Homo sapiens

101 known processes

GTF2H4

general transcription factor IIH, polypeptide 4, 52kDa

(Aliases: TFIIH,TFB2)

GTF2H4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 379 0.146
Yeast
post embryonic development GO:0009791 2 0.144
dna repair GO:0006281 198 0.092
Yeast
nucleoside catabolic process GO:0009164 408 0.091
nervous system development GO:0007399 293 0.085
regulation of dna metabolic process GO:0051052 153 0.080
determination of adult lifespan GO:0008340 2 0.074
multicellular organismal aging GO:0010259 3 0.071
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.070
purine nucleoside triphosphate catabolic process GO:0009146 392 0.068
vesicle mediated transport GO:0016192 371 0.067
purine nucleoside triphosphate metabolic process GO:0009144 412 0.065
purine nucleoside catabolic process GO:0006152 398 0.064
purine ribonucleotide catabolic process GO:0009154 404 0.063
cellular amino acid metabolic process GO:0006520 116 0.061
purine ribonucleoside metabolic process GO:0046128 437 0.059
purine nucleotide catabolic process GO:0006195 405 0.059
nucleoside triphosphate metabolic process GO:0009141 422 0.057
ribonucleoside triphosphate metabolic process GO:0009199 412 0.056
nucleotide excision repair dna incision GO:0033683 7 0.056
nucleotide catabolic process GO:0009166 408 0.055
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.053
regulation of cell cycle GO:0051726 393 0.053
nucleoside triphosphate catabolic process GO:0009143 394 0.050
nucleoside phosphate catabolic process GO:1901292 412 0.049
atp metabolic process GO:0046034 176 0.049
purine containing compound catabolic process GO:0072523 411 0.048
ribonucleoside catabolic process GO:0042454 406 0.048
regulation of cellular ketone metabolic process GO:0010565 50 0.048
ribonucleotide catabolic process GO:0009261 405 0.047
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.046
cellular ketone metabolic process GO:0042180 80 0.045
neurogenesis GO:0022008 169 0.044
cellular macromolecular complex assembly GO:0034622 324 0.041
positive regulation of cell death GO:0010942 263 0.041
purine ribonucleoside catabolic process GO:0046130 398 0.040
regulation of cellular amino acid metabolic process GO:0006521 6 0.040
cellular amine metabolic process GO:0044106 41 0.040
regulation of cell cycle process GO:0010564 266 0.039
ribonucleoside triphosphate catabolic process GO:0009203 391 0.039
rna processing GO:0006396 255 0.038
organophosphate catabolic process GO:0046434 430 0.037
positive regulation of programmed cell death GO:0043068 249 0.037
amine metabolic process GO:0009308 44 0.037
cellular macromolecule catabolic process GO:0044265 380 0.036
glycosyl compound catabolic process GO:1901658 413 0.036
cytoplasmic transport GO:0016482 379 0.035
rna splicing GO:0008380 131 0.035
regulation of mitotic cell cycle GO:0007346 189 0.035
ribonucleoside monophosphate catabolic process GO:0009158 158 0.034
response to abiotic stimulus GO:0009628 336 0.033
ribonucleoprotein complex biogenesis GO:0022613 116 0.032
regulation of cellular amine metabolic process GO:0033238 11 0.032
mitotic cell cycle process GO:1903047 286 0.032
endocytosis GO:0006897 159 0.032
negative regulation of cell cycle GO:0045786 193 0.031
mitochondrion organization GO:0007005 156 0.031
protein processing GO:0016485 226 0.030
chromatin organization GO:0006325 351 0.030
negative regulation of cellular protein metabolic process GO:0032269 353 0.030
positive regulation of apoptotic process GO:0043065 246 0.029
regulation of transferase activity GO:0051338 355 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
mrna metabolic process GO:0016071 175 0.029
negative regulation of protein metabolic process GO:0051248 391 0.029
positive regulation of developmental process GO:0051094 314 0.028
purine nucleoside monophosphate metabolic process GO:0009126 186 0.028
nucleoside monophosphate metabolic process GO:0009123 191 0.027
neuron differentiation GO:0030182 138 0.027
immune response GO:0006955 307 0.027
cellular protein complex assembly GO:0043623 188 0.027
posttranscriptional regulation of gene expression GO:0010608 213 0.026
female gamete generation GO:0007292 2 0.026
embryo development GO:0009790 123 0.026
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.026
purine nucleoside monophosphate catabolic process GO:0009128 158 0.026
mitotic cell cycle phase transition GO:0044772 162 0.026
nucleotide excision repair GO:0006289 31 0.025
Yeast
gtp catabolic process GO:0006184 237 0.025
protein dna complex subunit organization GO:0071824 80 0.025
response to uv GO:0009411 73 0.025
defense response GO:0006952 315 0.025
nucleoside monophosphate catabolic process GO:0009125 159 0.025
cell cycle phase transition GO:0044770 173 0.025
lipid metabolic process GO:0006629 381 0.025
negative regulation of catalytic activity GO:0043086 335 0.024
regulation of cellular response to stress GO:0080135 244 0.024
negative regulation of programmed cell death GO:0043069 321 0.024
protein maturation GO:0051604 233 0.024
response to other organism GO:0051707 261 0.024
hair cell differentiation GO:0035315 2 0.024
negative regulation of cellular amine metabolic process GO:0033239 3 0.024
locomotory behavior GO:0007626 1 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
generation of neurons GO:0048699 152 0.023
atp catabolic process GO:0006200 157 0.023
cell projection organization GO:0030030 252 0.023
endomembrane system organization GO:0010256 196 0.023
positive regulation of cellular component organization GO:0051130 376 0.023
response to oxidative stress GO:0006979 121 0.023
ion homeostasis GO:0050801 230 0.022
single organism membrane organization GO:0044802 268 0.022
response to radiation GO:0009314 151 0.022
phosphorylation of rna polymerase ii c terminal domain GO:0070816 3 0.022
Yeast
mitotic cell cycle GO:0000278 326 0.022
response to virus GO:0009615 126 0.022
chemical homeostasis GO:0048878 306 0.022
negative regulation of cell proliferation GO:0008285 228 0.021
regulation of cell differentiation GO:0045595 393 0.021
negative regulation of cell cycle process GO:0010948 121 0.021
response to oxygen containing compound GO:1901700 369 0.021
regulation of protein kinase activity GO:0045859 289 0.021
cell division GO:0051301 168 0.020
nucleobase containing compound transport GO:0015931 51 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.020
interspecies interaction between organisms GO:0044419 156 0.020
apoptotic signaling pathway GO:0097190 268 0.020
gtp metabolic process GO:0046039 239 0.020
response to external biotic stimulus GO:0043207 261 0.020
regulation of kinase activity GO:0043549 314 0.020
cellular homeostasis GO:0019725 196 0.020
positive regulation of catabolic process GO:0009896 310 0.019
dna templated transcription initiation GO:0006352 35 0.019
growth GO:0040007 202 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.019
positive regulation of cellular amine metabolic process GO:0033240 7 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
oxidation reduction process GO:0055114 396 0.019
mrna processing GO:0006397 133 0.019
histone modification GO:0016570 251 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
ras protein signal transduction GO:0007265 73 0.018
regulation of protein localization GO:0032880 296 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.018
guanosine containing compound catabolic process GO:1901069 239 0.018
regulation of nucleoside metabolic process GO:0009118 209 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
compound eye development GO:0048749 1 0.018
regulation of cell cycle phase transition GO:1901987 126 0.018
receptor mediated endocytosis GO:0006898 84 0.018
ion transmembrane transport GO:0034220 338 0.018
developmental programmed cell death GO:0010623 3 0.018
cell morphogenesis GO:0000902 296 0.017
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.017
response to biotic stimulus GO:0009607 276 0.017
epithelium development GO:0060429 227 0.017
regeneration GO:0031099 4 0.017
divalent metal ion transport GO:0070838 152 0.017
positive regulation of immune system process GO:0002684 283 0.017
positive regulation of transport GO:0051050 336 0.017
circulatory system development GO:0072359 262 0.017
eye photoreceptor cell differentiation GO:0001754 2 0.017
oogenesis GO:0048477 2 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
cellular lipid metabolic process GO:0044255 303 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
multi organism cellular process GO:0044764 156 0.017
protein ubiquitination GO:0016567 314 0.016
anterior posterior axis specification GO:0009948 2 0.016
viral process GO:0016032 146 0.016
system process GO:0003008 349 0.016
cellular component morphogenesis GO:0032989 314 0.016
epithelial cell differentiation GO:0030855 141 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
membrane organization GO:0061024 292 0.016
ribonucleoside monophosphate metabolic process GO:0009161 187 0.016
thymus development GO:0048538 3 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
response to light stimulus GO:0009416 87 0.016
negative regulation of protein modification process GO:0031400 200 0.016
protein catabolic process GO:0030163 325 0.016
photoreceptor cell differentiation GO:0046530 2 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
regulation of cell development GO:0060284 161 0.016
regulation of peptidase activity GO:0052547 180 0.016
protein localization to organelle GO:0033365 280 0.016
rho protein signal transduction GO:0007266 26 0.015
lipid biosynthetic process GO:0008610 177 0.015
chromatin modification GO:0016568 298 0.015
central nervous system development GO:0007417 123 0.015
regulation of immune response GO:0050776 201 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
transmembrane transport GO:0055085 399 0.015
regulation of mapk cascade GO:0043408 262 0.015
negative regulation of developmental process GO:0051093 247 0.015
response to cytokine GO:0034097 232 0.015
regulation of proteolysis GO:0030162 293 0.015
regulation of cellular component biogenesis GO:0044087 281 0.015
metal ion transport GO:0030001 272 0.015
cellular metal ion homeostasis GO:0006875 146 0.015
cellular component disassembly GO:0022411 92 0.015
regulation of growth GO:0040008 165 0.015
mrna splicing via spliceosome GO:0000398 89 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
regulation of cell growth GO:0001558 135 0.014
protein modification by small protein removal GO:0070646 92 0.014
ribonucleoprotein complex assembly GO:0022618 78 0.014
biological adhesion GO:0022610 331 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
neuromuscular junction development GO:0007528 3 0.014
dna recombination GO:0006310 77 0.014
single organism cellular localization GO:1902580 332 0.014
innate immune response GO:0045087 178 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
regulation of multi organism process GO:0043900 157 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
intracellular protein transport GO:0006886 270 0.014
nuclear export GO:0051168 69 0.014
cardiovascular system development GO:0072358 262 0.014
negative regulation of transferase activity GO:0051348 124 0.014
viral life cycle GO:0019058 132 0.014
meiotic chromosome segregation GO:0045132 4 0.014
regulation of response to external stimulus GO:0032101 222 0.014
hindbrain development GO:0030902 3 0.014
neuron development GO:0048666 113 0.014
spermatid differentiation GO:0048515 4 0.014
cell development GO:0048468 328 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
double strand break repair GO:0006302 101 0.014
rna splicing via transesterification reactions GO:0000375 90 0.014
response to oxygen levels GO:0070482 100 0.013
blastocyst development GO:0001824 3 0.013
covalent chromatin modification GO:0016569 254 0.013
negative regulation of cell death GO:0060548 345 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
cell part morphogenesis GO:0032990 137 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
maintenance of location GO:0051235 112 0.013
nitrogen compound transport GO:0071705 191 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
regulation of protein stability GO:0031647 87 0.013
cell projection morphogenesis GO:0048858 129 0.013
response to growth factor GO:0070848 205 0.013
cellular protein catabolic process GO:0044257 261 0.013
positive regulation of peptidase activity GO:0010952 88 0.013
protein modification by small protein conjugation GO:0032446 342 0.013
negative regulation of multicellular organismal process GO:0051241 317 0.013
adult locomotory behavior GO:0008344 1 0.013
cell adhesion GO:0007155 325 0.013
segmentation GO:0035282 4 0.013
immune system development GO:0002520 195 0.013
carbohydrate metabolic process GO:0005975 207 0.013
nuclear transport GO:0051169 179 0.013
cation homeostasis GO:0055080 189 0.013
regulation of meiotic cell cycle GO:0051445 4 0.013
dna damage checkpoint GO:0000077 68 0.013
base excision repair GO:0006284 21 0.012
regulation of meiosis GO:0040020 3 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
establishment of rna localization GO:0051236 39 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
ribonucleoprotein complex subunit organization GO:0071826 81 0.012
positive regulation of proteolysis GO:0045862 142 0.012
cellular chemical homeostasis GO:0055082 180 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.012
regulation of nucleotide catabolic process GO:0030811 205 0.012
cellular response to abiotic stimulus GO:0071214 117 0.012
cation transport GO:0006812 331 0.012
chromosome segregation GO:0007059 114 0.012
positive regulation of organelle organization GO:0010638 195 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
metencephalon development GO:0022037 2 0.012
response to lipid GO:0033993 206 0.012
response to decreased oxygen levels GO:0036293 96 0.012
single organism reproductive process GO:0044702 98 0.012
response to hypoxia GO:0001666 96 0.012
positive regulation of gtp catabolic process GO:0033126 166 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
calcium ion homeostasis GO:0055074 122 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
reproductive process GO:0022414 106 0.012
cellular response to oxygen containing compound GO:1901701 276 0.011
regulation of viral process GO:0050792 103 0.011
oocyte development GO:0048599 1 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
negative regulation of protein kinase activity GO:0006469 98 0.011
cellular ion homeostasis GO:0006873 168 0.011
microtubule based process GO:0007017 210 0.011
negative regulation of kinase activity GO:0033673 106 0.011
positive regulation of protein complex assembly GO:0031334 86 0.011
cellular divalent inorganic cation homeostasis GO:0072503 128 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
single organism carbohydrate metabolic process GO:0044723 193 0.011
regulation of intracellular transport GO:0032386 195 0.011
organelle assembly GO:0070925 176 0.011
astrocyte differentiation GO:0048708 4 0.011
divalent inorganic cation transport GO:0072511 158 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
mammary gland morphogenesis GO:0060443 2 0.011
oocyte differentiation GO:0009994 2 0.011
regulation of locomotion GO:0040012 329 0.011
blastoderm segmentation GO:0007350 2 0.011
cell activation GO:0001775 213 0.011
skin development GO:0043588 76 0.011
positive regulation of dna metabolic process GO:0051054 73 0.011
regulation of homeostatic process GO:0032844 121 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
dephosphorylation GO:0016311 209 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
regulation of nucleotide metabolic process GO:0006140 269 0.011
regulation of gtpase activity GO:0043087 180 0.011
leukocyte activation GO:0045321 164 0.011
organelle fission GO:0048285 149 0.011
actin filament based process GO:0030029 224 0.011
immune effector process GO:0002252 159 0.011
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.011
regulation of cell division GO:0051302 116 0.011
cell cycle checkpoint GO:0000075 117 0.011
translation GO:0006412 132 0.011
neuron projection development GO:0031175 106 0.011
reproductive system development GO:0061458 56 0.011
associative learning GO:0008306 1 0.011
positive regulation of endopeptidase activity GO:0010950 84 0.011
positive regulation of cell proliferation GO:0008284 301 0.010
glycerolipid metabolic process GO:0046486 107 0.010
positive regulation of immune response GO:0050778 159 0.010
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
establishment of protein localization to organelle GO:0072594 172 0.010
metal ion homeostasis GO:0055065 169 0.010
regulation of response to dna damage stimulus GO:2001020 94 0.010
regulation of ras gtpase activity GO:0032318 128 0.010
cytokine production GO:0001816 247 0.010
epidermal cell differentiation GO:0009913 45 0.010
regulation of gtp catabolic process GO:0033124 180 0.010
secretion by cell GO:0032940 226 0.010
regulation of mrna metabolic process GO:1903311 53 0.010
response to inorganic substance GO:0010035 127 0.010
response to organic cyclic compound GO:0014070 204 0.010
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.010
dna catabolic process GO:0006308 49 0.010
organophosphate biosynthetic process GO:0090407 163 0.010

GTF2H4 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.041
disease of cellular proliferation DOID:14566 174 0.041
organ system cancer DOID:0050686 164 0.036
disease of metabolism DOID:0014667 295 0.031
sensory system disease DOID:0050155 203 0.027
nervous system disease DOID:863 431 0.027
central nervous system disease DOID:331 186 0.026
eye and adnexa disease DOID:1492 150 0.024
retinal disease DOID:5679 118 0.024
retinal degeneration DOID:8466 89 0.024
eye disease DOID:5614 149 0.024
musculoskeletal system disease DOID:17 223 0.023
neurodegenerative disease DOID:1289 102 0.018
inherited metabolic disorder DOID:655 242 0.015
gastrointestinal system cancer DOID:3119 52 0.014
xeroderma pigmentosum DOID:0050427 8 0.011