Homo sapiens

113 known processes

CDK5

cyclin-dependent kinase 5

(Aliases: PSSALRE)

CDK5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of axon extension GO:0030517 2 0.685
Mouse
positive regulation of protein targeting to membrane GO:0090314 8 0.614
Mouse
biological adhesion GO:0022610 331 0.566
Mouse
negative regulation of axonogenesis GO:0050771 4 0.541
Mouse
post embryonic development GO:0009791 2 0.539
neuron cell cell adhesion GO:0007158 1 0.482
cell development GO:0048468 328 0.395
Zebrafish Mouse Rat Fly
regulation of cell growth GO:0001558 135 0.364
Mouse
regulation of cell cycle arrest GO:0071156 36 0.268
cerebral cortex radially oriented cell migration GO:0021799 1 0.242
Mouse
peptidyl serine modification GO:0018209 106 0.235
neuron differentiation GO:0030182 138 0.232
Zebrafish Mouse Rat Fly
negative regulation of multicellular organismal process GO:0051241 317 0.199
Mouse
negative regulation of cell growth GO:0030308 83 0.181
Mouse
positive regulation of cellular component organization GO:0051130 376 0.180
Mouse
limbic system development GO:0021761 3 0.175
Mouse
intracellular protein transport GO:0006886 270 0.174
Mouse
cell projection organization GO:0030030 252 0.167
Mouse Rat Fly
positive regulation of protein phosphorylation GO:0001934 313 0.161
Mouse
negative regulation of apoptotic process GO:0043066 316 0.157
Zebrafish
peptidyl threonine modification GO:0018210 45 0.153
Mouse
regulation of cell projection organization GO:0031344 107 0.153
Mouse
negative regulation of cellular component organization GO:0051129 235 0.151
Mouse
positive regulation of protein transport GO:0051222 135 0.148
Mouse
dephosphorylation GO:0016311 209 0.145
positive regulation of organelle organization GO:0010638 195 0.143
regulation of cell development GO:0060284 161 0.139
Mouse
cerebral cortex cell migration GO:0021795 3 0.135
Mouse
hemostasis GO:0007599 76 0.135
generation of neurons GO:0048699 152 0.129
Zebrafish Mouse Rat Fly
growth GO:0040007 202 0.127
Mouse Fly
protein localization to membrane GO:0072657 160 0.126
Mouse
single organism cell adhesion GO:0098602 179 0.124
small gtpase mediated signal transduction GO:0007264 78 0.122
embryonic retina morphogenesis in camera type eye GO:0060059 1 0.113
Zebrafish
tissue morphogenesis GO:0048729 96 0.113
Zebrafish
cell cycle arrest GO:0007050 71 0.109
cell growth GO:0016049 160 0.104
Mouse
peptidyl serine phosphorylation GO:0018105 101 0.102
regulation of protein transport GO:0051223 213 0.101
Mouse
negative regulation of growth GO:0045926 97 0.098
Mouse
amine metabolic process GO:0009308 44 0.097
regulation of cellular amine metabolic process GO:0033238 11 0.096
regulation of actin cytoskeleton organization GO:0032956 116 0.089
negative regulation of catalytic activity GO:0043086 335 0.088
neurogenesis GO:0022008 169 0.088
positive regulation of hydrolase activity GO:0051345 331 0.087
single organismal cell cell adhesion GO:0016337 148 0.087
serine phosphorylation of stat protein GO:0042501 4 0.086
Mouse
reactive oxygen species metabolic process GO:0072593 75 0.085
regulation of cellular amino acid metabolic process GO:0006521 6 0.085
regulation of proteolysis GO:0030162 293 0.085
hippocampus development GO:0021766 1 0.082
Mouse
cellular response to dna damage stimulus GO:0006974 379 0.082
negative regulation of phosphatase activity GO:0010923 61 0.081
hindbrain development GO:0030902 3 0.081
Mouse
positive regulation of transport GO:0051050 336 0.077
Mouse
single organism membrane organization GO:0044802 268 0.077
Mouse
positive regulation of transferase activity GO:0051347 227 0.077
Mouse
positive regulation of protein kinase activity GO:0045860 190 0.075
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.075
small molecule biosynthetic process GO:0044283 157 0.075
atp metabolic process GO:0046034 176 0.074
cellular response to cytokine stimulus GO:0071345 181 0.074
cell division GO:0051301 168 0.074
negative regulation of neuron differentiation GO:0045665 21 0.073
Mouse
cellular amine metabolic process GO:0044106 41 0.071
negative regulation of cell cycle GO:0045786 193 0.070
Mouse
cerebellum development GO:0021549 2 0.068
Mouse
sulfur compound metabolic process GO:0006790 101 0.067
retina layer formation GO:0010842 3 0.066
Zebrafish
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.065
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.064
cell projection morphogenesis GO:0048858 129 0.064
Mouse Rat Fly
purine nucleoside triphosphate catabolic process GO:0009146 392 0.064
regulation of protein localization GO:0032880 296 0.064
Mouse Worm
establishment of protein localization to membrane GO:0090150 121 0.063
Mouse
regulation of cellular component size GO:0032535 82 0.063
Mouse
cell morphogenesis GO:0000902 296 0.063
Mouse Rat Fly
positive regulation of peptidase activity GO:0010952 88 0.062
regulation of growth GO:0040008 165 0.062
Mouse Fly
regulation of intracellular protein transport GO:0033157 123 0.061
Mouse
cell adhesion GO:0007155 325 0.060
Mouse
regulation of neuron projection development GO:0010975 57 0.060
Mouse
negative regulation of programmed cell death GO:0043069 321 0.060
Zebrafish
lipid biosynthetic process GO:0008610 177 0.060
dendritic spine morphogenesis GO:0060997 3 0.060
Mouse
regulation of protein serine threonine kinase activity GO:0071900 179 0.060
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.060
carbohydrate metabolic process GO:0005975 207 0.059
chemotaxis GO:0006935 157 0.059
Mouse Fly
jak stat cascade GO:0007259 46 0.059
microtubule based process GO:0007017 210 0.058
cation transport GO:0006812 331 0.057
Mouse
regulation of cell cycle process GO:0010564 266 0.056
positive regulation of kinase activity GO:0033674 204 0.055
Mouse
actin filament based process GO:0030029 224 0.055
Rat
embryo development GO:0009790 123 0.053
Zebrafish Worm
fatty acid metabolic process GO:0006631 115 0.053
regulation of cell cycle GO:0051726 393 0.053
Zebrafish Mouse Rat Fly
cellular response to oxygen containing compound GO:1901701 276 0.053
cellular ketone metabolic process GO:0042180 80 0.052
purine containing compound catabolic process GO:0072523 411 0.052
microtubule cytoskeleton organization GO:0000226 176 0.051
protein targeting GO:0006605 187 0.050
Mouse
oogenesis GO:0048477 2 0.049
embryonic morphogenesis GO:0048598 85 0.049
Zebrafish
negative regulation of developmental process GO:0051093 247 0.048
Mouse
negative regulation of cell development GO:0010721 48 0.048
Mouse
nervous system development GO:0007399 293 0.048
negative regulation of cell death GO:0060548 345 0.047
cellular amino acid metabolic process GO:0006520 116 0.047
ribonucleoside monophosphate catabolic process GO:0009158 158 0.047
positive regulation of phosphorylation GO:0042327 394 0.045
Mouse
regulation of cell differentiation GO:0045595 393 0.045
Mouse
regulation of microtubule based process GO:0032886 74 0.044
regulation of neurogenesis GO:0050767 82 0.044
Mouse
regulation of cysteine type endopeptidase activity GO:2000116 127 0.044
positive regulation of nucleoside metabolic process GO:0045979 186 0.043
protein polymerization GO:0051258 71 0.043
regulation of microtubule cytoskeleton organization GO:0070507 61 0.042
positive regulation of intracellular protein transport GO:0090316 76 0.042
Mouse
regulation of peptidase activity GO:0052547 180 0.042
positive regulation of endopeptidase activity GO:0010950 84 0.041
regulation of generation of precursor metabolites and energy GO:0043467 27 0.040
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.039
Mouse
regulation of cellular component biogenesis GO:0044087 281 0.039
Fly
cellular cation homeostasis GO:0030003 163 0.039
single organism cellular localization GO:1902580 332 0.039
Mouse
cell part morphogenesis GO:0032990 137 0.039
Mouse Rat Fly
protein localization to organelle GO:0033365 280 0.038
purine ribonucleoside metabolic process GO:0046128 437 0.038
negative regulation of phosphorus metabolic process GO:0010563 267 0.038
vesicle mediated transport GO:0016192 371 0.038
Mouse Rat Worm
purine ribonucleoside catabolic process GO:0046130 398 0.037
cellular chemical homeostasis GO:0055082 180 0.037
nucleotide catabolic process GO:0009166 408 0.037
ribonucleoside catabolic process GO:0042454 406 0.037
ribonucleoside triphosphate catabolic process GO:0009203 391 0.037
regulation of cytoskeleton organization GO:0051493 177 0.036
enteroendocrine cell differentiation GO:0035883 6 0.036
glycosyl compound catabolic process GO:1901658 413 0.035
protein glycosylation GO:0006486 62 0.035
ion homeostasis GO:0050801 230 0.035
positive regulation of cellular amine metabolic process GO:0033240 7 0.034
transmembrane transport GO:0055085 399 0.034
peripheral nervous system development GO:0007422 2 0.034
Zebrafish Mouse
regulation of protein complex assembly GO:0043254 147 0.033
cellular component morphogenesis GO:0032989 314 0.033
Mouse Rat Fly
actin cytoskeleton organization GO:0030036 207 0.033
Rat
regulation of cellular ketone metabolic process GO:0010565 50 0.033
telencephalon cell migration GO:0022029 4 0.033
Mouse
sensory organ development GO:0007423 52 0.033
Zebrafish
regulation of anatomical structure size GO:0090066 101 0.033
Mouse
cellular lipid metabolic process GO:0044255 303 0.032
cation homeostasis GO:0055080 189 0.032
carboxylic acid biosynthetic process GO:0046394 97 0.032
regulation of protein targeting GO:1903533 91 0.031
Mouse
eye development GO:0001654 42 0.031
Zebrafish
blood coagulation GO:0007596 76 0.031
cell activation GO:0001775 213 0.031
ribonucleoside triphosphate metabolic process GO:0009199 412 0.030
negative regulation of protein modification process GO:0031400 200 0.030
Mouse
purine nucleoside monophosphate metabolic process GO:0009126 186 0.030
nucleoside monophosphate metabolic process GO:0009123 191 0.030
type b pancreatic cell development GO:0003323 4 0.029
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.029
ephrin receptor signaling pathway GO:0048013 15 0.029
sensory organ morphogenesis GO:0090596 21 0.029
Zebrafish
response to wounding GO:0009611 168 0.029
Rat
wound healing GO:0042060 115 0.029
negative regulation of hydrolase activity GO:0051346 182 0.029
regulation of nervous system development GO:0051960 88 0.029
Mouse Fly
multicellular organismal aging GO:0010259 3 0.029
Fly
regulation of purine nucleotide metabolic process GO:1900542 264 0.028
organic acid biosynthetic process GO:0016053 97 0.028
cellular ion homeostasis GO:0006873 168 0.027
neuron projection development GO:0031175 106 0.027
Mouse Rat Fly
purine nucleotide catabolic process GO:0006195 405 0.027
energy derivation by oxidation of organic compounds GO:0015980 43 0.027
positive regulation of catabolic process GO:0009896 310 0.027
cellular response to nutrient levels GO:0031669 69 0.026
regulation of endopeptidase activity GO:0052548 170 0.026
carbohydrate derivative biosynthetic process GO:1901137 207 0.026
regulation of actin filament based process GO:0032970 141 0.026
compound eye development GO:0048749 1 0.026
platelet activation GO:0030168 44 0.026
neuron development GO:0048666 113 0.026
Zebrafish Mouse Rat Fly
cell cycle phase transition GO:0044770 173 0.026
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.026
nucleoside phosphate catabolic process GO:1901292 412 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
anatomical structure formation involved in morphogenesis GO:0048646 284 0.025
Zebrafish Mouse
organophosphate catabolic process GO:0046434 430 0.024
regulation of apoptotic signaling pathway GO:2001233 175 0.024
chemical homeostasis GO:0048878 306 0.024
positive regulation of protein polymerization GO:0032273 45 0.024
regulation of phosphatase activity GO:0010921 81 0.024
membrane organization GO:0061024 292 0.024
Mouse
response to virus GO:0009615 126 0.023
dendritic spine development GO:0060996 6 0.023
Mouse
positive regulation of protein complex assembly GO:0031334 86 0.023
negative regulation of cell projection organization GO:0031345 22 0.023
Mouse
forebrain development GO:0030900 26 0.023
Mouse
negative regulation of phosphate metabolic process GO:0045936 267 0.023
response to cytokine GO:0034097 232 0.023
nucleoside monophosphate catabolic process GO:0009125 159 0.023
single organism carbohydrate metabolic process GO:0044723 193 0.023
generation of precursor metabolites and energy GO:0006091 68 0.022
endosomal transport GO:0016197 129 0.022
monocarboxylic acid biosynthetic process GO:0072330 67 0.022
positive regulation of cytoskeleton organization GO:0051495 83 0.022
nucleoside catabolic process GO:0009164 408 0.022
camera type eye development GO:0043010 25 0.022
Zebrafish
coagulation GO:0050817 78 0.022
positive regulation of cell cycle GO:0045787 140 0.022
ribonucleotide biosynthetic process GO:0009260 81 0.022
cellular homeostasis GO:0019725 196 0.021
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
nucleoside triphosphate metabolic process GO:0009141 422 0.021
cell projection assembly GO:0030031 126 0.021
regulation of reactive oxygen species metabolic process GO:2000377 41 0.021
response to extracellular stimulus GO:0009991 85 0.021
anatomical structure maturation GO:0071695 9 0.020
protein folding GO:0006457 38 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.020
regulation of intracellular transport GO:0032386 195 0.020
Mouse
ribonucleotide catabolic process GO:0009261 405 0.020
central nervous system development GO:0007417 123 0.020
negative regulation of nervous system development GO:0051961 28 0.020
Mouse
cellular response to extracellular stimulus GO:0031668 72 0.020
developmental maturation GO:0021700 28 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
taxis GO:0042330 157 0.019
Mouse Fly
atp catabolic process GO:0006200 157 0.019
system process GO:0003008 349 0.019
Mouse
cellular metal ion homeostasis GO:0006875 146 0.019
oocyte development GO:0048599 1 0.019
peptidyl tyrosine phosphorylation GO:0018108 170 0.019
positive regulation of intracellular transport GO:0032388 104 0.019
Mouse
positive regulation of cellular component biogenesis GO:0044089 158 0.019
peptidyl threonine phosphorylation GO:0018107 41 0.019
Mouse
protein targeting to membrane GO:0006612 42 0.019
Mouse
reproductive process GO:0022414 106 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
receptor mediated endocytosis GO:0006898 84 0.019
organ morphogenesis GO:0009887 147 0.019
Zebrafish
reproduction GO:0000003 63 0.018
Worm
regulation of purine nucleotide catabolic process GO:0033121 205 0.018
positive regulation of programmed cell death GO:0043068 249 0.018
Rat
regulation of jak stat cascade GO:0046425 44 0.018
Mouse
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
coenzyme metabolic process GO:0006732 65 0.018
microtubule polymerization or depolymerization GO:0031109 37 0.018
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.017
cell morphogenesis involved in differentiation GO:0000904 144 0.017
Mouse Fly
ribonucleoside monophosphate metabolic process GO:0009161 187 0.017
purine nucleoside triphosphate metabolic process GO:0009144 412 0.017
regulation of protein polymerization GO:0032271 63 0.017
cellular macromolecular complex assembly GO:0034622 324 0.017
regulation of cell division GO:0051302 116 0.017
response to metal ion GO:0010038 84 0.017
fibroblast proliferation GO:0048144 33 0.016
negative regulation of dephosphorylation GO:0035305 63 0.016
cerebral cortex development GO:0021987 10 0.016
Mouse
polysaccharide metabolic process GO:0005976 33 0.016
toxin transport GO:1901998 4 0.016
positive regulation of proteolysis GO:0045862 142 0.016
regulation of mapk cascade GO:0043408 262 0.016
developmental programmed cell death GO:0010623 3 0.016
homotypic cell cell adhesion GO:0034109 47 0.016
positive regulation of cell cycle process GO:0090068 106 0.015
regulation of heart growth GO:0060420 4 0.015
positive regulation of cell cycle arrest GO:0071158 23 0.015
ion transmembrane transport GO:0034220 338 0.015
monovalent inorganic cation transport GO:0015672 128 0.015
protein maturation GO:0051604 233 0.015
regulation of chromosome segregation GO:0051983 44 0.015
protein homooligomerization GO:0051260 100 0.015
protein dephosphorylation GO:0006470 81 0.015
response to radiation GO:0009314 151 0.015
Mouse
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.015
vasculature development GO:0001944 181 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.015
cardiovascular system development GO:0072358 262 0.015
endocytosis GO:0006897 159 0.015
Rat
renal system development GO:0072001 63 0.014
positive regulation of developmental process GO:0051094 314 0.014
neural nucleus development GO:0048857 47 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
Mouse
negative regulation of cell differentiation GO:0045596 171 0.014
Mouse
positive regulation of cell proliferation GO:0008284 301 0.014
apoptotic signaling pathway GO:0097190 268 0.014
Fly
double strand break repair GO:0006302 101 0.014
dna repair GO:0006281 198 0.014
neuron projection morphogenesis GO:0048812 50 0.014
Mouse Rat Fly
regulation of glycogen catabolic process GO:0005981 2 0.014
protein oligomerization GO:0051259 173 0.014
rna processing GO:0006396 255 0.014
negative regulation of organelle organization GO:0010639 126 0.014
mitotic cell cycle process GO:1903047 286 0.013
cellular response to acid chemical GO:0071229 44 0.013
regulation of gtp catabolic process GO:0033124 180 0.013
sister chromatid segregation GO:0000819 54 0.013
regulation of protein catabolic process GO:0042176 155 0.013
purine nucleoside monophosphate catabolic process GO:0009128 158 0.013
cilium organization GO:0044782 68 0.013
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.013
regulation of dna metabolic process GO:0051052 153 0.013
axonogenesis GO:0007409 31 0.013
Mouse Fly
steroid metabolic process GO:0008202 94 0.013
sensory perception of pain GO:0019233 4 0.013
Mouse
response to organonitrogen compound GO:0010243 156 0.013
Mouse
epithelial cell proliferation GO:0050673 128 0.013
cation transmembrane transport GO:0098655 238 0.013
regulation of developmental growth GO:0048638 30 0.013
Mouse Fly
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.013
Mouse Fly
cellular amide metabolic process GO:0043603 69 0.013
blood vessel development GO:0001568 172 0.012
response to lipid GO:0033993 206 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
reproductive structure development GO:0048608 55 0.012
regulation of nucleotide metabolic process GO:0006140 269 0.012
negative regulation of cellular protein metabolic process GO:0032269 353 0.012
negative regulation of neurogenesis GO:0050768 26 0.012
Mouse
regulation of ras protein signal transduction GO:0046578 155 0.012
oocyte differentiation GO:0009994 2 0.012
regulation of transporter activity GO:0032409 82 0.012
protein catabolic process GO:0030163 325 0.012
morphogenesis of an epithelium GO:0002009 60 0.012
response to abiotic stimulus GO:0009628 336 0.012
Mouse
vesicle organization GO:0016050 62 0.012
cellular protein complex assembly GO:0043623 188 0.012
regulation of extent of cell growth GO:0061387 9 0.012
Mouse
regulation of chromosome organization GO:0033044 103 0.012
osteoblast differentiation GO:0001649 92 0.012
mapk cascade GO:0000165 288 0.012
eye morphogenesis GO:0048592 16 0.012
Zebrafish
central nervous system projection neuron axonogenesis GO:0021952 3 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.012
lipid metabolic process GO:0006629 381 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
regulation of cellular component movement GO:0051270 334 0.012
Mouse
sperm egg recognition GO:0035036 3 0.011
proteasomal protein catabolic process GO:0010498 176 0.011
regulation of dephosphorylation GO:0035303 96 0.011
fatty acid biosynthetic process GO:0006633 46 0.011
organelle assembly GO:0070925 176 0.011
purine ribonucleoside biosynthetic process GO:0046129 23 0.011
metal ion homeostasis GO:0055065 169 0.011
response to nitrogen compound GO:1901698 184 0.011
Mouse
mitotic cell cycle phase transition GO:0044772 162 0.011
inorganic cation transmembrane transport GO:0098662 194 0.011
response to starvation GO:0042594 59 0.011
circulatory system development GO:0072359 262 0.011
response to oxidative stress GO:0006979 121 0.011
establishment of protein localization to plasma membrane GO:0090002 68 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
neuron projection extension GO:1990138 14 0.011
Mouse
regulation of kinase activity GO:0043549 314 0.011
Mouse
defense response GO:0006952 315 0.011
Fly
regulation of fibroblast proliferation GO:0048145 32 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
Mouse
organonitrogen compound biosynthetic process GO:1901566 200 0.011
organelle fission GO:0048285 149 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
regulation of mitosis GO:0007088 63 0.011
regulation of neuron differentiation GO:0045664 70 0.011
Mouse
cellular response to external stimulus GO:0071496 111 0.011
ras protein signal transduction GO:0007265 73 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.011
regulation of mitotic cell cycle GO:0007346 189 0.011
cofactor metabolic process GO:0051186 87 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.010
axon development GO:0061564 34 0.010
Mouse Fly
glycoprotein metabolic process GO:0009100 110 0.010
glycoprotein biosynthetic process GO:0009101 91 0.010
determination of adult lifespan GO:0008340 2 0.010
Fly
neural retina development GO:0003407 8 0.010
Zebrafish
organic hydroxy compound metabolic process GO:1901615 147 0.010
Fly
positive regulation of protein catabolic process GO:0045732 75 0.010
protein import GO:0017038 130 0.010
myeloid cell differentiation GO:0030099 117 0.010

CDK5 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.028
disease of cellular proliferation DOID:14566 174 0.025
central nervous system disease DOID:331 186 0.018
neurodegenerative disease DOID:1289 102 0.018
nervous system disease DOID:863 431 0.018
hematopoietic system disease DOID:74 100 0.012
skin disease DOID:37 33 0.010
integumentary system disease DOID:16 43 0.010