Homo sapiens

57 known processes

USP28

ubiquitin specific peptidase 28

(Aliases: KIAA1515)

USP28 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein removal GO:0070646 92 0.178
protein deubiquitination GO:0016579 79 0.140
protein k63 linked deubiquitination GO:0070536 21 0.073
Human
response to abiotic stimulus GO:0009628 336 0.061
cellular amino acid metabolic process GO:0006520 116 0.060
amine metabolic process GO:0009308 44 0.051
cellular ketone metabolic process GO:0042180 80 0.050
post embryonic development GO:0009791 2 0.048
regulation of cellular ketone metabolic process GO:0010565 50 0.044
regulation of cellular amino acid metabolic process GO:0006521 6 0.042
regulation of cellular amine metabolic process GO:0033238 11 0.042
apoptotic signaling pathway GO:0097190 268 0.041
cellular response to abiotic stimulus GO:0071214 117 0.037
multicellular organismal aging GO:0010259 3 0.036
female gamete generation GO:0007292 2 0.036
cellular amine metabolic process GO:0044106 41 0.036
cytoplasmic transport GO:0016482 379 0.036
negative regulation of cellular protein metabolic process GO:0032269 353 0.035
intrinsic apoptotic signaling pathway GO:0097193 127 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.035
determination of adult lifespan GO:0008340 2 0.034
mitotic cell cycle GO:0000278 326 0.031
chromatin organization GO:0006325 351 0.030
mitotic cell cycle process GO:1903047 286 0.030
negative regulation of catalytic activity GO:0043086 335 0.029
positive regulation of cellular amine metabolic process GO:0033240 7 0.029
histone modification GO:0016570 251 0.029
neuromuscular junction development GO:0007528 3 0.029
cellular response to dna damage stimulus GO:0006974 379 0.028
negative regulation of protein metabolic process GO:0051248 391 0.028
oogenesis GO:0048477 2 0.028
protein catabolic process GO:0030163 325 0.028
immune response GO:0006955 307 0.027
cell cycle checkpoint GO:0000075 117 0.027
positive regulation of catabolic process GO:0009896 310 0.027
maintenance of location GO:0051235 112 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.026
purine ribonucleoside metabolic process GO:0046128 437 0.026
negative regulation of developmental process GO:0051093 247 0.025
regeneration GO:0031099 4 0.025
posttranscriptional regulation of gene expression GO:0010608 213 0.025
response to uv GO:0009411 73 0.024
protein localization to organelle GO:0033365 280 0.024
nucleoside triphosphate metabolic process GO:0009141 422 0.024
cellular response to radiation GO:0071478 65 0.024
membrane organization GO:0061024 292 0.023
positive regulation of cellular component organization GO:0051130 376 0.023
positive regulation of cellular catabolic process GO:0031331 284 0.023
segmentation GO:0035282 4 0.023
organophosphate catabolic process GO:0046434 430 0.023
purine containing compound catabolic process GO:0072523 411 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.022
purine nucleoside triphosphate metabolic process GO:0009144 412 0.022
nucleotide catabolic process GO:0009166 408 0.022
protein k48 linked deubiquitination GO:0071108 19 0.022
Human
response to light stimulus GO:0009416 87 0.022
signal transduction by phosphorylation GO:0023014 297 0.022
chromatin modification GO:0016568 298 0.022
ribonucleoside triphosphate catabolic process GO:0009203 391 0.022
purine nucleoside catabolic process GO:0006152 398 0.022
regulation of kinase activity GO:0043549 314 0.022
regulation of proteolysis GO:0030162 293 0.021
response to ionizing radiation GO:0010212 65 0.021
regulation of protein localization GO:0032880 296 0.021
ribonucleotide catabolic process GO:0009261 405 0.021
protein maturation GO:0051604 233 0.021
positive regulation of hydrolase activity GO:0051345 331 0.020
nucleoside phosphate catabolic process GO:1901292 412 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
nucleoside triphosphate catabolic process GO:0009143 394 0.020
cellular lipid metabolic process GO:0044255 303 0.020
ribonucleoside triphosphate metabolic process GO:0009199 412 0.020
regulation of cell cycle GO:0051726 393 0.020
regulation of cell differentiation GO:0045595 393 0.020
endomembrane system organization GO:0010256 196 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.020
anterior posterior axis specification GO:0009948 2 0.020
negative regulation of multicellular organismal process GO:0051241 317 0.020
actin filament based process GO:0030029 224 0.020
signal transduction by p53 class mediator GO:0072331 72 0.020
regulation of transferase activity GO:0051338 355 0.020
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.020
ribonucleoside catabolic process GO:0042454 406 0.020
small gtpase mediated signal transduction GO:0007264 78 0.020
protein ubiquitination GO:0016567 314 0.020
positive regulation of transport GO:0051050 336 0.019
transmembrane transport GO:0055085 399 0.019
defense response GO:0006952 315 0.019
metal ion transport GO:0030001 272 0.019
locomotory behavior GO:0007626 1 0.019
cell projection organization GO:0030030 252 0.019
rho protein signal transduction GO:0007266 26 0.019
adult locomotory behavior GO:0008344 1 0.019
regulation of cell cycle process GO:0010564 266 0.019
single organism membrane organization GO:0044802 268 0.019
chemical homeostasis GO:0048878 306 0.019
proteasomal protein catabolic process GO:0010498 176 0.019
carbohydrate derivative biosynthetic process GO:1901137 207 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
cell morphogenesis GO:0000902 296 0.019
memory GO:0007613 3 0.019
carbohydrate metabolic process GO:0005975 207 0.019
cellular macromolecule catabolic process GO:0044265 380 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
ras protein signal transduction GO:0007265 73 0.019
system process GO:0003008 349 0.019
single organism cellular localization GO:1902580 332 0.019
negative regulation of programmed cell death GO:0043069 321 0.018
glycosyl compound catabolic process GO:1901658 413 0.018
cellular response to uv GO:0034644 32 0.018
rhythmic behavior GO:0007622 2 0.018
blastoderm segmentation GO:0007350 2 0.018
oxidation reduction process GO:0055114 396 0.018
oocyte development GO:0048599 1 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
response to oxygen containing compound GO:1901700 369 0.018
microtubule based process GO:0007017 210 0.018
positive regulation of immune system process GO:0002684 283 0.018
biological adhesion GO:0022610 331 0.018
regulation of protein kinase activity GO:0045859 289 0.018
nervous system development GO:0007399 293 0.018
Zebrafish
lipid metabolic process GO:0006629 381 0.018
cellular protein catabolic process GO:0044257 261 0.018
regulation of cellular component movement GO:0051270 334 0.018
dephosphorylation GO:0016311 209 0.018
cation transport GO:0006812 331 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
negative regulation of hydrolase activity GO:0051346 182 0.017
purine nucleotide catabolic process GO:0006195 405 0.017
cellular response to endogenous stimulus GO:0071495 336 0.017
negative regulation of cellular amine metabolic process GO:0033239 3 0.017
positive regulation of organelle organization GO:0010638 195 0.017
positive regulation of protein phosphorylation GO:0001934 313 0.017
nucleoside catabolic process GO:0009164 408 0.017
cellular component morphogenesis GO:0032989 314 0.017
regulation of protein transport GO:0051223 213 0.017
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.017
response to other organism GO:0051707 261 0.017
ion transmembrane transport GO:0034220 338 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
negative regulation of cell death GO:0060548 345 0.017
circadian behavior GO:0048512 2 0.017
purine nucleoside triphosphate catabolic process GO:0009146 392 0.017
regulation of locomotion GO:0040012 329 0.017
positive regulation of cell death GO:0010942 263 0.017
morphogenesis of embryonic epithelium GO:0016331 4 0.017
positive regulation of developmental process GO:0051094 314 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.017
regulation of protein catabolic process GO:0042176 155 0.017
innate immune response GO:0045087 178 0.017
organonitrogen compound biosynthetic process GO:1901566 200 0.017
positive regulation of apoptotic process GO:0043065 246 0.017
mapk cascade GO:0000165 288 0.016
regulation of mitotic cell cycle GO:0007346 189 0.016
protein processing GO:0016485 226 0.016
positive regulation of cell proliferation GO:0008284 301 0.016
regulation of response to external stimulus GO:0032101 222 0.016
mitochondrion organization GO:0007005 156 0.016
purine ribonucleoside catabolic process GO:0046130 398 0.016
protein targeting GO:0006605 187 0.016
regulation of cytokine production GO:0001817 232 0.016
response to external biotic stimulus GO:0043207 261 0.016
cardiac muscle cell contraction GO:0086003 4 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
rna interference GO:0016246 4 0.016
negative regulation of cellular component organization GO:0051129 235 0.016
spermatid differentiation GO:0048515 4 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.016
regulation of cell migration GO:0030334 289 0.016
hindbrain development GO:0030902 3 0.016
regulation of nucleoside metabolic process GO:0009118 209 0.016
secretion GO:0046903 254 0.016
intracellular protein transport GO:0006886 270 0.016
nitrogen compound transport GO:0071705 191 0.016
negative regulation of cell proliferation GO:0008285 228 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
regulation of cell motility GO:2000145 299 0.016
oocyte differentiation GO:0009994 2 0.016
dna repair GO:0006281 198 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
regulation of nucleotide metabolic process GO:0006140 269 0.015
regulation of immune response GO:0050776 201 0.015
secretion by cell GO:0032940 226 0.015
covalent chromatin modification GO:0016569 254 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
reactive oxygen species metabolic process GO:0072593 75 0.015
response to axon injury GO:0048678 1 0.015
nucleocytoplasmic transport GO:0006913 176 0.015
compound eye development GO:0048749 1 0.015
peripheral nervous system development GO:0007422 2 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.015
positive regulation of transferase activity GO:0051347 227 0.015
inner ear morphogenesis GO:0042472 4 0.015
negative regulation of protein modification process GO:0031400 200 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
cellular homeostasis GO:0019725 196 0.015
cell adhesion GO:0007155 325 0.015
cellular protein complex assembly GO:0043623 188 0.015
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
tripartite regional subdivision GO:0007351 2 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.015
glycoprotein metabolic process GO:0009100 110 0.015
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.015
cellular response to oxygen containing compound GO:1901701 276 0.014
associative learning GO:0008306 1 0.014
reactive oxygen species biosynthetic process GO:1903409 4 0.014
lipid biosynthetic process GO:0008610 177 0.014
negative regulation of proteolysis GO:0045861 132 0.014
mating GO:0007618 1 0.014
growth GO:0040007 202 0.014
regulation of meiotic cell cycle GO:0051445 4 0.014
response to radiation GO:0009314 151 0.014
nuclear transport GO:0051169 179 0.014
metencephalon development GO:0022037 2 0.014
small molecule biosynthetic process GO:0044283 157 0.014
guanosine containing compound catabolic process GO:1901069 239 0.014
regulation of cellular response to stress GO:0080135 244 0.014
cellular response to light stimulus GO:0071482 34 0.014
regulation of synaptic plasticity GO:0048167 3 0.014
regulation of secretion GO:0051046 194 0.014
motor neuron axon guidance GO:0008045 2 0.014
negative regulation of protein processing GO:0010955 142 0.014
actin mediated cell contraction GO:0070252 12 0.014
cation transmembrane transport GO:0098655 238 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
regulation of intracellular transport GO:0032386 195 0.014
vesicle mediated transport GO:0016192 371 0.014
reactive nitrogen species metabolic process GO:2001057 3 0.014
tissue regeneration GO:0042246 3 0.014
regulation of growth GO:0040008 165 0.013
ubiquitin dependent protein catabolic process GO:0006511 206 0.013
regulation of peptidase activity GO:0052547 180 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
nuclear division GO:0000280 128 0.013
spermatid development GO:0007286 4 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
circulatory system development GO:0072359 262 0.013
embryonic epithelial tube formation GO:0001838 4 0.013
organ formation GO:0048645 3 0.013
protein oligomerization GO:0051259 173 0.013
organelle assembly GO:0070925 176 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
mitotic nuclear division GO:0007067 119 0.013
positive regulation of phosphorylation GO:0042327 394 0.013
regulation of protein maturation GO:1903317 150 0.013
chromosome segregation GO:0007059 114 0.013
response to fungus GO:0009620 4 0.013
regulation of protein processing GO:0070613 150 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013
actin filament based movement GO:0030048 17 0.013
response to biotic stimulus GO:0009607 276 0.013
regulation of dna metabolic process GO:0051052 153 0.013
regulation of homeostatic process GO:0032844 121 0.013
ion homeostasis GO:0050801 230 0.013
response to cytokine GO:0034097 232 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
negative regulation of protein maturation GO:1903318 142 0.013
monocarboxylic acid metabolic process GO:0032787 185 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
negative regulation of cell differentiation GO:0045596 171 0.013
cellular cation homeostasis GO:0030003 163 0.013
sequestering of metal ion GO:0051238 24 0.013
negative regulation of cell cycle GO:0045786 193 0.013
cell fate determination GO:0001709 3 0.013
positive regulation of kinase activity GO:0033674 204 0.013
regulation of mapk cascade GO:0043408 262 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.013
cell division GO:0051301 168 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
inorganic cation transmembrane transport GO:0098662 194 0.013
positive regulation of proteolysis GO:0045862 142 0.013
cytokine production GO:0001816 247 0.013
neurotransmitter secretion GO:0007269 4 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
cell growth GO:0016049 160 0.012
regulation of multi organism process GO:0043900 157 0.012
nerve development GO:0021675 4 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
limbic system development GO:0021761 3 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
anion transport GO:0006820 161 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
rna splicing GO:0008380 131 0.012
endosomal transport GO:0016197 129 0.012
positive regulation of protein transport GO:0051222 135 0.012
cation homeostasis GO:0055080 189 0.012
neural tube formation GO:0001841 3 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
positive regulation of synaptic transmission GO:0050806 4 0.012
mitotic cell cycle phase transition GO:0044772 162 0.012
response to growth factor GO:0070848 205 0.012
wnt signaling pathway GO:0016055 156 0.012
sequestering of calcium ion GO:0051208 17 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
cell development GO:0048468 328 0.012
cell projection assembly GO:0030031 126 0.012
syncytium formation by plasma membrane fusion GO:0000768 2 0.012
neurological system process GO:0050877 163 0.012
sex determination GO:0007530 3 0.012
guanosine containing compound metabolic process GO:1901068 244 0.012
cofactor metabolic process GO:0051186 87 0.012
divalent inorganic cation transport GO:0072511 158 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
positive regulation of cytokine production GO:0001819 167 0.012
regulation of secretion by cell GO:1903530 177 0.012
morphogenesis of a polarized epithelium GO:0001738 3 0.012
metal ion homeostasis GO:0055065 169 0.012
atp metabolic process GO:0046034 176 0.012
multi organism cellular process GO:0044764 156 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
single organism cell adhesion GO:0098602 179 0.012
cerebellum development GO:0021549 2 0.012
negative regulation of transport GO:0051051 176 0.012
rna processing GO:0006396 255 0.012
gtp catabolic process GO:0006184 237 0.012
photoreceptor cell differentiation GO:0046530 2 0.012
gtp metabolic process GO:0046039 239 0.012
cardiovascular system development GO:0072358 262 0.011
meiosis i GO:0007127 4 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
cell projection morphogenesis GO:0048858 129 0.011
spinal cord development GO:0021510 4 0.011
endocytosis GO:0006897 159 0.011
interspecies interaction between organisms GO:0044419 156 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
protein localization to nucleus GO:0034504 136 0.011
protein import GO:0017038 130 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
thymus development GO:0048538 3 0.011
regulation of protein complex assembly GO:0043254 147 0.011
calcium ion transport GO:0006816 147 0.011
carboxylic acid biosynthetic process GO:0046394 97 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
glycoprotein biosynthetic process GO:0009101 91 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
regulation of nucleotide catabolic process GO:0030811 205 0.011
meiotic chromosome segregation GO:0045132 4 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
cell part morphogenesis GO:0032990 137 0.011
negative regulation of organelle organization GO:0010639 126 0.011
regulation of defense response GO:0031347 154 0.011
long term memory GO:0007616 2 0.011
positive regulation of cell migration GO:0030335 172 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
neuroblast proliferation GO:0007405 4 0.011
central nervous system development GO:0007417 123 0.011
Zebrafish
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
tube closure GO:0060606 3 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
defense response to fungus GO:0050832 4 0.011
actin cytoskeleton organization GO:0030036 207 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
regulation of cytoplasmic transport GO:1903649 149 0.011
positive regulation of cell cycle GO:0045787 140 0.011
response to wounding GO:0009611 168 0.011
salivary gland morphogenesis GO:0007435 4 0.011
methylation GO:0032259 106 0.011
regulation of actin filament based process GO:0032970 141 0.011
regulation of gtp catabolic process GO:0033124 180 0.011
regulation of gtpase activity GO:0043087 180 0.011
embryo development GO:0009790 123 0.011
peptidyl tyrosine modification GO:0018212 170 0.011
divalent metal ion transport GO:0070838 152 0.011
positive regulation of immune response GO:0050778 159 0.011
epithelium development GO:0060429 227 0.011
sensory perception of pain GO:0019233 4 0.011
neuron projection regeneration GO:0031102 1 0.010
single organism reproductive process GO:0044702 98 0.010
response to nitrogen compound GO:1901698 184 0.010
epithelial cell differentiation GO:0030855 141 0.010
macromolecule glycosylation GO:0043413 63 0.010
organic acid biosynthetic process GO:0016053 97 0.010
visual behavior GO:0007632 2 0.010
regulation of ion transport GO:0043269 189 0.010
sleep GO:0030431 2 0.010
regulation of cell division GO:0051302 116 0.010
cellular chemical homeostasis GO:0055082 180 0.010
negative regulation of transferase activity GO:0051348 124 0.010
cell cycle phase transition GO:0044770 173 0.010
axon regeneration GO:0031103 1 0.010
positive regulation of transcription during mitosis GO:0045897 2 0.010
generation of neurons GO:0048699 152 0.010
pituitary gland development GO:0021983 2 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.010
positive regulation of secretion GO:0051047 116 0.010
organelle fission GO:0048285 149 0.010
myoblast fusion GO:0007520 1 0.010
t cell differentiation in thymus GO:0033077 4 0.010
negative regulation of cell cycle process GO:0010948 121 0.010

USP28 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.037
inherited metabolic disorder DOID:655 242 0.025
sensory system disease DOID:0050155 203 0.025
nervous system disease DOID:863 431 0.025
musculoskeletal system disease DOID:17 223 0.023
central nervous system disease DOID:331 186 0.021
cancer DOID:162 167 0.017
disease of cellular proliferation DOID:14566 174 0.017
organ system cancer DOID:0050686 164 0.017
eye and adnexa disease DOID:1492 150 0.017
eye disease DOID:5614 149 0.017
muscular disease DOID:0080000 114 0.015
immune system disease DOID:2914 155 0.015
bone disease DOID:0080001 88 0.013
connective tissue disease DOID:65 109 0.013
myopathy DOID:423 104 0.013
muscle tissue disease DOID:66 113 0.013
neurodegenerative disease DOID:1289 102 0.012
brain disease DOID:936 73 0.011
hematopoietic system disease DOID:74 100 0.011
retinal disease DOID:5679 118 0.011
disease of mental health DOID:150 70 0.011
cardiovascular system disease DOID:1287 106 0.011
retinal degeneration DOID:8466 89 0.011
amino acid metabolic disorder DOID:9252 50 0.010