Homo sapiens

53 known processes

MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

(Aliases: NIK,FLH21957,HGK,FLJ20373,FLJ10410,KIAA0687,FLJ90111)

MAP4K4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amine metabolic process GO:0044106 41 0.381
amine metabolic process GO:0009308 44 0.272
neuron projection development GO:0031175 106 0.259
Human Worm Fly
regulation of cellular amine metabolic process GO:0033238 11 0.258
positive regulation of cellular amine metabolic process GO:0033240 7 0.253
regulation of cellular ketone metabolic process GO:0010565 50 0.251
cellular component morphogenesis GO:0032989 314 0.243
Human Worm Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.235
post embryonic development GO:0009791 2 0.220
Worm Fly
cellular amino acid metabolic process GO:0006520 116 0.219
regulation of cellular amino acid metabolic process GO:0006521 6 0.174
cellular ketone metabolic process GO:0042180 80 0.169
biological adhesion GO:0022610 331 0.156
Human
cell morphogenesis GO:0000902 296 0.151
Human Worm Fly
regulation of locomotion GO:0040012 329 0.151
Human
ras protein signal transduction GO:0007265 73 0.150
Fly
cell projection organization GO:0030030 252 0.149
Human Worm Fly
positive regulation of protein phosphorylation GO:0001934 313 0.148
Human
generation of neurons GO:0048699 152 0.142
Human Worm Fly
cell adhesion GO:0007155 325 0.138
Human
oogenesis GO:0048477 2 0.136
positive regulation of phosphorylation GO:0042327 394 0.136
Human
female gamete generation GO:0007292 2 0.130
nervous system development GO:0007399 293 0.125
Human Worm Fly
positive regulation of catabolic process GO:0009896 310 0.123
rho protein signal transduction GO:0007266 26 0.116
vesicle mediated transport GO:0016192 371 0.111
Worm
response to other organism GO:0051707 261 0.107
positive regulation of protein kinase activity GO:0045860 190 0.102
Human
neuron development GO:0048666 113 0.101
Human Worm Fly
cell matrix adhesion involved in ameboidal cell migration GO:0003366 2 0.100
regulation of ras protein signal transduction GO:0046578 155 0.100
Fly
purine nucleoside triphosphate catabolic process GO:0009146 392 0.100
glycosyl compound catabolic process GO:1901658 413 0.100
anatomical structure formation involved in morphogenesis GO:0048646 284 0.095
ribonucleoside catabolic process GO:0042454 406 0.090
negative regulation of apoptotic process GO:0043066 316 0.087
regulation of cell migration GO:0030334 289 0.087
Human
nucleoside catabolic process GO:0009164 408 0.087
actin cytoskeleton organization GO:0030036 207 0.086
Human
cell development GO:0048468 328 0.086
Human Worm Fly
neuron differentiation GO:0030182 138 0.085
Human Worm Fly
wnt signaling pathway GO:0016055 156 0.085
mapk cascade GO:0000165 288 0.084
cation transmembrane transport GO:0098655 238 0.080
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.080
purine ribonucleotide catabolic process GO:0009154 404 0.079
purine nucleoside triphosphate metabolic process GO:0009144 412 0.078
dephosphorylation GO:0016311 209 0.077
epithelium development GO:0060429 227 0.075
Fly
circulatory system development GO:0072359 262 0.075
oocyte differentiation GO:0009994 2 0.075
guanosine containing compound metabolic process GO:1901068 244 0.075
cell projection morphogenesis GO:0048858 129 0.075
Human Worm Fly
ribonucleoside triphosphate metabolic process GO:0009199 412 0.074
positive regulation of cellular component organization GO:0051130 376 0.074
single organismal cell cell adhesion GO:0016337 148 0.073
Human
memory GO:0007613 3 0.073
response to growth factor GO:0070848 205 0.073
regulation of cell adhesion GO:0030155 166 0.073
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.072
Human Fly
single organism cellular localization GO:1902580 332 0.072
purine containing compound catabolic process GO:0072523 411 0.071
nucleoside phosphate catabolic process GO:1901292 412 0.070
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.070
oocyte development GO:0048599 1 0.070
apoptotic signaling pathway GO:0097190 268 0.069
positive regulation of developmental process GO:0051094 314 0.069
regulation of cell projection organization GO:0031344 107 0.067
Human
ameboidal type cell migration GO:0001667 135 0.067
nucleotide catabolic process GO:0009166 408 0.067
regulation of protein localization GO:0032880 296 0.067
regulation of wnt signaling pathway GO:0030111 123 0.066
positive regulation of mapk cascade GO:0043410 190 0.066
Human
growth GO:0040007 202 0.065
Worm
single organism cell adhesion GO:0098602 179 0.065
Human
peptidyl tyrosine modification GO:0018212 170 0.065
actin filament based process GO:0030029 224 0.065
Human
chemotaxis GO:0006935 157 0.064
Worm Fly
taxis GO:0042330 157 0.063
Worm Fly
regulation of gtp catabolic process GO:0033124 180 0.062
regulation of nucleotide metabolic process GO:0006140 269 0.062
organophosphate catabolic process GO:0046434 430 0.061
positive regulation of hydrolase activity GO:0051345 331 0.061
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.060
ribonucleotide catabolic process GO:0009261 405 0.060
regulation of cell differentiation GO:0045595 393 0.060
Human
response to oxygen containing compound GO:1901700 369 0.059
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.059
small gtpase mediated signal transduction GO:0007264 78 0.059
Fly
ectoderm development GO:0007398 3 0.058
regulation of protein kinase activity GO:0045859 289 0.058
Human
nucleoside triphosphate catabolic process GO:0009143 394 0.058
endosomal transport GO:0016197 129 0.057
purine ribonucleoside catabolic process GO:0046130 398 0.057
peptidyl tyrosine phosphorylation GO:0018108 170 0.057
mitotic cell cycle GO:0000278 326 0.057
neurological system process GO:0050877 163 0.056
regulation of small gtpase mediated signal transduction GO:0051056 156 0.056
Fly
cell part morphogenesis GO:0032990 137 0.056
Human Worm Fly
regulation of cell development GO:0060284 161 0.056
Human
cell morphogenesis involved in differentiation GO:0000904 144 0.056
Human Worm Fly
cell substrate adhesion GO:0031589 132 0.055
Human
negative regulation of protein metabolic process GO:0051248 391 0.055
negative regulation of cell proliferation GO:0008285 228 0.055
protein catabolic process GO:0030163 325 0.055
epithelial cell differentiation GO:0030855 141 0.054
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.054
single organism membrane organization GO:0044802 268 0.054
determination of adult lifespan GO:0008340 2 0.053
guanosine containing compound catabolic process GO:1901069 239 0.053
regulation of cell morphogenesis GO:0022604 153 0.053
Human Fly
endomembrane system organization GO:0010256 196 0.053
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.053
morphogenesis of an epithelium GO:0002009 60 0.053
Fly
sensory perception of smell GO:0007608 2 0.052
multicellular organismal aging GO:0010259 3 0.052
negative regulation of programmed cell death GO:0043069 321 0.052
positive regulation of cell adhesion GO:0045785 84 0.051
cellular response to oxygen containing compound GO:1901701 276 0.051
microtubule based process GO:0007017 210 0.050
neurogenesis GO:0022008 169 0.050
Human Worm Fly
system process GO:0003008 349 0.050
cellular response to growth factor stimulus GO:0071363 197 0.050
gtp metabolic process GO:0046039 239 0.049
tube morphogenesis GO:0035239 95 0.049
mitotic cell cycle process GO:1903047 286 0.047
metal ion transport GO:0030001 272 0.047
cell cycle phase transition GO:0044770 173 0.047
cellular response to endogenous stimulus GO:0071495 336 0.046
regulation of epithelial cell migration GO:0010632 93 0.045
protein localization to organelle GO:0033365 280 0.044
regulation of transferase activity GO:0051338 355 0.044
Human
purine nucleotide catabolic process GO:0006195 405 0.044
cell fate determination GO:0001709 3 0.043
negative regulation of cellular protein metabolic process GO:0032269 353 0.043
negative regulation of catalytic activity GO:0043086 335 0.043
extrinsic apoptotic signaling pathway GO:0097191 119 0.043
morphogenesis of embryonic epithelium GO:0016331 4 0.042
Fly
positive regulation of transport GO:0051050 336 0.042
regulation of purine nucleotide catabolic process GO:0033121 205 0.042
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.042
calcium ion transmembrane transport GO:0070588 76 0.041
positive regulation of cell motility GO:2000147 177 0.041
regulation of cellular response to growth factor stimulus GO:0090287 76 0.041
epithelial cell migration GO:0010631 119 0.041
regulation of cytoskeleton organization GO:0051493 177 0.041
protein localization to membrane GO:0072657 160 0.041
lipid localization GO:0010876 106 0.041
Worm
regulation of nucleotide catabolic process GO:0030811 205 0.040
mating GO:0007618 1 0.040
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.040
regulation of dephosphorylation GO:0035303 96 0.040
response to activity GO:0014823 0 0.039
negative regulation of protein modification process GO:0031400 200 0.039
negative regulation of apoptotic signaling pathway GO:2001234 97 0.039
cytoplasmic transport GO:0016482 379 0.039
behavioral response to ethanol GO:0048149 2 0.039
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.039
Human Worm Fly
tissue morphogenesis GO:0048729 96 0.038
Fly
regulation of gtpase activity GO:0043087 180 0.038
cellular macromolecular complex assembly GO:0034622 324 0.038
neural tube formation GO:0001841 3 0.038
inorganic ion transmembrane transport GO:0098660 231 0.037
positive regulation of nucleotide catabolic process GO:0030813 185 0.037
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.037
positive regulation of nucleoside metabolic process GO:0045979 186 0.037
segmentation GO:0035282 4 0.037
locomotory behavior GO:0007626 1 0.037
regulation of neuron differentiation GO:0045664 70 0.037
Human
positive regulation of gtpase activity GO:0043547 166 0.036
associative learning GO:0008306 1 0.036
purine ribonucleoside metabolic process GO:0046128 437 0.036
cell type specific apoptotic process GO:0097285 125 0.036
nucleoside triphosphate metabolic process GO:0009141 422 0.036
regulation of cell cycle process GO:0010564 266 0.036
peptidyl serine phosphorylation GO:0018105 101 0.036
negative regulation of multicellular organismal process GO:0051241 317 0.036
chromatin organization GO:0006325 351 0.035
cellular protein complex assembly GO:0043623 188 0.035
modification dependent macromolecule catabolic process GO:0043632 212 0.035
response to external biotic stimulus GO:0043207 261 0.035
organ formation GO:0048645 3 0.035
gtp catabolic process GO:0006184 237 0.035
cell matrix adhesion GO:0007160 85 0.035
Human
behavior GO:0007610 112 0.035
response to transforming growth factor beta GO:0071559 94 0.035
organ morphogenesis GO:0009887 147 0.034
Fly
regulation of ras gtpase activity GO:0032318 128 0.034
microtubule cytoskeleton organization GO:0000226 176 0.034
motor neuron axon guidance GO:0008045 2 0.034
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.034
epithelium migration GO:0090132 119 0.034
reproductive process GO:0022414 106 0.034
Worm
defense response GO:0006952 315 0.033
cardiovascular system development GO:0072358 262 0.033
regulation of purine nucleotide metabolic process GO:1900542 264 0.033
positive regulation of locomotion GO:0040017 186 0.033
regulation of cellular component biogenesis GO:0044087 281 0.033
negative regulation of intracellular signal transduction GO:1902532 183 0.033
Fly
tissue migration GO:0090130 119 0.033
post embryonic organ development GO:0048569 1 0.032
Fly
positive regulation of gtp catabolic process GO:0033126 166 0.032
intracellular protein transport GO:0006886 270 0.031
positive regulation of programmed cell death GO:0043068 249 0.031
response to lipid GO:0033993 206 0.031
regulation of protein binding GO:0043393 66 0.031
positive regulation of ras gtpase activity GO:0032320 117 0.031
immune response GO:0006955 307 0.031
regulation of cell cell adhesion GO:0022407 57 0.031
Human
blood vessel development GO:0001568 172 0.031
membrane organization GO:0061024 292 0.030
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.030
positive regulation of transferase activity GO:0051347 227 0.030
Human
regulation of growth GO:0040008 165 0.030
pericardium development GO:0060039 2 0.030
cellular extravasation GO:0045123 21 0.030
renal system development GO:0072001 63 0.030
positive regulation of cell migration GO:0030335 172 0.030
kidney development GO:0001822 53 0.029
monovalent inorganic cation transport GO:0015672 128 0.029
secretion GO:0046903 254 0.029
regulation of kinase activity GO:0043549 314 0.029
Human
regulation of vesicle mediated transport GO:0060627 130 0.028
regeneration GO:0031099 4 0.028
mitotic cell cycle phase transition GO:0044772 162 0.028
establishment of protein localization to membrane GO:0090150 121 0.028
urogenital system development GO:0001655 65 0.028
negative regulation of phosphorus metabolic process GO:0010563 267 0.028
negative regulation of developmental process GO:0051093 247 0.028
organic acid biosynthetic process GO:0016053 97 0.027
regulation of protein catabolic process GO:0042176 155 0.027
negative regulation of cellular amine metabolic process GO:0033239 3 0.027
regulation of apoptotic signaling pathway GO:2001233 175 0.027
negative regulation of phosphate metabolic process GO:0045936 267 0.027
regulation of mapk cascade GO:0043408 262 0.027
pattern specification process GO:0007389 43 0.027
leukocyte migration GO:0050900 107 0.027
regulation of protein localization to plasma membrane GO:1903076 40 0.027
cation transport GO:0006812 331 0.027
negative regulation of locomotion GO:0040013 118 0.027
negative regulation of low density lipoprotein particle receptor biosynthetic process GO:0045715 3 0.027
peptidyl serine modification GO:0018209 106 0.027
cell chemotaxis GO:0060326 112 0.026
response to wounding GO:0009611 168 0.026
Fly
response to abiotic stimulus GO:0009628 336 0.026
salivary gland morphogenesis GO:0007435 4 0.026
negative regulation of cell migration GO:0030336 102 0.026
regulation of cell cycle GO:0051726 393 0.026
single organism reproductive process GO:0044702 98 0.026
Worm
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.026
axon regeneration GO:0031103 1 0.026
cellular macromolecule catabolic process GO:0044265 380 0.026
sensory perception GO:0007600 103 0.025
establishment of protein localization to plasma membrane GO:0090002 68 0.025
hindbrain development GO:0030902 3 0.025
glial cell migration GO:0008347 4 0.025
cell junction assembly GO:0034329 67 0.025
transmembrane transport GO:0055085 399 0.025
blastoderm segmentation GO:0007350 2 0.025
positive regulation of nucleotide metabolic process GO:0045981 230 0.025
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.025
regulation of protein serine threonine kinase activity GO:0071900 179 0.025
Human
blood vessel morphogenesis GO:0048514 162 0.024
angiogenesis GO:0001525 147 0.024
cell growth GO:0016049 160 0.024
Worm
positive regulation of cellular catabolic process GO:0031331 284 0.024
lipid transport GO:0006869 90 0.024
embryonic viscerocranium morphogenesis GO:0048703 1 0.024
nerve development GO:0021675 4 0.024
axonogenesis GO:0007409 31 0.024
Worm Fly
early endosome to late endosome transport GO:0045022 21 0.024
regulation of neuron projection development GO:0010975 57 0.023
Human
regulation of nucleoside metabolic process GO:0009118 209 0.023
positive regulation of kinase activity GO:0033674 204 0.023
Human
regulation of collagen catabolic process GO:0010710 3 0.023
response to bacterium GO:0009617 144 0.023
cellular protein catabolic process GO:0044257 261 0.023
maintenance of location GO:0051235 112 0.023
Worm
negative regulation of cell motility GO:2000146 104 0.023
ribonucleoside triphosphate catabolic process GO:0009203 391 0.023
visual learning GO:0008542 1 0.023
plasma membrane organization GO:0007009 115 0.023
multicellular organismal signaling GO:0035637 34 0.022
inorganic cation transmembrane transport GO:0098662 194 0.022
positive regulation of cell proliferation GO:0008284 301 0.022
cell division GO:0051301 168 0.022
protein localization to plasma membrane GO:0072659 93 0.022
cell activation GO:0001775 213 0.022
modification dependent protein catabolic process GO:0019941 209 0.022
negative regulation of glial cell proliferation GO:0060253 2 0.022
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.022
Human
regulation of innate immune response GO:0045088 97 0.022
monocarboxylic acid metabolic process GO:0032787 185 0.022
pattern recognition receptor signaling pathway GO:0002221 48 0.022
regulation of actin cytoskeleton organization GO:0032956 116 0.021
protein maturation GO:0051604 233 0.021
somitogenesis GO:0001756 2 0.021
response to hormone GO:0009725 175 0.021
cell migration involved in gastrulation GO:0042074 1 0.021
endodermal cell differentiation GO:0035987 31 0.021
organelle fission GO:0048285 149 0.021
substrate adhesion dependent cell spreading GO:0034446 41 0.021
protein autophosphorylation GO:0046777 123 0.021
Human
negative regulation of cell differentiation GO:0045596 171 0.021
chemical homeostasis GO:0048878 306 0.021
heterotypic cell cell adhesion GO:0034113 28 0.021
positive regulation of innate immune response GO:0045089 79 0.021
anterior posterior axis specification GO:0009948 2 0.021
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.021
regulation of nervous system development GO:0051960 88 0.020
Human
regulation of cell motility GO:2000145 299 0.020
Human
axon development GO:0061564 34 0.020
Worm Fly
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.020
negative regulation of phosphorylation GO:0042326 174 0.020
regulation of phosphatase activity GO:0010921 81 0.020
ion homeostasis GO:0050801 230 0.020
regulation of cytokine production GO:0001817 232 0.020
regulation of meiotic cell cycle GO:0051445 4 0.020
cell junction organization GO:0034330 79 0.020
cellular homeostasis GO:0019725 196 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
neuron projection morphogenesis GO:0048812 50 0.019
Human Worm Fly
cytokine production GO:0001816 247 0.019
covalent chromatin modification GO:0016569 254 0.019
organelle localization GO:0051640 84 0.019
Fly
activation of innate immune response GO:0002218 55 0.019
negative regulation of cellular component movement GO:0051271 106 0.019
response to axon injury GO:0048678 1 0.019
regulation of protein transport GO:0051223 213 0.019
anterior posterior axis specification embryo GO:0008595 2 0.019
positive regulation of map kinase activity GO:0043406 80 0.019
Human
vasculature development GO:0001944 181 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
response to mercury ion GO:0046689 4 0.018
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.018
immune response activating signal transduction GO:0002757 90 0.018
immune response regulating signaling pathway GO:0002764 97 0.018
regulation of rho protein signal transduction GO:0035023 79 0.018
central nervous system development GO:0007417 123 0.018
tube development GO:0035295 125 0.018
divalent inorganic cation transport GO:0072511 158 0.018
striated muscle contraction GO:0006941 52 0.018
embryonic morphogenesis GO:0048598 85 0.018
Fly
negative regulation of cell death GO:0060548 345 0.018
embryonic placenta development GO:0001892 1 0.018
regulation of actin filament based process GO:0032970 141 0.018
myosin filament assembly GO:0031034 2 0.018
cellular lipid metabolic process GO:0044255 303 0.018
neuron projection regeneration GO:0031102 1 0.018
leukocyte cell cell adhesion GO:0007159 37 0.018
sensory perception of pain GO:0019233 4 0.018
ubiquitin dependent protein catabolic process GO:0006511 206 0.018
protein processing GO:0016485 226 0.018
adult locomotory behavior GO:0008344 1 0.018
cell projection assembly GO:0030031 126 0.018
negative regulation of transport GO:0051051 176 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
rab protein signal transduction GO:0032482 4 0.017
regulation of binding GO:0051098 111 0.017
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.017
limbic system development GO:0021761 3 0.017
inner ear morphogenesis GO:0042472 4 0.017
regulation of protein homodimerization activity GO:0043496 9 0.017
i kappab kinase nf kappab signaling GO:0007249 166 0.017
regulation of chemotaxis GO:0050920 74 0.017
retrograde transport endosome to golgi GO:0042147 45 0.017
g protein coupled receptor signaling pathway GO:0007186 207 0.017
cellular response to organic cyclic compound GO:0071407 127 0.017
regulation of immune response GO:0050776 201 0.017
morphogenesis of an epithelial sheet GO:0002011 12 0.017
neurotransmitter secretion GO:0007269 4 0.017
reproduction GO:0000003 63 0.017
Worm
muscle cell fate commitment GO:0042693 4 0.017
digestive tract morphogenesis GO:0048546 56 0.017
organelle assembly GO:0070925 176 0.017
regulation of growth rate GO:0040009 1 0.017
skin development GO:0043588 76 0.016
primary neural tube formation GO:0014020 3 0.016
embryo development GO:0009790 123 0.016
Fly
proteasomal protein catabolic process GO:0010498 176 0.016
cell cell junction organization GO:0045216 69 0.016
response to organic cyclic compound GO:0014070 204 0.016
response to radiation GO:0009314 151 0.016
head development GO:0060322 108 0.016
endoderm formation GO:0001706 33 0.016
lipid metabolic process GO:0006629 381 0.016
negative regulation of cell cycle GO:0045786 193 0.016
striated muscle myosin thick filament assembly GO:0071688 2 0.016
patterning of blood vessels GO:0001569 2 0.016
reactive oxygen species biosynthetic process GO:1903409 4 0.016
small molecule biosynthetic process GO:0044283 157 0.016
visual behavior GO:0007632 2 0.016
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.016
embryonic camera type eye development GO:0031076 2 0.015
regulation of peptidase activity GO:0052547 180 0.015
somatic stem cell division GO:0048103 1 0.015
integrin mediated signaling pathway GO:0007229 32 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
histone modification GO:0016570 251 0.015
heart development GO:0007507 95 0.015
neuroblast proliferation GO:0007405 4 0.015
cellular cation homeostasis GO:0030003 163 0.015
copulation GO:0007620 1 0.015
rna processing GO:0006396 255 0.015
wound healing GO:0042060 115 0.015
enzyme linked receptor protein signaling pathway GO:0007167 303 0.015
regulation of glial cell proliferation GO:0060251 4 0.015
positive regulation of axon extension GO:0045773 4 0.015
lipoprotein metabolic process GO:0042157 42 0.015
negative regulation of phosphatase activity GO:0010923 61 0.015
golgi vesicle transport GO:0048193 80 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.015
actin filament bundle assembly GO:0051017 54 0.015
regulation of multi organism process GO:0043900 157 0.015
myosin filament organization GO:0031033 2 0.015
stem cell division GO:0017145 2 0.015
sensory perception of chemical stimulus GO:0007606 38 0.015
brain development GO:0007420 97 0.015
immune system development GO:0002520 195 0.015
embryonic epithelial tube formation GO:0001838 4 0.015
activation of immune response GO:0002253 114 0.015
regulation of cell growth GO:0001558 135 0.014
spinal cord development GO:0021510 4 0.014
mitotic nuclear division GO:0007067 119 0.014
innate immune response activating signal transduction GO:0002758 48 0.014
cellular response to lipid GO:0071396 127 0.014
regulation of phagocytosis engulfment GO:0060099 2 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.014
response to acid chemical GO:0001101 66 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
chromatin modification GO:0016568 298 0.014
reactive nitrogen species metabolic process GO:2001057 3 0.014
metal ion homeostasis GO:0055065 169 0.014
sodium ion transport GO:0006814 61 0.014
response to inorganic substance GO:0010035 127 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
positive regulation of ion transport GO:0043270 87 0.014
cytokinesis GO:0000910 96 0.014
regulation of lipoprotein metabolic process GO:0050746 7 0.014
nuclear division GO:0000280 128 0.014
endocytosis GO:0006897 159 0.014
Worm
regulation of establishment of protein localization GO:0070201 242 0.014
morphogenesis of a polarized epithelium GO:0001738 3 0.014
positive regulation of wnt signaling pathway GO:0030177 54 0.014
carbohydrate metabolic process GO:0005975 207 0.014
negative regulation of cellular component organization GO:0051129 235 0.014
muscle contraction GO:0006936 73 0.014
intrinsic apoptotic signaling pathway GO:0097193 127 0.014
atp metabolic process GO:0046034 176 0.014
response to nitrogen compound GO:1901698 184 0.014
cardiac muscle cell contraction GO:0086003 4 0.014
blood circulation GO:0008015 113 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
spermatid development GO:0007286 4 0.013
somatic muscle development GO:0007525 1 0.013
regulation of secretion by cell GO:1903530 177 0.013
negative regulation of binding GO:0051100 57 0.013
compound eye development GO:0048749 1 0.013
negative regulation of protein binding GO:0032091 35 0.013
axon cargo transport GO:0008088 2 0.013
regulation of synaptic plasticity GO:0048167 3 0.013
positive regulation of endocytosis GO:0045807 42 0.013
regulation of mitotic cell cycle GO:0007346 189 0.013
regulation of peptidyl serine phosphorylation GO:0033135 50 0.013
retina vasculature morphogenesis in camera type eye GO:0061299 3 0.013
negative regulation of protein maturation GO:1903318 142 0.013
carboxylic acid biosynthetic process GO:0046394 97 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.013
Human
regulation of cell division GO:0051302 116 0.013
regulation of behavior GO:0050795 82 0.013
tripartite regional subdivision GO:0007351 2 0.013
positive regulation of cell differentiation GO:0045597 211 0.013
single organism nuclear import GO:1902593 104 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
g1 s transition of mitotic cell cycle GO:0000082 78 0.013
cellular chemical homeostasis GO:0055082 180 0.013
actin filament organization GO:0007015 128 0.013
regulation of cellular component movement GO:0051270 334 0.013
Human
nephron development GO:0072006 30 0.013
positive regulation of epithelial cell migration GO:0010634 55 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
neuromuscular junction development GO:0007528 3 0.013
cilium morphogenesis GO:0060271 75 0.012
regulation of secretion GO:0051046 194 0.012
positive regulation of cell projection organization GO:0031346 64 0.012
establishment of nucleus localization GO:0040023 1 0.012
Fly

MAP4K4 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.019
nervous system disease DOID:863 431 0.019
cancer DOID:162 167 0.017
disease of cellular proliferation DOID:14566 174 0.017
organ system cancer DOID:0050686 164 0.017
disease of metabolism DOID:0014667 295 0.014