Homo sapiens

81 known processes

USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

(Aliases: TGT)

USP14 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular protein catabolic process GO:0044257 261 0.974
proteasome regulatory particle assembly GO:0070682 2 0.904
cellular response to dna damage stimulus GO:0006974 379 0.888
multicellular organismal aging GO:0010259 3 0.883
regulation of proteasomal protein catabolic process GO:0061136 87 0.856
protein catabolic process GO:0030163 325 0.833
modification dependent protein catabolic process GO:0019941 209 0.829
ubiquitin dependent protein catabolic process GO:0006511 206 0.788
cellular macromolecular complex assembly GO:0034622 324 0.787
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.746
cellular protein complex assembly GO:0043623 188 0.738
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.727
protein modification by small protein conjugation GO:0032446 342 0.715
Fly
regulation of protein localization GO:0032880 296 0.692
regulation of peptidase activity GO:0052547 180 0.650
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.633
modification dependent macromolecule catabolic process GO:0043632 212 0.622
proteasomal protein catabolic process GO:0010498 176 0.607
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.596
oogenesis GO:0048477 2 0.586
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 3 0.578
negative regulation of cell death GO:0060548 345 0.547
regulation of establishment of protein localization GO:0070201 242 0.545
positive regulation of nfat protein import into nucleus GO:0051533 3 0.524
post embryonic development GO:0009791 2 0.485
establishment of protein localization to organelle GO:0072594 172 0.454
protein import GO:0017038 130 0.444
protein modification by small protein removal GO:0070646 92 0.430
regulation of protein transport GO:0051223 213 0.422
regulation of cellular protein catabolic process GO:1903362 96 0.412
nuclear transport GO:0051169 179 0.412
regulation of protein import into nucleus GO:0042306 78 0.411
protein targeting GO:0006605 187 0.407
regulation of response to dna damage stimulus GO:2001020 94 0.407
regulation of intracellular protein transport GO:0033157 123 0.399
nuclear division GO:0000280 128 0.397
regulation of transcription factor import into nucleus GO:0042990 39 0.393
mitochondrion organization GO:0007005 156 0.373
blastocyst development GO:0001824 3 0.362
regulation of cardiac muscle hypertrophy in response to stress GO:1903242 2 0.354
mitotic cell cycle process GO:1903047 286 0.343
cellular macromolecule catabolic process GO:0044265 380 0.338
chemical homeostasis GO:0048878 306 0.328
regulation of protein localization to nucleus GO:1900180 85 0.323
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.316
positive regulation of proteolysis GO:0045862 142 0.315
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.315
protein localization to organelle GO:0033365 280 0.311
secretion GO:0046903 254 0.310
taxis GO:0042330 157 0.305
regulation of protein targeting GO:1903533 91 0.303
regulation of proteolysis GO:0030162 293 0.300
positive regulation of peptidase activity GO:0010952 88 0.298
regulation of mitotic cell cycle GO:0007346 189 0.294
negative regulation of apoptotic process GO:0043066 316 0.294
regulation of cytoplasmic transport GO:1903649 149 0.294
secretion by cell GO:0032940 226 0.286
regulation of intracellular transport GO:0032386 195 0.271
negative regulation of programmed cell death GO:0043069 321 0.269
determination of adult lifespan GO:0008340 2 0.268
apoptotic signaling pathway GO:0097190 268 0.260
regulation of cell cycle GO:0051726 393 0.257
single organism nuclear import GO:1902593 104 0.247
regulation of release of cytochrome c from mitochondria GO:0090199 29 0.237
regulation of apoptotic signaling pathway GO:2001233 175 0.232
positive regulation of cellular catabolic process GO:0031331 284 0.228
mitotic cell cycle GO:0000278 326 0.226
protein localization to nucleus GO:0034504 136 0.221
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.214
regulation of cellular component biogenesis GO:0044087 281 0.209
intracellular protein transport GO:0006886 270 0.209
regulation of nucleocytoplasmic transport GO:0046822 98 0.205
protein k63 linked deubiquitination GO:0070536 21 0.201
release of cytochrome c from mitochondria GO:0001836 35 0.192
apoptotic mitochondrial changes GO:0008637 57 0.190
single organism cellular localization GO:1902580 332 0.187
nucleocytoplasmic transport GO:0006913 176 0.186
positive regulation of protein complex assembly GO:0031334 86 0.184
nuclear import GO:0051170 106 0.178
positive regulation of endopeptidase activity GO:0010950 84 0.176
regulation of protein catabolic process GO:0042176 155 0.171
protein targeting to nucleus GO:0044744 104 0.169
organelle fission GO:0048285 149 0.162
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.154
regulation of protein complex assembly GO:0043254 147 0.147
negative regulation of proteolysis GO:0045861 132 0.144
protein import into nucleus GO:0006606 104 0.141
female gamete generation GO:0007292 2 0.137
peroxisome organization GO:0007031 28 0.131
positive regulation of protein phosphorylation GO:0001934 313 0.130
cellular response to oxygen containing compound GO:1901701 276 0.126
negative regulation of apoptotic signaling pathway GO:2001234 97 0.126
chemotaxis GO:0006935 157 0.125
positive regulation of phosphorylation GO:0042327 394 0.123
regulation of kinase activity GO:0043549 314 0.119
positive regulation of cellular component biogenesis GO:0044089 158 0.118
regulation of secretion GO:0051046 194 0.115
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.111
positive regulation of cardiac muscle adaptation GO:0010615 1 0.111
positive regulation of protein catabolic process GO:0045732 75 0.110
sleep GO:0030431 2 0.104
ribonucleoside monophosphate catabolic process GO:0009158 158 0.099
chromatin organization GO:0006325 351 0.096
aging GO:0007568 66 0.094
double strand break repair GO:0006302 101 0.093
regulation of protein ubiquitination GO:0031396 95 0.093
positive regulation of cytoplasmic transport GO:1903651 82 0.091
positive regulation of protein kinase activity GO:0045860 190 0.091
defense response GO:0006952 315 0.091
negative regulation of peptidase activity GO:0010466 91 0.089
dna repair GO:0006281 198 0.089
negative regulation of endopeptidase activity GO:0010951 84 0.089
cell development GO:0048468 328 0.088
regulation of cellular response to stress GO:0080135 244 0.084
positive regulation of transcription factor import into nucleus GO:0042993 25 0.082
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.082
microtubule cytoskeleton organization GO:0000226 176 0.082
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.078
cellular homeostasis GO:0019725 196 0.078
regulation of homeostatic process GO:0032844 121 0.078
regulation of transferase activity GO:0051338 355 0.076
associative learning GO:0008306 1 0.072
embryo development GO:0009790 123 0.072
mitotic spindle elongation GO:0000022 4 0.071
protein polyubiquitination GO:0000209 110 0.071
negative regulation of organelle organization GO:0010639 126 0.070
positive regulation of developmental process GO:0051094 314 0.070
regulation of cell growth GO:0001558 135 0.070
epithelium development GO:0060429 227 0.070
positive regulation of protein transport GO:0051222 135 0.069
sister chromatid segregation GO:0000819 54 0.068
reproduction GO:0000003 63 0.068
nervous system development GO:0007399 293 0.068
regulation of growth GO:0040008 165 0.067
vesicle mediated transport GO:0016192 371 0.067
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.067
monoubiquitinated protein deubiquitination GO:0035520 6 0.066
purine nucleoside monophosphate catabolic process GO:0009128 158 0.066
cellular chemical homeostasis GO:0055082 180 0.065
microtubule based process GO:0007017 210 0.065
positive regulation of transferase activity GO:0051347 227 0.065
nitrogen compound transport GO:0071705 191 0.064
protein ubiquitination GO:0016567 314 0.063
Fly
transcription factor import into nucleus GO:0042991 40 0.062
locomotory behavior GO:0007626 1 0.061
signal transduction by phosphorylation GO:0023014 297 0.061
anion transport GO:0006820 161 0.060
positive regulation of kinase activity GO:0033674 204 0.059
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.059
response to oxygen containing compound GO:1901700 369 0.058
nucleoside phosphate catabolic process GO:1901292 412 0.056
spermatid development GO:0007286 4 0.055
spermatid differentiation GO:0048515 4 0.055
ribonucleoside monophosphate metabolic process GO:0009161 187 0.054
positive regulation of intracellular transport GO:0032388 104 0.053
response to drug GO:0042493 81 0.052
monoubiquitinated histone h2a deubiquitination GO:0035522 3 0.052
negative regulation of cellular component organization GO:0051129 235 0.051
positive regulation of cellular component organization GO:0051130 376 0.051
proteasome assembly GO:0043248 7 0.051
chromatin modification GO:0016568 298 0.050
posttranscriptional regulation of gene expression GO:0010608 213 0.049
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.049
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.049
growth GO:0040007 202 0.049
amide transport GO:0042886 76 0.048
positive regulation of cell cycle GO:0045787 140 0.048
chromosome segregation GO:0007059 114 0.047
blood vessel development GO:0001568 172 0.046
mapk cascade GO:0000165 288 0.046
positive regulation of protein localization to nucleus GO:1900182 48 0.045
signal transduction in response to dna damage GO:0042770 57 0.045
negative regulation of phosphorylation GO:0042326 174 0.045
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.045
maintenance of location GO:0051235 112 0.044
response to radiation GO:0009314 151 0.044
cell growth GO:0016049 160 0.044
spindle elongation GO:0051231 4 0.042
negative regulation of cellular protein metabolic process GO:0032269 353 0.042
meiotic chromosome segregation GO:0045132 4 0.042
protein dna complex subunit organization GO:0071824 80 0.041
positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 1 0.041
peroxisome fission GO:0016559 10 0.041
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.040
chordate embryonic development GO:0043009 34 0.040
positive regulation of catabolic process GO:0009896 310 0.040
protein maturation GO:0051604 233 0.038
striated muscle adaptation GO:0014888 4 0.038
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.037
negative regulation of phosphate metabolic process GO:0045936 267 0.037
purine ribonucleotide catabolic process GO:0009154 404 0.036
protein processing GO:0016485 226 0.036
maintenance of location in cell GO:0051651 62 0.036
negative regulation of cell cycle process GO:0010948 121 0.035
regulation of protein processing GO:0070613 150 0.035
regulation of dna templated transcription initiation GO:2000142 9 0.035
purine ribonucleoside catabolic process GO:0046130 398 0.035
negative regulation of phosphorus metabolic process GO:0010563 267 0.035
maintenance of protein location in cell GO:0032507 56 0.034
regulation of muscle system process GO:0090257 53 0.034
i kappab kinase nf kappab signaling GO:0007249 166 0.034
regulation of protein kinase activity GO:0045859 289 0.034
nucleotide excision repair GO:0006289 31 0.034
protein secretion GO:0009306 98 0.034
positive regulation of protein import into nucleus GO:0042307 46 0.034
nucleoside monophosphate catabolic process GO:0009125 159 0.033
organic anion transport GO:0015711 103 0.033
metal ion transport GO:0030001 272 0.033
ossification GO:0001503 121 0.033
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.032
cell morphogenesis GO:0000902 296 0.032
recombinational repair GO:0000725 50 0.032
endocytosis GO:0006897 159 0.032
negative regulation of protein maturation GO:1903318 142 0.031
neurogenesis GO:0022008 169 0.031
system process GO:0003008 349 0.031
signal transduction by p53 class mediator GO:0072331 72 0.030
regulation of secretion by cell GO:1903530 177 0.030
regulation of protein serine threonine kinase activity GO:0071900 179 0.030
negative regulation of intracellular signal transduction GO:1902532 183 0.030
monoubiquitinated histone deubiquitination GO:0035521 3 0.029
anterograde axon cargo transport GO:0008089 1 0.029
regulation of cell cycle process GO:0010564 266 0.029
cell activation GO:0001775 213 0.029
memory GO:0007613 3 0.028
nucleotide catabolic process GO:0009166 408 0.028
regulation of mitochondrion organization GO:0010821 54 0.027
positive regulation of cellular protein catabolic process GO:1903364 37 0.027
nls bearing protein import into nucleus GO:0006607 2 0.027
negative regulation of transport GO:0051051 176 0.027
purine nucleoside catabolic process GO:0006152 398 0.027
response to inorganic substance GO:0010035 127 0.026
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.026
maintenance of protein location GO:0045185 57 0.026
glycosyl compound catabolic process GO:1901658 413 0.025
morphogenesis of embryonic epithelium GO:0016331 4 0.025
negative regulation of protein localization to nucleus GO:1900181 34 0.025
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.025
rna catabolic process GO:0006401 71 0.024
response to abiotic stimulus GO:0009628 336 0.024
skeletal muscle fiber development GO:0048741 12 0.024
cardiac muscle adaptation GO:0014887 4 0.024
intrinsic apoptotic signaling pathway GO:0097193 127 0.023
cytoplasmic transport GO:0016482 379 0.023
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.023
response to calcium ion GO:0051592 46 0.023
regulation of protein stability GO:0031647 87 0.023
protein deubiquitination GO:0016579 79 0.023
negative regulation of cell proliferation GO:0008285 228 0.023
ribonucleotide catabolic process GO:0009261 405 0.023
cellular ketone metabolic process GO:0042180 80 0.023
protein k63 linked ubiquitination GO:0070534 31 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
covalent chromatin modification GO:0016569 254 0.022
negative regulation of cell migration GO:0030336 102 0.022
cell cycle checkpoint GO:0000075 117 0.022
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.022
negative regulation of protein transport GO:0051224 75 0.022
atp metabolic process GO:0046034 176 0.022
regulation of cellular component movement GO:0051270 334 0.022
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.021
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 8 0.021
cardiac muscle hypertrophy in response to stress GO:0014898 4 0.021
regulation of signal transduction by p53 class mediator GO:1901796 26 0.021
hyperosmotic response GO:0006972 4 0.021
regulation of mitosis GO:0007088 63 0.021
multicellular organismal response to stress GO:0033555 1 0.021
organophosphate catabolic process GO:0046434 430 0.021
amine metabolic process GO:0009308 44 0.021
divalent metal ion transport GO:0070838 152 0.020
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.020
mitotic cell cycle phase transition GO:0044772 162 0.020
cation transport GO:0006812 331 0.020
double strand break repair via homologous recombination GO:0000724 50 0.020
calcium ion transport GO:0006816 147 0.020
response to organic cyclic compound GO:0014070 204 0.020
striated muscle hypertrophy GO:0014897 14 0.020
purine nucleoside triphosphate catabolic process GO:0009146 392 0.020
regulation of peptide transport GO:0090087 62 0.020
regulation of growth rate GO:0040009 1 0.020
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.019
lymphocyte activation GO:0046649 133 0.019
multicellular organism reproduction GO:0032504 42 0.018
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.018
nonribosomal peptide biosynthetic process GO:0019184 4 0.018
cell division GO:0051301 168 0.018
regulation of exit from mitosis GO:0007096 6 0.018
protein dephosphorylation GO:0006470 81 0.018
mitochondrial fission GO:0000266 14 0.018
ribonucleoside catabolic process GO:0042454 406 0.018
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.018
protein k48 linked deubiquitination GO:0071108 19 0.018
positive regulation of protein ubiquitination GO:0031398 53 0.018
developmental growth GO:0048589 48 0.017
cellular lipid metabolic process GO:0044255 303 0.017
cell part morphogenesis GO:0032990 137 0.017
cellular response to cytokine stimulus GO:0071345 181 0.017
response to biotic stimulus GO:0009607 276 0.017
neuron projection morphogenesis GO:0048812 50 0.017
second messenger mediated signaling GO:0019932 78 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
nucleoside monophosphate metabolic process GO:0009123 191 0.016
neurological system process GO:0050877 163 0.016
regulation of protein secretion GO:0050708 86 0.016
cell projection organization GO:0030030 252 0.016
negative regulation of mitotic cell cycle GO:0045930 102 0.016
cell cycle phase transition GO:0044770 173 0.016
response to nitrogen compound GO:1901698 184 0.016
ribonucleoside triphosphate catabolic process GO:0009203 391 0.016
eye development GO:0001654 42 0.016
immune system development GO:0002520 195 0.016
rrna metabolic process GO:0016072 40 0.016
lipid biosynthetic process GO:0008610 177 0.016
protein deneddylation GO:0000338 10 0.016
negative regulation of cytoplasmic transport GO:1903650 46 0.015
adult locomotory behavior GO:0008344 1 0.015
purine containing compound catabolic process GO:0072523 411 0.015
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 10 0.015
muscle system process GO:0003012 81 0.015
nucleoside triphosphate metabolic process GO:0009141 422 0.015
negative regulation of protein import into nucleus GO:0042308 30 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
regulation of cellular amino acid metabolic process GO:0006521 6 0.015
regulation of chromosome organization GO:0033044 103 0.015
generation of neurons GO:0048699 152 0.015
negative regulation of cell cycle GO:0045786 193 0.015
neuron development GO:0048666 113 0.014
ventricular system development GO:0021591 1 0.014
nf kappab import into nucleus GO:0042348 22 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
cell projection morphogenesis GO:0048858 129 0.014
cell cycle g1 s phase transition GO:0044843 80 0.014
cellular response to lipid GO:0071396 127 0.014
cell morphogenesis involved in differentiation GO:0000904 144 0.014
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.014
brain morphogenesis GO:0048854 1 0.014
negative regulation of protein processing GO:0010955 142 0.014
divalent inorganic cation transport GO:0072511 158 0.013
rna interference GO:0016246 4 0.013
positive regulation of intracellular protein transport GO:0090316 76 0.013
single organism membrane organization GO:0044802 268 0.013
dna catabolic process exonucleolytic GO:0000738 17 0.013
chromosome separation GO:0051304 23 0.013
nfat protein import into nucleus GO:0051531 5 0.013
regulation of membrane potential GO:0042391 95 0.013
positive regulation of meiotic cell cycle GO:0051446 2 0.013
organ morphogenesis GO:0009887 147 0.013
muscle structure development GO:0061061 98 0.013
mrna catabolic process GO:0006402 56 0.013
regulation of system process GO:0044057 101 0.013
negative regulation of response to dna damage stimulus GO:2001021 33 0.013
regulation of dna metabolic process GO:0051052 153 0.013
regulation of protein maturation GO:1903317 150 0.013
response to other organism GO:0051707 261 0.013
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 15 0.012
histone modification GO:0016570 251 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
metaphase anaphase transition of cell cycle GO:0044784 21 0.012
positive regulation of cell growth GO:0030307 48 0.012
segmentation GO:0035282 4 0.012
regulation of cell division GO:0051302 116 0.012
signal release GO:0023061 70 0.012
embryo development ending in birth or egg hatching GO:0009792 34 0.012
cognition GO:0050890 43 0.012
negative regulation of nucleocytoplasmic transport GO:0046823 37 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
nuclear transcribed mrna catabolic process GO:0000956 48 0.012
multi organism reproductive process GO:0044703 54 0.012
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.012
positive regulation of transport GO:0051050 336 0.012
dephosphorylation GO:0016311 209 0.011
negative regulation of mapk cascade GO:0043409 56 0.011
protein dna complex assembly GO:0065004 64 0.011
response to uv GO:0009411 73 0.011
innate immune response GO:0045087 178 0.011
regulation of transcription from rna polymerase i promoter GO:0006356 10 0.011
protein deglycosylation GO:0006517 2 0.011
mitotic sister chromatid segregation GO:0000070 53 0.011
response to bacterium GO:0009617 144 0.011
negative regulation of mitochondrion organization GO:0010823 22 0.011
viral life cycle GO:0019058 132 0.011
myotube differentiation GO:0014902 22 0.011
histone deubiquitination GO:0016578 16 0.011
positive regulation of growth GO:0045927 58 0.011
protein polymerization GO:0051258 71 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
cerebral cortex radially oriented cell migration GO:0021799 1 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
mitotic spindle organization GO:0007052 27 0.011
negative regulation of intracellular protein transport GO:0090317 42 0.010
microtubule organizing center organization GO:0031023 62 0.010
regulation of muscle hypertrophy GO:0014743 10 0.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.010
regulation of cell morphogenesis GO:0022604 153 0.010
protein tetramerization GO:0051262 47 0.010

USP14 disease predictions

Disease DO term ID Size Probability Func Analog Org