Homo sapiens

18 known processes

SPPL2A

signal peptide peptidase-like 2A

(Aliases: IMP3,PSL2)

SPPL2A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cation transport GO:0006812 331 0.114
post embryonic development GO:0009791 2 0.112
secretion GO:0046903 254 0.093
metal ion homeostasis GO:0055065 169 0.090
ribonucleoside triphosphate metabolic process GO:0009199 412 0.070
lipid metabolic process GO:0006629 381 0.067
metal ion transport GO:0030001 272 0.062
cellular homeostasis GO:0019725 196 0.061
cellular metal ion homeostasis GO:0006875 146 0.060
cation homeostasis GO:0055080 189 0.057
cellular cation homeostasis GO:0030003 163 0.055
regulation of response to external stimulus GO:0032101 222 0.054
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.050
intracellular protein transport GO:0006886 270 0.047
ion homeostasis GO:0050801 230 0.045
cellular macromolecule catabolic process GO:0044265 380 0.045
response to oxygen containing compound GO:1901700 369 0.045
cellular ion homeostasis GO:0006873 168 0.044
purine ribonucleoside metabolic process GO:0046128 437 0.044
cellular chemical homeostasis GO:0055082 180 0.043
organophosphate catabolic process GO:0046434 430 0.043
innate immune response GO:0045087 178 0.040
female gamete generation GO:0007292 2 0.039
purine containing compound catabolic process GO:0072523 411 0.037
negative regulation of cell death GO:0060548 345 0.036
regulation of cellular amino acid metabolic process GO:0006521 6 0.036
negative regulation of programmed cell death GO:0043069 321 0.035
defense response GO:0006952 315 0.035
divalent inorganic cation transport GO:0072511 158 0.035
ribonucleotide catabolic process GO:0009261 405 0.034
exocytosis GO:0006887 71 0.034
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.034
purine nucleoside triphosphate catabolic process GO:0009146 392 0.034
purine nucleoside triphosphate metabolic process GO:0009144 412 0.034
determination of adult lifespan GO:0008340 2 0.033
cellular protein catabolic process GO:0044257 261 0.033
nucleoside catabolic process GO:0009164 408 0.033
positive regulation of cellular component organization GO:0051130 376 0.033
immune response GO:0006955 307 0.033
purine ribonucleotide catabolic process GO:0009154 404 0.032
cytoplasmic transport GO:0016482 379 0.032
response to biotic stimulus GO:0009607 276 0.032
chemical homeostasis GO:0048878 306 0.031
regulation of immune response GO:0050776 201 0.031
regulation of protein localization GO:0032880 296 0.030
cellular lipid metabolic process GO:0044255 303 0.030
divalent inorganic cation homeostasis GO:0072507 136 0.029
purine nucleoside catabolic process GO:0006152 398 0.029
secretion by cell GO:0032940 226 0.029
organic anion transport GO:0015711 103 0.029
positive regulation of transport GO:0051050 336 0.029
multicellular organismal aging GO:0010259 3 0.029
ribonucleoside triphosphate catabolic process GO:0009203 391 0.028
cell adhesion GO:0007155 325 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.028
anion transport GO:0006820 161 0.028
signal transduction by phosphorylation GO:0023014 297 0.028
apoptotic signaling pathway GO:0097190 268 0.027
single organism cellular localization GO:1902580 332 0.027
cellular component morphogenesis GO:0032989 314 0.026
oogenesis GO:0048477 2 0.026
ribonucleoside catabolic process GO:0042454 406 0.026
negative regulation of phosphorus metabolic process GO:0010563 267 0.025
reactive oxygen species metabolic process GO:0072593 75 0.024
biological adhesion GO:0022610 331 0.024
transition metal ion transport GO:0000041 23 0.024
establishment of protein localization to organelle GO:0072594 172 0.024
organophosphate biosynthetic process GO:0090407 163 0.023
neurological system process GO:0050877 163 0.023
carbohydrate derivative biosynthetic process GO:1901137 207 0.023
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.023
negative regulation of intracellular signal transduction GO:1902532 183 0.023
nucleoside triphosphate metabolic process GO:0009141 422 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
lipid biosynthetic process GO:0008610 177 0.023
regulation of ion transport GO:0043269 189 0.023
nucleoside phosphate catabolic process GO:1901292 412 0.023
carbohydrate metabolic process GO:0005975 207 0.023
cellular response to endogenous stimulus GO:0071495 336 0.023
guanosine containing compound metabolic process GO:1901068 244 0.022
canonical wnt signaling pathway GO:0060070 116 0.022
regulation of secretion GO:0051046 194 0.022
positive regulation of cell proliferation GO:0008284 301 0.022
modification dependent macromolecule catabolic process GO:0043632 212 0.022
cellular response to oxygen containing compound GO:1901701 276 0.022
reactive nitrogen species metabolic process GO:2001057 3 0.021
compound eye development GO:0048749 1 0.021
regulation of defense response GO:0031347 154 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.021
regulation of cellular ketone metabolic process GO:0010565 50 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
i kappab kinase nf kappab signaling GO:0007249 166 0.021
cellular amino acid metabolic process GO:0006520 116 0.021
locomotory behavior GO:0007626 1 0.021
positive regulation of developmental process GO:0051094 314 0.021
regulation of purine nucleotide metabolic process GO:1900542 264 0.020
negative regulation of apoptotic process GO:0043066 316 0.020
immune system development GO:0002520 195 0.020
response to cytokine GO:0034097 232 0.020
inflammatory response GO:0006954 79 0.020
ras protein signal transduction GO:0007265 73 0.020
cell morphogenesis GO:0000902 296 0.019
negative regulation of apoptotic signaling pathway GO:2001234 97 0.019
peripheral nervous system development GO:0007422 2 0.019
positive regulation of cell migration GO:0030335 172 0.019
amine metabolic process GO:0009308 44 0.019
calcium ion homeostasis GO:0055074 122 0.019
immune effector process GO:0002252 159 0.019
negative regulation of developmental process GO:0051093 247 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
cellular amine metabolic process GO:0044106 41 0.019
oxidation reduction process GO:0055114 396 0.019
segmentation GO:0035282 4 0.018
regulation of cytokine production GO:0001817 232 0.018
embryonic hemopoiesis GO:0035162 4 0.018
nucleotide catabolic process GO:0009166 408 0.018
maintenance of location GO:0051235 112 0.018
negative regulation of catalytic activity GO:0043086 335 0.018
glycoprotein biosynthetic process GO:0009101 91 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
positive regulation of immune system process GO:0002684 283 0.018
oocyte differentiation GO:0009994 2 0.018
mapk cascade GO:0000165 288 0.018
divalent metal ion transport GO:0070838 152 0.018
cellular response to nitrogen compound GO:1901699 144 0.018
negative regulation of response to external stimulus GO:0032102 83 0.018
reactive oxygen species biosynthetic process GO:1903409 4 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
anatomical structure homeostasis GO:0060249 100 0.018
negative regulation of hydrolase activity GO:0051346 182 0.018
stem cell division GO:0017145 2 0.018
system process GO:0003008 349 0.018
regulation of innate immune response GO:0045088 97 0.018
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
negative regulation of protein metabolic process GO:0051248 391 0.017
actin filament based process GO:0030029 224 0.017
cell projection organization GO:0030030 252 0.017
response to tumor necrosis factor GO:0034612 76 0.017
protein localization to organelle GO:0033365 280 0.017
blood vessel morphogenesis GO:0048514 162 0.017
regulation of cell differentiation GO:0045595 393 0.017
response to other organism GO:0051707 261 0.017
guanosine containing compound catabolic process GO:1901069 239 0.017
gtp catabolic process GO:0006184 237 0.017
cell type specific apoptotic process GO:0097285 125 0.017
myeloid leukocyte differentiation GO:0002573 60 0.017
anatomical structure formation involved in morphogenesis GO:0048646 284 0.017
vesicle mediated transport GO:0016192 371 0.017
regulation of glial cell differentiation GO:0045685 3 0.017
small gtpase mediated signal transduction GO:0007264 78 0.016
cellular response to external stimulus GO:0071496 111 0.016
response to nitrogen compound GO:1901698 184 0.016
regulation of immune effector process GO:0002697 91 0.016
single organism membrane organization GO:0044802 268 0.016
regulation of cell motility GO:2000145 299 0.016
positive regulation of nucleoside metabolic process GO:0045979 186 0.016
response to organic cyclic compound GO:0014070 204 0.016
membrane organization GO:0061024 292 0.016
regulation of cell development GO:0060284 161 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.016
syncytium formation by plasma membrane fusion GO:0000768 2 0.016
photoreceptor cell differentiation GO:0046530 2 0.016
negative regulation of cellular protein metabolic process GO:0032269 353 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.015
regulation of cell cycle GO:0051726 393 0.015
blastoderm segmentation GO:0007350 2 0.015
purine ribonucleoside catabolic process GO:0046130 398 0.015
protein maturation GO:0051604 233 0.015
cellular response to starvation GO:0009267 58 0.015
response to bacterium GO:0009617 144 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
glycosyl compound catabolic process GO:1901658 413 0.015
cell development GO:0048468 328 0.015
regulation of cell migration GO:0030334 289 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.015
regulation of nucleotide catabolic process GO:0030811 205 0.015
myeloid cell differentiation GO:0030099 117 0.015
cell projection morphogenesis GO:0048858 129 0.015
glycoprotein metabolic process GO:0009100 110 0.015
wnt signaling pathway GO:0016055 156 0.015
positive regulation of catabolic process GO:0009896 310 0.015
memory GO:0007613 3 0.014
mitochondrion organization GO:0007005 156 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
response to external biotic stimulus GO:0043207 261 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
modification dependent protein catabolic process GO:0019941 209 0.014
organic hydroxy compound metabolic process GO:1901615 147 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.014
regulation of mapk cascade GO:0043408 262 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
glycerolipid metabolic process GO:0046486 107 0.014
inorganic cation transmembrane transport GO:0098662 194 0.014
purine nucleotide catabolic process GO:0006195 405 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
positive regulation of innate immune response GO:0045089 79 0.014
regulation of gtpase activity GO:0043087 180 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
ubiquitin dependent protein catabolic process GO:0006511 206 0.014
single organism carbohydrate metabolic process GO:0044723 193 0.014
cellular protein complex assembly GO:0043623 188 0.014
organic hydroxy compound biosynthetic process GO:1901617 71 0.014
regulation of response to wounding GO:1903034 101 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
monocarboxylic acid metabolic process GO:0032787 185 0.013
response to extracellular stimulus GO:0009991 85 0.013
cellular ketone metabolic process GO:0042180 80 0.013
regulation of reactive oxygen species metabolic process GO:2000377 41 0.013
myoblast fusion GO:0007520 1 0.013
regulation of small gtpase mediated signal transduction GO:0051056 156 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
regulation of multi organism process GO:0043900 157 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
regulation of intracellular transport GO:0032386 195 0.013
microtubule based process GO:0007017 210 0.013
regulation of cellular response to stress GO:0080135 244 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013
regulation of cytoplasmic transport GO:1903649 149 0.013
cation transmembrane transport GO:0098655 238 0.013
response to abiotic stimulus GO:0009628 336 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
regulation of proteolysis GO:0030162 293 0.013
regulation of homeostatic process GO:0032844 121 0.013
embryo development GO:0009790 123 0.013
regulation of canonical wnt signaling pathway GO:0060828 88 0.013
sulfur compound metabolic process GO:0006790 101 0.013
long term memory GO:0007616 2 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
protein catabolic process GO:0030163 325 0.013
endosomal transport GO:0016197 129 0.013
organelle assembly GO:0070925 176 0.013
regulation of kinase activity GO:0043549 314 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
ion transmembrane transport GO:0034220 338 0.013
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.012
cell growth GO:0016049 160 0.012
hemopoiesis GO:0030097 180 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
protein processing GO:0016485 226 0.012
erk1 and erk2 cascade GO:0070371 104 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
positive regulation of intracellular transport GO:0032388 104 0.012
cellular divalent inorganic cation homeostasis GO:0072503 128 0.012
response to fungus GO:0009620 4 0.012
protein localization to nucleus GO:0034504 136 0.012
hindbrain development GO:0030902 3 0.012
negative regulation of proteolysis GO:0045861 132 0.012
gastrulation with mouth forming second GO:0001702 1 0.012
sequestering of metal ion GO:0051238 24 0.012
regulation of protein processing GO:0070613 150 0.012
transition metal ion homeostasis GO:0055076 31 0.012
single organism cell adhesion GO:0098602 179 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.012
response to drug GO:0042493 81 0.012
protein import GO:0017038 130 0.012
positive regulation of gtpase activity GO:0043547 166 0.012
vacuolar transport GO:0007034 34 0.012
cellular response to oxidative stress GO:0034599 85 0.011
atp metabolic process GO:0046034 176 0.011
gtp metabolic process GO:0046039 239 0.011
cellular response to extracellular stimulus GO:0031668 72 0.011
astrocyte differentiation GO:0048708 4 0.011
nuclear transport GO:0051169 179 0.011
regulation of cell growth GO:0001558 135 0.011
response to lipid GO:0033993 206 0.011
cellular response to dna damage stimulus GO:0006974 379 0.011
positive regulation of cell differentiation GO:0045597 211 0.011
negative regulation of cell migration GO:0030336 102 0.011
purine ribonucleotide biosynthetic process GO:0009152 79 0.011
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.011
endomembrane system organization GO:0010256 196 0.011
phosphatidic acid biosynthetic process GO:0006654 4 0.011
inorganic ion transmembrane transport GO:0098660 231 0.011
organ formation GO:0048645 3 0.011
regulation of growth GO:0040008 165 0.011
rna interference GO:0016246 4 0.011
cellular response to hormone stimulus GO:0032870 125 0.011
regulation of gtp catabolic process GO:0033124 180 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
phospholipid metabolic process GO:0006644 99 0.011
cell cycle phase transition GO:0044770 173 0.011
cellular calcium ion homeostasis GO:0006874 117 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
lysosomal transport GO:0007041 33 0.011
generation of neurons GO:0048699 152 0.011
membrane lipid metabolic process GO:0006643 53 0.011
mitotic cell cycle GO:0000278 326 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
regulation of transferase activity GO:0051338 355 0.011
neuroblast proliferation GO:0007405 4 0.011
synaptic transmission GO:0007268 61 0.011
behavior GO:0007610 112 0.011
somitogenesis GO:0001756 2 0.011
response to inorganic substance GO:0010035 127 0.011
vasculature development GO:0001944 181 0.011
negative regulation of transport GO:0051051 176 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
golgi vesicle transport GO:0048193 80 0.011
carboxylic acid transport GO:0046942 63 0.011
circulatory system development GO:0072359 262 0.011
positive regulation of immune response GO:0050778 159 0.011
pharynx development GO:0060465 1 0.011
hair follicle morphogenesis GO:0031069 2 0.010
monovalent inorganic cation transport GO:0015672 128 0.010
nucleocytoplasmic transport GO:0006913 176 0.010
regulation of dna metabolic process GO:0051052 153 0.010
meiosis i GO:0007127 4 0.010
positive regulation of programmed cell death GO:0043068 249 0.010
embryonic forelimb morphogenesis GO:0035115 4 0.010
growth GO:0040007 202 0.010
response to wounding GO:0009611 168 0.010
ribonucleoside monophosphate catabolic process GO:0009158 158 0.010
regulation of protein transport GO:0051223 213 0.010
cell activation GO:0001775 213 0.010
protein localization to membrane GO:0072657 160 0.010
myosin filament organization GO:0031033 2 0.010
mitotic cell cycle phase transition GO:0044772 162 0.010
positive regulation of kinase activity GO:0033674 204 0.010
positive regulation of apoptotic process GO:0043065 246 0.010
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.010
negative regulation of protein modification process GO:0031400 200 0.010
regulation of synaptic plasticity GO:0048167 3 0.010
response to hormone GO:0009725 175 0.010
positive regulation of transferase activity GO:0051347 227 0.010
cell cell signaling GO:0007267 155 0.010
positive regulation of locomotion GO:0040017 186 0.010
blood vessel development GO:0001568 172 0.010
regulation of cell morphogenesis GO:0022604 153 0.010
epithelium development GO:0060429 227 0.010

SPPL2A disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.046
inherited metabolic disorder DOID:655 242 0.034
cancer DOID:162 167 0.026
disease of cellular proliferation DOID:14566 174 0.026
organ system cancer DOID:0050686 164 0.026
musculoskeletal system disease DOID:17 223 0.020
connective tissue disease DOID:65 109 0.020
sensory system disease DOID:0050155 203 0.017
nervous system disease DOID:863 431 0.017
bone disease DOID:0080001 88 0.012
central nervous system disease DOID:331 186 0.010
brain disease DOID:936 73 0.010