Homo sapiens

0 known processes

SETDB1

SET domain, bifurcated 1

(Aliases: KMT1E,KG1T,ESET,H3-K9-HMTase4,KIAA0067)

SETDB1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein catabolic process GO:0030163 325 0.706
negative regulation of cell differentiation GO:0045596 171 0.684
positive regulation of apoptotic process GO:0043065 246 0.682
negative regulation of developmental process GO:0051093 247 0.615
post embryonic development GO:0009791 2 0.548
Fly
cellular macromolecule catabolic process GO:0044265 380 0.542
dna hypermethylation GO:0044026 1 0.520
Fly
methylation GO:0032259 106 0.502
Human Mouse Fly
cellular response to endogenous stimulus GO:0071495 336 0.501
regulation of cell growth GO:0001558 135 0.477
regulation of response to external stimulus GO:0032101 222 0.460
negative regulation of protein metabolic process GO:0051248 391 0.459
protein modification by small protein conjugation GO:0032446 342 0.422
response to oxygen containing compound GO:1901700 369 0.414
positive regulation of cell death GO:0010942 263 0.391
positive regulation of cell proliferation GO:0008284 301 0.388
regulation of kinase activity GO:0043549 314 0.379
canonical wnt signaling pathway GO:0060070 116 0.368
pharynx development GO:0060465 1 0.350
developmental growth GO:0048589 48 0.317
Mouse
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.314
negative regulation of cellular protein metabolic process GO:0032269 353 0.297
oogenesis GO:0048477 2 0.286
Fly
negative regulation of multicellular organismal process GO:0051241 317 0.282
determination of adult lifespan GO:0008340 2 0.277
mitotic cell cycle GO:0000278 326 0.262
Human
negative regulation of protein modification process GO:0031400 200 0.223
ubiquitin dependent protein catabolic process GO:0006511 206 0.221
cellular response to nitrogen compound GO:1901699 144 0.210
negative regulation of axonogenesis GO:0050771 4 0.204
negative regulation of phosphorylation GO:0042326 174 0.191
regulation of growth GO:0040008 165 0.188
positive regulation of proteolysis GO:0045862 142 0.170
response to nitrogen compound GO:1901698 184 0.170
regulation of endopeptidase activity GO:0052548 170 0.167
regulation of cell development GO:0060284 161 0.167
protein modification by small protein removal GO:0070646 92 0.159
cellular response to organic cyclic compound GO:0071407 127 0.157
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.154
Mouse
wnt signaling pathway GO:0016055 156 0.149
transmission of nerve impulse GO:0019226 11 0.146
regulation of cellular amino acid metabolic process GO:0006521 6 0.142
protein ubiquitination GO:0016567 314 0.140
positive regulation of chromosome organization GO:2001252 41 0.138
cellular response to organonitrogen compound GO:0071417 124 0.136
response to radiation GO:0009314 151 0.133
covalent chromatin modification GO:0016569 254 0.131
Human Mouse Fly
nuclear migration GO:0007097 1 0.129
dna packaging GO:0006323 77 0.129
purine containing compound catabolic process GO:0072523 411 0.123
multicellular organismal aging GO:0010259 3 0.121
metencephalon development GO:0022037 2 0.117
regulation of cell cycle GO:0051726 393 0.114
endothelial cell proliferation GO:0001935 65 0.109
phospholipid catabolic process GO:0009395 12 0.109
epithelial cell migration GO:0010631 119 0.098
female gamete generation GO:0007292 2 0.094
Fly
positive regulation of transferase activity GO:0051347 227 0.094
collateral sprouting GO:0048668 2 0.091
positive regulation of protein kinase activity GO:0045860 190 0.088
regulation of protein ubiquitination GO:0031396 95 0.088
regulation of cysteine type endopeptidase activity GO:2000116 127 0.087
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.086
cellular response to oxygen containing compound GO:1901701 276 0.082
cellular protein catabolic process GO:0044257 261 0.082
cellular amino acid metabolic process GO:0006520 116 0.080
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.078
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.077
regulation of innate immune response GO:0045088 97 0.075
regulation of transferase activity GO:0051338 355 0.075
central nervous system development GO:0007417 123 0.074
histone modification GO:0016570 251 0.073
Human Mouse Fly
growth GO:0040007 202 0.072
Mouse
stress activated protein kinase signaling cascade GO:0031098 94 0.070
cellular response to growth factor stimulus GO:0071363 197 0.070
negative regulation of neurogenesis GO:0050768 26 0.069
taxis GO:0042330 157 0.069
cellular response to hypoxia GO:0071456 51 0.069
hindbrain development GO:0030902 3 0.067
activation of cysteine type endopeptidase activity GO:0097202 57 0.066
chromatin modification GO:0016568 298 0.065
Human Mouse Fly
translation GO:0006412 132 0.064
cellular response to oxidative stress GO:0034599 85 0.064
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.062
negative regulation of cell projection organization GO:0031345 22 0.062
positive regulation of cellular amine metabolic process GO:0033240 7 0.062
positive regulation of cell differentiation GO:0045597 211 0.060
modification dependent protein catabolic process GO:0019941 209 0.059
cellular response to decreased oxygen levels GO:0036294 51 0.059
regulation of cell division GO:0051302 116 0.059
cell division GO:0051301 168 0.058
Fly
signal transduction by p53 class mediator GO:0072331 72 0.057
regulation of translation GO:0006417 89 0.057
innate immune response GO:0045087 178 0.056
positive regulation of kinase activity GO:0033674 204 0.055
regulation of protein catabolic process GO:0042176 155 0.055
membrane organization GO:0061024 292 0.055
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.054
macromolecule methylation GO:0043414 97 0.053
Human Mouse Fly
positive regulation of cellular catabolic process GO:0031331 284 0.052
intrinsic apoptotic signaling pathway GO:0097193 127 0.052
lipid modification GO:0030258 84 0.051
reproductive system development GO:0061458 56 0.050
positive regulation of macroautophagy GO:0016239 12 0.049
amine metabolic process GO:0009308 44 0.048
defense response to other organism GO:0098542 129 0.048
modification dependent macromolecule catabolic process GO:0043632 212 0.048
negative regulation of programmed cell death GO:0043069 321 0.047
response to endoplasmic reticulum stress GO:0034976 49 0.047
negative regulation of growth GO:0045926 97 0.047
regulation of defense response GO:0031347 154 0.046
positive regulation of protein sumoylation GO:0033235 7 0.046
cellular response to peptide hormone stimulus GO:0071375 56 0.046
positive regulation of organelle organization GO:0010638 195 0.045
epithelium migration GO:0090132 119 0.045
negative regulation of cell cycle GO:0045786 193 0.044
neuronal action potential GO:0019228 9 0.044
regulation of cellular ketone metabolic process GO:0010565 50 0.044
regulation of cell cycle process GO:0010564 266 0.044
positive regulation of cellular protein catabolic process GO:1903364 37 0.043
dna methylation or demethylation GO:0044728 19 0.042
Fly
regulation of epithelial cell migration GO:0010632 93 0.042
positive regulation of catabolic process GO:0009896 310 0.042
negative regulation of protein ubiquitination GO:0031397 35 0.042
negative regulation of neuron differentiation GO:0045665 21 0.042
regulation of cellular amine metabolic process GO:0033238 11 0.042
regulation of glial cell proliferation GO:0060251 4 0.041
negative regulation of phosphate metabolic process GO:0045936 267 0.041
nucleosome assembly GO:0006334 50 0.041
positive regulation of chromatin modification GO:1903310 30 0.040
cell growth GO:0016049 160 0.040
system process GO:0003008 349 0.040
response to vitamin GO:0033273 13 0.040
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.040
stress activated mapk cascade GO:0051403 93 0.040
regulation of cell motility GO:2000145 299 0.039
regulation of cellular response to stress GO:0080135 244 0.039
regulation of neuroblast proliferation GO:1902692 3 0.039
intracellular receptor signaling pathway GO:0030522 104 0.038
cell cell junction organization GO:0045216 69 0.038
response to abiotic stimulus GO:0009628 336 0.038
endocytosis GO:0006897 159 0.038
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.037
regulation of mapk cascade GO:0043408 262 0.037
response to epidermal growth factor GO:0070849 14 0.037
regulation of response to nutrient levels GO:0032107 22 0.037
neurofilament bundle assembly GO:0033693 2 0.037
regulation of cell projection organization GO:0031344 107 0.037
axon development GO:0061564 34 0.037
cell development GO:0048468 328 0.037
Fly
negative regulation of protein phosphorylation GO:0001933 140 0.036
regulation of wnt signaling pathway GO:0030111 123 0.036
tissue migration GO:0090130 119 0.035
nucleus localization GO:0051647 1 0.035
response to organic cyclic compound GO:0014070 204 0.034
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.034
g2 m transition of mitotic cell cycle GO:0000086 41 0.034
response to extracellular stimulus GO:0009991 85 0.034
response to hormone GO:0009725 175 0.034
protein sumoylation GO:0016925 25 0.033
regulation of cell differentiation GO:0045595 393 0.033
embryo development GO:0009790 123 0.033
Mouse
purine nucleoside catabolic process GO:0006152 398 0.032
regulation of map kinase activity GO:0043405 108 0.032
cell adhesion GO:0007155 325 0.032
negative regulation of cell proliferation GO:0008285 228 0.032
apoptotic signaling pathway GO:0097190 268 0.032
regulation of axonogenesis GO:0050770 16 0.032
regulation of gene silencing GO:0060968 24 0.032
Fly
regulation of neuron differentiation GO:0045664 70 0.032
regulation of dna repair GO:0006282 47 0.032
regulation of cellular component movement GO:0051270 334 0.031
establishment of nucleus localization GO:0040023 1 0.031
negative regulation of t cell apoptotic process GO:0070233 4 0.031
regulation of gtp catabolic process GO:0033124 180 0.030
positive regulation of programmed cell death GO:0043068 249 0.030
cell cycle phase transition GO:0044770 173 0.030
single organism cellular localization GO:1902580 332 0.030
response to other organism GO:0051707 261 0.030
negative regulation of cellular component movement GO:0051271 106 0.030
positive regulation of protein catabolic process GO:0045732 75 0.030
regulation of endothelial cell migration GO:0010594 67 0.029
mitotic cell cycle phase transition GO:0044772 162 0.029
regulation of protein localization GO:0032880 296 0.029
regulation of epithelial cell proliferation GO:0050678 113 0.029
negative regulation of cellular component organization GO:0051129 235 0.029
negative regulation of cell growth GO:0030308 83 0.029
smooth muscle cell migration GO:0014909 18 0.028
caveolin mediated endocytosis GO:0072584 4 0.028
positive regulation of developmental process GO:0051094 314 0.027
multicellular organismal signaling GO:0035637 34 0.027
regulation of autophagy GO:0010506 52 0.027
glucan metabolic process GO:0044042 22 0.027
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.027
positive regulation of protein phosphorylation GO:0001934 313 0.027
endothelial cell migration GO:0043542 86 0.026
single organism carbohydrate metabolic process GO:0044723 193 0.026
regulation of dna methylation GO:0044030 2 0.026
Fly
regulation of response to biotic stimulus GO:0002831 55 0.025
internal peptidyl lysine acetylation GO:0018393 97 0.025
cellular response to hormone stimulus GO:0032870 125 0.025
negative regulation of transport GO:0051051 176 0.025
cellular senescence GO:0090398 34 0.025
vesicle mediated transport GO:0016192 371 0.025
positive regulation of endothelial cell migration GO:0010595 39 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
regulation of immune response GO:0050776 201 0.024
epithelial cell proliferation GO:0050673 128 0.024
cellular polysaccharide metabolic process GO:0044264 27 0.023
dna modification GO:0006304 27 0.023
Fly
immune response GO:0006955 307 0.023
positive regulation of mapk cascade GO:0043410 190 0.023
organic acid catabolic process GO:0016054 71 0.023
regulation of generation of precursor metabolites and energy GO:0043467 27 0.022
negative regulation of transferase activity GO:0051348 124 0.022
regulation of dna metabolic process GO:0051052 153 0.022
Fly
positive regulation of cell cycle GO:0045787 140 0.022
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.022
regulation of apoptotic signaling pathway GO:2001233 175 0.021
rna catabolic process GO:0006401 71 0.021
glandular epithelial cell differentiation GO:0002067 6 0.021
sex differentiation GO:0007548 45 0.021
cellular ketone metabolic process GO:0042180 80 0.021
regulation of anatomical structure morphogenesis GO:0022603 286 0.021
regulation of protein serine threonine kinase activity GO:0071900 179 0.021
regulation of collateral sprouting GO:0048670 2 0.021
cellular response to starvation GO:0009267 58 0.021
dna repair GO:0006281 198 0.021
oxidation reduction process GO:0055114 396 0.021
regulation of response to dna damage stimulus GO:2001020 94 0.021
cellular macromolecular complex assembly GO:0034622 324 0.021
response to nutrient GO:0007584 20 0.021
endomembrane system organization GO:0010256 196 0.020
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.020
regulation of neuron projection development GO:0010975 57 0.020
regulation of proteolysis GO:0030162 293 0.020
regulation of glucosylceramide catabolic process GO:2000752 1 0.020
protein acetylation GO:0006473 116 0.020
negative regulation of nervous system development GO:0051961 28 0.020
developmental process involved in reproduction GO:0003006 66 0.020
Fly
regulation of mitotic cell cycle GO:0007346 189 0.020
histone h3 k9 modification GO:0061647 11 0.020
Human Mouse Fly
protein alkylation GO:0008213 74 0.020
Human Mouse Fly
dna replication GO:0006260 116 0.019
posttranscriptional regulation of gene expression GO:0010608 213 0.019
cristae formation GO:0042407 3 0.019
single organism membrane organization GO:0044802 268 0.019
response to reactive oxygen species GO:0000302 61 0.019
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.019
astrocyte development GO:0014002 1 0.019
negative regulation of neuron projection development GO:0010977 15 0.019
cell part morphogenesis GO:0032990 137 0.019
regulation of axon guidance GO:1902667 3 0.019
neuromuscular junction development GO:0007528 3 0.019
regulation of mitosis GO:0007088 63 0.019
phagocytosis GO:0006909 42 0.019
defense response GO:0006952 315 0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.019
proteasomal protein catabolic process GO:0010498 176 0.018
regulation of protein kinase activity GO:0045859 289 0.018
apoptotic cell clearance GO:0043277 12 0.018
regulation of histone modification GO:0031056 47 0.018
striated muscle cell apoptotic process GO:0010658 3 0.018
sulfur compound metabolic process GO:0006790 101 0.018
positive regulation of vasoconstriction GO:0045907 3 0.018
glycogen biosynthetic process GO:0005978 16 0.018
positive regulation of response to extracellular stimulus GO:0032106 14 0.017
nucleoside triphosphate catabolic process GO:0009143 394 0.017
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.017
purine nucleoside monophosphate metabolic process GO:0009126 186 0.017
negative regulation of receptor mediated endocytosis GO:0048261 6 0.017
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.017
trna processing GO:0008033 23 0.017
cytoplasmic transport GO:0016482 379 0.017
nerve development GO:0021675 4 0.016
histone lysine methylation GO:0034968 50 0.016
Human Mouse Fly
brain development GO:0007420 97 0.016
reproductive process GO:0022414 106 0.016
Fly
regulation of histone methylation GO:0031060 16 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
cell type specific apoptotic process GO:0097285 125 0.016
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.016
regeneration GO:0031099 4 0.016
positive regulation of immune system process GO:0002684 283 0.016
positive regulation of innate immune response GO:0045089 79 0.015
neurogenesis GO:0022008 169 0.015
negative regulation of mitotic cell cycle GO:0045930 102 0.015
regulation of mitotic cell cycle phase transition GO:1901990 118 0.015
glycogen metabolic process GO:0005977 22 0.015
neuron projection development GO:0031175 106 0.015
establishment of planar polarity GO:0001736 3 0.015
head development GO:0060322 108 0.015
negative regulation of cell death GO:0060548 345 0.015
stem cell division GO:0017145 2 0.015
Fly
positive regulation of epithelial cell proliferation GO:0050679 65 0.015
response to nutrient levels GO:0031667 81 0.015
nucleocytoplasmic transport GO:0006913 176 0.014
response to peptide GO:1901652 65 0.014
signal transduction in response to dna damage GO:0042770 57 0.014
lymphocyte homeostasis GO:0002260 4 0.014
cellular response to peptide GO:1901653 59 0.014
single organism reproductive process GO:0044702 98 0.014
Fly
response to transforming growth factor beta GO:0071559 94 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
negative regulation of kinase activity GO:0033673 106 0.014
response to inorganic substance GO:0010035 127 0.014
ameboidal type cell migration GO:0001667 135 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.014
regulation of peptidase activity GO:0052547 180 0.014
cell cycle g2 m phase transition GO:0044839 43 0.014
regulation of neurogenesis GO:0050767 82 0.013
cell cycle g1 s phase transition GO:0044843 80 0.013
response to organonitrogen compound GO:0010243 156 0.013
negative regulation of apoptotic process GO:0043066 316 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
positive regulation of autophagy GO:0010508 24 0.013
regulation of leukocyte apoptotic process GO:2000106 25 0.013
negative regulation of response to external stimulus GO:0032102 83 0.013
autophagy GO:0006914 88 0.013
regulation of cellular protein catabolic process GO:1903362 96 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
positive regulation of response to dna damage stimulus GO:2001022 43 0.012
regulation of female gonad development GO:2000194 1 0.012
camera type eye development GO:0043010 25 0.012
cell junction organization GO:0034330 79 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
cellular response to nutrient levels GO:0031669 69 0.012
methylation dependent chromatin silencing GO:0006346 3 0.012
cellular response to insulin stimulus GO:0032869 41 0.012
negative regulation of wnt signaling pathway GO:0030178 69 0.012
positive regulation of superoxide anion generation GO:0032930 4 0.012
response to cytokine GO:0034097 232 0.012
regulation of endothelial cell proliferation GO:0001936 56 0.012
cellular amine metabolic process GO:0044106 41 0.012
monocarboxylic acid catabolic process GO:0072329 37 0.012
g1 s transition of mitotic cell cycle GO:0000082 78 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.012
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.012
protein dephosphorylation GO:0006470 81 0.012
adherens junction assembly GO:0034333 34 0.012
dna alkylation GO:0006305 7 0.012
Fly
peptidyl lysine acetylation GO:0018394 101 0.011
response to starvation GO:0042594 59 0.011
protein deubiquitination GO:0016579 79 0.011
biological adhesion GO:0022610 331 0.011
atp metabolic process GO:0046034 176 0.011
protein processing GO:0016485 226 0.011
regulation of chemotaxis GO:0050920 74 0.011
glucan biosynthetic process GO:0009250 16 0.011
nucleotide catabolic process GO:0009166 408 0.011
mitochondrion organization GO:0007005 156 0.011
regulation of behavior GO:0050795 82 0.011
carbohydrate homeostasis GO:0033500 31 0.011
positive regulation of glial cell proliferation GO:0060252 2 0.011
negative regulation of protein kinase activity GO:0006469 98 0.011
protein maturation GO:0051604 233 0.011
regulation of cell size GO:0008361 19 0.011
regulation of protein processing GO:0070613 150 0.011
rna processing GO:0006396 255 0.011
regulation of glycogen metabolic process GO:0070873 15 0.011
maintenance of location GO:0051235 112 0.011
cellular response to oxygen levels GO:0071453 55 0.011
spinal cord development GO:0021510 4 0.011
negative regulation of cellular catabolic process GO:0031330 83 0.011
response to alcohol GO:0097305 64 0.011
ribonucleotide biosynthetic process GO:0009260 81 0.011
response to decreased oxygen levels GO:0036293 96 0.011
rna modification GO:0009451 27 0.011
neuron projection morphogenesis GO:0048812 50 0.011
response to hypoxia GO:0001666 96 0.011
regulation of locomotion GO:0040012 329 0.011
negative regulation of collateral sprouting GO:0048671 1 0.011
negative regulation of cell development GO:0010721 48 0.011
thymus development GO:0048538 3 0.010
embryonic hindlimb morphogenesis GO:0035116 2 0.010
positive regulation of alpha beta t cell differentiation GO:0046638 4 0.010
positive regulation of t cell activation GO:0050870 54 0.010
negative regulation of immune system process GO:0002683 136 0.010
regulation of myelination GO:0031641 1 0.010
response to ionizing radiation GO:0010212 65 0.010
cellular response to monoamine stimulus GO:0071868 7 0.010
regulation of macroautophagy GO:0016241 19 0.010
response to oxidative stress GO:0006979 121 0.010
response to axon injury GO:0048678 1 0.010
regulation of glucose transport GO:0010827 23 0.010
t cell homeostasis GO:0043029 3 0.010
jnk cascade GO:0007254 80 0.010

SETDB1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.020
disease of cellular proliferation DOID:14566 174 0.020
organ system cancer DOID:0050686 164 0.020
congenital heart disease DOID:1682 16 0.018
heart septal defect DOID:1681 14 0.018
heart disease DOID:114 68 0.018
cardiovascular system disease DOID:1287 106 0.018
physical disorder DOID:0080015 41 0.011
gastrointestinal system cancer DOID:3119 52 0.011