Homo sapiens

31 known processes

POLR2L

polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

(Aliases: RPB7.6,RPABC5,RBP10,RPB10beta,RPB10,hRPB7.6,hsRPB10b)

POLR2L biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of apoptotic signaling pathway GO:2001233 175 0.307
cellular lipid metabolic process GO:0044255 303 0.275
membrane organization GO:0061024 292 0.231
vesicle mediated transport GO:0016192 371 0.226
regulation of cell cycle process GO:0010564 266 0.200
regulation of cell cycle GO:0051726 393 0.174
post embryonic development GO:0009791 2 0.147
negative regulation of apoptotic process GO:0043066 316 0.145
transcription from rna polymerase iii promoter GO:0006383 19 0.118
Yeast
single organism membrane organization GO:0044802 268 0.114
lipid metabolic process GO:0006629 381 0.091
oogenesis GO:0048477 2 0.089
negative regulation of phosphate metabolic process GO:0045936 267 0.081
positive regulation of transport GO:0051050 336 0.075
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.072
negative regulation of cellular protein metabolic process GO:0032269 353 0.069
fatty acid metabolic process GO:0006631 115 0.069
negative regulation of cell cycle GO:0045786 193 0.067
reactive oxygen species metabolic process GO:0072593 75 0.063
extrinsic apoptotic signaling pathway GO:0097191 119 0.062
apoptotic signaling pathway GO:0097190 268 0.060
positive regulation of cellular component organization GO:0051130 376 0.060
positive regulation of cell death GO:0010942 263 0.059
cell development GO:0048468 328 0.059
negative regulation of protein metabolic process GO:0051248 391 0.058
negative regulation of catalytic activity GO:0043086 335 0.053
mitotic cell cycle GO:0000278 326 0.053
posttranscriptional regulation of gene expression GO:0010608 213 0.052
mitochondrial membrane organization GO:0007006 40 0.051
regulation of peroxidase activity GO:2000468 2 0.050
cellular response to dna damage stimulus GO:0006974 379 0.050
single organism cellular localization GO:1902580 332 0.049
negative regulation of cell death GO:0060548 345 0.048
protein localization to membrane GO:0072657 160 0.046
regulation of mitotic cell cycle phase transition GO:1901990 118 0.045
mitochondrion organization GO:0007005 156 0.044
endocytosis GO:0006897 159 0.044
intracellular protein transport GO:0006886 270 0.043
negative regulation of programmed cell death GO:0043069 321 0.043
mapk cascade GO:0000165 288 0.042
cytoplasmic transport GO:0016482 379 0.041
regulation of endopeptidase activity GO:0052548 170 0.041
photoreceptor cell differentiation GO:0046530 2 0.040
positive regulation of cell proliferation GO:0008284 301 0.039
negative regulation of phosphorylation GO:0042326 174 0.038
immune response GO:0006955 307 0.037
female gamete generation GO:0007292 2 0.037
mitotic cell cycle process GO:1903047 286 0.037
regulation of mitotic cell cycle GO:0007346 189 0.035
regulation of growth GO:0040008 165 0.035
negative regulation of apoptotic signaling pathway GO:2001234 97 0.034
cellular amine metabolic process GO:0044106 41 0.033
neurogenesis GO:0022008 169 0.032
oxidation reduction process GO:0055114 396 0.032
negative regulation of mitotic cell cycle GO:0045930 102 0.032
regulation of kinase activity GO:0043549 314 0.031
positive regulation of nucleotide metabolic process GO:0045981 230 0.031
mitotic cell cycle phase transition GO:0044772 162 0.031
cellular ketone metabolic process GO:0042180 80 0.030
negative regulation of cell proliferation GO:0008285 228 0.030
rna interference GO:0016246 4 0.030
regulation of peptidase activity GO:0052547 180 0.030
interleukin 1 beta production GO:0032611 22 0.030
intrinsic apoptotic signaling pathway GO:0097193 127 0.030
positive regulation of hydrolase activity GO:0051345 331 0.029
regulation of protein localization GO:0032880 296 0.029
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.029
regulation of map kinase activity GO:0043405 108 0.028
regulation of cell division GO:0051302 116 0.028
negative regulation of intracellular signal transduction GO:1902532 183 0.027
response to oxygen containing compound GO:1901700 369 0.027
response to lipid GO:0033993 206 0.026
cellular response to oxygen containing compound GO:1901701 276 0.026
regulation of cell growth GO:0001558 135 0.026
cell division GO:0051301 168 0.026
cell cycle phase transition GO:0044770 173 0.026
organelle assembly GO:0070925 176 0.026
establishment of protein localization to organelle GO:0072594 172 0.025
regulation of protein serine threonine kinase activity GO:0071900 179 0.025
cellular response to lipid GO:0071396 127 0.025
cellular component morphogenesis GO:0032989 314 0.025
reproduction GO:0000003 63 0.025
organelle fission GO:0048285 149 0.025
positive regulation of apoptotic process GO:0043065 246 0.024
negative regulation of phosphorus metabolic process GO:0010563 267 0.024
positive regulation of programmed cell death GO:0043068 249 0.023
amine metabolic process GO:0009308 44 0.023
negative regulation of hydrolase activity GO:0051346 182 0.023
regulation of protein catabolic process GO:0042176 155 0.022
regulation of proteolysis GO:0030162 293 0.022
positive regulation of apoptotic signaling pathway GO:2001235 70 0.022
regulation of response to external stimulus GO:0032101 222 0.022
regulation of transferase activity GO:0051338 355 0.022
transmembrane transport GO:0055085 399 0.022
small molecule biosynthetic process GO:0044283 157 0.022
positive regulation of cellular amine metabolic process GO:0033240 7 0.022
establishment of protein localization to membrane GO:0090150 121 0.022
regulation of cell motility GO:2000145 299 0.021
defense response GO:0006952 315 0.021
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.020
defense response to other organism GO:0098542 129 0.020
positive regulation of developmental process GO:0051094 314 0.020
monocarboxylic acid metabolic process GO:0032787 185 0.019
spermatid differentiation GO:0048515 4 0.019
negative regulation of cell cycle phase transition GO:1901988 89 0.019
regulation of leukocyte activation GO:0002694 115 0.019
hematopoietic or lymphoid organ development GO:0048534 186 0.018
regulation of protein stability GO:0031647 87 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
response to radiation GO:0009314 151 0.018
secretion by cell GO:0032940 226 0.018
regulation of mapk cascade GO:0043408 262 0.018
regulation of anatomical structure morphogenesis GO:0022603 286 0.018
carbohydrate derivative biosynthetic process GO:1901137 207 0.018
protein localization to organelle GO:0033365 280 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
negative regulation of protein phosphorylation GO:0001933 140 0.017
regulation of intracellular transport GO:0032386 195 0.017
response to bacterium GO:0009617 144 0.017
cell cycle checkpoint GO:0000075 117 0.017
regulation of mitochondrion organization GO:0010821 54 0.017
response to reactive oxygen species GO:0000302 61 0.017
cellular response to external stimulus GO:0071496 111 0.016
glycerophospholipid metabolic process GO:0006650 84 0.016
replicative cell aging GO:0001302 3 0.016
cell growth GO:0016049 160 0.016
regulation of response to wounding GO:1903034 101 0.016
apoptotic mitochondrial changes GO:0008637 57 0.016
intracellular protein transmembrane import GO:0044743 23 0.016
response to light stimulus GO:0009416 87 0.016
actin filament based process GO:0030029 224 0.016
protein import GO:0017038 130 0.015
cellular protein catabolic process GO:0044257 261 0.015
protein targeting GO:0006605 187 0.015
phospholipid metabolic process GO:0006644 99 0.015
negative regulation of kinase activity GO:0033673 106 0.015
response to uv GO:0009411 73 0.015
purine ribonucleoside metabolic process GO:0046128 437 0.015
nuclear division GO:0000280 128 0.015
cellular macromolecule catabolic process GO:0044265 380 0.015
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.015
negative regulation of transferase activity GO:0051348 124 0.015
cellular amino acid metabolic process GO:0006520 116 0.015
nervous system development GO:0007399 293 0.014
nucleoside catabolic process GO:0009164 408 0.014
response to acid chemical GO:0001101 66 0.014
cell activation GO:0001775 213 0.014
glycosyl compound catabolic process GO:1901658 413 0.014
leukocyte proliferation GO:0070661 74 0.014
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.014
regulation of immune response GO:0050776 201 0.014
innate immune response GO:0045087 178 0.014
cellular amide metabolic process GO:0043603 69 0.014
single organism reproductive process GO:0044702 98 0.014
positive regulation of organelle organization GO:0010638 195 0.014
negative regulation of cell cycle process GO:0010948 121 0.014
carboxylic acid biosynthetic process GO:0046394 97 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.014
Worm
inner mitochondrial membrane organization GO:0007007 8 0.014
negative regulation of protein modification process GO:0031400 200 0.014
regulation of protein kinase activity GO:0045859 289 0.013
dna replication GO:0006260 116 0.013
positive regulation of cellular component movement GO:0051272 181 0.013
response to abiotic stimulus GO:0009628 336 0.013
negative regulation of growth GO:0045926 97 0.013
cytokine production GO:0001816 247 0.013
response to other organism GO:0051707 261 0.013
negative regulation of proteolysis GO:0045861 132 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
regulation of gene expression epigenetic GO:0040029 73 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
glutathione metabolic process GO:0006749 20 0.013
cellular response to glucocorticoid stimulus GO:0071385 4 0.013
regulation of protein transport GO:0051223 213 0.013
response to external biotic stimulus GO:0043207 261 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
regulation of jnk cascade GO:0046328 73 0.013
positive regulation of proteolysis GO:0045862 142 0.013
release of cytochrome c from mitochondria GO:0001836 35 0.013
negative regulation of immune system process GO:0002683 136 0.013
regulation of oxidoreductase activity GO:0051341 43 0.013
response to mercury ion GO:0046689 4 0.013
fatty acid derivative metabolic process GO:1901568 35 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.012
oocyte development GO:0048599 1 0.012
reproductive process GO:0022414 106 0.012
regulation of intracellular protein transport GO:0033157 123 0.012
cell part morphogenesis GO:0032990 137 0.012
regulation of cytokine production GO:0001817 232 0.012
regulation of lymphocyte activation GO:0051249 103 0.012
regulation of locomotion GO:0040012 329 0.012
stress activated protein kinase signaling cascade GO:0031098 94 0.012
cell aging GO:0007569 52 0.012
endomembrane system organization GO:0010256 196 0.012
unsaturated fatty acid metabolic process GO:0033559 37 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
actin cytoskeleton organization GO:0030036 207 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
erk1 and erk2 cascade GO:0070371 104 0.012
regulation of protein processing GO:0070613 150 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.011
negative regulation of monocyte chemotactic protein 1 production GO:0071638 3 0.011
cellular modified amino acid metabolic process GO:0006575 64 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
regulation of protein maturation GO:1903317 150 0.011
growth GO:0040007 202 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
cell type specific apoptotic process GO:0097285 125 0.011
negative regulation of mapk cascade GO:0043409 56 0.011
nuclear transport GO:0051169 179 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
response to hormone GO:0009725 175 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.011
regulation of erk1 and erk2 cascade GO:0070372 99 0.011
response to biotic stimulus GO:0009607 276 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
regulation of cell cycle phase transition GO:1901987 126 0.010
plasma membrane organization GO:0007009 115 0.010
protein localization to mitochondrion GO:0070585 25 0.010
response to nitrogen compound GO:1901698 184 0.010
negative regulation of erk1 and erk2 cascade GO:0070373 14 0.010
negative regulation of catabolic process GO:0009895 104 0.010
chromosome segregation GO:0007059 114 0.010
purine ribonucleoside catabolic process GO:0046130 398 0.010
cellular response to nitrogen compound GO:1901699 144 0.010
negative regulation of cell growth GO:0030308 83 0.010

POLR2L disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.028
disease of cellular proliferation DOID:14566 174 0.028
organ system cancer DOID:0050686 164 0.024
endocrine gland cancer DOID:170 26 0.014