Homo sapiens

16 known processes

PARL

presenilin associated, rhomboid-like

(Aliases: PSARL1,PSENIP2,RHBDS1,PSARL)

PARL biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.202
vesicle mediated transport GO:0016192 371 0.102
multicellular organismal aging GO:0010259 3 0.099
female gamete generation GO:0007292 2 0.061
purine nucleoside monophosphate metabolic process GO:0009126 186 0.057
cellular macromolecule catabolic process GO:0044265 380 0.056
purine ribonucleoside metabolic process GO:0046128 437 0.054
determination of adult lifespan GO:0008340 2 0.051
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.051
nucleoside monophosphate metabolic process GO:0009123 191 0.049
oogenesis GO:0048477 2 0.048
nucleoside triphosphate metabolic process GO:0009141 422 0.047
lipid metabolic process GO:0006629 381 0.044
membrane organization GO:0061024 292 0.041
Fly
purine nucleoside triphosphate metabolic process GO:0009144 412 0.041
negative regulation of protein metabolic process GO:0051248 391 0.041
protein maturation GO:0051604 233 0.038
Fly
cellular ketone metabolic process GO:0042180 80 0.036
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.036
modification dependent macromolecule catabolic process GO:0043632 212 0.035
ribonucleoside monophosphate metabolic process GO:0009161 187 0.033
cellular lipid metabolic process GO:0044255 303 0.033
negative regulation of cellular protein metabolic process GO:0032269 353 0.032
cytoplasmic transport GO:0016482 379 0.032
regulation of cellular amine metabolic process GO:0033238 11 0.032
endocytosis GO:0006897 159 0.031
regulation of cellular amino acid metabolic process GO:0006521 6 0.031
cellular amino acid metabolic process GO:0006520 116 0.030
ribonucleoside triphosphate metabolic process GO:0009199 412 0.030
cellular amine metabolic process GO:0044106 41 0.030
amine metabolic process GO:0009308 44 0.029
mitochondrion organization GO:0007005 156 0.029
Fly
neuromuscular junction development GO:0007528 3 0.028
negative regulation of cell proliferation GO:0008285 228 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
system process GO:0003008 349 0.028
carbohydrate derivative biosynthetic process GO:1901137 207 0.027
apoptotic signaling pathway GO:0097190 268 0.027
protein catabolic process GO:0030163 325 0.027
monocarboxylic acid metabolic process GO:0032787 185 0.026
regulation of proteolysis GO:0030162 293 0.026
regulation of cellular ketone metabolic process GO:0010565 50 0.026
mrna metabolic process GO:0016071 175 0.025
positive regulation of catabolic process GO:0009896 310 0.025
posttranscriptional regulation of gene expression GO:0010608 213 0.024
response to abiotic stimulus GO:0009628 336 0.024
ubiquitin dependent protein catabolic process GO:0006511 206 0.024
adult locomotory behavior GO:0008344 1 0.024
single organism membrane organization GO:0044802 268 0.024
Fly
positive regulation of transport GO:0051050 336 0.024
modification dependent protein catabolic process GO:0019941 209 0.024
regulation of cell cycle GO:0051726 393 0.024
regulation of cell cycle process GO:0010564 266 0.024
regulation of cell differentiation GO:0045595 393 0.024
cellular protein catabolic process GO:0044257 261 0.024
regulation of nucleotide metabolic process GO:0006140 269 0.024
negative regulation of cellular component organization GO:0051129 235 0.023
protein processing GO:0016485 226 0.023
Fly
defense response GO:0006952 315 0.023
positive regulation of cellular component organization GO:0051130 376 0.023
mitotic cell cycle process GO:1903047 286 0.022
cellular component morphogenesis GO:0032989 314 0.022
positive regulation of cellular catabolic process GO:0031331 284 0.022
negative regulation of multicellular organismal process GO:0051241 317 0.022
mitotic cell cycle GO:0000278 326 0.022
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.022
growth GO:0040007 202 0.022
organonitrogen compound biosynthetic process GO:1901566 200 0.022
negative regulation of programmed cell death GO:0043069 321 0.021
regulation of mitotic cell cycle GO:0007346 189 0.021
nitrogen compound transport GO:0071705 191 0.021
locomotory behavior GO:0007626 1 0.021
embryo development GO:0009790 123 0.020
regulation of translation GO:0006417 89 0.020
regulation of protein kinase activity GO:0045859 289 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
cofactor metabolic process GO:0051186 87 0.020
regulation of kinase activity GO:0043549 314 0.020
negative regulation of catalytic activity GO:0043086 335 0.020
cellular response to dna damage stimulus GO:0006974 379 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.020
cell development GO:0048468 328 0.020
positive regulation of cellular amine metabolic process GO:0033240 7 0.019
organophosphate biosynthetic process GO:0090407 163 0.019
positive regulation of phosphorylation GO:0042327 394 0.019
single organism cellular localization GO:1902580 332 0.018
microtubule based process GO:0007017 210 0.018
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
cation homeostasis GO:0055080 189 0.018
regulation of anatomical structure morphogenesis GO:0022603 286 0.018
regulation of peptidase activity GO:0052547 180 0.018
regulation of intracellular transport GO:0032386 195 0.018
neurological system process GO:0050877 163 0.018
regulation of purine nucleotide metabolic process GO:1900542 264 0.018
negative regulation of cell differentiation GO:0045596 171 0.018
regulation of nucleoside metabolic process GO:0009118 209 0.018
immune response GO:0006955 307 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
positive regulation of apoptotic process GO:0043065 246 0.017
positive regulation of nucleoside metabolic process GO:0045979 186 0.017
metal ion homeostasis GO:0055065 169 0.017
cell morphogenesis GO:0000902 296 0.017
protein localization to organelle GO:0033365 280 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
regulation of cellular response to stress GO:0080135 244 0.017
intracellular protein transport GO:0006886 270 0.017
maintenance of location GO:0051235 112 0.017
transmembrane transport GO:0055085 399 0.017
rna processing GO:0006396 255 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
regulation of transferase activity GO:0051338 355 0.016
segmentation GO:0035282 4 0.016
innate immune response GO:0045087 178 0.016
reactive oxygen species metabolic process GO:0072593 75 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
regulation of intracellular protein transport GO:0033157 123 0.016
protein modification by small protein conjugation GO:0032446 342 0.016
cellular macromolecular complex assembly GO:0034622 324 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
nucleotide catabolic process GO:0009166 408 0.016
chemical homeostasis GO:0048878 306 0.016
negative regulation of cell death GO:0060548 345 0.016
oxidation reduction process GO:0055114 396 0.016
positive regulation of hydrolase activity GO:0051345 331 0.016
proteasomal protein catabolic process GO:0010498 176 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
fatty acid metabolic process GO:0006631 115 0.016
mitotic cell cycle phase transition GO:0044772 162 0.016
cell division GO:0051301 168 0.016
positive regulation of cell death GO:0010942 263 0.016
regulation of growth GO:0040008 165 0.016
response to cytokine GO:0034097 232 0.016
protein targeting GO:0006605 187 0.016
cellular ion homeostasis GO:0006873 168 0.015
purine nucleoside catabolic process GO:0006152 398 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
organophosphate catabolic process GO:0046434 430 0.015
receptor mediated endocytosis GO:0006898 84 0.015
regulation of cellular component biogenesis GO:0044087 281 0.015
nucleoside phosphate biosynthetic process GO:1901293 109 0.015
cell cycle phase transition GO:0044770 173 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.015
ribonucleoside catabolic process GO:0042454 406 0.015
ion homeostasis GO:0050801 230 0.015
positive regulation of nucleotide catabolic process GO:0030813 185 0.015
response to biotic stimulus GO:0009607 276 0.015
negative regulation of protein processing GO:0010955 142 0.015
regulation of protein maturation GO:1903317 150 0.014
regeneration GO:0031099 4 0.014
oocyte differentiation GO:0009994 2 0.014
translation GO:0006412 132 0.014
oocyte development GO:0048599 1 0.014
chromatin modification GO:0016568 298 0.014
cellular cation homeostasis GO:0030003 163 0.014
negative regulation of protein modification process GO:0031400 200 0.014
small gtpase mediated signal transduction GO:0007264 78 0.014
negative regulation of developmental process GO:0051093 247 0.014
purine nucleotide catabolic process GO:0006195 405 0.014
nerve development GO:0021675 4 0.014
cell growth GO:0016049 160 0.014
dephosphorylation GO:0016311 209 0.014
regulation of cysteine type endopeptidase activity GO:2000116 127 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
reproductive structure development GO:0048608 55 0.013
multi organism cellular process GO:0044764 156 0.013
cytokine production GO:0001816 247 0.013
histone modification GO:0016570 251 0.013
cell adhesion GO:0007155 325 0.013
ribose phosphate biosynthetic process GO:0046390 82 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
positive regulation of organelle organization GO:0010638 195 0.013
reproductive process GO:0022414 106 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
nucleoside phosphate catabolic process GO:1901292 412 0.013
cellular chemical homeostasis GO:0055082 180 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
protein ubiquitination GO:0016567 314 0.013
purine ribonucleoside catabolic process GO:0046130 398 0.013
cellular metal ion homeostasis GO:0006875 146 0.013
carbohydrate metabolic process GO:0005975 207 0.013
regulation of multi organism process GO:0043900 157 0.013
generation of precursor metabolites and energy GO:0006091 68 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
response to oxygen containing compound GO:1901700 369 0.012
cellular homeostasis GO:0019725 196 0.012
actin filament based process GO:0030029 224 0.012
divalent inorganic cation homeostasis GO:0072507 136 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
response to other organism GO:0051707 261 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.012
purine ribonucleotide biosynthetic process GO:0009152 79 0.012
regulation of protein processing GO:0070613 150 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
negative regulation of proteolysis GO:0045861 132 0.012
regulation of cytokine production GO:0001817 232 0.012
regulation of protein catabolic process GO:0042176 155 0.012
macromolecule methylation GO:0043414 97 0.012
mitotic nuclear division GO:0007067 119 0.012
protein oligomerization GO:0051259 173 0.012
purine containing compound catabolic process GO:0072523 411 0.012
regulation of protein transport GO:0051223 213 0.012
purine nucleotide biosynthetic process GO:0006164 84 0.012
ras protein signal transduction GO:0007265 73 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.012
secretion GO:0046903 254 0.012
cell part morphogenesis GO:0032990 137 0.012
regulation of locomotion GO:0040012 329 0.012
protein acylation GO:0043543 138 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
ribonucleotide biosynthetic process GO:0009260 81 0.011
negative regulation of cell cycle GO:0045786 193 0.011
regulation of protein localization GO:0032880 296 0.011
protein localization to membrane GO:0072657 160 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
regulation of cellular component movement GO:0051270 334 0.011
negative regulation of organelle organization GO:0010639 126 0.011
apoptotic mitochondrial changes GO:0008637 57 0.011
negative regulation of protein maturation GO:1903318 142 0.011
spermatid differentiation GO:0048515 4 0.011
regulation of viral process GO:0050792 103 0.011
generation of neurons GO:0048699 152 0.011
positive regulation of immune system process GO:0002684 283 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
ion transmembrane transport GO:0034220 338 0.011
methylation GO:0032259 106 0.011
positive regulation of proteolysis GO:0045862 142 0.011
regulation of response to external stimulus GO:0032101 222 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
regulation of defense response GO:0031347 154 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
neuroblast proliferation GO:0007405 4 0.011
covalent chromatin modification GO:0016569 254 0.011
immune system development GO:0002520 195 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
cell cell signaling GO:0007267 155 0.011
gtp metabolic process GO:0046039 239 0.011
nucleoside catabolic process GO:0009164 408 0.011
hindbrain development GO:0030902 3 0.011
single organism reproductive process GO:0044702 98 0.011
central nervous system development GO:0007417 123 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
negative regulation of catabolic process GO:0009895 104 0.011
atp metabolic process GO:0046034 176 0.011
negative regulation of transferase activity GO:0051348 124 0.011
organelle assembly GO:0070925 176 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
biological adhesion GO:0022610 331 0.011
purine containing compound biosynthetic process GO:0072522 88 0.010
cellular protein complex assembly GO:0043623 188 0.010
cell projection organization GO:0030030 252 0.010
protein import GO:0017038 130 0.010
regulation of nucleotide catabolic process GO:0030811 205 0.010
endomembrane system organization GO:0010256 196 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010
organelle localization GO:0051640 84 0.010
protein modification by small protein removal GO:0070646 92 0.010
regulation of cell cycle phase transition GO:1901987 126 0.010
positive regulation of immune response GO:0050778 159 0.010
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.010
citrate metabolic process GO:0006101 2 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.010
regulation of protein complex assembly GO:0043254 147 0.010
head development GO:0060322 108 0.010
response to external biotic stimulus GO:0043207 261 0.010
signal transduction by phosphorylation GO:0023014 297 0.010
metal ion transport GO:0030001 272 0.010
positive regulation of transferase activity GO:0051347 227 0.010
chromatin organization GO:0006325 351 0.010

PARL disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.039
eye and adnexa disease DOID:1492 150 0.039
nervous system disease DOID:863 431 0.039
eye disease DOID:5614 149 0.035
disease of metabolism DOID:0014667 295 0.027
retinal disease DOID:5679 118 0.022
cancer DOID:162 167 0.021
disease of cellular proliferation DOID:14566 174 0.021
organ system cancer DOID:0050686 164 0.020
retinal degeneration DOID:8466 89 0.017
inherited metabolic disorder DOID:655 242 0.017
central nervous system disease DOID:331 186 0.012
musculoskeletal system disease DOID:17 223 0.011