Homo sapiens

68 known processes

CDK4

cyclin-dependent kinase 4

(Aliases: PSK-J3,CMM3,MGC14458)

CDK4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cell cycle GO:0045786 193 0.995
cellular response to dna damage stimulus GO:0006974 379 0.977
negative regulation of apoptotic process GO:0043066 316 0.965
growth GO:0040007 202 0.948
Fly
mitotic cell cycle GO:0000278 326 0.941
negative regulation of programmed cell death GO:0043069 321 0.937
regulation of cell cycle GO:0051726 393 0.867
mitotic cell cycle phase transition GO:0044772 162 0.851
negative regulation of cell death GO:0060548 345 0.846
type b pancreatic cell development GO:0003323 4 0.845
Human
regulation of cell growth GO:0001558 135 0.820
negative regulation of cellular protein metabolic process GO:0032269 353 0.815
negative regulation of cell proliferation GO:0008285 228 0.813
Human
protein maturation GO:0051604 233 0.807
regulation of cellular response to stress GO:0080135 244 0.798
Human
regulation of growth GO:0040008 165 0.781
glandular epithelial cell development GO:0002068 5 0.768
Human
cell cycle phase transition GO:0044770 173 0.753
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.750
protein processing GO:0016485 226 0.748
regulation of cell cycle arrest GO:0071156 36 0.745
cell adhesion GO:0007155 325 0.736
Human
positive regulation of cell death GO:0010942 263 0.728
regulation of epithelial cell proliferation GO:0050678 113 0.726
Human
negative regulation of mitotic cell cycle GO:0045930 102 0.723
enteroendocrine cell differentiation GO:0035883 6 0.709
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.676
cell cycle g2 m phase transition GO:0044839 43 0.657
negative regulation of cell growth GO:0030308 83 0.636
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.607
regulation of response to dna damage stimulus GO:2001020 94 0.606
negative regulation of developmental process GO:0051093 247 0.598
Human
regulation of kinase activity GO:0043549 314 0.596
regulation of cell cycle process GO:0010564 266 0.577
negative regulation of multicellular organismal process GO:0051241 317 0.556
Human
regulation of transferase activity GO:0051338 355 0.540
regulation of protein kinase activity GO:0045859 289 0.527
g1 s transition of mitotic cell cycle GO:0000082 78 0.508
nuclear division GO:0000280 128 0.491
Worm
negative regulation of phosphorylation GO:0042326 174 0.474
negative regulation of cell cycle phase transition GO:1901988 89 0.440
negative regulation of phosphorus metabolic process GO:0010563 267 0.438
epithelial cell proliferation GO:0050673 128 0.422
Human
post embryonic development GO:0009791 2 0.420
Worm
cell substrate adhesion GO:0031589 132 0.420
Human
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.406
response to light stimulus GO:0009416 87 0.396
apoptotic signaling pathway GO:0097190 268 0.383
cellular response to oxygen containing compound GO:1901701 276 0.383
embryo development ending in birth or egg hatching GO:0009792 34 0.381
Worm
cell cycle arrest GO:0007050 71 0.379
jak stat cascade GO:0007259 46 0.370
Fly
negative regulation of catalytic activity GO:0043086 335 0.369
negative regulation of growth GO:0045926 97 0.341
nucleotide biosynthetic process GO:0009165 109 0.335
oogenesis GO:0048477 2 0.334
negative regulation of phosphate metabolic process GO:0045936 267 0.326
negative regulation of protein phosphorylation GO:0001933 140 0.296
covalent chromatin modification GO:0016569 254 0.295
response to organonitrogen compound GO:0010243 156 0.295
positive regulation of g2 m transition of mitotic cell cycle GO:0010971 8 0.293
dna repair GO:0006281 198 0.292
embryo development GO:0009790 123 0.290
Worm Fly
positive regulation of cell cycle GO:0045787 140 0.286
cellular component morphogenesis GO:0032989 314 0.286
regulation of protein serine threonine kinase activity GO:0071900 179 0.284
dna dependent dna replication GO:0006261 44 0.283
cellular macromolecular complex assembly GO:0034622 324 0.277
dna integrity checkpoint GO:0031570 71 0.274
negative regulation of myeloid cell differentiation GO:0045638 42 0.264
Human
negative regulation of epithelial cell proliferation GO:0050680 48 0.263
Human
dna replication GO:0006260 116 0.252
organ morphogenesis GO:0009887 147 0.242
single organism reproductive process GO:0044702 98 0.242
Worm
cell growth GO:0016049 160 0.241
Fly
response to radiation GO:0009314 151 0.238
cell cycle g1 s phase transition GO:0044843 80 0.234
female gamete generation GO:0007292 2 0.233
blastocyst development GO:0001824 3 0.231
chemical homeostasis GO:0048878 306 0.229
regulation of cellular protein catabolic process GO:1903362 96 0.223
regulation of cellular amino acid metabolic process GO:0006521 6 0.221
protein ubiquitination GO:0016567 314 0.218
hemopoiesis GO:0030097 180 0.218
Human
cell aging GO:0007569 52 0.216
Human
regulation of mitotic cell cycle GO:0007346 189 0.208
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.196
positive regulation of apoptotic process GO:0043065 246 0.195
system process GO:0003008 349 0.182
cell dedifferentiation GO:0043697 1 0.180
Human
intrinsic apoptotic signaling pathway GO:0097193 127 0.180
cation transport GO:0006812 331 0.179
cellular amino acid metabolic process GO:0006520 116 0.174
negative regulation of kinase activity GO:0033673 106 0.173
positive regulation of transport GO:0051050 336 0.166
mitochondrion organization GO:0007005 156 0.163
Fly
determination of adult lifespan GO:0008340 2 0.161
cell type specific apoptotic process GO:0097285 125 0.158
response to abiotic stimulus GO:0009628 336 0.156
response to endoplasmic reticulum stress GO:0034976 49 0.155
epithelium development GO:0060429 227 0.153
Human
nervous system development GO:0007399 293 0.152
Human
negative regulation of protein metabolic process GO:0051248 391 0.150
hematopoietic or lymphoid organ development GO:0048534 186 0.145
Human
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.144
positive regulation of transferase activity GO:0051347 227 0.144
type b pancreatic cell differentiation GO:0003309 5 0.142
Human
response to cytokine GO:0034097 232 0.139
regulation of dna metabolic process GO:0051052 153 0.138
regulation of cell cycle phase transition GO:1901987 126 0.138
negative regulation of organelle organization GO:0010639 126 0.137
response to inorganic substance GO:0010035 127 0.136
positive regulation of cell cycle process GO:0090068 106 0.133
regulation of protein processing GO:0070613 150 0.131
peptidyl tyrosine phosphorylation GO:0018108 170 0.131
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.130
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.130
mitotic cell cycle checkpoint GO:0007093 68 0.129
cellular ketone metabolic process GO:0042180 80 0.128
negative regulation of cellular component organization GO:0051129 235 0.126
response to metal ion GO:0010038 84 0.123
sensory perception GO:0007600 103 0.121
positive regulation of developmental process GO:0051094 314 0.120
cell development GO:0048468 328 0.120
Human
stem cell differentiation GO:0048863 93 0.120
response to nitrogen compound GO:1901698 184 0.119
macromolecule methylation GO:0043414 97 0.119
nuclear transport GO:0051169 179 0.118
dna packaging GO:0006323 77 0.116
regulation of peptidase activity GO:0052547 180 0.115
camera type eye development GO:0043010 25 0.114
response to other organism GO:0051707 261 0.110
Human
organelle assembly GO:0070925 176 0.110
reproductive process GO:0022414 106 0.104
Worm
negative regulation of cell cycle process GO:0010948 121 0.104
dna damage checkpoint GO:0000077 68 0.104
dephosphorylation GO:0016311 209 0.101
hematopoietic progenitor cell differentiation GO:0002244 38 0.100
negative regulation of immune system process GO:0002683 136 0.099
Human
mitotic cell cycle process GO:1903047 286 0.095
cellular macromolecule catabolic process GO:0044265 380 0.093
mitotic dna damage checkpoint GO:0044773 28 0.091
negative regulation of transferase activity GO:0051348 124 0.091
aging GO:0007568 66 0.088
Human
reproductive structure development GO:0048608 55 0.087
Worm
positive regulation of dna metabolic process GO:0051054 73 0.087
peptidyl serine phosphorylation GO:0018105 101 0.087
cell activation GO:0001775 213 0.084
cellular response to endogenous stimulus GO:0071495 336 0.084
regulation of mapk cascade GO:0043408 262 0.083
regulation of binding GO:0051098 111 0.083
positive regulation of catabolic process GO:0009896 310 0.083
negative regulation of cell differentiation GO:0045596 171 0.082
Human
posttranscriptional regulation of gene expression GO:0010608 213 0.082
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.082
nucleoside triphosphate metabolic process GO:0009141 422 0.081
rna processing GO:0006396 255 0.081
negative regulation of cell cycle arrest GO:0071157 12 0.081
positive regulation of response to dna damage stimulus GO:2001022 43 0.080
regulation of protein ubiquitination GO:0031396 95 0.079
regulation of proteolysis GO:0030162 293 0.078
positive regulation of cell cycle g2 m phase transition GO:1902751 8 0.076
cellular response to cytokine stimulus GO:0071345 181 0.074
positive regulation of protein phosphorylation GO:0001934 313 0.073
positive regulation of cell proliferation GO:0008284 301 0.072
positive regulation of programmed cell death GO:0043068 249 0.071
epithelial cell differentiation GO:0030855 141 0.070
Human
cell division GO:0051301 168 0.069
protein catabolic process GO:0030163 325 0.069
organonitrogen compound biosynthetic process GO:1901566 200 0.066
negative regulation of protein kinase activity GO:0006469 98 0.065
response to external biotic stimulus GO:0043207 261 0.065
Human
monovalent inorganic cation transport GO:0015672 128 0.064
eye development GO:0001654 42 0.063
response to drug GO:0042493 81 0.061
ribonucleoside triphosphate metabolic process GO:0009199 412 0.060
cellular lipid metabolic process GO:0044255 303 0.060
positive regulation of hydrolase activity GO:0051345 331 0.060
immune effector process GO:0002252 159 0.059
immune response GO:0006955 307 0.057
biological adhesion GO:0022610 331 0.056
Human
regulation of cell cycle g1 s phase transition GO:1902806 42 0.055
Worm
cellular response to insulin stimulus GO:0032869 41 0.055
organophosphate biosynthetic process GO:0090407 163 0.055
ribose phosphate biosynthetic process GO:0046390 82 0.055
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.054
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.054
protein autophosphorylation GO:0046777 123 0.054
regulation of cell aging GO:0090342 18 0.054
Human
response to peptide hormone GO:0043434 61 0.053
positive regulation of cellular component organization GO:0051130 376 0.052
regulation of gtpase activity GO:0043087 180 0.052
cellular response to nitrogen compound GO:1901699 144 0.052
metal ion transport GO:0030001 272 0.050
regulation of nucleotide metabolic process GO:0006140 269 0.049
regulation of mitotic cell cycle phase transition GO:1901990 118 0.048
regulation of cell adhesion GO:0030155 166 0.047
Human
protein localization to organelle GO:0033365 280 0.047
protein dna complex subunit organization GO:0071824 80 0.047
regulation of cellular amine metabolic process GO:0033238 11 0.046
cellular response to hypoxia GO:0071456 51 0.044
regulation of mammary gland epithelial cell proliferation GO:0033599 6 0.044
nucleocytoplasmic transport GO:0006913 176 0.044
autophagic cell death GO:0048102 3 0.043
regulation of translation GO:0006417 89 0.043
mononuclear cell proliferation GO:0032943 71 0.043
regulation of cell substrate adhesion GO:0010810 68 0.043
Human
amine metabolic process GO:0009308 44 0.043
negative regulation of protein modification process GO:0031400 200 0.043
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.042
response to uv GO:0009411 73 0.041
dna modification GO:0006304 27 0.040
dna demethylation GO:0080111 12 0.040
cytoplasmic transport GO:0016482 379 0.040
multicellular organismal aging GO:0010259 3 0.039
negative regulation of protein processing GO:0010955 142 0.039
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.039
regulation of locomotion GO:0040012 329 0.039
tube development GO:0035295 125 0.038
regulation of endopeptidase activity GO:0052548 170 0.037
translation GO:0006412 132 0.037
reproduction GO:0000003 63 0.035
Worm
cell morphogenesis GO:0000902 296 0.034
positive regulation of cell substrate adhesion GO:0010811 37 0.034
Human
viral process GO:0016032 146 0.033
neurological system process GO:0050877 163 0.033
mitotic dna integrity checkpoint GO:0044774 30 0.033
vesicle mediated transport GO:0016192 371 0.033
regeneration GO:0031099 4 0.033
response to insulin GO:0032868 45 0.032
multi organism reproductive process GO:0044703 54 0.032
t cell activation GO:0042110 99 0.032
positive regulation of organelle organization GO:0010638 195 0.032
regulation of cell differentiation GO:0045595 393 0.032
Human
cell cycle checkpoint GO:0000075 117 0.031
cellular response to abiotic stimulus GO:0071214 117 0.031
cellular amine metabolic process GO:0044106 41 0.031
response to hormone GO:0009725 175 0.030
endoplasmic reticulum unfolded protein response GO:0030968 16 0.030
purine containing compound biosynthetic process GO:0072522 88 0.030
positive regulation of cellular catabolic process GO:0031331 284 0.030
peptidyl serine modification GO:0018209 106 0.030
ion homeostasis GO:0050801 230 0.029
regulation of purine nucleotide metabolic process GO:1900542 264 0.029
segmentation GO:0035282 4 0.028
Fly
response to nutrient levels GO:0031667 81 0.027
response to acid chemical GO:0001101 66 0.027
regulation of protein catabolic process GO:0042176 155 0.027
negative regulation of intracellular signal transduction GO:1902532 183 0.027
signal transduction by p53 class mediator GO:0072331 72 0.027
response to organic cyclic compound GO:0014070 204 0.027
cellular protein complex assembly GO:0043623 188 0.027
immune system development GO:0002520 195 0.027
Human
mitotic nuclear division GO:0007067 119 0.026
Worm
lymphocyte activation GO:0046649 133 0.026
oxidation reduction process GO:0055114 396 0.026
regulation of apoptotic signaling pathway GO:2001233 175 0.026
regulation of nucleoside metabolic process GO:0009118 209 0.026
regulation of fibroblast proliferation GO:0048145 32 0.026
leukocyte proliferation GO:0070661 74 0.025
neuron apoptotic process GO:0051402 39 0.025
multi organism cellular process GO:0044764 156 0.025
blastoderm segmentation GO:0007350 2 0.024
Fly
muscle cell differentiation GO:0042692 63 0.024
single organism carbohydrate metabolic process GO:0044723 193 0.024
g2 m transition of mitotic cell cycle GO:0000086 41 0.024
regulation of purine nucleotide catabolic process GO:0033121 205 0.024
cellular response to hormone stimulus GO:0032870 125 0.024
mammary gland morphogenesis GO:0060443 2 0.024
negative regulation of dephosphorylation GO:0035305 63 0.024
carbohydrate derivative biosynthetic process GO:1901137 207 0.023
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.023
lymphocyte proliferation GO:0046651 70 0.023
regulation of multi organism process GO:0043900 157 0.023
mammary gland development GO:0030879 17 0.023
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.023
regulation of meiotic cell cycle GO:0051445 4 0.022
organelle fission GO:0048285 149 0.022
Worm
mammary gland epithelium development GO:0061180 10 0.022
morphogenesis of an epithelium GO:0002009 60 0.022
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.022
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.022
negative regulation of cellular senescence GO:2000773 5 0.021
Human
chordate embryonic development GO:0043009 34 0.021
negative regulation of hydrolase activity GO:0051346 182 0.021
cellular modified amino acid metabolic process GO:0006575 64 0.021
negative regulation of cellular catabolic process GO:0031330 83 0.021
regulation of dephosphorylation GO:0035303 96 0.020
multicellular organism reproduction GO:0032504 42 0.020
blood circulation GO:0008015 113 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.020
epithelial tube morphogenesis GO:0060562 38 0.020
t cell differentiation in thymus GO:0033077 4 0.019
response to oxygen containing compound GO:1901700 369 0.019
reproductive system development GO:0061458 56 0.019
Worm
regulation of cell development GO:0060284 161 0.019
cell matrix adhesion GO:0007160 85 0.019
Human
regulation of myeloid cell differentiation GO:0045637 81 0.019
Human
dna dealkylation GO:0035510 13 0.019
leukocyte activation GO:0045321 164 0.019
ribonucleotide biosynthetic process GO:0009260 81 0.019
secretion by cell GO:0032940 226 0.019
negative regulation of response to dna damage stimulus GO:2001021 33 0.019
regulation of secretion GO:0051046 194 0.018
purine ribonucleoside monophosphate biosynthetic process GO:0009168 16 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
response to extracellular stimulus GO:0009991 85 0.018
endocytosis GO:0006897 159 0.018
cell projection organization GO:0030030 252 0.018
pattern specification process GO:0007389 43 0.018
Fly
cellular response to peptide GO:1901653 59 0.017
negative regulation of apoptotic signaling pathway GO:2001234 97 0.017
regulation of defense response GO:0031347 154 0.017
eye morphogenesis GO:0048592 16 0.017
regulation of mitosis GO:0007088 63 0.017
defense response GO:0006952 315 0.017
response to transforming growth factor beta GO:0071559 94 0.017
protein modification by small protein conjugation GO:0032446 342 0.017
viral life cycle GO:0019058 132 0.016
response to growth factor GO:0070848 205 0.016
notch signaling pathway GO:0007219 31 0.016
gliogenesis GO:0042063 21 0.016
Human
positive regulation of endopeptidase activity GO:0010950 84 0.016
regulation of leukocyte differentiation GO:1902105 61 0.016
regulation of nucleotide catabolic process GO:0030811 205 0.016
response to magnesium ion GO:0032026 3 0.016
gland development GO:0048732 48 0.015
myosin filament assembly GO:0031034 2 0.015
myosin filament organization GO:0031033 2 0.015
energy derivation by oxidation of organic compounds GO:0015980 43 0.015
secretion GO:0046903 254 0.015
regulation of nervous system development GO:0051960 88 0.015
regulation of t cell activation GO:0050863 77 0.015
response to camp GO:0051591 25 0.015
regulation of cell division GO:0051302 116 0.015
regulation of ubiquitin protein transferase activity GO:0051438 28 0.015
cellular response to peptide hormone stimulus GO:0071375 56 0.014
regulation of cellular component movement GO:0051270 334 0.014
hematopoietic stem cell differentiation GO:0060218 4 0.014
nitrogen compound transport GO:0071705 191 0.014
demethylation GO:0070988 37 0.014
single organism cellular localization GO:1902580 332 0.014
negative regulation of peptidase activity GO:0010466 91 0.014
transmembrane transport GO:0055085 399 0.014
ncrna processing GO:0034470 83 0.014
response to peptide GO:1901652 65 0.014
generation of precursor metabolites and energy GO:0006091 68 0.014
positive regulation of proteolysis GO:0045862 142 0.013
b cell proliferation GO:0042100 22 0.013
neuron death GO:0070997 65 0.013
positive regulation of mitotic cell cycle phase transition GO:1901992 19 0.013
leukocyte apoptotic process GO:0071887 31 0.013
regulation of protein maturation GO:1903317 150 0.013
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.013
ion transmembrane transport GO:0034220 338 0.013
tissue morphogenesis GO:0048729 96 0.013
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000058 7 0.012
mapk cascade GO:0000165 288 0.012
cellular chemical homeostasis GO:0055082 180 0.012
negative regulation of neuron death GO:1901215 32 0.012
negative regulation of proteolysis GO:0045861 132 0.012
alpha amino acid metabolic process GO:1901605 72 0.012
negative regulation of leukocyte differentiation GO:1902106 24 0.012
development of primary sexual characteristics GO:0045137 35 0.012
Worm
regulation of neuron death GO:1901214 56 0.012
nucleoside phosphate biosynthetic process GO:1901293 109 0.012
cardiovascular system development GO:0072358 262 0.012
developmental growth GO:0048589 48 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.011
generation of neurons GO:0048699 152 0.011
microtubule based process GO:0007017 210 0.011
ras protein signal transduction GO:0007265 73 0.011
regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266 8 0.011
cellular response to radiation GO:0071478 65 0.011
response to alcohol GO:0097305 64 0.011
cellular response to decreased oxygen levels GO:0036294 51 0.011
neuromuscular junction development GO:0007528 3 0.011
small gtpase mediated signal transduction GO:0007264 78 0.011
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.011
gtp catabolic process GO:0006184 237 0.011
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.011
Worm
cell part morphogenesis GO:0032990 137 0.011
regulation of generation of precursor metabolites and energy GO:0043467 27 0.011
signal transduction by phosphorylation GO:0023014 297 0.011
protein targeting GO:0006605 187 0.011
developmental process involved in reproduction GO:0003006 66 0.010
Worm
positive regulation of phosphorylation GO:0042327 394 0.010
negative regulation of endopeptidase activity GO:0010951 84 0.010

CDK4 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.057
disease of cellular proliferation DOID:14566 174 0.057
organ system cancer DOID:0050686 164 0.057