Homo sapiens

7 known processes

USP21

ubiquitin specific peptidase 21

(Aliases: MGC3394,USP16,USP23)

USP21 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein deubiquitination GO:0016579 79 0.660
Human Yeast Mouse Fly
nervous system development GO:0007399 293 0.207
protein modification by small protein removal GO:0070646 92 0.185
Human Yeast Mouse Fly
regulation of cell differentiation GO:0045595 393 0.176
cell development GO:0048468 328 0.105
positive regulation of cell death GO:0010942 263 0.095
positive regulation of apoptotic process GO:0043065 246 0.090
regulation of cellular ketone metabolic process GO:0010565 50 0.086
neuroblast proliferation GO:0007405 4 0.086
segmentation GO:0035282 4 0.079
positive regulation of programmed cell death GO:0043068 249 0.072
positive regulation of cellular amine metabolic process GO:0033240 7 0.071
negative regulation of developmental process GO:0051093 247 0.071
neural tube formation GO:0001841 3 0.067
positive regulation of anoikis GO:2000210 4 0.067
rna processing GO:0006396 255 0.064
signal transduction by phosphorylation GO:0023014 297 0.060
neuron differentiation GO:0030182 138 0.059
central nervous system development GO:0007417 123 0.054
primary neural tube formation GO:0014020 3 0.053
embryonic epithelial tube formation GO:0001838 4 0.052
regulation of mapk cascade GO:0043408 262 0.050
cellular amino acid metabolic process GO:0006520 116 0.050
amine metabolic process GO:0009308 44 0.049
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.049
generation of neurons GO:0048699 152 0.049
establishment of planar polarity GO:0001736 3 0.048
neurogenesis GO:0022008 169 0.046
positive regulation of cell differentiation GO:0045597 211 0.045
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.044
Human
regulation of protein kinase activity GO:0045859 289 0.044
mrna metabolic process GO:0016071 175 0.044
protein ubiquitination GO:0016567 314 0.043
single organism carbohydrate metabolic process GO:0044723 193 0.042
axis elongation GO:0003401 4 0.040
peripheral nervous system development GO:0007422 2 0.039
cellular component morphogenesis GO:0032989 314 0.038
cell division GO:0051301 168 0.037
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
cell morphogenesis GO:0000902 296 0.037
neuron development GO:0048666 113 0.037
morphogenesis of embryonic epithelium GO:0016331 4 0.037
locomotory behavior GO:0007626 1 0.037
chromatin organization GO:0006325 351 0.036
Mouse
regulation of cell development GO:0060284 161 0.036
growth GO:0040007 202 0.036
lipid metabolic process GO:0006629 381 0.035
negative regulation of cell differentiation GO:0045596 171 0.035
female gamete generation GO:0007292 2 0.035
negative regulation of multicellular organismal process GO:0051241 317 0.035
negative regulation of protein metabolic process GO:0051248 391 0.034
regulation of transferase activity GO:0051338 355 0.033
cell projection organization GO:0030030 252 0.033
peptidyl lysine acetylation GO:0018394 101 0.033
rab protein signal transduction GO:0032482 4 0.033
morphogenesis of a polarized epithelium GO:0001738 3 0.033
protein k63 linked deubiquitination GO:0070536 21 0.032
Human
cellular amine metabolic process GO:0044106 41 0.032
cell fate determination GO:0001709 3 0.032
positive regulation of cytokine production GO:0001819 167 0.031
cellular ketone metabolic process GO:0042180 80 0.030
protein polyubiquitination GO:0000209 110 0.030
carbohydrate metabolic process GO:0005975 207 0.030
post embryonic development GO:0009791 2 0.030
regulation of dna metabolic process GO:0051052 153 0.029
Yeast
mrna processing GO:0006397 133 0.029
mapk cascade GO:0000165 288 0.029
negative regulation of catalytic activity GO:0043086 335 0.029
neuron projection development GO:0031175 106 0.028
single organism cellular localization GO:1902580 332 0.028
Yeast
microtubule based process GO:0007017 210 0.027
cellular protein catabolic process GO:0044257 261 0.026
Yeast Fly
regulation of carbohydrate metabolic process GO:0006109 54 0.026
positive regulation of developmental process GO:0051094 314 0.026
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.026
protein k48 linked deubiquitination GO:0071108 19 0.026
Human Fly
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.026
mitotic cell cycle process GO:1903047 286 0.026
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.025
Yeast Fly
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.025
cellular response to endogenous stimulus GO:0071495 336 0.025
protein catabolic process GO:0030163 325 0.025
Yeast Fly
covalent chromatin modification GO:0016569 254 0.025
Mouse
somitogenesis GO:0001756 2 0.025
negative regulation of phosphorus metabolic process GO:0010563 267 0.025
protein modification by small protein conjugation GO:0032446 342 0.024
multicellular organismal aging GO:0010259 3 0.024
regulation of protein serine threonine kinase activity GO:0071900 179 0.024
cell part morphogenesis GO:0032990 137 0.024
cellular lipid metabolic process GO:0044255 303 0.024
dna repair GO:0006281 198 0.024
determination of adult lifespan GO:0008340 2 0.024
response to decreased oxygen levels GO:0036293 96 0.024
protein autophosphorylation GO:0046777 123 0.023
establishment of protein localization to organelle GO:0072594 172 0.023
regulation of cellular amine metabolic process GO:0033238 11 0.023
regulation of endopeptidase activity GO:0052548 170 0.023
nucleocytoplasmic transport GO:0006913 176 0.023
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
tube closure GO:0060606 3 0.022
neuromuscular junction development GO:0007528 3 0.022
actin filament based process GO:0030029 224 0.022
regulation of cell cycle GO:0051726 393 0.022
Human
neural tube closure GO:0001843 3 0.022
rhythmic behavior GO:0007622 2 0.022
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.021
circadian behavior GO:0048512 2 0.021
cytokine production GO:0001816 247 0.021
regulation of peptidase activity GO:0052547 180 0.021
regulation of cellular response to stress GO:0080135 244 0.021
intracellular receptor signaling pathway GO:0030522 104 0.021
negative regulation of transferase activity GO:0051348 124 0.021
positive regulation of phosphorylation GO:0042327 394 0.021
cellular macromolecular complex assembly GO:0034622 324 0.021
central nervous system neuron axonogenesis GO:0021955 3 0.020
epithelium development GO:0060429 227 0.020
modification dependent macromolecule catabolic process GO:0043632 212 0.020
Yeast
oogenesis GO:0048477 2 0.020
cytoplasmic transport GO:0016482 379 0.020
phospholipid metabolic process GO:0006644 99 0.019
microtubule cytoskeleton organization GO:0000226 176 0.019
negative regulation of kinase activity GO:0033673 106 0.019
wnt signaling pathway GO:0016055 156 0.019
regulation of kinase activity GO:0043549 314 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
central nervous system projection neuron axonogenesis GO:0021952 3 0.018
establishment of tissue polarity GO:0007164 3 0.018
sensory perception of pain GO:0019233 4 0.018
glycerolipid metabolic process GO:0046486 107 0.018
protein maturation GO:0051604 233 0.018
regulation of multi organism process GO:0043900 157 0.018
Fly
positive regulation of peptidase activity GO:0010952 88 0.018
negative regulation of cell proliferation GO:0008285 228 0.017
histone modification GO:0016570 251 0.017
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.017
hindbrain development GO:0030902 3 0.017
glycerophospholipid metabolic process GO:0006650 84 0.017
proteasomal protein catabolic process GO:0010498 176 0.017
Fly
peptidyl tyrosine phosphorylation GO:0018108 170 0.016
peptidyl tyrosine modification GO:0018212 170 0.016
regulation of meiotic cell cycle GO:0051445 4 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
negative regulation of cell cycle GO:0045786 193 0.016
response to oxygen containing compound GO:1901700 369 0.016
positive regulation of hydrolase activity GO:0051345 331 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
ubiquitin dependent protein catabolic process GO:0006511 206 0.016
Yeast
cell morphogenesis involved in differentiation GO:0000904 144 0.016
cellular macromolecule catabolic process GO:0044265 380 0.016
Yeast Fly
regulation of cysteine type endopeptidase activity GO:2000116 127 0.015
ras protein signal transduction GO:0007265 73 0.015
dna templated transcription initiation GO:0006352 35 0.015
regulation of growth rate GO:0040009 1 0.015
regulation of cytokine production GO:0001817 232 0.015
metencephalon development GO:0022037 2 0.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.015
small gtpase mediated signal transduction GO:0007264 78 0.014
cellular response to oxygen containing compound GO:1901701 276 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
regulation of rna splicing GO:0043484 62 0.014
negative regulation of protein modification process GO:0031400 200 0.014
rna splicing GO:0008380 131 0.014
circulatory system development GO:0072359 262 0.014
head development GO:0060322 108 0.014
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.014
monosaccharide metabolic process GO:0005996 74 0.014
schwann cell differentiation GO:0014037 1 0.014
regulation of wnt signaling pathway GO:0030111 123 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
memory GO:0007613 3 0.013
positive regulation of proteolysis GO:0045862 142 0.013
Fly
endocytosis GO:0006897 159 0.013
Yeast
oxidation reduction process GO:0055114 396 0.013
neurological system process GO:0050877 163 0.013
single organism reproductive process GO:0044702 98 0.013
regulation of meiosis GO:0040020 3 0.013
oocyte development GO:0048599 1 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
regulation of response to wounding GO:1903034 101 0.013
response to light stimulus GO:0009416 87 0.013
response to abiotic stimulus GO:0009628 336 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.013
inflammatory response GO:0006954 79 0.013
regulation of ras protein signal transduction GO:0046578 155 0.013
stem cell division GO:0017145 2 0.012
protein processing GO:0016485 226 0.012
positive regulation of endopeptidase activity GO:0010950 84 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.012
oocyte differentiation GO:0009994 2 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
Human
negative regulation of wnt signaling pathway GO:0030178 69 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.012
dna methylation or demethylation GO:0044728 19 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.012
tissue morphogenesis GO:0048729 96 0.012
macromolecule methylation GO:0043414 97 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
system process GO:0003008 349 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
protein dna complex subunit organization GO:0071824 80 0.011
negative regulation of locomotion GO:0040013 118 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
regulation of cell division GO:0051302 116 0.011
translation GO:0006412 132 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
multi organism reproductive process GO:0044703 54 0.011
mitotic cell cycle GO:0000278 326 0.011
Human
peptidyl serine phosphorylation GO:0018105 101 0.011
positive regulation of transferase activity GO:0051347 227 0.011
blastoderm segmentation GO:0007350 2 0.011
cellular response to nitrogen compound GO:1901699 144 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.011
anterior posterior axis specification GO:0009948 2 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
regulation of response to external stimulus GO:0032101 222 0.011
Fly
regulation of ras gtpase activity GO:0032318 128 0.011
cation transport GO:0006812 331 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
response to hypoxia GO:0001666 96 0.011
innate immune response GO:0045087 178 0.011
Fly
negative regulation of transport GO:0051051 176 0.011
chromatin modification GO:0016568 298 0.011
Mouse
positive regulation of cell development GO:0010720 92 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
regulation of protein complex assembly GO:0043254 147 0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.010
cellular carbohydrate metabolic process GO:0044262 84 0.010
monocarboxylic acid metabolic process GO:0032787 185 0.010
endomembrane system organization GO:0010256 196 0.010
Human
response to hormone GO:0009725 175 0.010
mating GO:0007618 1 0.010
apoptotic signaling pathway GO:0097190 268 0.010
negative regulation of mapk cascade GO:0043409 56 0.010
dephosphorylation GO:0016311 209 0.010
asymmetric neuroblast division GO:0055059 1 0.010
ion transmembrane transport GO:0034220 338 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.010
negative regulation of cell cycle process GO:0010948 121 0.010
regulation of protein catabolic process GO:0042176 155 0.010
Fly

USP21 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.015
nervous system disease DOID:863 431 0.015
epilepsy syndrome DOID:1826 41 0.013
brain disease DOID:936 73 0.013
sensory system disease DOID:0050155 203 0.012