Homo sapiens

130 known processes

HLA-B

major histocompatibility complex, class I, B

(Aliases: SPDA1,Bw-48,HLA-B27,HLA-B73,HLAB,AS,HLA-B-5601,MGC111087,Bw-45,HLA-B-6701,Bw-56)

HLA-B biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
detection of chemical stimulus involved in sensory perception GO:0050907 33 1.000
antigen processing and presentation via mhc class ib GO:0002475 3 1.000
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 1.000
regulation of dendritic cell differentiation GO:2001198 3 1.000
sensory perception of taste GO:0050909 36 1.000
detection of chemical stimulus GO:0009593 55 1.000
detection of external biotic stimulus GO:0098581 19 1.000
positive regulation of regulatory t cell differentiation GO:0045591 3 1.000
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 1.000
positive regulation of natural killer cell mediated immunity GO:0002717 12 1.000
positive regulation of t cell tolerance induction GO:0002666 2 1.000
regulation of regulatory t cell differentiation GO:0045589 4 1.000
dendritic cell differentiation GO:0097028 13 1.000
sensory perception of chemical stimulus GO:0007606 38 1.000
retina homeostasis GO:0001895 42 1.000
detection of biotic stimulus GO:0009595 21 1.000
sensory perception of bitter taste GO:0050913 28 1.000
negative regulation of dendritic cell differentiation GO:2001199 2 0.999
negative regulation of leukocyte mediated cytotoxicity GO:0001911 5 0.999
negative regulation of t cell proliferation GO:0042130 8 0.998
immune response inhibiting signal transduction GO:0002765 4 0.998
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.997
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway GO:0002484 3 0.997
detection of stimulus GO:0051606 85 0.997
t cell tolerance induction GO:0002517 4 0.996
positive regulation of lymphocyte differentiation GO:0045621 13 0.995
antigen processing and presentation of peptide antigen GO:0048002 18 0.994
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap independent GO:0002486 3 0.991
detection of other organism GO:0098543 13 0.989
iron ion import into cell GO:0097459 2 0.988
transition metal ion transport GO:0000041 23 0.988
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 5 0.987
antigen processing and presentation of endogenous antigen GO:0019883 7 0.984
detection of stimulus involved in sensory perception GO:0050906 43 0.983
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 6 0.980
negative regulation of leukocyte mediated immunity GO:0002704 14 0.980
negative regulation of cell proliferation GO:0008285 228 0.980
antigen processing and presentation GO:0019882 33 0.977
regulation of cell killing GO:0031341 22 0.975
negative regulation of leukocyte differentiation GO:1902106 24 0.974
antigen processing and presentation of peptide antigen via mhc class ib GO:0002428 2 0.960
positive regulation of interleukin 12 production GO:0032735 8 0.950
negative regulation of leukocyte activation GO:0002695 26 0.949
regulation of t cell mediated immunity GO:0002709 18 0.948
regulation of t cell tolerance induction GO:0002664 4 0.944
positive regulation of defense response GO:0031349 87 0.937
positive regulation of cytokine production GO:0001819 167 0.935
cytokine production GO:0001816 247 0.929
hematopoietic or lymphoid organ development GO:0048534 186 0.927
regulation of leukocyte proliferation GO:0070663 67 0.927
regulation of leukocyte differentiation GO:1902105 61 0.926
regulation of t cell mediated cytotoxicity GO:0001914 8 0.924
negative regulation of innate immune response GO:0045824 18 0.923
regulation of t cell activation GO:0050863 77 0.917
lymphocyte proliferation GO:0046651 70 0.916
natural killer cell mediated cytotoxicity GO:0042267 23 0.913
positive regulation of interferon gamma production GO:0032729 26 0.909
inorganic cation import into cell GO:0098659 2 0.909
negative regulation of t cell activation GO:0050868 18 0.908
cell adhesion GO:0007155 325 0.907
cation transport GO:0006812 331 0.906
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.904
detection of bacterium GO:0016045 13 0.903
regulation of leukocyte mediated immunity GO:0002703 38 0.895
interferon gamma production GO:0032609 39 0.890
t cell mediated cytotoxicity GO:0001913 9 0.889
cell killing GO:0001906 34 0.888
regulation of cytokine production GO:0001817 232 0.885
multicellular organismal homeostasis GO:0048871 67 0.881
mononuclear cell proliferation GO:0032943 71 0.880
interleukin 12 production GO:0032615 15 0.872
tissue homeostasis GO:0001894 63 0.870
negative regulation of defense response GO:0031348 47 0.869
positive regulation of memory t cell activation GO:2000568 1 0.865
import into cell GO:0098657 2 0.864
protection from natural killer cell mediated cytotoxicity GO:0042270 3 0.861
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 5 0.858
negative regulation of cell differentiation GO:0045596 171 0.850
positive regulation of adaptive immune response GO:0002821 21 0.845
defense response GO:0006952 315 0.844
positive regulation of innate immune response GO:0045089 79 0.841
positive regulation of t cell mediated immunity GO:0002711 12 0.831
tolerance induction GO:0002507 6 0.828
regulation of t cell proliferation GO:0042129 42 0.826
regulation of natural killer cell mediated immunity GO:0002715 16 0.825
t cell mediated immunity GO:0002456 25 0.818
negative regulation of lymphocyte mediated immunity GO:0002707 12 0.815
innate immune response GO:0045087 178 0.812
natural killer cell mediated immunity GO:0002228 23 0.812
immune response regulating signaling pathway GO:0002764 97 0.807
metal ion transport GO:0030001 272 0.806
regulation of mononuclear cell proliferation GO:0032944 65 0.803
positive regulation of leukocyte activation GO:0002696 80 0.802
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.801
regulation of leukocyte activation GO:0002694 115 0.797
negative regulation of multicellular organismal process GO:0051241 317 0.794
immune response GO:0006955 307 0.792
regulation of interferon gamma production GO:0032649 36 0.780
response to bacterium GO:0009617 144 0.780
leukocyte proliferation GO:0070661 74 0.779
memory t cell activation GO:0035709 1 0.776
immune system development GO:0002520 195 0.774
regulation of lymphocyte differentiation GO:0045619 22 0.773
positive regulation of developmental process GO:0051094 314 0.765
regulation of lymphocyte proliferation GO:0050670 64 0.764
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.763
leukocyte mediated immunity GO:0002443 59 0.760
regulation of adaptive immune response GO:0002819 33 0.744
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.742
t cell activation GO:0042110 99 0.737
leukocyte mediated cytotoxicity GO:0001909 27 0.737
positive regulation of tolerance induction GO:0002645 2 0.736
regulation of defense response GO:0031347 154 0.732
antigen processing and presentation of endogenous peptide antigen GO:0002483 6 0.732
response to other organism GO:0051707 261 0.727
regulation of memory t cell activation GO:2000567 1 0.723
leukocyte differentiation GO:0002521 98 0.723
negative regulation of immune system process GO:0002683 136 0.714
regulation of innate immune response GO:0045088 97 0.708
lymphocyte mediated immunity GO:0002449 48 0.707
regulation of cell differentiation GO:0045595 393 0.706
positive regulation of cell activation GO:0050867 81 0.705
antigen processing and presentation of endogenous peptide antigen via mhc class ib GO:0002476 2 0.685
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.685
negative regulation of developmental process GO:0051093 247 0.682
positive regulation of t cell differentiation GO:0045582 11 0.680
positive regulation of immune system process GO:0002684 283 0.677
negative regulation of leukocyte proliferation GO:0070664 16 0.677
positive regulation of leukocyte differentiation GO:1902107 37 0.670
positive regulation of cell killing GO:0031343 19 0.668
inorganic ion import into cell GO:0099587 2 0.666
positive regulation of t cell activation GO:0050870 54 0.660
regulation of cell activation GO:0050865 125 0.652
positive regulation of cell differentiation GO:0045597 211 0.650
hemopoiesis GO:0030097 180 0.633
positive regulation of lymphocyte activation GO:0051251 73 0.616
immune effector process GO:0002252 159 0.612
response to external biotic stimulus GO:0043207 261 0.612
anatomical structure homeostasis GO:0060249 100 0.609
negative regulation of immune effector process GO:0002698 38 0.583
regulation of tolerance induction GO:0002643 4 0.576
adaptive immune response GO:0002250 49 0.575
t cell proliferation GO:0042098 45 0.573
neurological system process GO:0050877 163 0.572
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.559
negative regulation of cell activation GO:0050866 33 0.551
sensory perception GO:0007600 103 0.537
positive regulation of leukocyte mediated immunity GO:0002705 24 0.532
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.513
regulation of interleukin 12 production GO:0032655 15 0.490
cd8 positive alpha beta t cell activation GO:0036037 3 0.487
regulation of lymphocyte activation GO:0051249 103 0.482
positive regulation of immune response GO:0050778 159 0.472
response to biotic stimulus GO:0009607 276 0.468
leukocyte activation GO:0045321 164 0.462
type i interferon signaling pathway GO:0060337 11 0.453
positive regulation of leukocyte mediated cytotoxicity GO:0001912 16 0.452
regulation of osteoblast differentiation GO:0045667 38 0.442
lymphocyte activation GO:0046649 133 0.441
negative regulation of immune response GO:0050777 40 0.440
regulation of immune effector process GO:0002697 91 0.413
negative regulation of mononuclear cell proliferation GO:0032945 15 0.401
lymphocyte differentiation GO:0030098 35 0.394
iron ion transport GO:0006826 12 0.389
cell activation GO:0001775 213 0.379
system process GO:0003008 349 0.378
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.362
t cell differentiation GO:0030217 29 0.352
regulatory t cell differentiation GO:0045066 5 0.349
positive regulation of t cell mediated cytotoxicity GO:0001916 7 0.348
negative regulation of cell killing GO:0031342 5 0.321
biological adhesion GO:0022610 331 0.299
regulation of t cell differentiation GO:0045580 19 0.269
positive regulation of immune effector process GO:0002699 40 0.248
negative regulation of lymphocyte activation GO:0051250 24 0.240
regulation of immune response GO:0050776 201 0.220
regulation of lymphocyte mediated immunity GO:0002706 33 0.201
t cell differentiation in thymus GO:0033077 4 0.171
response to interferon gamma GO:0034341 39 0.148
negative regulation of lymphocyte proliferation GO:0050672 15 0.131
ubiquitin dependent protein catabolic process GO:0006511 206 0.129
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 28 0.124
post embryonic development GO:0009791 2 0.121
ossification GO:0001503 121 0.120
negative regulation of cellular protein metabolic process GO:0032269 353 0.117
regulation of secretion GO:0051046 194 0.105
cell projection organization GO:0030030 252 0.103
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.092
cellular response to oxidative stress GO:0034599 85 0.085
positive regulation of cellular amine metabolic process GO:0033240 7 0.078
negative regulation of phosphorylation GO:0042326 174 0.075
cellular homeostasis GO:0019725 196 0.064
regulation of cellular ketone metabolic process GO:0010565 50 0.063
modification dependent macromolecule catabolic process GO:0043632 212 0.062
negative regulation of intracellular signal transduction GO:1902532 183 0.056
metal ion homeostasis GO:0055065 169 0.055
modification dependent protein catabolic process GO:0019941 209 0.054
multicellular organismal aging GO:0010259 3 0.051
response to metal ion GO:0010038 84 0.051
cytoplasmic transport GO:0016482 379 0.050
cellular amino acid metabolic process GO:0006520 116 0.050
mapk cascade GO:0000165 288 0.043
regulation of growth GO:0040008 165 0.042
response to thyroid hormone GO:0097066 9 0.041
chemical homeostasis GO:0048878 306 0.040
cation homeostasis GO:0055080 189 0.040
intracellular protein transport GO:0006886 270 0.039
regulation of viral genome replication GO:0045069 48 0.038
regulation of cellular amino acid metabolic process GO:0006521 6 0.035
cellular macromolecule catabolic process GO:0044265 380 0.035
viral gene expression GO:0019080 35 0.034
secretion by cell GO:0032940 226 0.032
cellular response to interferon gamma GO:0071346 24 0.032
cellular protein catabolic process GO:0044257 261 0.032
atp metabolic process GO:0046034 176 0.031
purine ribonucleoside metabolic process GO:0046128 437 0.030
regulation of cell migration GO:0030334 289 0.030
iron ion import GO:0097286 5 0.030
blastoderm segmentation GO:0007350 2 0.030
mitotic cell cycle process GO:1903047 286 0.030
regulation of cellular component movement GO:0051270 334 0.030
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 2 0.029
cellular amine metabolic process GO:0044106 41 0.029
proteasomal protein catabolic process GO:0010498 176 0.027
regulation of cellular response to stress GO:0080135 244 0.026
ion homeostasis GO:0050801 230 0.026
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.025
negative regulation of cell development GO:0010721 48 0.025
regulation of locomotion GO:0040012 329 0.025
determination of adult lifespan GO:0008340 2 0.024
response to inorganic substance GO:0010035 127 0.023
carbohydrate homeostasis GO:0033500 31 0.023
embryo development GO:0009790 123 0.023
oocyte differentiation GO:0009994 2 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
regulation of cell cycle GO:0051726 393 0.022
purine containing compound catabolic process GO:0072523 411 0.022
regulation of membrane potential GO:0042391 95 0.021
ribonucleoside triphosphate metabolic process GO:0009199 412 0.021
purine ribonucleotide catabolic process GO:0009154 404 0.021
purine nucleoside monophosphate metabolic process GO:0009126 186 0.020
growth GO:0040007 202 0.018
atp catabolic process GO:0006200 157 0.018
response to peptidoglycan GO:0032494 3 0.018
negative regulation of fibroblast proliferation GO:0048147 12 0.018
segmentation GO:0035282 4 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.018
negative regulation of cell death GO:0060548 345 0.018
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.017
neuron projection development GO:0031175 106 0.017
secretion GO:0046903 254 0.017
cellular ion homeostasis GO:0006873 168 0.017
single organism cellular localization GO:1902580 332 0.017
cytokine production involved in immune response GO:0002367 27 0.016
regulation of calcium ion transport GO:0051924 79 0.016
mitotic spindle organization GO:0007052 27 0.016
protein localization to organelle GO:0033365 280 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
regulation of proteolysis GO:0030162 293 0.016
single organism membrane organization GO:0044802 268 0.015
negative regulation of protein metabolic process GO:0051248 391 0.015
amine metabolic process GO:0009308 44 0.015
vesicle mediated transport GO:0016192 371 0.015
regulation of response to wounding GO:1903034 101 0.015
response to type i interferon GO:0034340 14 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
cellular lipid metabolic process GO:0044255 303 0.015
protein maturation GO:0051604 233 0.015
oogenesis GO:0048477 2 0.015
ribonucleotide catabolic process GO:0009261 405 0.015
neuron development GO:0048666 113 0.014
negative regulation of protein modification process GO:0031400 200 0.014
regulation of cell motility GO:2000145 299 0.014
mitochondrion organization GO:0007005 156 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
circulatory system development GO:0072359 262 0.014
regulation of interleukin 10 secretion GO:2001179 4 0.014
microtubule cytoskeleton organization GO:0000226 176 0.014
single organismal cell cell adhesion GO:0016337 148 0.014
signal transduction by phosphorylation GO:0023014 297 0.014
receptor internalization GO:0031623 43 0.014
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.014
response to axon injury GO:0048678 1 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
defense response to bacterium GO:0042742 63 0.013
myosin filament organization GO:0031033 2 0.013
cellular protein complex assembly GO:0043623 188 0.013
lipid metabolic process GO:0006629 381 0.013
microtubule based process GO:0007017 210 0.013
cell development GO:0048468 328 0.013
tube morphogenesis GO:0035239 95 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
chromosome segregation GO:0007059 114 0.012
protein oligomerization GO:0051259 173 0.012
nervous system development GO:0007399 293 0.012
regulation of protein localization GO:0032880 296 0.012
regulation of mapk cascade GO:0043408 262 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
mitotic sister chromatid segregation GO:0000070 53 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
fibroblast proliferation GO:0048144 33 0.012
blood vessel maturation GO:0001955 1 0.012
response to oxygen containing compound GO:1901700 369 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
regulation of chromosome organization GO:0033044 103 0.011
positive regulation of endocytosis GO:0045807 42 0.011
generation of neurons GO:0048699 152 0.011
epithelium development GO:0060429 227 0.011
response to peptide GO:1901652 65 0.011
cellular ketone metabolic process GO:0042180 80 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.011
detection of muramyl dipeptide GO:0032498 1 0.011
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.011
purine ribonucleotide biosynthetic process GO:0009152 79 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.011
nucleoside catabolic process GO:0009164 408 0.011
generation of precursor metabolites and energy GO:0006091 68 0.011
sister chromatid segregation GO:0000819 54 0.011
pattern recognition receptor signaling pathway GO:0002221 48 0.011
tripartite regional subdivision GO:0007351 2 0.011
response to wounding GO:0009611 168 0.011
protein ubiquitination GO:0016567 314 0.010
single organism reproductive process GO:0044702 98 0.010
negative regulation of catalytic activity GO:0043086 335 0.010
positive regulation of secretion GO:0051047 116 0.010
regulation of purine nucleotide metabolic process GO:1900542 264 0.010
entry into host cell GO:0030260 25 0.010
i kappab kinase nf kappab signaling GO:0007249 166 0.010
defense response to other organism GO:0098542 129 0.010
cellular response to dna damage stimulus GO:0006974 379 0.010
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.010

HLA-B disease predictions

Disease DO term ID Size Probability Func Analog Org
acquired immunodeficiency syndrome DOID:635 13 0.763
disease by infectious agent DOID:0050117 34 0.763
viral infectious disease DOID:934 13 0.763
human immunodeficiency virus infectious disease DOID:526 13 0.763
integumentary system disease DOID:16 43 0.240
skin disease DOID:37 33 0.061
immune system disease DOID:2914 155 0.033
primary immunodeficiency disease DOID:612 36 0.019
severe combined immunodeficiency DOID:627 10 0.019
combined t cell and b cell immunodeficiency DOID:628 12 0.019
disease of cellular proliferation DOID:14566 174 0.018
musculoskeletal system disease DOID:17 223 0.014
bone disease DOID:0080001 88 0.009
connective tissue disease DOID:65 109 0.009
bone inflammation disease DOID:3342 10 0.001