Homo sapiens

155 known processes

GEN1

Gen homolog 1, endonuclease (Drosophila)

(Aliases: DKFZp781F0986,Gen,FLJ40869)

GEN1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleoside triphosphate metabolic process GO:0009141 422 0.073
meiotic chromosome segregation GO:0045132 4 0.046
post embryonic development GO:0009791 2 0.045
purine ribonucleotide catabolic process GO:0009154 404 0.043
nucleoside triphosphate catabolic process GO:0009143 394 0.041
purine ribonucleoside metabolic process GO:0046128 437 0.041
purine ribonucleoside catabolic process GO:0046130 398 0.040
ribonucleoside catabolic process GO:0042454 406 0.040
purine containing compound catabolic process GO:0072523 411 0.040
mitotic cell cycle GO:0000278 326 0.040
ribonucleotide catabolic process GO:0009261 405 0.040
purine nucleotide catabolic process GO:0006195 405 0.038
ribonucleoside triphosphate catabolic process GO:0009203 391 0.038
nucleoside phosphate catabolic process GO:1901292 412 0.037
negative regulation of programmed cell death GO:0043069 321 0.036
maintenance of location GO:0051235 112 0.036
regulation of cell cycle GO:0051726 393 0.035
multicellular organismal aging GO:0010259 3 0.034
response to abiotic stimulus GO:0009628 336 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.034
female gamete generation GO:0007292 2 0.032
regulation of cytoskeleton organization GO:0051493 177 0.032
glycosyl compound catabolic process GO:1901658 413 0.031
determination of adult lifespan GO:0008340 2 0.030
organelle assembly GO:0070925 176 0.030
actin filament based process GO:0030029 224 0.029
positive regulation of organelle organization GO:0010638 195 0.029
regulation of cell cycle process GO:0010564 266 0.029
recombinational repair GO:0000725 50 0.029
cellular macromolecule catabolic process GO:0044265 380 0.029
microtubule based process GO:0007017 210 0.029
negative regulation of phosphate metabolic process GO:0045936 267 0.028
negative regulation of catalytic activity GO:0043086 335 0.027
cellular ketone metabolic process GO:0042180 80 0.027
regulation of cellular ketone metabolic process GO:0010565 50 0.027
amine metabolic process GO:0009308 44 0.027
cellular amino acid metabolic process GO:0006520 116 0.027
organelle fission GO:0048285 149 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.026
rna processing GO:0006396 255 0.026
organophosphate catabolic process GO:0046434 430 0.026
regulation of cellular amino acid metabolic process GO:0006521 6 0.026
response to radiation GO:0009314 151 0.025
regulation of anatomical structure morphogenesis GO:0022603 286 0.025
nucleotide catabolic process GO:0009166 408 0.025
embryonic epithelial tube formation GO:0001838 4 0.025
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
purine nucleoside triphosphate catabolic process GO:0009146 392 0.024
response to caffeine GO:0031000 3 0.024
purine nucleoside catabolic process GO:0006152 398 0.023
circulatory system development GO:0072359 262 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
cellular response to dna damage stimulus GO:0006974 379 0.023
negative regulation of multicellular organismal process GO:0051241 317 0.023
regulation of purine nucleotide metabolic process GO:1900542 264 0.023
cellular amine metabolic process GO:0044106 41 0.022
regulation of locomotion GO:0040012 329 0.022
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.022
regulation of cell cycle phase transition GO:1901987 126 0.022
regulation of cellular amine metabolic process GO:0033238 11 0.022
mitotic cell cycle phase transition GO:0044772 162 0.021
regulation of cell migration GO:0030334 289 0.021
regulation of mitotic cell cycle phase transition GO:1901990 118 0.021
regulation of nucleotide metabolic process GO:0006140 269 0.021
oogenesis GO:0048477 2 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
negative regulation of cell cycle GO:0045786 193 0.020
cellular response to endogenous stimulus GO:0071495 336 0.020
covalent chromatin modification GO:0016569 254 0.020
cytoplasmic transport GO:0016482 379 0.020
positive regulation of gtpase activity GO:0043547 166 0.020
positive regulation of phosphorylation GO:0042327 394 0.020
regulation of gtpase activity GO:0043087 180 0.020
regulation of mitotic cell cycle GO:0007346 189 0.020
regulation of protein kinase activity GO:0045859 289 0.020
regulation of cellular response to stress GO:0080135 244 0.019
regulation of kinase activity GO:0043549 314 0.019
negative regulation of cell death GO:0060548 345 0.019
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.019
lipid metabolic process GO:0006629 381 0.019
tissue regeneration GO:0042246 3 0.019
anatomical structure homeostasis GO:0060249 100 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
cellular component morphogenesis GO:0032989 314 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.018
ribonucleoside triphosphate metabolic process GO:0009199 412 0.018
protein ubiquitination GO:0016567 314 0.018
regulation of transferase activity GO:0051338 355 0.018
regulation of microtubule based process GO:0032886 74 0.018
protein localization to organelle GO:0033365 280 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.018
regulation of protein localization GO:0032880 296 0.018
negative regulation of protein metabolic process GO:0051248 391 0.018
negative regulation of cell cycle process GO:0010948 121 0.018
guanosine containing compound metabolic process GO:1901068 244 0.018
regulation of mapk cascade GO:0043408 262 0.018
negative regulation of apoptotic process GO:0043066 316 0.017
growth GO:0040007 202 0.017
maintenance of location in cell GO:0051651 62 0.017
nuclear division GO:0000280 128 0.017
double strand break repair GO:0006302 101 0.017
maintenance of protein location in cell GO:0032507 56 0.017
oxidation reduction process GO:0055114 396 0.017
regulation of nucleoside metabolic process GO:0009118 209 0.017
response to cytokine GO:0034097 232 0.017
endomembrane system organization GO:0010256 196 0.017
cellular response to abiotic stimulus GO:0071214 117 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
positive regulation of nucleotide metabolic process GO:0045981 230 0.016
defense response GO:0006952 315 0.016
mapk cascade GO:0000165 288 0.016
blood vessel morphogenesis GO:0048514 162 0.016
regulation of gtp catabolic process GO:0033124 180 0.016
cellular response to radiation GO:0071478 65 0.016
double strand break repair via homologous recombination GO:0000724 50 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
mitotic cell cycle process GO:1903047 286 0.016
organ morphogenesis GO:0009887 147 0.016
positive regulation of gtp catabolic process GO:0033126 166 0.016
regulation of cellular component biogenesis GO:0044087 281 0.016
guanosine containing compound catabolic process GO:1901069 239 0.016
response to organonitrogen compound GO:0010243 156 0.016
regulation of cell motility GO:2000145 299 0.016
regulation of cytokine production GO:0001817 232 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.015
regulation of cellular component movement GO:0051270 334 0.015
cell morphogenesis GO:0000902 296 0.015
secretion GO:0046903 254 0.015
blood vessel development GO:0001568 172 0.015
regulation of purine nucleotide catabolic process GO:0033121 205 0.015
ras protein signal transduction GO:0007265 73 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
negative regulation of protein modification process GO:0031400 200 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
negative regulation of hydrolase activity GO:0051346 182 0.015
nucleoside monophosphate catabolic process GO:0009125 159 0.015
vesicle mediated transport GO:0016192 371 0.015
cardiovascular system development GO:0072358 262 0.015
regulation of cell division GO:0051302 116 0.015
vasculature development GO:0001944 181 0.014
lens development in camera type eye GO:0002088 2 0.014
response to ionizing radiation GO:0010212 65 0.014
regulation of organelle assembly GO:1902115 40 0.014
small gtpase mediated signal transduction GO:0007264 78 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
response to nitrogen compound GO:1901698 184 0.014
regulation of cell morphogenesis GO:0022604 153 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.014
primary neural tube formation GO:0014020 3 0.014
positive regulation of kinase activity GO:0033674 204 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
regulation of dephosphorylation GO:0035303 96 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
cellular response to cytokine stimulus GO:0071345 181 0.014
chemical homeostasis GO:0048878 306 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
angiogenesis GO:0001525 147 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
biological adhesion GO:0022610 331 0.014
head development GO:0060322 108 0.014
purine nucleoside monophosphate catabolic process GO:0009128 158 0.014
innate immune response GO:0045087 178 0.014
positive regulation of transport GO:0051050 336 0.014
hindbrain development GO:0030902 3 0.014
gtp catabolic process GO:0006184 237 0.014
rho protein signal transduction GO:0007266 26 0.013
protein modification by small protein conjugation GO:0032446 342 0.013
positive regulation of cell death GO:0010942 263 0.013
protein maturation GO:0051604 233 0.013
snrna metabolic process GO:0016073 15 0.013
locomotory behavior GO:0007626 1 0.013
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.013
ribonucleoside monophosphate catabolic process GO:0009158 158 0.013
negative regulation of immune system process GO:0002683 136 0.013
cell division GO:0051301 168 0.013
regulation of protein transport GO:0051223 213 0.013
cellular protein complex assembly GO:0043623 188 0.013
actin cytoskeleton organization GO:0030036 207 0.013
oocyte development GO:0048599 1 0.013
ncrna processing GO:0034470 83 0.013
regulation of growth GO:0040008 165 0.013
negative regulation of phosphatase activity GO:0010923 61 0.013
neural tube closure GO:0001843 3 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
actin filament based movement GO:0030048 17 0.013
hemopoiesis GO:0030097 180 0.013
protein catabolic process GO:0030163 325 0.013
single organism membrane organization GO:0044802 268 0.013
microtubule cytoskeleton organization GO:0000226 176 0.013
epithelium development GO:0060429 227 0.013
system process GO:0003008 349 0.013
regulation of response to external stimulus GO:0032101 222 0.013
morphogenesis of embryonic epithelium GO:0016331 4 0.013
histone modification GO:0016570 251 0.012
response to purine containing compound GO:0014074 40 0.012
regulation of proteolysis GO:0030162 293 0.012
cellular response to oxygen containing compound GO:1901701 276 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
secretion by cell GO:0032940 226 0.012
chromatin organization GO:0006325 351 0.012
regulation of immune response GO:0050776 201 0.012
maintenance of protein location GO:0045185 57 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
protein autophosphorylation GO:0046777 123 0.012
response to organic cyclic compound GO:0014070 204 0.012
regulation of cell growth GO:0001558 135 0.012
chromatin modification GO:0016568 298 0.012
stem cell division GO:0017145 2 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.012
tissue migration GO:0090130 119 0.012
cell activation GO:0001775 213 0.012
dephosphorylation GO:0016311 209 0.012
methylation dependent chromatin silencing GO:0006346 3 0.012
protein targeting GO:0006605 187 0.012
dna replication GO:0006260 116 0.012
cellular response to oxidative stress GO:0034599 85 0.012
positive regulation of cell cycle GO:0045787 140 0.012
positive regulation of meiotic cell cycle GO:0051446 2 0.012
centrosome cycle GO:0007098 32 0.012
g2 m transition of mitotic cell cycle GO:0000086 41 0.012
regulation of response to dna damage stimulus GO:2001020 94 0.012
cilium assembly GO:0042384 63 0.012
dna recombination GO:0006310 77 0.012
segmentation GO:0035282 4 0.011
cell adhesion GO:0007155 325 0.011
embryo development GO:0009790 123 0.011
tissue morphogenesis GO:0048729 96 0.011
negative regulation of organelle organization GO:0010639 126 0.011
myeloid cell differentiation GO:0030099 117 0.011
meiosis i GO:0007127 4 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
single organism carbohydrate metabolic process GO:0044723 193 0.011
blastocyst development GO:0001824 3 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
actin filament organization GO:0007015 128 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
mitotic nuclear division GO:0007067 119 0.011
cytokine production GO:0001816 247 0.011
epithelial cell differentiation GO:0030855 141 0.011
oocyte differentiation GO:0009994 2 0.011
cellular homeostasis GO:0019725 196 0.011
immune response GO:0006955 307 0.011
nervous system development GO:0007399 293 0.011
interspecies interaction between organisms GO:0044419 156 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
cell part morphogenesis GO:0032990 137 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
cilium morphogenesis GO:0060271 75 0.011
protein secretion GO:0009306 98 0.011
regeneration GO:0031099 4 0.010
cell projection organization GO:0030030 252 0.010
positive regulation of cytokine production GO:0001819 167 0.010
regulation of small gtpase mediated signal transduction GO:0051056 156 0.010
negative regulation of developmental process GO:0051093 247 0.010
regulation of nucleotide catabolic process GO:0030811 205 0.010
regulation of multi organism process GO:0043900 157 0.010
ameboidal type cell migration GO:0001667 135 0.010
positive regulation of secretion GO:0051047 116 0.010
regulation of meiotic cell cycle GO:0051445 4 0.010
response to oxygen containing compound GO:1901700 369 0.010
negative regulation of apoptotic signaling pathway GO:2001234 97 0.010
actin mediated cell contraction GO:0070252 12 0.010
hematopoietic or lymphoid organ development GO:0048534 186 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
leukocyte activation GO:0045321 164 0.010

GEN1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.112
hematopoietic system disease DOID:74 100 0.062
physical disorder DOID:0080015 41 0.028
congenital nervous system abnormality DOID:2490 21 0.028
cancer DOID:162 167 0.028
disease of cellular proliferation DOID:14566 174 0.028
anemia DOID:2355 55 0.016
organ system cancer DOID:0050686 164 0.015
disease of metabolism DOID:0014667 295 0.013