Homo sapiens

220 known processes

SCRIB

scribbled homolog (Drosophila)

(Aliases: SCRIB1,CRIB1,Vartul,SCRB1)

SCRIB biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
limbic system development GO:0021761 3 0.396
negative regulation of intracellular signal transduction GO:1902532 183 0.203
post embryonic development GO:0009791 2 0.202
regulation of locomotion GO:0040012 329 0.177
regulation of cellular ketone metabolic process GO:0010565 50 0.136
central nervous system development GO:0007417 123 0.127
Mouse
telencephalon development GO:0021537 17 0.110
hippocampus development GO:0021766 1 0.093
maintenance of location in cell GO:0051651 62 0.091
chromatin modification GO:0016568 298 0.091
cell cell junction organization GO:0045216 69 0.088
Worm
regulation of cell differentiation GO:0045595 393 0.087
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 2 0.087
regulation of cellular amino acid metabolic process GO:0006521 6 0.085
regulation of establishment of protein localization GO:0070201 242 0.082
establishment of protein localization to organelle GO:0072594 172 0.082
regulation of cell migration GO:0030334 289 0.080
astrocyte cell migration GO:0043615 1 0.074
Rat
protein import GO:0017038 130 0.073
protein localization to nucleus GO:0034504 136 0.070
maintenance of protein location GO:0045185 57 0.070
response to oxygen containing compound GO:1901700 369 0.069
locomotory behavior GO:0007626 1 0.068
amine metabolic process GO:0009308 44 0.067
cell development GO:0048468 328 0.067
cell junction organization GO:0034330 79 0.066
Worm
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.066
negative regulation of hippo signaling GO:0035331 6 0.065
cell projection morphogenesis GO:0048858 129 0.064
negative regulation of cellular protein metabolic process GO:0032269 353 0.063
single organism cell adhesion GO:0098602 179 0.060
head development GO:0060322 108 0.059
Mouse
single organism nuclear import GO:1902593 104 0.059
hindbrain development GO:0030902 3 0.059
Mouse
prostate gland development GO:0030850 3 0.058
vesicle mediated transport GO:0016192 371 0.057
Mouse
regulation of cell motility GO:2000145 299 0.057
nucleoside triphosphate metabolic process GO:0009141 422 0.057
brain development GO:0007420 97 0.057
Mouse
negative regulation of protein transport GO:0051224 75 0.056
cellular response to endogenous stimulus GO:0071495 336 0.056
regulation of protein transport GO:0051223 213 0.056
cellular amino acid metabolic process GO:0006520 116 0.055
taxis GO:0042330 157 0.054
embryonic forelimb morphogenesis GO:0035115 4 0.054
covalent chromatin modification GO:0016569 254 0.052
protein localization to organelle GO:0033365 280 0.050
organelle assembly GO:0070925 176 0.050
peptidyl lysine acetylation GO:0018394 101 0.049
protein targeting GO:0006605 187 0.048
microtubule cytoskeleton organization GO:0000226 176 0.048
Zebrafish
regulation of odontogenesis GO:0042481 4 0.047
protein targeting to nucleus GO:0044744 104 0.047
maintenance of location GO:0051235 112 0.047
internal protein amino acid acetylation GO:0006475 101 0.044
protein modification by small protein conjugation GO:0032446 342 0.044
oogenesis GO:0048477 2 0.043
protein catabolic process GO:0030163 325 0.043
oocyte development GO:0048599 1 0.043
internal peptidyl lysine acetylation GO:0018393 97 0.042
cell morphogenesis involved in differentiation GO:0000904 144 0.042
Mouse
chromatin organization GO:0006325 351 0.041
maintenance of protein location in cell GO:0032507 56 0.041
single organism cellular localization GO:1902580 332 0.040
Zebrafish
regulation of cellular amine metabolic process GO:0033238 11 0.040
protein import into nucleus GO:0006606 104 0.040
regulation of intracellular protein transport GO:0033157 123 0.040
negative regulation of apoptotic process GO:0043066 316 0.039
protein dephosphorylation GO:0006470 81 0.039
intracellular protein transport GO:0006886 270 0.039
posttranscriptional regulation of gene expression GO:0010608 213 0.039
determination of adult lifespan GO:0008340 2 0.039
nucleocytoplasmic transport GO:0006913 176 0.039
response to lipid GO:0033993 206 0.038
positive regulation of cell migration GO:0030335 172 0.038
protein depolymerization GO:0051261 30 0.038
histone acetylation GO:0016573 93 0.038
canonical wnt signaling pathway GO:0060070 116 0.037
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.037
regulation of cellular component movement GO:0051270 334 0.036
photoreceptor cell differentiation GO:0046530 2 0.036
maintenance of cell polarity GO:0030011 2 0.035
Worm
cellular ketone metabolic process GO:0042180 80 0.035
cellular amine metabolic process GO:0044106 41 0.035
negative regulation of cell proliferation GO:0008285 228 0.035
regulation of microtubule cytoskeleton organization GO:0070507 61 0.035
negative regulation of phosphate metabolic process GO:0045936 267 0.035
negative regulation of catalytic activity GO:0043086 335 0.034
oocyte differentiation GO:0009994 2 0.034
multicellular organismal aging GO:0010259 3 0.034
positive regulation of cellular component movement GO:0051272 181 0.033
nuclear transport GO:0051169 179 0.033
cellular response to organonitrogen compound GO:0071417 124 0.033
negative regulation of protein kinase b signaling GO:0051898 17 0.033
regulation of cell cycle GO:0051726 393 0.033
intracellular mrna localization GO:0008298 1 0.032
response to growth factor GO:0070848 205 0.032
peptidyl lysine modification GO:0018205 144 0.032
cytoplasmic transport GO:0016482 379 0.031
mitotic cell cycle process GO:1903047 286 0.031
Zebrafish
positive regulation of cell motility GO:2000147 177 0.031
immune response GO:0006955 307 0.031
regulation of lamellipodium morphogenesis GO:2000392 4 0.030
positive regulation of protein transport GO:0051222 135 0.029
regulation of cellular response to stress GO:0080135 244 0.029
neural tube formation GO:0001841 3 0.029
gene silencing by mirna GO:0035195 23 0.028
negative regulation of programmed cell death GO:0043069 321 0.028
small gtpase mediated signal transduction GO:0007264 78 0.028
negative regulation of cell death GO:0060548 345 0.028
forebrain development GO:0030900 26 0.028
regulation of protein kinase activity GO:0045859 289 0.028
response to abiotic stimulus GO:0009628 336 0.028
protein kinase c signaling GO:0070528 17 0.028
intracellular receptor signaling pathway GO:0030522 104 0.028
gene silencing by rna GO:0031047 26 0.027
cellular macromolecule catabolic process GO:0044265 380 0.027
ameboidal type cell migration GO:0001667 135 0.027
positive regulation of locomotion GO:0040017 186 0.027
cellular response to organic cyclic compound GO:0071407 127 0.027
response to hormone GO:0009725 175 0.027
reproductive structure development GO:0048608 55 0.026
Worm
cellular component morphogenesis GO:0032989 314 0.026
Mouse
regulation of protein targeting GO:1903533 91 0.026
pallium development GO:0021543 10 0.026
positive regulation of gtp catabolic process GO:0033126 166 0.026
modification dependent protein catabolic process GO:0019941 209 0.026
cell fate determination GO:0001709 3 0.026
actin filament based process GO:0030029 224 0.025
Worm
regulation of protein import into nucleus GO:0042306 78 0.025
positive regulation of cell development GO:0010720 92 0.025
regulation of proteolysis GO:0030162 293 0.025
hematopoietic or lymphoid organ development GO:0048534 186 0.025
single organismal cell cell adhesion GO:0016337 148 0.025
regulation of intracellular transport GO:0032386 195 0.025
regulation of cell cycle process GO:0010564 266 0.025
negative regulation of protein metabolic process GO:0051248 391 0.024
eye photoreceptor cell differentiation GO:0001754 2 0.024
regulation of glutamine family amino acid metabolic process GO:0000820 2 0.024
regulation of immune response GO:0050776 201 0.024
nitrogen compound transport GO:0071705 191 0.024
myosin filament assembly GO:0031034 2 0.023
modification dependent macromolecule catabolic process GO:0043632 212 0.023
protein acylation GO:0043543 138 0.023
dephosphorylation GO:0016311 209 0.023
cell projection organization GO:0030030 252 0.023
Mouse
regulation of response to external stimulus GO:0032101 222 0.023
positive regulation of transport GO:0051050 336 0.023
female gamete generation GO:0007292 2 0.023
Worm
negative regulation of cell cycle GO:0045786 193 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.022
purine containing compound catabolic process GO:0072523 411 0.022
positive regulation of intracellular protein transport GO:0090316 76 0.022
mapk cascade GO:0000165 288 0.022
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.022
segmentation GO:0035282 4 0.022
adherens junction organization GO:0034332 36 0.022
positive regulation of catabolic process GO:0009896 310 0.022
regulation of protein localization GO:0032880 296 0.021
regulation of protein complex assembly GO:0043254 147 0.021
behavior GO:0007610 112 0.021
regulation of cytoskeleton organization GO:0051493 177 0.021
Worm
neuromuscular junction development GO:0007528 3 0.021
response to decreased oxygen levels GO:0036293 96 0.021
embryonic epithelial tube formation GO:0001838 4 0.021
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.021
protein acetylation GO:0006473 116 0.021
regulation of multi organism process GO:0043900 157 0.021
regulation of cell development GO:0060284 161 0.021
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.021
regulation of gtp catabolic process GO:0033124 180 0.020
response to nitrogen compound GO:1901698 184 0.020
protein ubiquitination GO:0016567 314 0.020
negative regulation of organelle organization GO:0010639 126 0.020
regulation of cellular component biogenesis GO:0044087 281 0.020
glutamate metabolic process GO:0006536 10 0.020
regulation of binding GO:0051098 111 0.020
mitotic cell cycle GO:0000278 326 0.020
protein kinase b signaling GO:0043491 69 0.020
response to organic cyclic compound GO:0014070 204 0.020
neuron development GO:0048666 113 0.019
Mouse
response to oxygen levels GO:0070482 100 0.019
negative regulation of nucleocytoplasmic transport GO:0046823 37 0.019
regulation of oocyte development GO:0060281 1 0.019
regulation of protein catabolic process GO:0042176 155 0.019
cell projection assembly GO:0030031 126 0.019
morphogenesis of embryonic epithelium GO:0016331 4 0.019
mitochondrion organization GO:0007005 156 0.019
positive regulation of protein import into nucleus GO:0042307 46 0.019
immune system development GO:0002520 195 0.019
nervous system development GO:0007399 293 0.019
nuclear import GO:0051170 106 0.019
regulation of mitotic cell cycle GO:0007346 189 0.018
monocarboxylic acid metabolic process GO:0032787 185 0.018
embryonic hindlimb morphogenesis GO:0035116 2 0.018
cellular response to oxidative stress GO:0034599 85 0.018
nucleoside phosphate biosynthetic process GO:1901293 109 0.018
negative regulation of kinase activity GO:0033673 106 0.018
endocytosis GO:0006897 159 0.018
Mouse
regulation of protein serine threonine kinase activity GO:0071900 179 0.018
striated muscle myosin thick filament assembly GO:0071688 2 0.018
negative regulation of intracellular transport GO:0032387 60 0.018
wnt signaling pathway GO:0016055 156 0.018
carbohydrate derivative biosynthetic process GO:1901137 207 0.018
growth GO:0040007 202 0.018
negative regulation of cytoplasmic transport GO:1903650 46 0.017
regulation of microtubule based process GO:0032886 74 0.017
positive regulation of cytoplasmic transport GO:1903651 82 0.017
regulation of wnt signaling pathway GO:0030111 123 0.017
cell activation GO:0001775 213 0.017
cellular component assembly involved in morphogenesis GO:0010927 73 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
positive regulation of cellular component organization GO:0051130 376 0.017
organophosphate biosynthetic process GO:0090407 163 0.017
glial cell migration GO:0008347 4 0.017
Rat
response to alcohol GO:0097305 64 0.017
system process GO:0003008 349 0.017
negative regulation of intracellular protein transport GO:0090317 42 0.017
positive regulation of protein localization to nucleus GO:1900182 48 0.017
regulation of neuroblast proliferation GO:1902692 3 0.017
regulation of endopeptidase activity GO:0052548 170 0.016
lipid metabolic process GO:0006629 381 0.016
apoptotic signaling pathway GO:0097190 268 0.016
cellular protein catabolic process GO:0044257 261 0.016
reproductive system development GO:0061458 56 0.016
Worm
regulation of neurogenesis GO:0050767 82 0.016
development of primary sexual characteristics GO:0045137 35 0.016
Worm
positive regulation of cell differentiation GO:0045597 211 0.016
positive regulation of cellular component biogenesis GO:0044089 158 0.016
cellular response to abiotic stimulus GO:0071214 117 0.016
spermatid development GO:0007286 4 0.016
regulation of cytoplasmic transport GO:1903649 149 0.016
translation GO:0006412 132 0.015
regulation of cell maturation GO:1903429 3 0.015
dna conformation change GO:0071103 113 0.015
histone h4 acetylation GO:0043967 47 0.015
response to molecule of bacterial origin GO:0002237 82 0.015
histone modification GO:0016570 251 0.015
embryo development GO:0009790 123 0.015
cellular protein complex disassembly GO:0043624 36 0.015
epidermis morphogenesis GO:0048730 3 0.015
rna processing GO:0006396 255 0.015
chromosome segregation GO:0007059 114 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
mitotic nuclear division GO:0007067 119 0.015
regulation of histone modification GO:0031056 47 0.015
mrna metabolic process GO:0016071 175 0.015
nucleotide biosynthetic process GO:0009165 109 0.015
biological adhesion GO:0022610 331 0.015
cellular response to nitrogen compound GO:1901699 144 0.015
metencephalon development GO:0022037 2 0.015
Mouse
positive regulation of gtpase activity GO:0043547 166 0.015
cell morphogenesis GO:0000902 296 0.014
Mouse
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.014
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.014
regulation of neural precursor cell proliferation GO:2000177 4 0.014
cellular response to oxygen levels GO:0071453 55 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
protein deubiquitination GO:0016579 79 0.014
blastoderm segmentation GO:0007350 2 0.014
spermatid differentiation GO:0048515 4 0.014
neurogenesis GO:0022008 169 0.014
Zebrafish Mouse Rat
generation of neurons GO:0048699 152 0.014
Zebrafish Mouse
cellular response to hypoxia GO:0071456 51 0.014
trachea development GO:0060438 1 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
neuron projection development GO:0031175 106 0.014
response to radiation GO:0009314 151 0.014
tripartite regional subdivision GO:0007351 2 0.014
single organism reproductive process GO:0044702 98 0.014
Worm
signal transduction by phosphorylation GO:0023014 297 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
anterior posterior axis specification GO:0009948 2 0.014
regulation of protein kinase b signaling GO:0051896 61 0.014
autonomic nervous system development GO:0048483 1 0.013
negative regulation of wnt signaling pathway GO:0030178 69 0.013
muscle cell cellular homeostasis GO:0046716 3 0.013
primary neural tube formation GO:0014020 3 0.013
regulation of gene expression epigenetic GO:0040029 73 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
regionalization GO:0003002 29 0.013
tube closure GO:0060606 3 0.013
carbohydrate metabolic process GO:0005975 207 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.013
microtubule organizing center organization GO:0031023 62 0.013
protein oligomerization GO:0051259 173 0.013
regulation of peptidase activity GO:0052547 180 0.013
purine nucleotide catabolic process GO:0006195 405 0.013
negative regulation of protein localization to nucleus GO:1900181 34 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
guanosine containing compound metabolic process GO:1901068 244 0.013
meiotic chromosome segregation GO:0045132 4 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
regulation of ras gtpase activity GO:0032318 128 0.013
microtubule based process GO:0007017 210 0.013
Zebrafish
motor neuron axon guidance GO:0008045 2 0.013
thymus development GO:0048538 3 0.013
i kappab kinase nf kappab signaling GO:0007249 166 0.013
neuroblast proliferation GO:0007405 4 0.013
positive regulation of protein catabolic process GO:0045732 75 0.012
cytoplasmic sequestering of protein GO:0051220 12 0.012
endodermal cell fate commitment GO:0001711 4 0.012
meiosis i GO:0007127 4 0.012
cellular response to dna damage stimulus GO:0006974 379 0.012
positive regulation of cell proliferation GO:0008284 301 0.012
regulation of gene silencing by rna GO:0060966 6 0.012
organonitrogen compound biosynthetic process GO:1901566 200 0.012
reproduction GO:0000003 63 0.012
Worm
reproductive process GO:0022414 106 0.012
Worm
rhythmic process GO:0048511 31 0.012
glutamine family amino acid metabolic process GO:0009064 17 0.012
negative regulation of mitotic cell cycle GO:0045930 102 0.012
regulation of transferase activity GO:0051338 355 0.012
forelimb morphogenesis GO:0035136 4 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
regulation of canonical wnt signaling pathway GO:0060828 88 0.012
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.012
circadian rhythm GO:0007623 21 0.012
regulation of mapk cascade GO:0043408 262 0.012
erbb signaling pathway GO:0038127 44 0.012
skeletal system development GO:0001501 79 0.012
defense response GO:0006952 315 0.012
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
pharynx development GO:0060465 1 0.012
Worm
ribonucleoside triphosphate catabolic process GO:0009203 391 0.012
positive regulation of transcription factor import into nucleus GO:0042993 25 0.012
purine ribonucleoside metabolic process GO:0046128 437 0.012
positive regulation of cell adhesion GO:0045785 84 0.012
myosin filament organization GO:0031033 2 0.012
negative regulation of cellular component organization GO:0051129 235 0.012
regulation of rho gtpase activity GO:0032319 66 0.012
positive regulation of intracellular transport GO:0032388 104 0.012
positive regulation of cellular amine metabolic process GO:0033240 7 0.012
organelle fission GO:0048285 149 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
regulation of response to wounding GO:1903034 101 0.011
regulation of protein localization to nucleus GO:1900180 85 0.011
protein modification by small protein removal GO:0070646 92 0.011
regulation of protein kinase c signaling GO:0090036 8 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
nuclear division GO:0000280 128 0.011
negative regulation of developmental process GO:0051093 247 0.011
endodermal cell fate specification GO:0001714 4 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
reciprocal dna recombination GO:0035825 4 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
protein localization to adherens junction GO:0071896 2 0.011
regulation of chromosome organization GO:0033044 103 0.011
cellular response to hormone stimulus GO:0032870 125 0.011
startle response GO:0001964 3 0.011
protein localization to membrane GO:0072657 160 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
multicellular organismal reproductive process GO:0048609 40 0.011
Worm
lamellipodium organization GO:0097581 30 0.011
axonogenesis GO:0007409 31 0.011
positive regulation of mapk cascade GO:0043410 190 0.011
response to hypoxia GO:0001666 96 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
positive regulation of protein complex assembly GO:0031334 86 0.011
response to starvation GO:0042594 59 0.011
ribonucleoside triphosphate metabolic process GO:0009199 412 0.011
epithelial cell differentiation GO:0030855 141 0.011
Mouse
negative regulation of protein phosphorylation GO:0001933 140 0.010
peptidyl tyrosine phosphorylation GO:0018108 170 0.010
neurotransmitter secretion GO:0007269 4 0.010
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.010
cell cycle arrest GO:0007050 71 0.010
alpha amino acid metabolic process GO:1901605 72 0.010
negative regulation of transport GO:0051051 176 0.010
purine nucleoside monophosphate metabolic process GO:0009126 186 0.010
sensory perception GO:0007600 103 0.010
regulation of microtubule polymerization GO:0031113 12 0.010
positive regulation of immune system process GO:0002684 283 0.010
nucleoside phosphate catabolic process GO:1901292 412 0.010
glycosyl compound catabolic process GO:1901658 413 0.010
regulation of gtpase activity GO:0043087 180 0.010
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.010
Worm
cellular macromolecular complex assembly GO:0034622 324 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.010
Mouse
single organism carbohydrate metabolic process GO:0044723 193 0.010
gtp metabolic process GO:0046039 239 0.010
tissue migration GO:0090130 119 0.010
cellular response to decreased oxygen levels GO:0036294 51 0.010

SCRIB disease predictions

Disease DO term ID Size Probability Func Analog Org
hepatobiliary disease DOID:3118 7 0.158
gastrointestinal system disease DOID:77 36 0.158
liver disease DOID:409 7 0.158
musculoskeletal system disease DOID:17 223 0.042
gastrointestinal system cancer DOID:3119 52 0.035
cancer DOID:162 167 0.035
disease of cellular proliferation DOID:14566 174 0.035
organ system cancer DOID:0050686 164 0.035
muscular disease DOID:0080000 114 0.021
disease of metabolism DOID:0014667 295 0.018
myopathy DOID:423 104 0.014
muscle tissue disease DOID:66 113 0.014
central nervous system disease DOID:331 186 0.013
nervous system disease DOID:863 431 0.013
connective tissue disease DOID:65 109 0.013
neurodegenerative disease DOID:1289 102 0.012
bone disease DOID:0080001 88 0.011
large intestine cancer DOID:5672 29 0.010
intestinal cancer DOID:10155 29 0.010
colorectal cancer DOID:9256 29 0.010