Homo sapiens

19 known processes

HLA-C

major histocompatibility complex, class I, C

(Aliases: HLA-Cw,FLJ27082,HLA-JY3,PSORS1,D6S204,HLC-C)

HLA-C biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
antigen processing and presentation via mhc class ib GO:0002475 3 1.000
Human
detection of chemical stimulus involved in sensory perception GO:0050907 33 1.000
Human
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 1.000
Human
regulation of regulatory t cell differentiation GO:0045589 4 1.000
Human
detection of external biotic stimulus GO:0098581 19 1.000
Human
positive regulation of natural killer cell mediated immunity GO:0002717 12 1.000
Human
sensory perception of chemical stimulus GO:0007606 38 1.000
Human
positive regulation of regulatory t cell differentiation GO:0045591 3 1.000
Human
sensory perception of bitter taste GO:0050913 28 1.000
Human
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 1.000
Human
regulation of dendritic cell differentiation GO:2001198 3 1.000
Human
positive regulation of t cell tolerance induction GO:0002666 2 1.000
Human
dendritic cell differentiation GO:0097028 13 1.000
Human
sensory perception of taste GO:0050909 36 1.000
Human
detection of biotic stimulus GO:0009595 21 1.000
Human
detection of other organism GO:0098543 13 1.000
Human
antigen processing and presentation of endogenous antigen GO:0019883 7 1.000
detection of chemical stimulus GO:0009593 55 1.000
Human
negative regulation of t cell proliferation GO:0042130 8 1.000
Human
regulation of natural killer cell mediated immunity GO:0002715 16 1.000
Human
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 5 0.999
Human
negative regulation of leukocyte mediated immunity GO:0002704 14 0.999
Human
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.999
Human
positive regulation of lymphocyte differentiation GO:0045621 13 0.998
Human
immune response inhibiting signal transduction GO:0002765 4 0.998
Human
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway GO:0002484 3 0.998
retina homeostasis GO:0001895 42 0.997
Human
negative regulation of leukocyte differentiation GO:1902106 24 0.996
Human
transition metal ion transport GO:0000041 23 0.995
Human
natural killer cell mediated immunity GO:0002228 23 0.995
Human
positive regulation of tolerance induction GO:0002645 2 0.994
Human
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap independent GO:0002486 3 0.992
t cell tolerance induction GO:0002517 4 0.992
Human
tolerance induction GO:0002507 6 0.992
Human
antigen processing and presentation of peptide antigen via mhc class ib GO:0002428 2 0.991
Human
detection of stimulus GO:0051606 85 0.989
Human
iron ion import into cell GO:0097459 2 0.989
Human
negative regulation of cell proliferation GO:0008285 228 0.986
Human
response to other organism GO:0051707 261 0.984
Human
cell killing GO:0001906 34 0.978
Human
regulation of cell killing GO:0031341 22 0.975
Human
antigen processing and presentation GO:0019882 33 0.973
negative regulation of lymphocyte mediated immunity GO:0002707 12 0.973
Human
t cell mediated cytotoxicity GO:0001913 9 0.970
Human
adaptive immune response GO:0002250 49 0.969
Human
memory t cell activation GO:0035709 1 0.967
Human
positive regulation of leukocyte mediated immunity GO:0002705 24 0.966
Human
negative regulation of leukocyte activation GO:0002695 26 0.964
Human
antigen processing and presentation of peptide antigen GO:0048002 18 0.963
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.961
Human
detection of bacterium GO:0016045 13 0.961
Human
regulation of t cell mediated cytotoxicity GO:0001914 8 0.961
Human
regulation of memory t cell activation GO:2000567 1 0.961
Human
negative regulation of cell killing GO:0031342 5 0.958
Human
tissue homeostasis GO:0001894 63 0.957
Human
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.956
Human
inorganic cation import into cell GO:0098659 2 0.951
Human
response to biotic stimulus GO:0009607 276 0.942
Human
positive regulation of memory t cell activation GO:2000568 1 0.936
Human
positive regulation of cell killing GO:0031343 19 0.936
Human
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 6 0.936
positive regulation of t cell mediated immunity GO:0002711 12 0.936
Human
regulation of leukocyte differentiation GO:1902105 61 0.927
Human
regulation of leukocyte mediated immunity GO:0002703 38 0.921
Human
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.919
Human
regulation of lymphocyte mediated immunity GO:0002706 33 0.917
Human
immune effector process GO:0002252 159 0.914
Human
regulation of tolerance induction GO:0002643 4 0.909
Human
import into cell GO:0098657 2 0.909
Human
cation transport GO:0006812 331 0.908
Human
lymphocyte mediated immunity GO:0002449 48 0.906
Human
negative regulation of defense response GO:0031348 47 0.904
Human
regulation of t cell activation GO:0050863 77 0.904
Human
response to bacterium GO:0009617 144 0.902
Human
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.901
Human
innate immune response GO:0045087 178 0.900
Human
regulation of t cell mediated immunity GO:0002709 18 0.897
Human
negative regulation of leukocyte mediated cytotoxicity GO:0001911 5 0.896
Human
response to external biotic stimulus GO:0043207 261 0.894
Human
multicellular organismal homeostasis GO:0048871 67 0.890
Human
regulation of innate immune response GO:0045088 97 0.885
Human
regulation of cytokine production GO:0001817 232 0.876
Human
regulation of adaptive immune response GO:0002819 33 0.876
Human
regulation of t cell tolerance induction GO:0002664 4 0.872
Human
positive regulation of leukocyte mediated cytotoxicity GO:0001912 16 0.867
Human
leukocyte mediated cytotoxicity GO:0001909 27 0.864
Human
positive regulation of cytokine production GO:0001819 167 0.863
Human
regulation of immune response GO:0050776 201 0.863
Human
positive regulation of interleukin 12 production GO:0032735 8 0.860
Human
immune system development GO:0002520 195 0.859
Human
antigen processing and presentation of endogenous peptide antigen GO:0002483 6 0.854
interleukin 12 production GO:0032615 15 0.854
Human
negative regulation of dendritic cell differentiation GO:2001199 2 0.853
Human
positive regulation of leukocyte differentiation GO:1902107 37 0.851
Human
type i interferon signaling pathway GO:0060337 11 0.843
cytokine production GO:0001816 247 0.842
Human
negative regulation of immune system process GO:0002683 136 0.839
Human
defense response GO:0006952 315 0.824
Human
leukocyte differentiation GO:0002521 98 0.818
Human
natural killer cell mediated cytotoxicity GO:0042267 23 0.816
Human
positive regulation of immune response GO:0050778 159 0.807
Human
immune response regulating signaling pathway GO:0002764 97 0.807
Human
negative regulation of immune response GO:0050777 40 0.799
Human
inorganic ion import into cell GO:0099587 2 0.796
Human
leukocyte mediated immunity GO:0002443 59 0.789
Human
hemopoiesis GO:0030097 180 0.787
Human
negative regulation of multicellular organismal process GO:0051241 317 0.764
Human
regulation of immune effector process GO:0002697 91 0.761
Human
lymphocyte proliferation GO:0046651 70 0.760
Human
negative regulation of innate immune response GO:0045824 18 0.753
Human
positive regulation of defense response GO:0031349 87 0.744
Human
positive regulation of interferon gamma production GO:0032729 26 0.742
Human
negative regulation of immune effector process GO:0002698 38 0.740
Human
positive regulation of innate immune response GO:0045089 79 0.730
Human
positive regulation of developmental process GO:0051094 314 0.728
Human
leukocyte activation GO:0045321 164 0.709
Human
positive regulation of immune system process GO:0002684 283 0.709
Human
regulation of leukocyte proliferation GO:0070663 67 0.705
Human
positive regulation of leukocyte activation GO:0002696 80 0.704
Human
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.666
Human
positive regulation of cell differentiation GO:0045597 211 0.658
Human
regulation of defense response GO:0031347 154 0.657
Human
regulation of cell activation GO:0050865 125 0.646
Human
hematopoietic or lymphoid organ development GO:0048534 186 0.631
Human
iron ion transport GO:0006826 12 0.631
Human
positive regulation of immune effector process GO:0002699 40 0.617
Human
cell activation GO:0001775 213 0.606
Human
immune response GO:0006955 307 0.601
Human
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 5 0.598
positive regulation of adaptive immune response GO:0002821 21 0.595
Human
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.594
protection from natural killer cell mediated cytotoxicity GO:0042270 3 0.591
Human
anatomical structure homeostasis GO:0060249 100 0.565
Human
regulation of cell differentiation GO:0045595 393 0.556
Human
negative regulation of leukocyte proliferation GO:0070664 16 0.553
Human
system process GO:0003008 349 0.543
Human
regulation of leukocyte activation GO:0002694 115 0.543
Human
leukocyte proliferation GO:0070661 74 0.513
Human
mononuclear cell proliferation GO:0032943 71 0.504
Human
detection of stimulus involved in sensory perception GO:0050906 43 0.480
Human
antigen processing and presentation of endogenous peptide antigen via mhc class ib GO:0002476 2 0.478
Human
regulation of interferon gamma production GO:0032649 36 0.476
Human
neurological system process GO:0050877 163 0.444
Human
regulation of mononuclear cell proliferation GO:0032944 65 0.443
Human
interferon gamma production GO:0032609 39 0.433
Human
positive regulation of t cell mediated cytotoxicity GO:0001916 7 0.418
Human
t cell mediated immunity GO:0002456 25 0.417
Human
negative regulation of developmental process GO:0051093 247 0.401
Human
positive regulation of t cell differentiation GO:0045582 11 0.392
Human
t cell activation GO:0042110 99 0.370
Human
regulation of interleukin 12 production GO:0032655 15 0.366
Human
negative regulation of cell differentiation GO:0045596 171 0.363
Human
lymphocyte differentiation GO:0030098 35 0.355
Human
positive regulation of cell activation GO:0050867 81 0.335
Human
regulation of lymphocyte proliferation GO:0050670 64 0.318
Human
positive regulation of t cell activation GO:0050870 54 0.305
Human
lymphocyte activation GO:0046649 133 0.266
Human
cell adhesion GO:0007155 325 0.241
Human
regulation of t cell proliferation GO:0042129 42 0.232
Human
negative regulation of cell activation GO:0050866 33 0.203
Human
sensory perception GO:0007600 103 0.203
Human
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.198
Human
regulation of lymphocyte activation GO:0051249 103 0.190
Human
regulation of t cell differentiation GO:0045580 19 0.184
Human
interleukin 6 production GO:0032635 37 0.166
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 28 0.136
Human
t cell differentiation GO:0030217 29 0.135
Human
regulation of lymphocyte differentiation GO:0045619 22 0.133
Human
astrocyte chemotaxis GO:0035700 1 0.118
negative regulation of cellular protein metabolic process GO:0032269 353 0.115
post embryonic development GO:0009791 2 0.106
metal ion transport GO:0030001 272 0.105
Human
negative regulation of multi organism process GO:0043901 92 0.103
biological adhesion GO:0022610 331 0.103
Human
t cell differentiation in thymus GO:0033077 4 0.096
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.089
response to interferon gamma GO:0034341 39 0.079
negative regulation of lymphocyte proliferation GO:0050672 15 0.076
Human
response to type i interferon GO:0034340 14 0.073
detection of muramyl dipeptide GO:0032498 1 0.065
negative regulation of lymphocyte activation GO:0051250 24 0.063
Human
mapk cascade GO:0000165 288 0.063
regulation of calcium ion transport GO:0051924 79 0.062
cell projection organization GO:0030030 252 0.059
cellular response to oxidative stress GO:0034599 85 0.055
cytoplasmic transport GO:0016482 379 0.055
intracellular protein transport GO:0006886 270 0.047
negative regulation of phosphorylation GO:0042326 174 0.046
chemical homeostasis GO:0048878 306 0.046
ribonucleoside triphosphate catabolic process GO:0009203 391 0.045
negative regulation of t cell activation GO:0050868 18 0.045
Human
purine containing compound catabolic process GO:0072523 411 0.044
t cell proliferation GO:0042098 45 0.044
Human
iron ion homeostasis GO:0055072 15 0.043
cytokine production involved in immune response GO:0002367 27 0.043
positive regulation of interleukin 13 production GO:0032736 4 0.043
negative regulation of protein metabolic process GO:0051248 391 0.043
ossification GO:0001503 121 0.041
negative regulation of mononuclear cell proliferation GO:0032945 15 0.040
Human
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.039
Human
nucleoside catabolic process GO:0009164 408 0.039
interaction with host GO:0051701 42 0.038
protein maturation GO:0051604 233 0.037
purine ribonucleoside metabolic process GO:0046128 437 0.037
motor neuron axon guidance GO:0008045 2 0.035
regulatory t cell differentiation GO:0045066 5 0.034
Human
multicellular organismal aging GO:0010259 3 0.033
purine nucleoside monophosphate metabolic process GO:0009126 186 0.033
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.033
cellular amine metabolic process GO:0044106 41 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.031
tissue regeneration GO:0042246 3 0.029
ribonucleoside monophosphate metabolic process GO:0009161 187 0.029
atp catabolic process GO:0006200 157 0.028
negative regulation of transport GO:0051051 176 0.027
ribonucleoside triphosphate metabolic process GO:0009199 412 0.027
regulation of cellular ketone metabolic process GO:0010565 50 0.026
cellular response to type i interferon GO:0071357 12 0.025
ribonucleotide catabolic process GO:0009261 405 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.025
protein ubiquitination GO:0016567 314 0.025
divalent inorganic cation transport GO:0072511 158 0.025
entry into host cell GO:0030260 25 0.024
regulation of mast cell chemotaxis GO:0060753 4 0.023
negative regulation of cell death GO:0060548 345 0.023
ribonucleoside monophosphate catabolic process GO:0009158 158 0.023
secretion by cell GO:0032940 226 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.023
cell growth GO:0016049 160 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
negative regulation of catalytic activity GO:0043086 335 0.021
regulation of viral transcription GO:0046782 34 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.021
positive regulation of cellular amine metabolic process GO:0033240 7 0.021
secretion GO:0046903 254 0.021
regulation of cell migration GO:0030334 289 0.021
defense response to other organism GO:0098542 129 0.021
inflammatory response GO:0006954 79 0.021
ion homeostasis GO:0050801 230 0.021
negative regulation of intracellular signal transduction GO:1902532 183 0.020
cellular macromolecule catabolic process GO:0044265 380 0.020
lipid metabolic process GO:0006629 381 0.019
cation homeostasis GO:0055080 189 0.019
cellular ketone metabolic process GO:0042180 80 0.019
cellular response to lipid GO:0071396 127 0.018
maintenance of location GO:0051235 112 0.018
regulation of secretion GO:0051046 194 0.018
detection of peptidoglycan GO:0032499 1 0.018
cellular response to cytokine stimulus GO:0071345 181 0.018
heart contraction GO:0060047 62 0.018
glycoprotein metabolic process GO:0009100 110 0.018
regulation of cell cycle GO:0051726 393 0.017
growth GO:0040007 202 0.017
nucleoside monophosphate metabolic process GO:0009123 191 0.017
nucleoside monophosphate catabolic process GO:0009125 159 0.017
regulation of ligase activity GO:0051340 29 0.017
negative regulation of protein modification process GO:0031400 200 0.016
positive regulation of cell death GO:0010942 263 0.016
movement in environment of other organism involved in symbiotic interaction GO:0052192 25 0.016
rna catabolic process GO:0006401 71 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 1 0.016
nucleoside triphosphate catabolic process GO:0009143 394 0.015
regulation of proteolysis GO:0030162 293 0.015
epithelial cell differentiation GO:0030855 141 0.015
cellular protein catabolic process GO:0044257 261 0.015
purine nucleotide catabolic process GO:0006195 405 0.015
regulation of intracellular transport GO:0032386 195 0.015
response to thyroid hormone GO:0097066 9 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
determination of adult lifespan GO:0008340 2 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
purine nucleoside monophosphate catabolic process GO:0009128 158 0.013
negative regulation of peptidase activity GO:0010466 91 0.013
response to inorganic substance GO:0010035 127 0.013
atp metabolic process GO:0046034 176 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
immune response activating signal transduction GO:0002757 90 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
organophosphate catabolic process GO:0046434 430 0.012
osteoblast differentiation GO:0001649 92 0.012
defense response to virus GO:0051607 71 0.012
negative regulation of cell motility GO:2000146 104 0.012
single organism membrane organization GO:0044802 268 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
nucleoside triphosphate metabolic process GO:0009141 422 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
entry into host GO:0044409 25 0.012
regulation of angiogenesis GO:0045765 92 0.012
regulation of protein maturation GO:1903317 150 0.012
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
epithelium development GO:0060429 227 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
mitotic cell cycle process GO:1903047 286 0.011
regulation of cell motility GO:2000145 299 0.011
pattern recognition receptor signaling pathway GO:0002221 48 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
regulation of purine nucleotide metabolic process GO:1900542 264 0.011
regulation of homeostatic process GO:0032844 121 0.011
cellular homeostasis GO:0019725 196 0.011
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.011
negative regulation of viral process GO:0048525 66 0.011
negative regulation of response to external stimulus GO:0032102 83 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
regulation of membrane potential GO:0042391 95 0.010
single organism reproductive process GO:0044702 98 0.010
multi organism metabolic process GO:0044033 41 0.010
blastoderm segmentation GO:0007350 2 0.010
negative regulation of apoptotic process GO:0043066 316 0.010
amine metabolic process GO:0009308 44 0.010
regulation of protein localization GO:0032880 296 0.010
regulation of complement activation lectin pathway GO:0001868 2 0.010
nucleotide catabolic process GO:0009166 408 0.010
cellular response to oxygen containing compound GO:1901701 276 0.010
regulation of camp metabolic process GO:0030814 52 0.010
circulatory system development GO:0072359 262 0.010
negative regulation of cellular component organization GO:0051129 235 0.010

HLA-C disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.828
disease of metabolism DOID:0014667 295 0.547
Human
inherited metabolic disorder DOID:655 242 0.196
Human
lipid storage disease DOID:9455 28 0.100
lysosomal storage disease DOID:3211 47 0.100
neuronal ceroid lipofuscinosis DOID:14503 11 0.100
bone disease DOID:0080001 88 0.076
connective tissue disease DOID:65 109 0.076
primary immunodeficiency disease DOID:612 36 0.040
severe combined immunodeficiency DOID:627 10 0.040
combined t cell and b cell immunodeficiency DOID:628 12 0.040
immune system disease DOID:2914 155 0.040
artery disease DOID:0050828 23 0.022
vascular disease DOID:178 25 0.022
cardiovascular system disease DOID:1287 106 0.022
central nervous system disease DOID:331 186 0.011
Human
nervous system disease DOID:863 431 0.011
Human
sensory system disease DOID:0050155 203 0.010
disease by infectious agent DOID:0050117 34 0.002
integumentary system disease DOID:16 43 0.001
skin disease DOID:37 33 0.000
psoriasis DOID:8893 4 0.000
viral infectious disease DOID:934 13 0.000
human immunodeficiency virus infectious disease DOID:526 13 0.000
acquired immunodeficiency syndrome DOID:635 13 0.000