Homo sapiens

180 known processes

UBE2N

ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)

(Aliases: MGC131857,UBC13,UbcH-ben,MGC8489)

UBE2N biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein polyubiquitination GO:0000209 110 1.000
protein ubiquitination GO:0016567 314 1.000
protein modification by small protein conjugation GO:0032446 342 1.000
protein k48 linked ubiquitination GO:0070936 38 1.000
protein k63 linked ubiquitination GO:0070534 31 1.000
ubiquitin dependent protein catabolic process GO:0006511 206 1.000
Mouse
modification dependent macromolecule catabolic process GO:0043632 212 0.999
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.999
Mouse
cellular macromolecule catabolic process GO:0044265 380 0.998
modification dependent protein catabolic process GO:0019941 209 0.998
Mouse
cellular protein catabolic process GO:0044257 261 0.995
Mouse
protein catabolic process GO:0030163 325 0.987
Mouse
protein autoubiquitination GO:0051865 37 0.961
cellular response to dna damage stimulus GO:0006974 379 0.946
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.904
regulation of response to dna damage stimulus GO:2001020 94 0.901
defense response GO:0006952 315 0.834
histone ubiquitination GO:0016574 31 0.829
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.775
positive regulation of protein ubiquitination GO:0031398 53 0.722
double strand break repair GO:0006302 101 0.660
protein monoubiquitination GO:0006513 39 0.631
response to radiation GO:0009314 151 0.599
response to abiotic stimulus GO:0009628 336 0.539
response to ionizing radiation GO:0010212 65 0.534
regulation of protein ubiquitination GO:0031396 95 0.527
proteasomal protein catabolic process GO:0010498 176 0.472
regulation of proteolysis GO:0030162 293 0.462
negative regulation of apoptotic process GO:0043066 316 0.456
transmembrane transport GO:0055085 399 0.451
intracellular protein transmembrane import GO:0044743 23 0.435
dna repair GO:0006281 198 0.386
regulation of cellular response to stress GO:0080135 244 0.379
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.341
positive regulation of dna repair GO:0045739 25 0.341
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.320
negative regulation of cell death GO:0060548 345 0.305
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.302
i kappab kinase nf kappab signaling GO:0007249 166 0.280
regulation of protein catabolic process GO:0042176 155 0.274
positive regulation of cellular component organization GO:0051130 376 0.259
positive regulation of protein catabolic process GO:0045732 75 0.257
cellular macromolecular complex assembly GO:0034622 324 0.254
protein import into mitochondrial matrix GO:0030150 1 0.236
nitrogen compound transport GO:0071705 191 0.230
vesicle mediated transport GO:0016192 371 0.219
regulation of cellular protein catabolic process GO:1903362 96 0.218
positive regulation of response to dna damage stimulus GO:2001022 43 0.218
positive regulation of dna metabolic process GO:0051054 73 0.217
protein localization to organelle GO:0033365 280 0.191
meiotic chromosome segregation GO:0045132 4 0.188
post embryonic development GO:0009791 2 0.181
immune response GO:0006955 307 0.169
negative regulation of protein metabolic process GO:0051248 391 0.154
protein polymerization GO:0051258 71 0.145
chromatin modification GO:0016568 298 0.140
regulation of defense response GO:0031347 154 0.139
positive regulation of proteolysis GO:0045862 142 0.130
multicellular organismal aging GO:0010259 3 0.128
positive regulation of cell cycle GO:0045787 140 0.110
Fly
cellular protein complex assembly GO:0043623 188 0.102
regulation of dna repair GO:0006282 47 0.102
carboxylic acid biosynthetic process GO:0046394 97 0.094
protein transmembrane transport GO:0071806 25 0.091
negative regulation of multi organism process GO:0043901 92 0.090
endocytosis GO:0006897 159 0.088
response to cytokine GO:0034097 232 0.087
negative regulation of cellular protein metabolic process GO:0032269 353 0.086
positive regulation of catabolic process GO:0009896 310 0.085
regulation of homeostatic process GO:0032844 121 0.085
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.085
positive regulation of transferase activity GO:0051347 227 0.081
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.080
determination of adult lifespan GO:0008340 2 0.079
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.074
intracellular protein transmembrane transport GO:0065002 24 0.072
neurogenesis GO:0022008 169 0.071
Fly
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.071
regulation of cell cycle process GO:0010564 266 0.069
regulation of apoptotic signaling pathway GO:2001233 175 0.069
single organism cellular localization GO:1902580 332 0.068
locomotory behavior GO:0007626 1 0.067
Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.065
mitochondrion organization GO:0007005 156 0.064
intracellular protein transport GO:0006886 270 0.063
regulation of ion transmembrane transport GO:0034765 132 0.061
protein modification by small protein removal GO:0070646 92 0.059
positive regulation of cellular component biogenesis GO:0044089 158 0.057
protein localization to mitochondrion GO:0070585 25 0.057
cytoplasmic transport GO:0016482 379 0.057
nervous system development GO:0007399 293 0.057
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.056
multi organism cellular process GO:0044764 156 0.055
intrinsic apoptotic signaling pathway GO:0097193 127 0.055
negative regulation of catalytic activity GO:0043086 335 0.055
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.055
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.053
establishment of protein localization to mitochondrion GO:0072655 22 0.053
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.053
secretion by cell GO:0032940 226 0.053
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.052
regulation of ion transport GO:0043269 189 0.050
positive regulation of developmental process GO:0051094 314 0.049
Fly
immune system development GO:0002520 195 0.047
negative regulation of cell cycle GO:0045786 193 0.046
response to other organism GO:0051707 261 0.046
chromosome segregation GO:0007059 114 0.046
protein targeting GO:0006605 187 0.046
negative regulation of intracellular signal transduction GO:1902532 183 0.046
regulation of proteasomal protein catabolic process GO:0061136 87 0.045
regulation of transmembrane transport GO:0034762 139 0.045
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.044
negative regulation of protein processing GO:0010955 142 0.042
rna processing GO:0006396 255 0.041
protein targeting to mitochondrion GO:0006626 19 0.040
immune effector process GO:0002252 159 0.039
cell growth GO:0016049 160 0.038
negative regulation of protein ubiquitination GO:0031397 35 0.038
reproduction GO:0000003 63 0.037
secretion GO:0046903 254 0.037
negative regulation of programmed cell death GO:0043069 321 0.036
growth GO:0040007 202 0.034
Fly
response to biotic stimulus GO:0009607 276 0.034
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.033
defense response to other organism GO:0098542 129 0.032
innate immune response GO:0045087 178 0.031
response to organic cyclic compound GO:0014070 204 0.031
regulation of mitotic cell cycle GO:0007346 189 0.030
Fly
response to light stimulus GO:0009416 87 0.030
negative regulation of cell proliferation GO:0008285 228 0.029
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.029
nuclear division GO:0000280 128 0.029
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.028
negative regulation of viral process GO:0048525 66 0.027
free ubiquitin chain polymerization GO:0010994 2 0.027
interspecies interaction between organisms GO:0044419 156 0.026
receptor mediated endocytosis GO:0006898 84 0.026
organelle localization GO:0051640 84 0.026
aging GO:0007568 66 0.026
postreplication repair GO:0006301 12 0.026
regulation of transferase activity GO:0051338 355 0.025
ribonucleotide biosynthetic process GO:0009260 81 0.024
organelle fission GO:0048285 149 0.024
protein import GO:0017038 130 0.024
regulation of cellular component biogenesis GO:0044087 281 0.024
fertilization GO:0009566 12 0.024
cell activation GO:0001775 213 0.023
cell development GO:0048468 328 0.023
Fly
positive regulation of cell differentiation GO:0045597 211 0.023
establishment of protein localization to organelle GO:0072594 172 0.023
cell morphogenesis GO:0000902 296 0.023
Fly
nuclear migration GO:0007097 1 0.022
covalent chromatin modification GO:0016569 254 0.022
neuron development GO:0048666 113 0.021
Fly
chordate embryonic development GO:0043009 34 0.021
regulation of cell development GO:0060284 161 0.021
negative regulation of endopeptidase activity GO:0010951 84 0.021
enzyme linked receptor protein signaling pathway GO:0007167 303 0.020
ncrna metabolic process GO:0034660 108 0.020
positive regulation of nervous system development GO:0051962 54 0.020
cell part morphogenesis GO:0032990 137 0.020
Fly
mrna processing GO:0006397 133 0.020
actin cytoskeleton organization GO:0030036 207 0.020
positive regulation of neuron projection development GO:0010976 34 0.020
adaptive immune response GO:0002250 49 0.020
spermatid differentiation GO:0048515 4 0.019
negative regulation of cellular component organization GO:0051129 235 0.019
oogenesis GO:0048477 2 0.019
maintenance of location GO:0051235 112 0.019
small molecule biosynthetic process GO:0044283 157 0.019
mitotic dna integrity checkpoint GO:0044774 30 0.018
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.018
response to oxygen containing compound GO:1901700 369 0.018
response to virus GO:0009615 126 0.018
segmentation GO:0035282 4 0.018
female gamete generation GO:0007292 2 0.018
regulation of binding GO:0051098 111 0.017
dna templated transcription elongation GO:0006354 25 0.017
regulation of ubiquitin protein transferase activity GO:0051438 28 0.017
positive regulation of locomotion GO:0040017 186 0.017
rna catabolic process GO:0006401 71 0.017
signal transduction by p53 class mediator GO:0072331 72 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
mrna metabolic process GO:0016071 175 0.016
histone modification GO:0016570 251 0.016
regeneration GO:0031099 4 0.016
regulation of kinase activity GO:0043549 314 0.016
negative regulation of immune response GO:0050777 40 0.016
ncrna processing GO:0034470 83 0.016
negative regulation of cell cycle process GO:0010948 121 0.016
negative regulation of cell cycle phase transition GO:1901988 89 0.015
regulation of cell differentiation GO:0045595 393 0.015
negative regulation of hydrolase activity GO:0051346 182 0.015
regulation of dna metabolic process GO:0051052 153 0.015
spermatid development GO:0007286 4 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
detection of stimulus GO:0051606 85 0.015
Zebrafish
nucleus localization GO:0051647 1 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.015
lipid localization GO:0010876 106 0.015
negative regulation of mitotic cell cycle GO:0045930 102 0.014
regulation of cytokine production GO:0001817 232 0.014
regulation of protein binding GO:0043393 66 0.014
response to external biotic stimulus GO:0043207 261 0.014
multicellular organism reproduction GO:0032504 42 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
organic acid biosynthetic process GO:0016053 97 0.014
tripartite regional subdivision GO:0007351 2 0.014
negative regulation of catabolic process GO:0009895 104 0.014
negative regulation of protein maturation GO:1903318 142 0.014
anterior posterior axis specification GO:0009948 2 0.014
mitotic cell cycle GO:0000278 326 0.013
Fly
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.013
rna interference GO:0016246 4 0.013
negative regulation of proteolysis GO:0045861 132 0.013
actin filament based process GO:0030029 224 0.013
chromatin organization GO:0006325 351 0.013
positive regulation of cell development GO:0010720 92 0.013
apoptotic signaling pathway GO:0097190 268 0.013
response to lipid GO:0033993 206 0.013
chaperone cofactor dependent protein refolding GO:0070389 4 0.013
oocyte differentiation GO:0009994 2 0.012
cellular lipid metabolic process GO:0044255 303 0.012
cellular homeostasis GO:0019725 196 0.012
single organism reproductive process GO:0044702 98 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
positive regulation of cellular component movement GO:0051272 181 0.012
macromolecular complex disassembly GO:0032984 60 0.012
mrna catabolic process GO:0006402 56 0.012
positive regulation of apoptotic signaling pathway GO:2001235 70 0.012
positive regulation of immune response GO:0050778 159 0.012
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.011
regulation of protein processing GO:0070613 150 0.011
cellular response to lipid GO:0071396 127 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.011
regulation of notch signaling pathway GO:0008593 18 0.010
leukocyte mediated immunity GO:0002443 59 0.010
negative regulation of phosphate metabolic process GO:0045936 267 0.010
response to bacterium GO:0009617 144 0.010
regulation of immune response GO:0050776 201 0.010
regulation of ion transmembrane transporter activity GO:0032412 72 0.010
negative regulation of immune system process GO:0002683 136 0.010
regulation of neuron differentiation GO:0045664 70 0.010

UBE2N disease predictions

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 104 0.020
muscular disease DOID:0080000 114 0.020
muscular dystrophy DOID:9884 51 0.020
musculoskeletal system disease DOID:17 223 0.020
muscle tissue disease DOID:66 113 0.020