Homo sapiens

349 known processes

LEF1

lymphoid enhancer-binding factor 1

(Aliases: DKFZp586H0919,FLJ46390,TCF1ALPHA)

LEF1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.754
Human Mouse
wnt signaling pathway GO:0016055 156 0.534
negative regulation of wnt signaling pathway GO:0030178 69 0.397
regulation of wnt signaling pathway GO:0030111 123 0.269
post embryonic development GO:0009791 2 0.233
Worm Fly
regulation of canonical wnt signaling pathway GO:0060828 88 0.226
cellular component morphogenesis GO:0032989 314 0.190
positive regulation of developmental process GO:0051094 314 0.187
oogenesis GO:0048477 2 0.174
cell morphogenesis GO:0000902 296 0.170
regulation of cell differentiation GO:0045595 393 0.168
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.154
canonical wnt signaling pathway GO:0060070 116 0.154
hematopoietic or lymphoid organ development GO:0048534 186 0.153
negative regulation of cell death GO:0060548 345 0.152
regulation of anatomical structure morphogenesis GO:0022603 286 0.142
neuron fate commitment GO:0048663 2 0.142
negative regulation of programmed cell death GO:0043069 321 0.140
chromatin organization GO:0006325 351 0.132
cell development GO:0048468 328 0.132
female gamete generation GO:0007292 2 0.128
cell morphogenesis involved in differentiation GO:0000904 144 0.123
segmentation GO:0035282 4 0.120
Zebrafish Mouse
digestive system development GO:0055123 75 0.117
Mouse Worm
cell projection organization GO:0030030 252 0.106
nervous system development GO:0007399 293 0.104
Zebrafish Mouse Worm
somatic stem cell maintenance GO:0035019 4 0.101
cellular ketone metabolic process GO:0042180 80 0.100
Zebrafish
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.100
regulation of cell development GO:0060284 161 0.099
regulation of cell cycle GO:0051726 393 0.099
positive regulation of cell differentiation GO:0045597 211 0.096
cellular response to endogenous stimulus GO:0071495 336 0.096
hemopoiesis GO:0030097 180 0.091
response to growth factor GO:0070848 205 0.090
cellular lipid metabolic process GO:0044255 303 0.090
Zebrafish
mitotic cell cycle GO:0000278 326 0.087
Worm
biological adhesion GO:0022610 331 0.085
regulation of nervous system development GO:0051960 88 0.084
Zebrafish
tube morphogenesis GO:0035239 95 0.084
Mouse Worm
anatomical structure formation involved in morphogenesis GO:0048646 284 0.084
Zebrafish Mouse Worm
negative regulation of cell differentiation GO:0045596 171 0.084
embryonic epithelial tube formation GO:0001838 4 0.081
positive regulation of cell proliferation GO:0008284 301 0.080
small gtpase mediated signal transduction GO:0007264 78 0.080
mesenchymal cell development GO:0014031 50 0.078
positive regulation of cellular component organization GO:0051130 376 0.076
cellular amino acid metabolic process GO:0006520 116 0.075
regulation of protein transport GO:0051223 213 0.075
Human
negative regulation of apoptotic process GO:0043066 316 0.074
regulation of neurogenesis GO:0050767 82 0.072
Zebrafish
stem cell differentiation GO:0048863 93 0.072
determination of adult lifespan GO:0008340 2 0.070
positive regulation of programmed cell death GO:0043068 249 0.070
cell activation GO:0001775 213 0.070
Mouse
thymus development GO:0048538 3 0.069
histone modification GO:0016570 251 0.068
digestive tract morphogenesis GO:0048546 56 0.067
Mouse Worm
positive regulation of cell death GO:0010942 263 0.066
forelimb morphogenesis GO:0035136 4 0.066
single organism cellular localization GO:1902580 332 0.066
negative regulation of cell proliferation GO:0008285 228 0.064
regulation of protein localization GO:0032880 296 0.064
Human
negative regulation of developmental process GO:0051093 247 0.063
Mouse Worm
neurogenesis GO:0022008 169 0.062
Zebrafish Mouse Worm
cell type specific apoptotic process GO:0097285 125 0.062
leukocyte activation GO:0045321 164 0.062
Mouse
tube development GO:0035295 125 0.061
Mouse Worm
negative regulation of smoothened signaling pathway GO:0045879 3 0.061
regulation of cell projection organization GO:0031344 107 0.060
neuroendocrine cell differentiation GO:0061101 2 0.060
multicellular organismal aging GO:0010259 3 0.059
negative regulation of multicellular organismal process GO:0051241 317 0.059
peripheral nervous system development GO:0007422 2 0.059
morphogenesis of embryonic epithelium GO:0016331 4 0.058
epithelium development GO:0060429 227 0.057
Zebrafish Mouse Rat
system process GO:0003008 349 0.056
Mouse Worm
actin filament based process GO:0030029 224 0.056
generation of neurons GO:0048699 152 0.055
Zebrafish Mouse Worm
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 2 0.055
i kappab kinase nf kappab signaling GO:0007249 166 0.055
somitogenesis GO:0001756 2 0.055
Zebrafish Mouse
regulation of cell motility GO:2000145 299 0.055
epithelial cell differentiation GO:0030855 141 0.055
Rat
defense response GO:0006952 315 0.055
mitotic cell cycle process GO:1903047 286 0.054
Worm
negative regulation of gliogenesis GO:0014014 3 0.054
osteoblast differentiation GO:0001649 92 0.053
nucleocytoplasmic transport GO:0006913 176 0.053
Human
neuron projection development GO:0031175 106 0.053
intracellular protein transport GO:0006886 270 0.053
Human
cell fate determination GO:0001709 3 0.053
Worm
cardiac muscle cell contraction GO:0086003 4 0.053
response to cytokine GO:0034097 232 0.052
regulation of hormone levels GO:0010817 125 0.052
Human Zebrafish
response to oxygen containing compound GO:1901700 369 0.052
amine metabolic process GO:0009308 44 0.052
positive regulation of immune system process GO:0002684 283 0.051
pituitary gland development GO:0021983 2 0.051
pharynx development GO:0060465 1 0.050
Worm
neuron differentiation GO:0030182 138 0.050
Zebrafish Worm
chromatin modification GO:0016568 298 0.050
reproductive process GO:0022414 106 0.050
Mouse Worm
regulation of proteolysis GO:0030162 293 0.050
response to lipid GO:0033993 206 0.050
neural tube formation GO:0001841 3 0.050
enzyme linked receptor protein signaling pathway GO:0007167 303 0.050
Mouse
t cell activation GO:0042110 99 0.049
Mouse
cellular response to dna damage stimulus GO:0006974 379 0.049
regulation of lymphocyte activation GO:0051249 103 0.049
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.049
Human
regulation of cell cycle process GO:0010564 266 0.048
negative regulation of protein metabolic process GO:0051248 391 0.048
regulation of intracellular transport GO:0032386 195 0.048
Human
regulation of cell migration GO:0030334 289 0.048
cell projection morphogenesis GO:0048858 129 0.048
leukocyte differentiation GO:0002521 98 0.048
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.046
Mouse
ras protein signal transduction GO:0007265 73 0.046
vesicle mediated transport GO:0016192 371 0.046
regulation of cytokine production GO:0001817 232 0.046
cellular response to growth factor stimulus GO:0071363 197 0.046
blood vessel development GO:0001568 172 0.046
Human Mouse
taxis GO:0042330 157 0.046
regulation of mitotic cell cycle GO:0007346 189 0.045
peptidyl lysine modification GO:0018205 144 0.045
cytokine production GO:0001816 247 0.045
positive regulation of cell cycle GO:0045787 140 0.045
multi organism cellular process GO:0044764 156 0.045
regulation of neuron differentiation GO:0045664 70 0.045
regeneration GO:0031099 4 0.045
Zebrafish Rat
lymphocyte activation GO:0046649 133 0.045
Mouse
regulation of establishment of protein localization GO:0070201 242 0.044
Human
regulation of cellular amine metabolic process GO:0033238 11 0.044
positive regulation of cytoplasmic transport GO:1903651 82 0.044
Human
immune system development GO:0002520 195 0.044
regulation of organ formation GO:0003156 4 0.044
regulation of neuron projection development GO:0010975 57 0.044
organophosphate catabolic process GO:0046434 430 0.043
endodermal cell fate commitment GO:0001711 4 0.043
purine nucleotide catabolic process GO:0006195 405 0.043
apoptotic signaling pathway GO:0097190 268 0.042
Human
epithelial cell proliferation GO:0050673 128 0.042
negative regulation of cellular protein metabolic process GO:0032269 353 0.042
ossification GO:0001503 121 0.041
regulation of transferase activity GO:0051338 355 0.041
regulation of cell growth GO:0001558 135 0.041
positive regulation of catabolic process GO:0009896 310 0.041
protein localization to organelle GO:0033365 280 0.040
nuclear transport GO:0051169 179 0.040
Human
circulatory system development GO:0072359 262 0.040
Human Mouse Fly
skin development GO:0043588 76 0.040
Rat
anterior posterior axis specification GO:0009948 2 0.039
embryonic forelimb morphogenesis GO:0035115 4 0.039
regulation of cellular component biogenesis GO:0044087 281 0.039
viral life cycle GO:0019058 132 0.039
growth GO:0040007 202 0.038
posttranscriptional regulation of gene expression GO:0010608 213 0.038
Worm
hair follicle morphogenesis GO:0031069 2 0.038
response to transforming growth factor beta GO:0071559 94 0.038
negative regulation of phosphate metabolic process GO:0045936 267 0.038
negative regulation of intracellular signal transduction GO:1902532 183 0.037
locomotory behavior GO:0007626 1 0.037
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.037
Human
response to wounding GO:0009611 168 0.037
Zebrafish
heart formation GO:0060914 2 0.037
stem cell development GO:0048864 69 0.037
single organism reproductive process GO:0044702 98 0.037
Mouse Worm
central nervous system development GO:0007417 123 0.037
Zebrafish Mouse
mapk cascade GO:0000165 288 0.037
gland development GO:0048732 48 0.037
Mouse Fly
protein targeting GO:0006605 187 0.036
embryonic organ development GO:0048568 36 0.036
Mouse
nitrogen compound transport GO:0071705 191 0.036
Human
regulation of leukocyte differentiation GO:1902105 61 0.036
cell part morphogenesis GO:0032990 137 0.036
muscle cell differentiation GO:0042692 63 0.036
Human Zebrafish
negative regulation of cell cycle GO:0045786 193 0.035
Human
hindlimb morphogenesis GO:0035137 2 0.035
regulation of cell morphogenesis GO:0022604 153 0.035
regulation of intracellular protein transport GO:0033157 123 0.035
Human
positive regulation of transport GO:0051050 336 0.035
Human
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.035
axis elongation GO:0003401 4 0.034
cytoplasmic transport GO:0016482 379 0.034
Human
positive regulation of intracellular protein transport GO:0090316 76 0.034
Human
divalent metal ion transport GO:0070838 152 0.034
regulation of mapk cascade GO:0043408 262 0.034
actin cytoskeleton organization GO:0030036 207 0.034
regulation of locomotion GO:0040012 329 0.034
regulation of nucleocytoplasmic transport GO:0046822 98 0.033
Human
positive regulation of cell migration GO:0030335 172 0.033
primary neural tube formation GO:0014020 3 0.033
cell adhesion GO:0007155 325 0.033
establishment of protein localization to organelle GO:0072594 172 0.033
purine nucleoside triphosphate catabolic process GO:0009146 392 0.033
cellular response to oxygen containing compound GO:1901701 276 0.033
immune response GO:0006955 307 0.033
Mouse
negative regulation of catalytic activity GO:0043086 335 0.033
regulation of cell cycle phase transition GO:1901987 126 0.032
t cell differentiation in thymus GO:0033077 4 0.032
dna conformation change GO:0071103 113 0.032
response to abiotic stimulus GO:0009628 336 0.032
digestive tract development GO:0048565 75 0.032
Mouse Worm
glycosyl compound catabolic process GO:1901658 413 0.032
lipid metabolic process GO:0006629 381 0.032
Zebrafish
cellular macromolecule catabolic process GO:0044265 380 0.032
positive regulation of locomotion GO:0040017 186 0.032
negative regulation of phosphorus metabolic process GO:0010563 267 0.032
embryo development GO:0009790 123 0.032
Zebrafish Mouse Worm Fly
viral process GO:0016032 146 0.031
regulation of multi organism process GO:0043900 157 0.031
embryonic hindlimb morphogenesis GO:0035116 2 0.031
mesenchyme development GO:0060485 59 0.031
positive regulation of cell development GO:0010720 92 0.031
regulation of cell adhesion GO:0030155 166 0.031
neuron development GO:0048666 113 0.031
Worm
single organism cell adhesion GO:0098602 179 0.031
motor neuron axon guidance GO:0008045 2 0.031
neuroblast proliferation GO:0007405 4 0.031
Mouse
regulation of cellular response to stress GO:0080135 244 0.031
glycoprotein metabolic process GO:0009100 110 0.031
Human
regulation of peptidase activity GO:0052547 180 0.030
ribonucleoside triphosphate catabolic process GO:0009203 391 0.030
positive regulation of cellular catabolic process GO:0031331 284 0.030
regulation of cell activation GO:0050865 125 0.030
purine ribonucleoside metabolic process GO:0046128 437 0.030
response to external biotic stimulus GO:0043207 261 0.030
interspecies interaction between organisms GO:0044419 156 0.030
protein modification by small protein conjugation GO:0032446 342 0.030
glycoprotein biosynthetic process GO:0009101 91 0.030
Human
cation transport GO:0006812 331 0.030
rho protein signal transduction GO:0007266 26 0.030
positive regulation of apoptotic process GO:0043065 246 0.030
chemical homeostasis GO:0048878 306 0.029
Human
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.029
regulation of cellular amino acid metabolic process GO:0006521 6 0.029
nephron tubule formation GO:0072079 1 0.029
stem cell division GO:0017145 2 0.029
Mouse
cell migration involved in gastrulation GO:0042074 1 0.029
cellular response to cytokine stimulus GO:0071345 181 0.029
negative regulation of immune system process GO:0002683 136 0.029
positive regulation of cell motility GO:2000147 177 0.029
proteoglycan metabolic process GO:0006029 29 0.029
Human
neurological system process GO:0050877 163 0.028
Mouse
regulation of endothelial cell differentiation GO:0045601 4 0.028
regulation of protein serine threonine kinase activity GO:0071900 179 0.028
regulation of cytoplasmic transport GO:1903649 149 0.028
Human
macromolecule methylation GO:0043414 97 0.028
regulation of response to external stimulus GO:0032101 222 0.028
photoreceptor cell differentiation GO:0046530 2 0.028
positive regulation of hydrolase activity GO:0051345 331 0.028
neuromuscular junction development GO:0007528 3 0.027
regulation of epithelial to mesenchymal transition GO:0010717 37 0.027
cell division GO:0051301 168 0.027
Mouse Worm
maintenance of location GO:0051235 112 0.027
response to nitrogen compound GO:1901698 184 0.027
oocyte differentiation GO:0009994 2 0.027
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.027
positive regulation of cellular component movement GO:0051272 181 0.027
developmental programmed cell death GO:0010623 3 0.027
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.027
Human
negative regulation of transport GO:0051051 176 0.027
protein alkylation GO:0008213 74 0.027
positive regulation of cell adhesion GO:0045785 84 0.027
regulation of growth GO:0040008 165 0.027
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.027
negative regulation of locomotion GO:0040013 118 0.027
Zebrafish
cranial nerve development GO:0021545 4 0.027
appendage morphogenesis GO:0035107 16 0.027
Zebrafish Mouse Fly
positive regulation of keratinocyte proliferation GO:0010838 4 0.026
vasculature development GO:0001944 181 0.026
Human Mouse
embryonic eye morphogenesis GO:0048048 2 0.026
positive regulation of leukocyte differentiation GO:1902107 37 0.026
regulation of glial cell differentiation GO:0045685 3 0.026
lymphocyte proliferation GO:0046651 70 0.026
Mouse
protein catabolic process GO:0030163 325 0.026
regulation of purine nucleotide catabolic process GO:0033121 205 0.026
modification dependent macromolecule catabolic process GO:0043632 212 0.026
lens development in camera type eye GO:0002088 2 0.026
dna packaging GO:0006323 77 0.026
protein acylation GO:0043543 138 0.026
positive regulation of protein phosphorylation GO:0001934 313 0.026
cerebral cortex radially oriented cell migration GO:0021799 1 0.026
mitotic cell cycle phase transition GO:0044772 162 0.026
negative regulation of apoptotic signaling pathway GO:2001234 97 0.026
Human
formation of primary germ layer GO:0001704 42 0.026
Mouse Worm
response to organic cyclic compound GO:0014070 204 0.026
blastocyst development GO:0001824 3 0.025
positive regulation of intracellular transport GO:0032388 104 0.025
Human
ion transmembrane transport GO:0034220 338 0.025
regulation of protein kinase activity GO:0045859 289 0.025
regulation of immune response GO:0050776 201 0.025
protein import GO:0017038 130 0.025
cellular amine metabolic process GO:0044106 41 0.025
heart development GO:0007507 95 0.025
Fly
protein localization to nucleus GO:0034504 136 0.025
modification dependent protein catabolic process GO:0019941 209 0.025
organelle assembly GO:0070925 176 0.025
positive regulation of immune response GO:0050778 159 0.025
prostate gland development GO:0030850 3 0.025
cell substrate adhesion GO:0031589 132 0.025
signal transduction by phosphorylation GO:0023014 297 0.025
nucleoside triphosphate metabolic process GO:0009141 422 0.025
microtubule based process GO:0007017 210 0.025
Worm
trophectodermal cell differentiation GO:0001829 3 0.025
response to biotic stimulus GO:0009607 276 0.025
carbohydrate derivative biosynthetic process GO:1901137 207 0.025
Human
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.024
positive regulation of cellular amine metabolic process GO:0033240 7 0.024
internal peptidyl lysine acetylation GO:0018393 97 0.024
ectoderm development GO:0007398 3 0.024
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.024
compound eye development GO:0048749 1 0.024
cell fate commitment GO:0045165 27 0.024
Human Worm
regulation of secretion by cell GO:1903530 177 0.024
Human
positive regulation of protein transport GO:0051222 135 0.024
Human
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.024
blastocyst formation GO:0001825 3 0.024
mesenchymal cell differentiation GO:0048762 52 0.024
regulation of apoptotic signaling pathway GO:2001233 175 0.024
Human
sulfur compound biosynthetic process GO:0044272 38 0.024
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
mesodermal cell fate commitment GO:0001710 2 0.024
Worm
inner ear morphogenesis GO:0042472 4 0.023
ribonucleoside catabolic process GO:0042454 406 0.023
methylation GO:0032259 106 0.023
positive regulation of mapk cascade GO:0043410 190 0.023
regulation of cellular response to growth factor stimulus GO:0090287 76 0.023
response to virus GO:0009615 126 0.023
neural crest cell migration GO:0001755 2 0.023
Zebrafish
ribonucleoside triphosphate metabolic process GO:0009199 412 0.023
microtubule cytoskeleton organization GO:0000226 176 0.023
Worm
oocyte development GO:0048599 1 0.023
epidermis morphogenesis GO:0048730 3 0.023
small molecule biosynthetic process GO:0044283 157 0.023
Zebrafish
protein maturation GO:0051604 233 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
regulation of epithelial cell proliferation GO:0050678 113 0.023
monocarboxylic acid metabolic process GO:0032787 185 0.023
Zebrafish
protein processing GO:0016485 226 0.023
covalent chromatin modification GO:0016569 254 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.023
single organism nuclear import GO:1902593 104 0.022
neural crest cell development GO:0014032 3 0.022
Zebrafish
negative regulation of proteolysis GO:0045861 132 0.022
regulation of mitotic cell cycle phase transition GO:1901990 118 0.022
nucleoside triphosphate catabolic process GO:0009143 394 0.022
regulation of endopeptidase activity GO:0052548 170 0.022
rna interference GO:0016246 4 0.022
Worm
positive regulation of nucleotide metabolic process GO:0045981 230 0.022
peptide secretion GO:0002790 51 0.022
Human
cell growth GO:0016049 160 0.022
regulation of cellular ketone metabolic process GO:0010565 50 0.022
Zebrafish
nucleotide catabolic process GO:0009166 408 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.022
prostate gland morphogenesis GO:0060512 1 0.022
reproductive structure development GO:0048608 55 0.022
Mouse Worm
histone methylation GO:0016571 60 0.022
purine containing compound catabolic process GO:0072523 411 0.022
single organismal cell cell adhesion GO:0016337 148 0.022
gastrulation with mouth forming second GO:0001702 1 0.022
dephosphorylation GO:0016311 209 0.022
cell cycle phase transition GO:0044770 173 0.021
negative regulation of cell motility GO:2000146 104 0.021
Zebrafish
sulfur compound metabolic process GO:0006790 101 0.021
Human
cell cell signaling GO:0007267 155 0.021
Human
lipid biosynthetic process GO:0008610 177 0.021
Zebrafish
regulation of cell division GO:0051302 116 0.021
Worm
positive regulation of phosphorylation GO:0042327 394 0.021
regulation of cellular component movement GO:0051270 334 0.021
chemotaxis GO:0006935 157 0.021
skeletal system development GO:0001501 79 0.021
regulation of nucleotide metabolic process GO:0006140 269 0.021
metencephalon development GO:0022037 2 0.021
regulation of kinase activity GO:0043549 314 0.021
midgut development GO:0007494 1 0.021
negative regulation of cell growth GO:0030308 83 0.021
intracellular receptor signaling pathway GO:0030522 104 0.021
negative regulation of multi organism process GO:0043901 92 0.021
organ formation GO:0048645 3 0.021
t cell differentiation GO:0030217 29 0.021
Mouse
forebrain generation of neurons GO:0021872 3 0.021
Zebrafish Mouse
blastoderm segmentation GO:0007350 2 0.021
tube closure GO:0060606 3 0.021
mononuclear cell proliferation GO:0032943 71 0.021
Mouse
regulation of viral process GO:0050792 103 0.021
response to other organism GO:0051707 261 0.021
cell chemotaxis GO:0060326 112 0.021
morphogenesis of a polarized epithelium GO:0001738 3 0.020
negative regulation of cell fate specification GO:0009996 3 0.020
negative regulation of growth GO:0045926 97 0.020
divalent inorganic cation transport GO:0072511 158 0.020
regulation of actin filament based process GO:0032970 141 0.020
positive regulation of epithelial to mesenchymal transition GO:0010718 22 0.020
histone acetylation GO:0016573 93 0.020
reproductive system development GO:0061458 56 0.020
Mouse Worm
protein targeting to nucleus GO:0044744 104 0.020
positive regulation of nucleoside metabolic process GO:0045979 186 0.020
nucleoside catabolic process GO:0009164 408 0.020
cardiac muscle cell cardiac muscle cell adhesion GO:0086042 1 0.020
blood vessel morphogenesis GO:0048514 162 0.020
Mouse
anatomical structure homeostasis GO:0060249 100 0.020
Zebrafish
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
oxidation reduction process GO:0055114 396 0.020
positive regulation of leukocyte activation GO:0002696 80 0.020
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.020
negative regulation of peptidase activity GO:0010466 91 0.020
immune effector process GO:0002252 159 0.020
Mouse
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.020
extrinsic apoptotic signaling pathway GO:0097191 119 0.020
Human
negative regulation of axonogenesis GO:0050771 4 0.020
regulation of glial cell proliferation GO:0060251 4 0.019
adult locomotory behavior GO:0008344 1 0.019
sex differentiation GO:0007548 45 0.019
Worm
negative regulation of cell migration GO:0030336 102 0.019
Zebrafish
leukocyte proliferation GO:0070661 74 0.019
Mouse
organic hydroxy compound metabolic process GO:1901615 147 0.019
regulation of transmembrane transport GO:0034762 139 0.019
myeloid cell differentiation GO:0030099 117 0.019
proteasomal protein catabolic process GO:0010498 176 0.019
positive regulation of organelle organization GO:0010638 195 0.019
cellular protein catabolic process GO:0044257 261 0.019
hormone secretion GO:0046879 65 0.019
Human
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
regulation of secretion GO:0051046 194 0.019
Human Worm
cell cycle g1 s phase transition GO:0044843 80 0.019
cellular response to lipid GO:0071396 127 0.019
gtp catabolic process GO:0006184 237 0.019
establishment of organelle localization GO:0051656 59 0.019
ubiquitin dependent protein catabolic process GO:0006511 206 0.019
cellular response to organic cyclic compound GO:0071407 127 0.019
secretion by cell GO:0032940 226 0.019
Human
negative regulation of phosphorylation GO:0042326 174 0.019
regulation of neuroblast proliferation GO:1902692 3 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.018
negative regulation of hydrolase activity GO:0051346 182 0.018
rna processing GO:0006396 255 0.018
heart field specification GO:0003128 2 0.018
positive regulation of protein kinase activity GO:0045860 190 0.018
negative regulation of protein modification process GO:0031400 200 0.018
regulation of leukocyte activation GO:0002694 115 0.018
regulation of membrane potential GO:0042391 95 0.018
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.018
regulation of protein import into nucleus GO:0042306 78 0.018
nuclear import GO:0051170 106 0.018
embryo development ending in birth or egg hatching GO:0009792 34 0.018
Zebrafish Mouse Worm
positive regulation of neuroblast proliferation GO:0002052 2 0.018
cilium morphogenesis GO:0060271 75 0.018
regulation of binding GO:0051098 111 0.018
lung associated mesenchyme development GO:0060484 1 0.018
defense response to other organism GO:0098542 129 0.018
organ morphogenesis GO:0009887 147 0.018
Mouse Fly
protein autophosphorylation GO:0046777 123 0.018
regulation of lipid metabolic process GO:0019216 96 0.018
Zebrafish
guanosine containing compound metabolic process GO:1901068 244 0.018
angiogenesis GO:0001525 147 0.018
Mouse
actin mediated cell contraction GO:0070252 12 0.018
negative regulation of protein maturation GO:1903318 142 0.018
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.018
cerebellum development GO:0021549 2 0.018
embryonic morphogenesis GO:0048598 85 0.018
Mouse Worm
regulation of nucleoside metabolic process GO:0009118 209 0.018
cardiac cell fate specification GO:0060912 1 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.018
memory GO:0007613 3 0.018
negative regulation of binding GO:0051100 57 0.018
negative regulation of glial cell differentiation GO:0045686 1 0.018
organelle localization GO:0051640 84 0.018
convergent extension GO:0060026 1 0.018
axon regeneration GO:0031103 1 0.018
positive regulation of lymphocyte activation GO:0051251 73 0.017
ribonucleotide catabolic process GO:0009261 405 0.017
ion homeostasis GO:0050801 230 0.017
cerebral cortex cell migration GO:0021795 3 0.017
post embryonic organ development GO:0048569 1 0.017
Worm Fly
regulation of ras protein signal transduction GO:0046578 155 0.017
negative regulation of protein phosphorylation GO:0001933 140 0.017
establishment of tissue polarity GO:0007164 3 0.017
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.017
cellular chemical homeostasis GO:0055082 180 0.017
bmp signaling pathway GO:0030509 49 0.017
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 412 0.017

LEF1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.039
musculoskeletal system disease DOID:17 223 0.038
cancer DOID:162 167 0.028
organ system cancer DOID:0050686 164 0.024
connective tissue disease DOID:65 109 0.023
bone disease DOID:0080001 88 0.022
disease of metabolism DOID:0014667 295 0.022
Human
sensory system disease DOID:0050155 203 0.017
nervous system disease DOID:863 431 0.017
central nervous system disease DOID:331 186 0.017