Homo sapiens

0 known processes

USP18

ubiquitin specific peptidase 18

(Aliases: ISG43,UBP43)

USP18 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
viral life cycle GO:0019058 132 0.476
nucleoside phosphate biosynthetic process GO:1901293 109 0.398
negative regulation of multi organism process GO:0043901 92 0.225
protein modification by small protein conjugation GO:0032446 342 0.186
chemical homeostasis GO:0048878 306 0.179
response to other organism GO:0051707 261 0.178
response to cytokine GO:0034097 232 0.175
response to biotic stimulus GO:0009607 276 0.167
cellular response to cytokine stimulus GO:0071345 181 0.153
multi organism cellular process GO:0044764 156 0.133
regulation of defense response to virus GO:0050688 33 0.131
regulation of viral genome replication GO:0045069 48 0.122
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.117
regulation of multi organism process GO:0043900 157 0.117
defense response to other organism GO:0098542 129 0.114
positive regulation of myeloid cell differentiation GO:0045639 39 0.111
protein catabolic process GO:0030163 325 0.109
regulation of intracellular transport GO:0032386 195 0.107
cytokine production GO:0001816 247 0.094
negative regulation of protein metabolic process GO:0051248 391 0.088
cytoplasmic transport GO:0016482 379 0.085
carbohydrate derivative biosynthetic process GO:1901137 207 0.083
nuclear transport GO:0051169 179 0.081
response to external biotic stimulus GO:0043207 261 0.081
single organism cellular localization GO:1902580 332 0.080
viral genome replication GO:0019079 50 0.080
cellular macromolecule catabolic process GO:0044265 380 0.079
defense response GO:0006952 315 0.076
defense response to virus GO:0051607 71 0.075
positive regulation of cell death GO:0010942 263 0.075
negative regulation of viral process GO:0048525 66 0.074
lipoprotein metabolic process GO:0042157 42 0.071
interspecies interaction between organisms GO:0044419 156 0.071
immune effector process GO:0002252 159 0.070
organophosphate biosynthetic process GO:0090407 163 0.070
immune response GO:0006955 307 0.067
rna interference GO:0016246 4 0.065
glycoprotein biosynthetic process GO:0009101 91 0.065
negative regulation of catalytic activity GO:0043086 335 0.063
response to interferon alpha GO:0035455 11 0.061
purine nucleotide biosynthetic process GO:0006164 84 0.061
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.060
carbohydrate metabolic process GO:0005975 207 0.057
response to virus GO:0009615 126 0.056
negative regulation of cellular protein metabolic process GO:0032269 353 0.055
regulation of homeostatic process GO:0032844 121 0.054
organonitrogen compound biosynthetic process GO:1901566 200 0.053
protein ubiquitination GO:0016567 314 0.052
regulation of defense response to virus by host GO:0050691 22 0.051
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.050
regulation of cytokine production GO:0001817 232 0.049
cellular macromolecular complex assembly GO:0034622 324 0.048
protein localization to organelle GO:0033365 280 0.048
nucleotide biosynthetic process GO:0009165 109 0.048
negative regulation of programmed cell death GO:0043069 321 0.048
negative regulation of protein modification process GO:0031400 200 0.046
glycosylation GO:0070085 71 0.045
positive regulation of interferon alpha production GO:0032727 11 0.045
ion homeostasis GO:0050801 230 0.045
interferon beta production GO:0032608 23 0.045
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.044
modification dependent protein catabolic process GO:0019941 209 0.043
regulation of myeloid cell differentiation GO:0045637 81 0.043
negative regulation of cell death GO:0060548 345 0.042
positive regulation of erythrocyte differentiation GO:0045648 11 0.042
cellular response to organic cyclic compound GO:0071407 127 0.040
innate immune response GO:0045087 178 0.040
lipoprotein biosynthetic process GO:0042158 33 0.039
glucose metabolic process GO:0006006 45 0.039
protein acylation GO:0043543 138 0.037
positive regulation of homeostatic process GO:0032846 47 0.037
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.036
cellular protein catabolic process GO:0044257 261 0.035
positive regulation of cell differentiation GO:0045597 211 0.034
regulation of cellular component movement GO:0051270 334 0.034
purine containing compound biosynthetic process GO:0072522 88 0.033
modification dependent macromolecule catabolic process GO:0043632 212 0.033
regulation of viral process GO:0050792 103 0.032
regulation of anatomical structure morphogenesis GO:0022603 286 0.032
positive regulation of hydrolase activity GO:0051345 331 0.032
viral process GO:0016032 146 0.032
positive regulation of programmed cell death GO:0043068 249 0.031
negative regulation of apoptotic signaling pathway GO:2001234 97 0.031
positive regulation of rig i signaling pathway GO:1900246 4 0.031
positive regulation of immune system process GO:0002684 283 0.030
response to type i interferon GO:0034340 14 0.030
regulation of nucleocytoplasmic transport GO:0046822 98 0.030
positive regulation of proteolysis GO:0045862 142 0.030
regulation of cell motility GO:2000145 299 0.029
single organism membrane organization GO:0044802 268 0.028
negative regulation of viral genome replication GO:0045071 35 0.028
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.027
glycoprotein metabolic process GO:0009100 110 0.027
regulation of protein ubiquitination GO:0031396 95 0.027
myeloid cell differentiation GO:0030099 117 0.027
posttranscriptional regulation of gene expression GO:0010608 213 0.027
negative regulation of apoptotic process GO:0043066 316 0.026
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.026
positive regulation of intracellular protein transport GO:0090316 76 0.026
negative regulation of response to external stimulus GO:0032102 83 0.025
immune system development GO:0002520 195 0.025
regulation of defense response GO:0031347 154 0.025
response to lipid GO:0033993 206 0.025
macromolecule glycosylation GO:0043413 63 0.025
negative regulation of protein ubiquitination GO:0031397 35 0.024
erythrocyte homeostasis GO:0034101 31 0.024
ribonucleoside triphosphate catabolic process GO:0009203 391 0.024
hemopoiesis GO:0030097 180 0.024
cellular response to interferon alpha GO:0035457 4 0.024
homeostasis of number of cells GO:0048872 40 0.023
regulation of apoptotic signaling pathway GO:2001233 175 0.023
nucleoside triphosphate metabolic process GO:0009141 422 0.023
negative regulation of intracellular signal transduction GO:1902532 183 0.023
chromatin organization GO:0006325 351 0.023
protein myristoylation GO:0018377 1 0.023
female gamete generation GO:0007292 2 0.023
nucleoside catabolic process GO:0009164 408 0.023
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.023
protein import GO:0017038 130 0.022
regulation of cytoplasmic transport GO:1903649 149 0.022
nitrogen compound transport GO:0071705 191 0.022
multicellular organismal aging GO:0010259 3 0.022
regulation of peptidase activity GO:0052547 180 0.022
cellular response to endogenous stimulus GO:0071495 336 0.022
mitochondrion organization GO:0007005 156 0.022
protein localization to nucleus GO:0034504 136 0.022
nuclear import GO:0051170 106 0.021
locomotory behavior GO:0007626 1 0.021
regulation of protein catabolic process GO:0042176 155 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
regulation of response to biotic stimulus GO:0002831 55 0.021
nucleocytoplasmic transport GO:0006913 176 0.021
negative regulation of hydrolase activity GO:0051346 182 0.021
regulation of membrane potential GO:0042391 95 0.021
ribonucleoside catabolic process GO:0042454 406 0.021
cellular amino acid metabolic process GO:0006520 116 0.021
single organism nuclear import GO:1902593 104 0.021
nucleoside triphosphate catabolic process GO:0009143 394 0.021
positive regulation of cytoplasmic transport GO:1903651 82 0.021
regulation of nuclease activity GO:0032069 11 0.021
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.021
cellular response to dsrna GO:0071359 19 0.021
organic hydroxy compound metabolic process GO:1901615 147 0.020
regulation of transferase activity GO:0051338 355 0.020
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.020
cellular response to oxygen containing compound GO:1901701 276 0.020
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.020
enzyme linked receptor protein signaling pathway GO:0007167 303 0.020
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.020
regulation of protein transport GO:0051223 213 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
positive regulation of apoptotic process GO:0043065 246 0.019
positive regulation of catabolic process GO:0009896 310 0.019
organophosphate catabolic process GO:0046434 430 0.019
hexose metabolic process GO:0019318 55 0.019
response to abiotic stimulus GO:0009628 336 0.019
regulation of cell differentiation GO:0045595 393 0.019
protein targeting GO:0006605 187 0.019
determination of adult lifespan GO:0008340 2 0.019
myeloid cell homeostasis GO:0002262 34 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
positive regulation of type i interferon production GO:0032481 20 0.019
post embryonic development GO:0009791 2 0.019
rna processing GO:0006396 255 0.018
nucleotide catabolic process GO:0009166 408 0.018
mitotic cell cycle process GO:1903047 286 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
single organism carbohydrate metabolic process GO:0044723 193 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
ribonucleoprotein complex subunit organization GO:0071826 81 0.018
atp metabolic process GO:0046034 176 0.018
regulation of ion homeostasis GO:2000021 73 0.018
protein processing GO:0016485 226 0.018
glycosyl compound catabolic process GO:1901658 413 0.017
protein lipidation GO:0006497 33 0.017
purine ribonucleotide catabolic process GO:0009154 404 0.017
protein glycosylation GO:0006486 62 0.017
posttranscriptional gene silencing GO:0016441 25 0.017
response to nitrogen compound GO:1901698 184 0.017
positive regulation of transferase activity GO:0051347 227 0.017
purine nucleoside triphosphate metabolic process GO:0009144 412 0.016
behavioral response to ethanol GO:0048149 2 0.016
nucleoside phosphate catabolic process GO:1901292 412 0.016
positive regulation of intracellular transport GO:0032388 104 0.016
protein oligomerization GO:0051259 173 0.016
negative regulation of mitochondrial depolarization GO:0051902 2 0.016
cellular response to glucocorticoid stimulus GO:0071385 4 0.016
actin filament based process GO:0030029 224 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
regulation of cellular response to stress GO:0080135 244 0.016
regulation of intracellular protein transport GO:0033157 123 0.015
regulation of erythrocyte differentiation GO:0045646 17 0.015
dsrna fragmentation GO:0031050 13 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
negative regulation of peptidase activity GO:0010466 91 0.015
erythrocyte differentiation GO:0030218 28 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
positive regulation of endopeptidase activity GO:0010950 84 0.015
dephosphorylation GO:0016311 209 0.015
positive regulation of multi organism process GO:0043902 56 0.015
regulation of protein maturation GO:1903317 150 0.015
membrane organization GO:0061024 292 0.015
regulation of cellular ketone metabolic process GO:0010565 50 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
small gtpase mediated signal transduction GO:0007264 78 0.014
regulation of cysteine type endopeptidase activity GO:2000116 127 0.014
negative regulation of kinase activity GO:0033673 106 0.014
regulation of interferon beta production GO:0032648 22 0.014
regulation of response to external stimulus GO:0032101 222 0.014
cellular protein complex assembly GO:0043623 188 0.014
protein import into nucleus GO:0006606 104 0.014
negative regulation of defense response to virus by host GO:0050689 4 0.014
glucose homeostasis GO:0042593 31 0.014
purine containing compound catabolic process GO:0072523 411 0.014
hematopoietic or lymphoid organ development GO:0048534 186 0.014
regulation of cellular amino acid metabolic process GO:0006521 6 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
ras protein signal transduction GO:0007265 73 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.014
negative regulation of cellular component organization GO:0051129 235 0.014
positive regulation of synaptic transmission GO:0050806 4 0.013
protein targeting to nucleus GO:0044744 104 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
release of cytochrome c from mitochondria GO:0001836 35 0.013
stress activated mapk cascade GO:0051403 93 0.013
small molecule biosynthetic process GO:0044283 157 0.013
epinephrine transport GO:0048241 1 0.013
response to organic cyclic compound GO:0014070 204 0.013
mitotic cell cycle GO:0000278 326 0.013
response to growth factor GO:0070848 205 0.013
regulation of interferon gamma production GO:0032649 36 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
regulation of protein kinase activity GO:0045859 289 0.013
protein maturation GO:0051604 233 0.013
type i interferon signaling pathway GO:0060337 11 0.013
positive regulation of peptidase activity GO:0010952 88 0.013
muscle structure development GO:0061061 98 0.013
negative regulation of defense response to virus GO:0050687 10 0.013
intracellular transport of viral protein in host cell GO:0019060 4 0.013
cellular component morphogenesis GO:0032989 314 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
atp catabolic process GO:0006200 157 0.012
growth GO:0040007 202 0.012
cell growth GO:0016049 160 0.012
chromatin modification GO:0016568 298 0.012
regulation of protein localization to nucleus GO:1900180 85 0.012
regulation of stress activated mapk cascade GO:0032872 84 0.012
cellular response to hormone stimulus GO:0032870 125 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
negative regulation of proteolysis GO:0045861 132 0.012
isg15 protein conjugation GO:0032020 5 0.012
regulation of mapk cascade GO:0043408 262 0.012
ncrna processing GO:0034470 83 0.012
positive regulation of cytokine production GO:0001819 167 0.012
mapk cascade GO:0000165 288 0.012
response to oxygen containing compound GO:1901700 369 0.012
adult locomotory behavior GO:0008344 1 0.012
activation of cysteine type endopeptidase activity GO:0097202 57 0.012
organic acid biosynthetic process GO:0016053 97 0.012
epithelial cell proliferation GO:0050673 128 0.012
negative regulation of protein maturation GO:1903318 142 0.012
wnt signaling pathway GO:0016055 156 0.012
negative regulation of growth GO:0045926 97 0.012
ribonucleoside monophosphate metabolic process GO:0009161 187 0.012
negative regulation of phosphorylation GO:0042326 174 0.011
memory GO:0007613 3 0.011
actin mediated cell contraction GO:0070252 12 0.011
mrna metabolic process GO:0016071 175 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
nuclear export GO:0051168 69 0.011
positive regulation of cellular component organization GO:0051130 376 0.011
regulation of cell migration GO:0030334 289 0.011
ncrna metabolic process GO:0034660 108 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.011
regulation of membrane depolarization GO:0003254 19 0.011
defense response to bacterium GO:0042742 63 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.011
circulatory system development GO:0072359 262 0.011
monosaccharide metabolic process GO:0005996 74 0.011
covalent chromatin modification GO:0016569 254 0.011
hindbrain development GO:0030902 3 0.011
cellular homeostasis GO:0019725 196 0.011
neuromuscular junction development GO:0007528 3 0.011
regeneration GO:0031099 4 0.011
regulation of protein localization GO:0032880 296 0.011
regulation of cellular amine metabolic process GO:0033238 11 0.011
regulation of mda 5 signaling pathway GO:0039533 4 0.011
nervous system development GO:0007399 293 0.011
protein sumoylation GO:0016925 25 0.011
regulation of ribonuclease activity GO:0060700 3 0.011
intracellular protein transport GO:0006886 270 0.011
inner ear morphogenesis GO:0042472 4 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
negative regulation of cell motility GO:2000146 104 0.010
vesicle mediated transport GO:0016192 371 0.010
negative regulation of transferase activity GO:0051348 124 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010
negative regulation of transport GO:0051051 176 0.010
regulation of proteolysis GO:0030162 293 0.010
nucleoside monophosphate catabolic process GO:0009125 159 0.010
regulation of growth GO:0040008 165 0.010
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.010
ribonucleoprotein complex assembly GO:0022618 78 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
regulation of nucleotide metabolic process GO:0006140 269 0.010
transcription factor import into nucleus GO:0042991 40 0.010
nucleoside monophosphate metabolic process GO:0009123 191 0.010
cellular lipid metabolic process GO:0044255 303 0.010
regulation of neural precursor cell proliferation GO:2000177 4 0.010
regulation of ras protein signal transduction GO:0046578 155 0.010
purine ribonucleoside metabolic process GO:0046128 437 0.010
response to dsrna GO:0043331 25 0.010
protein homooligomerization GO:0051260 100 0.010
positive regulation of wnt signaling pathway GO:0030177 54 0.010
intracellular receptor signaling pathway GO:0030522 104 0.010

USP18 disease predictions

Disease DO term ID Size Probability Func Analog Org
diabetes mellitus DOID:9351 31 0.027
disease of metabolism DOID:0014667 295 0.027
carbohydrate metabolism disease DOID:0050013 32 0.027
glucose metabolism disease DOID:4194 32 0.027
acquired metabolic disease DOID:0060158 58 0.027
musculoskeletal system disease DOID:17 223 0.024
connective tissue disease DOID:65 109 0.024
bone development disease DOID:0080006 55 0.019
bone disease DOID:0080001 88 0.019
sensory system disease DOID:0050155 203 0.017
nervous system disease DOID:863 431 0.017
eye and adnexa disease DOID:1492 150 0.012
eye disease DOID:5614 149 0.012
central nervous system disease DOID:331 186 0.011