Homo sapiens

130 known processes

GTF2H2

general transcription factor IIH, polypeptide 2, 44kDa

(Aliases: T-BTF2P44,BTF2P44,TFIIH,BTF2,MGC102806)

GTF2H2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
phosphorylation of rna polymerase ii c terminal domain GO:0070816 3 0.856
Yeast
nucleoside catabolic process GO:0009164 408 0.577
dna repair GO:0006281 198 0.558
Yeast
nucleotide excision repair GO:0006289 31 0.536
Yeast
purine nucleotide catabolic process GO:0006195 405 0.509
purine nucleoside triphosphate catabolic process GO:0009146 392 0.505
nucleoside triphosphate catabolic process GO:0009143 394 0.487
purine ribonucleoside catabolic process GO:0046130 398 0.475
nucleoside triphosphate metabolic process GO:0009141 422 0.449
atp catabolic process GO:0006200 157 0.439
purine ribonucleotide catabolic process GO:0009154 404 0.433
ribonucleotide catabolic process GO:0009261 405 0.395
nucleotide catabolic process GO:0009166 408 0.372
ribonucleoside monophosphate metabolic process GO:0009161 187 0.318
organophosphate catabolic process GO:0046434 430 0.302
nucleoside monophosphate catabolic process GO:0009125 159 0.299
atp metabolic process GO:0046034 176 0.279
protein autoubiquitination GO:0051865 37 0.274
nucleoside monophosphate metabolic process GO:0009123 191 0.259
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.251
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.245
purine ribonucleoside metabolic process GO:0046128 437 0.223
ribonucleoside triphosphate catabolic process GO:0009203 391 0.211
glycosyl compound catabolic process GO:1901658 413 0.196
nucleoside phosphate catabolic process GO:1901292 412 0.177
protein polyubiquitination GO:0000209 110 0.174
ribonucleoside catabolic process GO:0042454 406 0.167
ribonucleoside triphosphate metabolic process GO:0009199 412 0.156
response to abiotic stimulus GO:0009628 336 0.151
response to light stimulus GO:0009416 87 0.150
response to radiation GO:0009314 151 0.146
purine nucleoside triphosphate metabolic process GO:0009144 412 0.137
response to oxidative stress GO:0006979 121 0.128
purine containing compound catabolic process GO:0072523 411 0.122
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.121
cellular response to dna damage stimulus GO:0006974 379 0.116
Yeast
purine nucleoside monophosphate metabolic process GO:0009126 186 0.112
purine nucleoside catabolic process GO:0006152 398 0.105
ribonucleoside monophosphate catabolic process GO:0009158 158 0.093
purine nucleoside monophosphate catabolic process GO:0009128 158 0.089
response to ionizing radiation GO:0010212 65 0.088
positive regulation of dna repair GO:0045739 25 0.078
transcription coupled nucleotide excision repair GO:0006283 8 0.074
positive regulation of response to dna damage stimulus GO:2001022 43 0.070
regulation of protein kinase activity GO:0045859 289 0.070
regulation of dna repair GO:0006282 47 0.068
protein ubiquitination GO:0016567 314 0.066
regulation of dna metabolic process GO:0051052 153 0.061
amine metabolic process GO:0009308 44 0.061
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.058
regulation of transferase activity GO:0051338 355 0.057
cellular macromolecule catabolic process GO:0044265 380 0.057
cellular amine metabolic process GO:0044106 41 0.056
positive regulation of dna metabolic process GO:0051054 73 0.055
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.053
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.052
protein catabolic process GO:0030163 325 0.050
regulation of cellular response to stress GO:0080135 244 0.049
regulation of cellular ketone metabolic process GO:0010565 50 0.048
regulation of cell cycle GO:0051726 393 0.046
mitotic cell cycle process GO:1903047 286 0.046
modification dependent protein catabolic process GO:0019941 209 0.045
rna capping GO:0036260 10 0.044
ubiquitin dependent protein catabolic process GO:0006511 206 0.043
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.042
response to uv GO:0009411 73 0.042
rna processing GO:0006396 255 0.042
cellular protein catabolic process GO:0044257 261 0.037
determination of adult lifespan GO:0008340 2 0.036
modification dependent macromolecule catabolic process GO:0043632 212 0.035
regulation of protein serine threonine kinase activity GO:0071900 179 0.035
multicellular organismal aging GO:0010259 3 0.034
positive regulation of programmed cell death GO:0043068 249 0.033
regulation of cellular amino acid metabolic process GO:0006521 6 0.033
negative regulation of catalytic activity GO:0043086 335 0.031
cytoplasmic transport GO:0016482 379 0.030
regulation of response to dna damage stimulus GO:2001020 94 0.030
proteasomal protein catabolic process GO:0010498 176 0.030
transmembrane transport GO:0055085 399 0.028
post embryonic development GO:0009791 2 0.027
ribonucleoprotein complex assembly GO:0022618 78 0.026
cellular amino acid metabolic process GO:0006520 116 0.025
cellular ketone metabolic process GO:0042180 80 0.024
endocytosis GO:0006897 159 0.024
negative regulation of programmed cell death GO:0043069 321 0.023
reproductive process GO:0022414 106 0.023
vesicle mediated transport GO:0016192 371 0.023
positive regulation of cell death GO:0010942 263 0.023
dna recombination GO:0006310 77 0.023
female gamete generation GO:0007292 2 0.023
positive regulation of phosphorylation GO:0042327 394 0.022
regulation of anatomical structure morphogenesis GO:0022603 286 0.022
guanosine containing compound metabolic process GO:1901068 244 0.022
single organism membrane organization GO:0044802 268 0.022
ribonucleoprotein complex biogenesis GO:0022613 116 0.022
mrna metabolic process GO:0016071 175 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.021
nucleotide excision repair dna incision GO:0033683 7 0.021
negative regulation of protein metabolic process GO:0051248 391 0.021
mitotic cell cycle GO:0000278 326 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
macromolecule methylation GO:0043414 97 0.021
positive regulation of protein phosphorylation GO:0001934 313 0.021
oogenesis GO:0048477 2 0.020
locomotory behavior GO:0007626 1 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.020
mitochondrion organization GO:0007005 156 0.020
gtp metabolic process GO:0046039 239 0.019
cell projection organization GO:0030030 252 0.019
cardiovascular system development GO:0072358 262 0.019
ribonucleoprotein complex subunit organization GO:0071826 81 0.019
regulation of kinase activity GO:0043549 314 0.019
regulation of cellular amine metabolic process GO:0033238 11 0.019
dna geometric change GO:0032392 32 0.019
dephosphorylation GO:0016311 209 0.019
cellular macromolecular complex assembly GO:0034622 324 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
cation transmembrane transport GO:0098655 238 0.018
negative regulation of hydrolase activity GO:0051346 182 0.018
segmentation GO:0035282 4 0.017
histone modification GO:0016570 251 0.017
negative regulation of cellular amine metabolic process GO:0033239 3 0.017
rna interference GO:0016246 4 0.017
cell morphogenesis GO:0000902 296 0.017
regulation of protein transport GO:0051223 213 0.017
membrane organization GO:0061024 292 0.017
cell growth GO:0016049 160 0.017
regulation of cell differentiation GO:0045595 393 0.017
epithelium development GO:0060429 227 0.017
regulation of mitotic cell cycle phase transition GO:1901990 118 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.016
embryo development GO:0009790 123 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
nervous system development GO:0007399 293 0.016
regulation of growth GO:0040008 165 0.016
chromatin organization GO:0006325 351 0.016
guanosine containing compound catabolic process GO:1901069 239 0.015
epithelial cell differentiation GO:0030855 141 0.015
intracellular protein transport GO:0006886 270 0.015
cranial nerve development GO:0021545 4 0.015
response to hypoxia GO:0001666 96 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
negative regulation of cell cycle GO:0045786 193 0.015
ncrna metabolic process GO:0034660 108 0.015
adult locomotory behavior GO:0008344 1 0.014
negative regulation of cell death GO:0060548 345 0.014
regulation of protein localization GO:0032880 296 0.014
cation transport GO:0006812 331 0.014
actin filament based process GO:0030029 224 0.014
positive regulation of cellular component organization GO:0051130 376 0.014
positive regulation of kinase activity GO:0033674 204 0.014
single organism cellular localization GO:1902580 332 0.014
inorganic cation transmembrane transport GO:0098662 194 0.014
protein maturation GO:0051604 233 0.014
immune response GO:0006955 307 0.014
cellular component morphogenesis GO:0032989 314 0.014
mrna 3 end processing GO:0031124 24 0.014
7 methylguanosine mrna capping GO:0006370 7 0.014
nerve development GO:0021675 4 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
biological adhesion GO:0022610 331 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
response to decreased oxygen levels GO:0036293 96 0.013
protein oligomerization GO:0051259 173 0.013
positive regulation of synaptic transmission GO:0050806 4 0.013
defense response GO:0006952 315 0.013
metal ion transport GO:0030001 272 0.013
innate immune response GO:0045087 178 0.013
single organism reproductive process GO:0044702 98 0.013
nitrogen compound transport GO:0071705 191 0.013
mitotic nuclear division GO:0007067 119 0.013
ion transmembrane transport GO:0034220 338 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.013
neuromuscular junction development GO:0007528 3 0.013
gtp catabolic process GO:0006184 237 0.013
chromatin modification GO:0016568 298 0.013
ras protein signal transduction GO:0007265 73 0.013
t cell differentiation in thymus GO:0033077 4 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
regulation of rna splicing GO:0043484 62 0.012
peptidyl lysine modification GO:0018205 144 0.012
oxidation reduction process GO:0055114 396 0.012
cell adhesion GO:0007155 325 0.012
negative regulation of protein modification process GO:0031400 200 0.012
negative regulation of protein maturation GO:1903318 142 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.012
response to oxygen containing compound GO:1901700 369 0.012
response to external biotic stimulus GO:0043207 261 0.012
maintenance of location GO:0051235 112 0.012
cellular response to oxygen containing compound GO:1901701 276 0.012
response to biotic stimulus GO:0009607 276 0.012
regulation of mapk cascade GO:0043408 262 0.012
regeneration GO:0031099 4 0.012
regulation of cytokine production GO:0001817 232 0.012
cellular homeostasis GO:0019725 196 0.012
protein localization to organelle GO:0033365 280 0.012
response to oxygen levels GO:0070482 100 0.012
regulation of protein maturation GO:1903317 150 0.012
small molecule biosynthetic process GO:0044283 157 0.012
positive regulation of developmental process GO:0051094 314 0.012
signal transduction by phosphorylation GO:0023014 297 0.012
positive regulation of cell proliferation GO:0008284 301 0.012
actin cytoskeleton organization GO:0030036 207 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
negative regulation of apoptotic process GO:0043066 316 0.011
regulation of cell growth GO:0001558 135 0.011
cellular lipid metabolic process GO:0044255 303 0.011
positive regulation of immune system process GO:0002684 283 0.011
rna splicing GO:0008380 131 0.011
generation of neurons GO:0048699 152 0.011
protein targeting GO:0006605 187 0.011
regulation of cell cycle process GO:0010564 266 0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.011
mapk cascade GO:0000165 288 0.011
hindbrain development GO:0030902 3 0.011
methylation GO:0032259 106 0.011
microtubule based process GO:0007017 210 0.011
response to other organism GO:0051707 261 0.011
peripheral nervous system development GO:0007422 2 0.011
anterior posterior axis specification embryo GO:0008595 2 0.011
regulation of purine nucleotide metabolic process GO:1900542 264 0.011
hemopoiesis GO:0030097 180 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
immune system development GO:0002520 195 0.011
nuclear transport GO:0051169 179 0.011
regulation of proteolysis GO:0030162 293 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
regulation of phosphatase activity GO:0010921 81 0.011
protein processing GO:0016485 226 0.011
regulation of protein processing GO:0070613 150 0.011
response to lipid GO:0033993 206 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
response to cytokine GO:0034097 232 0.010
negative regulation of phosphorylation GO:0042326 174 0.010
rho protein signal transduction GO:0007266 26 0.010
response to inorganic substance GO:0010035 127 0.010
positive regulation of protein kinase activity GO:0045860 190 0.010
establishment of protein localization to membrane GO:0090150 121 0.010
compound eye development GO:0048749 1 0.010
mrna processing GO:0006397 133 0.010
regulation of dephosphorylation GO:0035303 96 0.010
establishment of protein localization to organelle GO:0072594 172 0.010
apoptotic signaling pathway GO:0097190 268 0.010

GTF2H2 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.049
eye and adnexa disease DOID:1492 150 0.049
nervous system disease DOID:863 431 0.049
eye disease DOID:5614 149 0.044
retinal disease DOID:5679 118 0.032
disease of cellular proliferation DOID:14566 174 0.017
musculoskeletal system disease DOID:17 223 0.014
connective tissue disease DOID:65 109 0.014
cancer DOID:162 167 0.014
central nervous system disease DOID:331 186 0.013
disease of metabolism DOID:0014667 295 0.011
immune system disease DOID:2914 155 0.011