Homo sapiens

54 known processes

KIAA0174

KIAA0174

(Aliases: IST1,MGC117220)

KIAA0174 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.181
positive regulation of cell migration GO:0030335 172 0.139
positive regulation of cell motility GO:2000147 177 0.129
positive regulation of locomotion GO:0040017 186 0.113
regulation of locomotion GO:0040012 329 0.091
cell fate determination GO:0001709 3 0.082
positive regulation of developmental process GO:0051094 314 0.078
regulation of cellular component movement GO:0051270 334 0.075
ameboidal type cell migration GO:0001667 135 0.069
regulation of cell differentiation GO:0045595 393 0.067
forebrain dorsal ventral pattern formation GO:0021798 1 0.061
lipid localization GO:0010876 106 0.061
post embryonic development GO:0009791 2 0.059
regulation of cell motility GO:2000145 299 0.059
regulation of epithelial cell migration GO:0010632 93 0.055
maintenance of location GO:0051235 112 0.055
regulation of cell migration GO:0030334 289 0.052
memory GO:0007613 3 0.049
neuron fate commitment GO:0048663 2 0.049
positive regulation of cellular component movement GO:0051272 181 0.049
vesicle mediated transport GO:0016192 371 0.048
muscle cell fate commitment GO:0042693 4 0.047
cellular macromolecular complex assembly GO:0034622 324 0.047
epithelium migration GO:0090132 119 0.046
forebrain generation of neurons GO:0021872 3 0.046
membrane organization GO:0061024 292 0.045
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.045
epithelial cell migration GO:0010631 119 0.044
metencephalon development GO:0022037 2 0.043
positive regulation of epithelial cell migration GO:0010634 55 0.043
cell morphogenesis GO:0000902 296 0.042
positive regulation of cell differentiation GO:0045597 211 0.040
cellular component morphogenesis GO:0032989 314 0.039
tube morphogenesis GO:0035239 95 0.038
somatic stem cell maintenance GO:0035019 4 0.038
forebrain regionalization GO:0021871 3 0.037
tissue morphogenesis GO:0048729 96 0.036
female gamete generation GO:0007292 2 0.036
purine nucleotide catabolic process GO:0006195 405 0.036
positive regulation of catabolic process GO:0009896 310 0.035
regulation of cell development GO:0060284 161 0.035
response to external biotic stimulus GO:0043207 261 0.035
amine metabolic process GO:0009308 44 0.034
negative regulation of cell proliferation GO:0008285 228 0.034
neuromuscular junction development GO:0007528 3 0.034
renal sodium ion absorption GO:0070294 2 0.034
kidney development GO:0001822 53 0.033
compound eye development GO:0048749 1 0.032
ribonucleoside catabolic process GO:0042454 406 0.032
cytoplasmic transport GO:0016482 379 0.032
associative learning GO:0008306 1 0.031
generation of neurons GO:0048699 152 0.030
response to abiotic stimulus GO:0009628 336 0.030
anterior posterior axis specification GO:0009948 2 0.030
ribonucleotide catabolic process GO:0009261 405 0.030
cellular macromolecule catabolic process GO:0044265 380 0.030
system process GO:0003008 349 0.030
regulation of wnt signaling pathway involved in heart development GO:0003307 3 0.030
syncytium formation by plasma membrane fusion GO:0000768 2 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.029
tube development GO:0035295 125 0.029
negative regulation of cellular component organization GO:0051129 235 0.029
cell projection organization GO:0030030 252 0.029
purine ribonucleoside catabolic process GO:0046130 398 0.029
secondary heart field specification GO:0003139 2 0.028
behavioral response to ethanol GO:0048149 2 0.028
covalent chromatin modification GO:0016569 254 0.028
long term memory GO:0007616 2 0.027
atp catabolic process GO:0006200 157 0.027
pituitary gland development GO:0021983 2 0.027
nervous system development GO:0007399 293 0.027
nucleoside catabolic process GO:0009164 408 0.027
cell development GO:0048468 328 0.026
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
glycosyl compound catabolic process GO:1901658 413 0.026
neurogenesis GO:0022008 169 0.025
metal ion transport GO:0030001 272 0.025
purine nucleoside triphosphate metabolic process GO:0009144 412 0.025
negative regulation of catalytic activity GO:0043086 335 0.025
circulatory system development GO:0072359 262 0.025
negative regulation of programmed cell death GO:0043069 321 0.025
multicellular organismal aging GO:0010259 3 0.025
positive regulation of cellular component organization GO:0051130 376 0.025
glial cell migration GO:0008347 4 0.025
mesodermal cell fate specification GO:0007501 2 0.025
cation transport GO:0006812 331 0.025
regulation of cellular amino acid metabolic process GO:0006521 6 0.025
regulation of cellular amine metabolic process GO:0033238 11 0.024
ion homeostasis GO:0050801 230 0.024
regulation of cellular ketone metabolic process GO:0010565 50 0.024
response to other organism GO:0051707 261 0.024
regulation of cell cycle GO:0051726 393 0.024
central nervous system development GO:0007417 123 0.024
nucleotide catabolic process GO:0009166 408 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
tissue migration GO:0090130 119 0.023
actin filament based process GO:0030029 224 0.023
oogenesis GO:0048477 2 0.023
determination of adult lifespan GO:0008340 2 0.023
spermatid differentiation GO:0048515 4 0.023
ribonucleoside triphosphate metabolic process GO:0009199 412 0.023
neurological system process GO:0050877 163 0.023
cell division GO:0051301 168 0.023
specification of organ identity GO:0010092 3 0.022
nephric duct development GO:0072176 4 0.022
atp metabolic process GO:0046034 176 0.022
negative regulation of cellular protein metabolic process GO:0032269 353 0.022
adult locomotory behavior GO:0008344 1 0.022
pericardium development GO:0060039 2 0.022
limbic system development GO:0021761 3 0.022
regulation of cytoskeleton organization GO:0051493 177 0.022
small molecule biosynthetic process GO:0044283 157 0.022
embryonic placenta development GO:0001892 1 0.022
midgut development GO:0007494 1 0.022
cardiovascular system development GO:0072358 262 0.022
hindbrain development GO:0030902 3 0.022
blastoderm segmentation GO:0007350 2 0.022
rna processing GO:0006396 255 0.021
muscle structure development GO:0061061 98 0.021
stem cell differentiation GO:0048863 93 0.021
cellular amide metabolic process GO:0043603 69 0.021
negative regulation of developmental process GO:0051093 247 0.021
negative regulation of cell death GO:0060548 345 0.021
positive regulation of apoptotic process GO:0043065 246 0.021
regulation of cell division GO:0051302 116 0.020
regulation of cell cycle process GO:0010564 266 0.020
dephosphorylation GO:0016311 209 0.020
nucleoside triphosphate metabolic process GO:0009141 422 0.020
response to oxygen containing compound GO:1901700 369 0.020
gtp catabolic process GO:0006184 237 0.020
morphogenesis of embryonic epithelium GO:0016331 4 0.020
negative regulation of multicellular organismal process GO:0051241 317 0.020
cell proliferation in forebrain GO:0021846 1 0.020
protein modification by small protein conjugation GO:0032446 342 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
response to lipid GO:0033993 206 0.019
mitotic cell cycle GO:0000278 326 0.019
regulation of meiotic cell cycle GO:0051445 4 0.019
inner ear morphogenesis GO:0042472 4 0.019
monovalent inorganic cation transport GO:0015672 128 0.019
regulation of meiosis GO:0040020 3 0.019
negative regulation of synaptic transmission GO:0050805 2 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
protein k48 linked ubiquitination GO:0070936 38 0.019
spermatid development GO:0007286 4 0.019
single organism membrane organization GO:0044802 268 0.019
embryonic epithelial tube formation GO:0001838 4 0.019
biological adhesion GO:0022610 331 0.019
rho protein signal transduction GO:0007266 26 0.019
photoreceptor cell differentiation GO:0046530 2 0.019
cell growth GO:0016049 160 0.019
golgi vesicle transport GO:0048193 80 0.019
positive regulation of dendrite morphogenesis GO:0050775 3 0.018
segmentation GO:0035282 4 0.018
regulation of ossification GO:0030278 58 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
ossification GO:0001503 121 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
cellular amino acid metabolic process GO:0006520 116 0.018
organ morphogenesis GO:0009887 147 0.018
cellular response to oxygen containing compound GO:1901701 276 0.018
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.018
purine nucleoside monophosphate metabolic process GO:0009126 186 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
ras protein signal transduction GO:0007265 73 0.018
immune response GO:0006955 307 0.018
neuron projection development GO:0031175 106 0.018
lipid metabolic process GO:0006629 381 0.018
innate immune response GO:0045087 178 0.018
cellular response to dna damage stimulus GO:0006974 379 0.018
nitrogen compound transport GO:0071705 191 0.017
digestive system development GO:0055123 75 0.017
negative regulation of apoptotic process GO:0043066 316 0.017
cellular protein catabolic process GO:0044257 261 0.017
apoptotic signaling pathway GO:0097190 268 0.017
digestive tract development GO:0048565 75 0.017
regulation of kinase activity GO:0043549 314 0.017
transmembrane transport GO:0055085 399 0.017
modification dependent macromolecule catabolic process GO:0043632 212 0.017
positive regulation of protein phosphorylation GO:0001934 313 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
ribonucleoprotein complex biogenesis GO:0022613 116 0.017
distal tubule development GO:0072017 4 0.017
ribonucleoside monophosphate metabolic process GO:0009161 187 0.017
organelle assembly GO:0070925 176 0.017
positive regulation of nucleoside metabolic process GO:0045979 186 0.017
growth GO:0040007 202 0.017
urogenital system development GO:0001655 65 0.017
epithelium development GO:0060429 227 0.016
digestive tract morphogenesis GO:0048546 56 0.016
regulation of protein catabolic process GO:0042176 155 0.016
proteasomal protein catabolic process GO:0010498 176 0.016
organophosphate biosynthetic process GO:0090407 163 0.016
renal sodium ion transport GO:0003096 2 0.016
membrane lipid metabolic process GO:0006643 53 0.016
blood vessel remodeling GO:0001974 2 0.016
cell part morphogenesis GO:0032990 137 0.016
rna splicing GO:0008380 131 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
regulation of metal ion transport GO:0010959 120 0.016
regulation of neuron differentiation GO:0045664 70 0.016
protein catabolic process GO:0030163 325 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
cellular homeostasis GO:0019725 196 0.016
protein localization to organelle GO:0033365 280 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.016
cytokine production GO:0001816 247 0.015
regulation of lymphocyte activation GO:0051249 103 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
protein localization to plasma membrane GO:0072659 93 0.015
endosomal transport GO:0016197 129 0.015
blood vessel morphogenesis GO:0048514 162 0.015
regulation of response to external stimulus GO:0032101 222 0.015
organonitrogen compound biosynthetic process GO:1901566 200 0.015
regulation of transferase activity GO:0051338 355 0.015
sensory perception of chemical stimulus GO:0007606 38 0.015
protein polyubiquitination GO:0000209 110 0.015
enzyme linked receptor protein signaling pathway GO:0007167 303 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
regulation of cell morphogenesis GO:0022604 153 0.015
response to nitrogen compound GO:1901698 184 0.015
locomotory behavior GO:0007626 1 0.015
regulation of actin filament based process GO:0032970 141 0.015
regulation of mitotic cell cycle GO:0007346 189 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
posttranscriptional regulation of gene expression GO:0010608 213 0.014
positive regulation of synaptic transmission GO:0050806 4 0.014
protein localization to membrane GO:0072657 160 0.014
alcohol metabolic process GO:0006066 114 0.014
myoblast fusion GO:0007520 1 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
lipid biosynthetic process GO:0008610 177 0.014
cell projection morphogenesis GO:0048858 129 0.014
renal system development GO:0072001 63 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
primary neural tube formation GO:0014020 3 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
regeneration GO:0031099 4 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
sleep GO:0030431 2 0.014
sphingolipid metabolic process GO:0006665 38 0.014
visual behavior GO:0007632 2 0.014
single organism cellular localization GO:1902580 332 0.014
neural tube formation GO:0001841 3 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
oocyte development GO:0048599 1 0.014
hemopoiesis GO:0030097 180 0.014
morphogenesis of an epithelium GO:0002009 60 0.014
lung alveolus development GO:0048286 4 0.014
protein oligomerization GO:0051259 173 0.014
lipid storage GO:0019915 28 0.014
positive regulation of transport GO:0051050 336 0.014
retrograde transport endosome to golgi GO:0042147 45 0.014
male meiosis GO:0007140 1 0.014
response to biotic stimulus GO:0009607 276 0.013
somatic muscle development GO:0007525 1 0.013
hair cell differentiation GO:0035315 2 0.013
neural crest cell development GO:0014032 3 0.013
negative regulation of protein metabolic process GO:0051248 391 0.013
kidney epithelium development GO:0072073 25 0.013
histone methylation GO:0016571 60 0.013
response to cytokine GO:0034097 232 0.013
protein autophosphorylation GO:0046777 123 0.013
ectoderm development GO:0007398 3 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
regulation of protein localization GO:0032880 296 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
hematopoietic stem cell differentiation GO:0060218 4 0.013
regulation of phosphatase activity GO:0010921 81 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
rhythmic behavior GO:0007622 2 0.013
positive regulation of neurogenesis GO:0050769 49 0.013
ion transmembrane transport GO:0034220 338 0.013
lipid transport GO:0006869 90 0.013
positive regulation of gliogenesis GO:0014015 4 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.013
response to oxygen levels GO:0070482 100 0.013
cellular amine metabolic process GO:0044106 41 0.013
myosin filament organization GO:0031033 2 0.013
epithelial tube morphogenesis GO:0060562 38 0.013
plasma membrane organization GO:0007009 115 0.013
translation GO:0006412 132 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.013
somitogenesis GO:0001756 2 0.013
cerebellum development GO:0021549 2 0.013
cellular ketone metabolic process GO:0042180 80 0.013
positive regulation of glial cell proliferation GO:0060252 2 0.013
neuron development GO:0048666 113 0.013
convergent extension GO:0060026 1 0.013
protein k33 linked ubiquitination GO:1990390 1 0.013
post embryonic organ development GO:0048569 1 0.013
nuclear transport GO:0051169 179 0.013
protein maturation GO:0051604 233 0.013
positive regulation of cell development GO:0010720 92 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
regulation of membrane potential GO:0042391 95 0.013
organ formation GO:0048645 3 0.013
striated muscle myosin thick filament assembly GO:0071688 2 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.012
cellular lipid metabolic process GO:0044255 303 0.012
negative regulation of organelle organization GO:0010639 126 0.012
regulation of cell growth GO:0001558 135 0.012
endochondral bone morphogenesis GO:0060350 3 0.012
sensory perception of pain GO:0019233 4 0.012
cardiac muscle cell fate commitment GO:0060923 4 0.012
oocyte differentiation GO:0009994 2 0.012
positive regulation of cell death GO:0010942 263 0.012
angiogenesis GO:0001525 147 0.012
regulation of growth GO:0040008 165 0.012
regulation of gtp catabolic process GO:0033124 180 0.012
regulation of multi organism process GO:0043900 157 0.012
skeletal system development GO:0001501 79 0.012
regulation of vesicle mediated transport GO:0060627 130 0.012
regulation of heart growth GO:0060420 4 0.012
negative regulation of protein processing GO:0010955 142 0.012
negative regulation of cell cycle GO:0045786 193 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
mesodermal cell fate commitment GO:0001710 2 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
brain morphogenesis GO:0048854 1 0.012
convergent extension involved in gastrulation GO:0060027 1 0.012
response to inorganic substance GO:0010035 127 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.012
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
ureter development GO:0072189 3 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
regulation of ras gtpase activity GO:0032318 128 0.012
circadian behavior GO:0048512 2 0.012
sebaceous gland development GO:0048733 1 0.012
copii vesicle coating GO:0048208 2 0.012
gtp metabolic process GO:0046039 239 0.012
distal tubule morphogenesis GO:0072156 3 0.012
heart development GO:0007507 95 0.011
negative regulation of transport GO:0051051 176 0.011
cellular ion homeostasis GO:0006873 168 0.011
secretion GO:0046903 254 0.011
regulation of cardiac muscle cell proliferation GO:0060043 4 0.011
i kappab kinase nf kappab signaling GO:0007249 166 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
response to bacterium GO:0009617 144 0.011
response to fungus GO:0009620 4 0.011
regulation of homeostatic process GO:0032844 121 0.011
immune system development GO:0002520 195 0.011
positive regulation of cell projection organization GO:0031346 64 0.011
neuronal stem cell division GO:0036445 1 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
leukocyte proliferation GO:0070661 74 0.011
peptidyl lysine modification GO:0018205 144 0.011
myosin filament assembly GO:0031034 2 0.011
autophagic cell death GO:0048102 3 0.011
trabecula morphogenesis GO:0061383 2 0.011
axis elongation GO:0003401 4 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
neural crest cell migration GO:0001755 2 0.011
regulation of endothelial cell differentiation GO:0045601 4 0.011
intracellular receptor signaling pathway GO:0030522 104 0.011
peripheral nervous system development GO:0007422 2 0.011
oxidation reduction process GO:0055114 396 0.011
positive regulation of cell cycle GO:0045787 140 0.011
inorganic cation transmembrane transport GO:0098662 194 0.011
rna catabolic process GO:0006401 71 0.011
cell activation GO:0001775 213 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.011
regulation of gtpase activity GO:0043087 180 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
cell cycle phase transition GO:0044770 173 0.011
sex determination GO:0007530 3 0.011
actin cytoskeleton organization GO:0030036 207 0.011
hippocampus development GO:0021766 1 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
brain development GO:0007420 97 0.011
tripartite regional subdivision GO:0007351 2 0.011
regulation of satellite cell proliferation GO:0014842 1 0.011
visual learning GO:0008542 1 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
regulation of cytokine production GO:0001817 232 0.011
tube closure GO:0060606 3 0.011
carbohydrate metabolic process GO:0005975 207 0.011
negative regulation of collagen metabolic process GO:0010713 3 0.010
cytokinesis GO:0000910 96 0.010
cellular response to organic cyclic compound GO:0071407 127 0.010
mrna metabolic process GO:0016071 175 0.010
negative regulation of growth GO:0045926 97 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.010
lens development in camera type eye GO:0002088 2 0.010
positive regulation of ossification GO:0045778 32 0.010
signal transduction by phosphorylation GO:0023014 297 0.010
positive regulation of nervous system development GO:0051962 54 0.010
regulation of ion transport GO:0043269 189 0.010
positive regulation of organelle organization GO:0010638 195 0.010
aorta development GO:0035904 2 0.010
protein methylation GO:0006479 74 0.010
tissue regeneration GO:0042246 3 0.010
heart field specification GO:0003128 2 0.010
regulation of canonical wnt signaling pathway GO:0060828 88 0.010
mesenchymal cell differentiation GO:0048762 52 0.010
regulation of neurogenesis GO:0050767 82 0.010
positive regulation of gtpase activity GO:0043547 166 0.010
chromatin modification GO:0016568 298 0.010
response to molecule of bacterial origin GO:0002237 82 0.010
cartilage development involved in endochondral bone morphogenesis GO:0060351 2 0.010
regulation of response to wounding GO:1903034 101 0.010
regulation of protein maturation GO:1903317 150 0.010
regulation of protein kinase activity GO:0045859 289 0.010

KIAA0174 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.059
eye and adnexa disease DOID:1492 150 0.059
nervous system disease DOID:863 431 0.059
eye disease DOID:5614 149 0.059
meckel syndrome DOID:0050778 11 0.049
myopathy DOID:423 104 0.042
muscular disease DOID:0080000 114 0.042
musculoskeletal system disease DOID:17 223 0.042
muscle tissue disease DOID:66 113 0.042
muscular dystrophy DOID:9884 51 0.033
central nervous system disease DOID:331 186 0.029
disease of metabolism DOID:0014667 295 0.027
inherited metabolic disorder DOID:655 242 0.017
neurodegenerative disease DOID:1289 102 0.016
neuropathy DOID:870 52 0.013
retinal disease DOID:5679 118 0.013
spinocerebellar degeneration DOID:2478 27 0.012
retinal degeneration DOID:8466 89 0.011