regulation of immune system process GO:0002683 136 0.012
nuclear transcribed mrna catabolic process GO:0000956 48 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
regionalization GO:0003002 29 0.012
posttranscriptional gene silencing by rna GO:0035194 25 0.012
chemotaxis GO:0006935 157 0.012
engulfment of apoptotic cell GO:0043652 2 0.012
gonad development GO:0008406 34 0.012
Worm
nuclear import GO:0051170 106 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
histone modification GO:0016570 251 0.011
peptidyl lysine modification GO:0018205 144 0.011
regulation of chromosome organization GO:0033044 103 0.011
regulation of chromatin organization GO:1902275 56 0.011
protein dephosphorylation GO:0006470 81 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
sexual reproduction GO:0019953 37 0.011
regulation of multicellular organism growth GO:0040014 8 0.011
protein polyubiquitination GO:0000209 110 0.011
regulation of nervous system development GO:0051960 88 0.010
striated muscle contraction GO:0006941 52 0.010
tube development GO:0035295 125 0.010
cell growth GO:0016049 160 0.010

POLR2B disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.014
nervous system disease DOID:863 431 0.014
neurodegenerative disease DOID:1289 102 0.010