Homo sapiens

17 known processes

UBE2M

ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)

(Aliases: UBC12,hUbc12,UBC-RS2)

UBE2M biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation GO:0032446 342 0.830
cellular macromolecule catabolic process GO:0044265 380 0.724
modification dependent protein catabolic process GO:0019941 209 0.685
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.663
mitotic cell cycle GO:0000278 326 0.662
negative regulation of cell cycle GO:0045786 193 0.656
ubiquitin dependent protein catabolic process GO:0006511 206 0.628
protein ubiquitination GO:0016567 314 0.624
cellular protein catabolic process GO:0044257 261 0.577
mitotic cell cycle process GO:1903047 286 0.576
post embryonic development GO:0009791 2 0.526
protein neddylation GO:0045116 7 0.518
regulation of cell cycle GO:0051726 393 0.442
proteasomal protein catabolic process GO:0010498 176 0.394
protein polyubiquitination GO:0000209 110 0.333
regulation of protein ubiquitination GO:0031396 95 0.317
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.314
ion transmembrane transport GO:0034220 338 0.306
protein catabolic process GO:0030163 325 0.262
determination of adult lifespan GO:0008340 2 0.248
cell cycle phase transition GO:0044770 173 0.247
vesicle mediated transport GO:0016192 371 0.236
positive regulation of protein ubiquitination GO:0031398 53 0.231
regulation of mitotic cell cycle GO:0007346 189 0.206
mitotic cell cycle checkpoint GO:0007093 68 0.200
regulation of ubiquitin protein transferase activity GO:0051438 28 0.186
transmembrane transport GO:0055085 399 0.185
reproductive system development GO:0061458 56 0.169
negative regulation of mitotic cell cycle GO:0045930 102 0.168
negative regulation of cell cycle process GO:0010948 121 0.161
oogenesis GO:0048477 2 0.161
cell development GO:0048468 328 0.157
positive regulation of cell death GO:0010942 263 0.157
regulation of mitotic cell cycle phase transition GO:1901990 118 0.156
chromosome segregation GO:0007059 114 0.155
multicellular organismal aging GO:0010259 3 0.142
protein k63 linked ubiquitination GO:0070534 31 0.141
cell cycle checkpoint GO:0000075 117 0.138
mitotic cell cycle phase transition GO:0044772 162 0.137
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.131
regulation of transferase activity GO:0051338 355 0.126
nervous system development GO:0007399 293 0.123
reproductive process GO:0022414 106 0.123
establishment of nucleus localization GO:0040023 1 0.123
meiotic chromosome segregation GO:0045132 4 0.112
negative regulation of cell cycle phase transition GO:1901988 89 0.111
mitotic nuclear division GO:0007067 119 0.111
cell fate determination GO:0001709 3 0.106
dna integrity checkpoint GO:0031570 71 0.105
metal ion transport GO:0030001 272 0.102
enzyme linked receptor protein signaling pathway GO:0007167 303 0.101
embryo development GO:0009790 123 0.096
female gamete generation GO:0007292 2 0.095
modification dependent macromolecule catabolic process GO:0043632 212 0.094
cation transmembrane transport GO:0098655 238 0.094
free ubiquitin chain polymerization GO:0010994 2 0.094
regulation of cell cycle phase transition GO:1901987 126 0.091
cellular homeostasis GO:0019725 196 0.090
developmental process involved in reproduction GO:0003006 66 0.087
positive regulation of transferase activity GO:0051347 227 0.086
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.086
neuron differentiation GO:0030182 138 0.084
endocytosis GO:0006897 159 0.077
oocyte differentiation GO:0009994 2 0.075
generation of neurons GO:0048699 152 0.074
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.071
secretion by cell GO:0032940 226 0.071
divalent metal ion transport GO:0070838 152 0.071
neurogenesis GO:0022008 169 0.070
multi organism reproductive process GO:0044703 54 0.070
neuron development GO:0048666 113 0.068
cell cycle arrest GO:0007050 71 0.067
regulation of ion transmembrane transport GO:0034765 132 0.066
reproduction GO:0000003 63 0.064
cation transport GO:0006812 331 0.059
secretion GO:0046903 254 0.059
regulation of actin filament based process GO:0032970 141 0.058
positive regulation of protein phosphorylation GO:0001934 313 0.057
sex differentiation GO:0007548 45 0.057
organelle fission GO:0048285 149 0.057
calcium ion transport GO:0006816 147 0.056
mrna processing GO:0006397 133 0.056
mapk cascade GO:0000165 288 0.054
protein k48 linked ubiquitination GO:0070936 38 0.054
single organism membrane organization GO:0044802 268 0.051
cell projection organization GO:0030030 252 0.051
cellular response to oxygen containing compound GO:1901701 276 0.050
g2 dna damage checkpoint GO:0031572 26 0.050
receptor mediated endocytosis GO:0006898 84 0.050
lipid localization GO:0010876 106 0.049
intracellular protein transport GO:0006886 270 0.049
carboxylic acid biosynthetic process GO:0046394 97 0.048
microtubule cytoskeleton organization GO:0000226 176 0.048
maintenance of location GO:0051235 112 0.048
regulation of cellular component biogenesis GO:0044087 281 0.046
protein secretion GO:0009306 98 0.046
positive regulation of phosphorylation GO:0042327 394 0.045
divalent inorganic cation transport GO:0072511 158 0.045
embryo development ending in birth or egg hatching GO:0009792 34 0.044
cell morphogenesis involved in differentiation GO:0000904 144 0.044
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.043
regulation of cellular ketone metabolic process GO:0010565 50 0.043
cellular response to dna damage stimulus GO:0006974 379 0.043
behavior GO:0007610 112 0.042
ncrna metabolic process GO:0034660 108 0.042
positive regulation of proteolysis GO:0045862 142 0.042
regulation of proteolysis GO:0030162 293 0.042
cellular component morphogenesis GO:0032989 314 0.042
single organism reproductive process GO:0044702 98 0.041
regulation of cellular amine metabolic process GO:0033238 11 0.040
cell morphogenesis GO:0000902 296 0.040
oocyte development GO:0048599 1 0.040
positive regulation of ubiquitin protein transferase activity GO:0051443 18 0.040
positive regulation of cellular catabolic process GO:0031331 284 0.040
segmentation GO:0035282 4 0.039
regulation of cell cycle process GO:0010564 266 0.039
protein monoubiquitination GO:0006513 39 0.038
positive regulation of apoptotic process GO:0043065 246 0.037
cell growth GO:0016049 160 0.037
regeneration GO:0031099 4 0.036
cellular lipid metabolic process GO:0044255 303 0.036
multicellular organism reproduction GO:0032504 42 0.035
regulation of secretion by cell GO:1903530 177 0.034
regulation of cell projection organization GO:0031344 107 0.034
nucleoside triphosphate metabolic process GO:0009141 422 0.034
anion transport GO:0006820 161 0.033
positive regulation of ligase activity GO:0051351 19 0.033
posttranscriptional regulation of gene expression GO:0010608 213 0.032
development of primary sexual characteristics GO:0045137 35 0.032
positive regulation of cellular amine metabolic process GO:0033240 7 0.032
positive regulation of locomotion GO:0040017 186 0.032
immune response GO:0006955 307 0.032
smoothened signaling pathway GO:0007224 14 0.032
Fly
regulation of transporter activity GO:0032409 82 0.031
nuclear division GO:0000280 128 0.031
cellular amino acid metabolic process GO:0006520 116 0.031
nucleotide catabolic process GO:0009166 408 0.030
apoptotic signaling pathway GO:0097190 268 0.030
cellular response to organonitrogen compound GO:0071417 124 0.030
inorganic ion transmembrane transport GO:0098660 231 0.029
regulation of cellular amino acid metabolic process GO:0006521 6 0.029
regulation of ion transport GO:0043269 189 0.029
cellular ketone metabolic process GO:0042180 80 0.029
positive regulation of catabolic process GO:0009896 310 0.029
protein dephosphorylation GO:0006470 81 0.029
blastocyst development GO:0001824 3 0.028
monocarboxylic acid metabolic process GO:0032787 185 0.028
negative regulation of intracellular signal transduction GO:1902532 183 0.028
single organism cellular localization GO:1902580 332 0.028
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.028
dephosphorylation GO:0016311 209 0.028
reproductive structure development GO:0048608 55 0.028
positive regulation of programmed cell death GO:0043068 249 0.027
digestive tract development GO:0048565 75 0.027
regulation of cytoskeleton organization GO:0051493 177 0.027
positive regulation of hydrolase activity GO:0051345 331 0.027
chemical homeostasis GO:0048878 306 0.027
nucleus localization GO:0051647 1 0.027
regulation of dna repair GO:0006282 47 0.027
organ morphogenesis GO:0009887 147 0.027
positive regulation of organelle organization GO:0010638 195 0.027
negative regulation of ion transport GO:0043271 39 0.027
regulation of map kinase activity GO:0043405 108 0.026
anterior posterior axis specification GO:0009948 2 0.026
microtubule based process GO:0007017 210 0.026
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.025
regulation of mapk cascade GO:0043408 262 0.025
negative regulation of phosphorus metabolic process GO:0010563 267 0.025
peripheral nervous system development GO:0007422 2 0.025
positive regulation of protein catabolic process GO:0045732 75 0.025
protein k11 linked ubiquitination GO:0070979 24 0.024
cell division GO:0051301 168 0.024
regulation of purine nucleotide metabolic process GO:1900542 264 0.024
regulation of ion transmembrane transporter activity GO:0032412 72 0.024
calcium ion transmembrane transport GO:0070588 76 0.024
regulation of cell migration GO:0030334 289 0.024
angiogenesis GO:0001525 147 0.024
blastoderm segmentation GO:0007350 2 0.024
actin filament based process GO:0030029 224 0.024
ras protein signal transduction GO:0007265 73 0.023
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.023
regulation of ligase activity GO:0051340 29 0.023
nuclear migration GO:0007097 1 0.023
response to biotic stimulus GO:0009607 276 0.023
biological adhesion GO:0022610 331 0.022
neuron projection development GO:0031175 106 0.022
regulation of actin cytoskeleton organization GO:0032956 116 0.022
tube development GO:0035295 125 0.022
establishment of protein localization to organelle GO:0072594 172 0.022
multicellular organismal reproductive process GO:0048609 40 0.022
positive regulation of cell proliferation GO:0008284 301 0.022
regulation of homeostatic process GO:0032844 121 0.021
regulation of apoptotic signaling pathway GO:2001233 175 0.021
regulation of transmembrane transport GO:0034762 139 0.021
regulation of growth GO:0040008 165 0.021
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.021
cofactor catabolic process GO:0051187 7 0.021
positive regulation of cellular protein catabolic process GO:1903364 37 0.021
regulation of anatomical structure size GO:0090066 101 0.021
regulation of small gtpase mediated signal transduction GO:0051056 156 0.021
regulation of protein localization GO:0032880 296 0.021
spermatid differentiation GO:0048515 4 0.021
regulation of calcium ion transport GO:0051924 79 0.021
multi multicellular organism process GO:0044706 18 0.021
protein localization to membrane GO:0072657 160 0.020
positive regulation of adenylate cyclase activity GO:0045762 12 0.020
regulation of synaptic plasticity GO:0048167 3 0.020
organophosphate biosynthetic process GO:0090407 163 0.020
cardiac muscle cell contraction GO:0086003 4 0.020
membrane fusion GO:0061025 43 0.020
negative regulation of hydrolase activity GO:0051346 182 0.020
fatty acid metabolic process GO:0006631 115 0.019
actin filament organization GO:0007015 128 0.019
negative regulation of transmembrane transport GO:0034763 29 0.019
response to metal ion GO:0010038 84 0.019
negative regulation of cell proliferation GO:0008285 228 0.019
regulation of mrna metabolic process GO:1903311 53 0.019
central nervous system projection neuron axonogenesis GO:0021952 3 0.019
immune system development GO:0002520 195 0.019
growth GO:0040007 202 0.019
exocytosis GO:0006887 71 0.019
regulation of cellular protein catabolic process GO:1903362 96 0.019
lipid metabolic process GO:0006629 381 0.018
inorganic cation transmembrane transport GO:0098662 194 0.018
cellular senescence GO:0090398 34 0.018
dna repair GO:0006281 198 0.018
positive regulation of cellular component biogenesis GO:0044089 158 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.017
cellular amine metabolic process GO:0044106 41 0.017
positive regulation of apoptotic signaling pathway GO:2001235 70 0.017
metaphase anaphase transition of cell cycle GO:0044784 21 0.016
protein targeting GO:0006605 187 0.016
tube morphogenesis GO:0035239 95 0.016
tissue morphogenesis GO:0048729 96 0.016
negative regulation of catalytic activity GO:0043086 335 0.016
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.016
mitotic g2 m transition checkpoint GO:0044818 9 0.016
regulation of cellular component movement GO:0051270 334 0.016
establishment of protein localization to mitochondrion GO:0072655 22 0.016
mitotic g2 dna damage checkpoint GO:0007095 7 0.016
chemotaxis GO:0006935 157 0.016
purine ribonucleoside metabolic process GO:0046128 437 0.016
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.016
regulation of purine nucleotide catabolic process GO:0033121 205 0.015
response to organonitrogen compound GO:0010243 156 0.015
regulation of lipid metabolic process GO:0019216 96 0.015
cell cell signaling GO:0007267 155 0.015
aging GO:0007568 66 0.015
response to nitrogen compound GO:1901698 184 0.015
amine metabolic process GO:0009308 44 0.015
oxidation reduction process GO:0055114 396 0.015
negative regulation of transport GO:0051051 176 0.015
cellular macromolecular complex assembly GO:0034622 324 0.015
gonad development GO:0008406 34 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.014
cell projection morphogenesis GO:0048858 129 0.014
erk1 and erk2 cascade GO:0070371 104 0.014
nitrogen compound transport GO:0071705 191 0.014
signal transduction by phosphorylation GO:0023014 297 0.014
positive regulation of lipid biosynthetic process GO:0046889 22 0.014
ribose phosphate biosynthetic process GO:0046390 82 0.014
immune effector process GO:0002252 159 0.014
regulation of protein stability GO:0031647 87 0.014
circulatory system development GO:0072359 262 0.014
energy derivation by oxidation of organic compounds GO:0015980 43 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
mitochondrial transport GO:0006839 60 0.014
response to virus GO:0009615 126 0.014
cytokinesis GO:0000910 96 0.014
cell cycle g2 m phase transition GO:0044839 43 0.014
regulation of dna metabolic process GO:0051052 153 0.014
long chain fatty acid metabolic process GO:0001676 30 0.014
regulation of erbb signaling pathway GO:1901184 27 0.014
mitotic sister chromatid separation GO:0051306 18 0.014
termination of rna polymerase ii transcription GO:0006369 1 0.013
compound eye development GO:0048749 1 0.013
negative regulation of transporter activity GO:0032410 25 0.013
sleep GO:0030431 2 0.013
innate immune response GO:0045087 178 0.013
regulation of protein catabolic process GO:0042176 155 0.013
sexual reproduction GO:0019953 37 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
purine nucleotide biosynthetic process GO:0006164 84 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
protein polymerization GO:0051258 71 0.013
regulation of metal ion transport GO:0010959 120 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
regulation of protein complex assembly GO:0043254 147 0.013
blood vessel morphogenesis GO:0048514 162 0.012
negative regulation of camp mediated signaling GO:0043951 4 0.012
positive regulation of developmental process GO:0051094 314 0.012
cytoplasmic transport GO:0016482 379 0.012
second messenger mediated signaling GO:0019932 78 0.012
retrograde transport endosome to golgi GO:0042147 45 0.012
hydrogen transport GO:0006818 23 0.012
establishment of organelle localization GO:0051656 59 0.012
plasma membrane organization GO:0007009 115 0.012
digestive system development GO:0055123 75 0.012
dna replication GO:0006260 116 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
system process GO:0003008 349 0.012
g2 m transition of mitotic cell cycle GO:0000086 41 0.012
monovalent inorganic cation transport GO:0015672 128 0.012
lipid storage GO:0019915 28 0.012
positive regulation of kinase activity GO:0033674 204 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
dendritic spine organization GO:0097061 4 0.012
cell adhesion GO:0007155 325 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
negative regulation of programmed cell death GO:0043069 321 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.012
tripartite regional subdivision GO:0007351 2 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
cardiovascular system development GO:0072358 262 0.012
regulation of locomotion GO:0040012 329 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
response to peptide hormone GO:0043434 61 0.012
response to external biotic stimulus GO:0043207 261 0.011
response to organic cyclic compound GO:0014070 204 0.011
regulation of response to dna damage stimulus GO:2001020 94 0.011
membrane organization GO:0061024 292 0.011
cellular response to hormone stimulus GO:0032870 125 0.011
response to oxygen containing compound GO:1901700 369 0.011
defense response GO:0006952 315 0.011
regulation of peptidase activity GO:0052547 180 0.011
spermatid development GO:0007286 4 0.011
negative regulation of dna metabolic process GO:0051053 57 0.011
g protein coupled receptor signaling pathway GO:0007186 207 0.011
nuclear transport GO:0051169 179 0.011
rna interference GO:0016246 4 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.011
cellular protein complex assembly GO:0043623 188 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.011
negative regulation of cellular protein metabolic process GO:0032269 353 0.011
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.011
coenzyme catabolic process GO:0009109 5 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
regulation of cellular response to stress GO:0080135 244 0.011
cell fate commitment GO:0045165 27 0.011
muscle system process GO:0003012 81 0.011
protein maturation GO:0051604 233 0.011
canonical wnt signaling pathway GO:0060070 116 0.010
positive regulation of cell cycle GO:0045787 140 0.010
negative regulation of multicellular organismal process GO:0051241 317 0.010
cellular response to endogenous stimulus GO:0071495 336 0.010
response to mercury ion GO:0046689 4 0.010
spindle elongation GO:0051231 4 0.010
cellular chemical homeostasis GO:0055082 180 0.010
purine nucleotide catabolic process GO:0006195 405 0.010
regulation of ras gtpase activity GO:0032318 128 0.010

UBE2M disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.030
disease of cellular proliferation DOID:14566 174 0.030
urinary system disease DOID:18 40 0.025
organ system cancer DOID:0050686 164 0.025
endocrine gland cancer DOID:170 26 0.020
immune system disease DOID:2914 155 0.017
anemia DOID:2355 55 0.017
hematopoietic system disease DOID:74 100 0.017
disease of metabolism DOID:0014667 295 0.011
carbohydrate metabolism disease DOID:0050013 32 0.011
acquired metabolic disease DOID:0060158 58 0.011