Homo sapiens

36 known processes

DEFA1

defensin, alpha 1

(Aliases: DEF1,HNP-1,HP-1,MRS,DEFA2,MGC138393,DEFA1B,HP1)

DEFA1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.095
segmentation GO:0035282 4 0.090
cardiac right ventricle morphogenesis GO:0003215 3 0.082
anterior posterior axis specification GO:0009948 2 0.072
morphogenesis of embryonic epithelium GO:0016331 4 0.069
female gamete generation GO:0007292 2 0.067
embryonic epithelial tube formation GO:0001838 4 0.067
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.059
negative regulation of protein metabolic process GO:0051248 391 0.059
right ventricular cardiac muscle tissue morphogenesis GO:0003221 2 0.056
response to biotic stimulus GO:0009607 276 0.049
microtubule cytoskeleton organization GO:0000226 176 0.047
tripartite regional subdivision GO:0007351 2 0.047
oogenesis GO:0048477 2 0.047
blastoderm segmentation GO:0007350 2 0.045
locomotory behavior GO:0007626 1 0.045
actin filament based process GO:0030029 224 0.044
negative regulation of smoothened signaling pathway GO:0045879 3 0.043
defense response GO:0006952 315 0.041
negative regulation of hydrolase activity GO:0051346 182 0.041
microtubule based process GO:0007017 210 0.040
oocyte differentiation GO:0009994 2 0.036
single organism carbohydrate metabolic process GO:0044723 193 0.036
regulation of establishment of protein localization GO:0070201 242 0.035
carbohydrate metabolic process GO:0005975 207 0.035
regulation of gtp catabolic process GO:0033124 180 0.035
oocyte development GO:0048599 1 0.034
negative regulation of catalytic activity GO:0043086 335 0.034
neural tube formation GO:0001841 3 0.034
defense response to bacterium GO:0042742 63 0.034
innate immune response GO:0045087 178 0.033
defense response to other organism GO:0098542 129 0.033
cell adhesion GO:0007155 325 0.032
regulation of phospholipase c activating g protein coupled receptor signaling pathway GO:1900736 1 0.032
purine nucleoside catabolic process GO:0006152 398 0.032
purine nucleoside triphosphate metabolic process GO:0009144 412 0.032
cellular macromolecule catabolic process GO:0044265 380 0.032
regulation of ion transport GO:0043269 189 0.032
positive regulation of intracellular transport GO:0032388 104 0.031
humoral immune response GO:0006959 49 0.031
negative regulation of phosphorus metabolic process GO:0010563 267 0.031
oxidation reduction process GO:0055114 396 0.031
cellular amine metabolic process GO:0044106 41 0.030
purine nucleotide catabolic process GO:0006195 405 0.030
biological adhesion GO:0022610 331 0.029
anatomical structure formation involved in morphogenesis GO:0048646 284 0.029
negative regulation of jun kinase activity GO:0043508 4 0.029
hindbrain development GO:0030902 3 0.029
memory GO:0007613 3 0.028
tissue morphogenesis GO:0048729 96 0.028
cellular amino acid metabolic process GO:0006520 116 0.027
maintenance of location GO:0051235 112 0.027
ribonucleoside triphosphate catabolic process GO:0009203 391 0.027
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.026
spermatid differentiation GO:0048515 4 0.026
regulation of protein serine threonine kinase activity GO:0071900 179 0.026
positive regulation of synaptic transmission GO:0050806 4 0.026
neural tube patterning GO:0021532 2 0.026
circulatory system development GO:0072359 262 0.026
primary neural tube formation GO:0014020 3 0.026
purine ribonucleoside metabolic process GO:0046128 437 0.026
cellular lipid metabolic process GO:0044255 303 0.026
single organism cellular localization GO:1902580 332 0.026
regulation of cellular amine metabolic process GO:0033238 11 0.025
negative regulation of multicellular organismal process GO:0051241 317 0.025
cellular ketone metabolic process GO:0042180 80 0.025
positive regulation of transport GO:0051050 336 0.025
guanosine containing compound metabolic process GO:1901068 244 0.025
small gtpase mediated signal transduction GO:0007264 78 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.025
negative regulation of developmental process GO:0051093 247 0.025
myeloid cell differentiation GO:0030099 117 0.025
positive regulation of nucleotide metabolic process GO:0045981 230 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
purine ribonucleotide catabolic process GO:0009154 404 0.024
ribonucleotide catabolic process GO:0009261 405 0.024
immune response GO:0006955 307 0.024
maintenance of location in cell GO:0051651 62 0.024
intracellular protein transport GO:0006886 270 0.024
regulation of cellular ketone metabolic process GO:0010565 50 0.024
immune system development GO:0002520 195 0.024
post embryonic development GO:0009791 2 0.024
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
regulation of cell differentiation GO:0045595 393 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
syncytium formation by plasma membrane fusion GO:0000768 2 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.023
proteasomal protein catabolic process GO:0010498 176 0.023
thymus development GO:0048538 3 0.023
negative regulation of phosphate metabolic process GO:0045936 267 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
protein polymerization GO:0051258 71 0.022
regulation of protein kinase activity GO:0045859 289 0.022
nucleocytoplasmic transport GO:0006913 176 0.022
regulation of intracellular transport GO:0032386 195 0.022
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.021
regulation of kinase activity GO:0043549 314 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.021
gtp metabolic process GO:0046039 239 0.021
multicellular organismal aging GO:0010259 3 0.021
tube closure GO:0060606 3 0.021
positive regulation of cellular component organization GO:0051130 376 0.021
cardiovascular system development GO:0072358 262 0.021
cation transport GO:0006812 331 0.021
regulation of protein localization GO:0032880 296 0.021
regulation of cell adhesion GO:0030155 166 0.021
regeneration GO:0031099 4 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
heart development GO:0007507 95 0.021
positive regulation of protein kinase activity GO:0045860 190 0.020
inositol phosphate mediated signaling GO:0048016 16 0.020
dephosphorylation GO:0016311 209 0.020
regulation of gtpase activity GO:0043087 180 0.020
negative regulation of phosphorylation GO:0042326 174 0.020
regulation of transferase activity GO:0051338 355 0.020
response to oxygen containing compound GO:1901700 369 0.020
organophosphate catabolic process GO:0046434 430 0.020
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.020
purine nucleoside triphosphate catabolic process GO:0009146 392 0.020
negative regulation of protein modification process GO:0031400 200 0.020
positive regulation of gtp catabolic process GO:0033126 166 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
neurotransmitter secretion GO:0007269 4 0.020
regulation of mapk cascade GO:0043408 262 0.020
cell morphogenesis GO:0000902 296 0.020
regulation of calcium ion transport GO:0051924 79 0.020
anion transport GO:0006820 161 0.019
membrane organization GO:0061024 292 0.019
carbohydrate derivative biosynthetic process GO:1901137 207 0.019
positive regulation of developmental process GO:0051094 314 0.019
cerebral cortex development GO:0021987 10 0.019
epithelial cell proliferation GO:0050673 128 0.019
regulation of synaptic plasticity GO:0048167 3 0.019
ventricular septum morphogenesis GO:0060412 3 0.019
ribonucleoside catabolic process GO:0042454 406 0.019
regulation of nucleotide catabolic process GO:0030811 205 0.019
negative regulation of embryonic development GO:0045992 4 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
guanosine containing compound catabolic process GO:1901069 239 0.019
regulation of intracellular protein transport GO:0033157 123 0.018
cellular response to oxygen containing compound GO:1901701 276 0.018
positive regulation of cytoplasmic transport GO:1903651 82 0.018
positive regulation of cell differentiation GO:0045597 211 0.018
transmembrane transport GO:0055085 399 0.018
regulation of immune response GO:0050776 201 0.018
regulation of cytoskeleton organization GO:0051493 177 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.018
spermatid development GO:0007286 4 0.018
positive regulation of cell death GO:0010942 263 0.018
organonitrogen compound biosynthetic process GO:1901566 200 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
cellular response to dna damage stimulus GO:0006974 379 0.018
regulation of cellular response to stress GO:0080135 244 0.018
reproductive process GO:0022414 106 0.018
negative regulation of transport GO:0051051 176 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
regulation of cellular component biogenesis GO:0044087 281 0.018
response to other organism GO:0051707 261 0.018
embryonic camera type eye development GO:0031076 2 0.017
microtubule anchoring GO:0034453 24 0.017
neurological system process GO:0050877 163 0.017
ras protein signal transduction GO:0007265 73 0.017
protein localization to organelle GO:0033365 280 0.017
maintenance of protein location GO:0045185 57 0.017
embryonic eye morphogenesis GO:0048048 2 0.017
regulation of protein transport GO:0051223 213 0.017
hemopoiesis GO:0030097 180 0.017
regulation of neural precursor cell proliferation GO:2000177 4 0.017
cellular protein complex assembly GO:0043623 188 0.017
osteoblast differentiation GO:0001649 92 0.017
neuromuscular junction development GO:0007528 3 0.017
nucleoside triphosphate metabolic process GO:0009141 422 0.017
purine containing compound catabolic process GO:0072523 411 0.017
cytoplasmic transport GO:0016482 379 0.017
compound eye development GO:0048749 1 0.017
synaptic transmission GO:0007268 61 0.017
regulation of protein maturation GO:1903317 150 0.017
defense response to fungus GO:0050832 4 0.016
metal ion transport GO:0030001 272 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
gtp catabolic process GO:0006184 237 0.016
protein processing GO:0016485 226 0.016
cerebral cortex cell migration GO:0021795 3 0.016
negative regulation of protein kinase activity GO:0006469 98 0.016
positive regulation of gtpase activity GO:0043547 166 0.016
regulation of cell cycle GO:0051726 393 0.016
cellular protein catabolic process GO:0044257 261 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
cytokine production GO:0001816 247 0.016
epithelium development GO:0060429 227 0.016
protein catabolic process GO:0030163 325 0.016
regulation of lipid metabolic process GO:0019216 96 0.015
regulation of protein processing GO:0070613 150 0.015
nucleoside phosphate catabolic process GO:1901292 412 0.015
nucleotide catabolic process GO:0009166 408 0.015
actin cytoskeleton organization GO:0030036 207 0.015
organelle assembly GO:0070925 176 0.015
negative regulation of programmed cell death GO:0043069 321 0.015
outflow tract septum morphogenesis GO:0003148 4 0.015
intracellular mrna localization GO:0008298 1 0.015
atrioventricular valve development GO:0003171 3 0.015
protein oligomerization GO:0051259 173 0.015
positive regulation of protein transport GO:0051222 135 0.015
viral process GO:0016032 146 0.015
myoblast fusion GO:0007520 1 0.015
positive regulation of cytokine production GO:0001819 167 0.015
positive regulation of cellular component biogenesis GO:0044089 158 0.015
forebrain generation of neurons GO:0021872 3 0.015
negative regulation of protein maturation GO:1903318 142 0.015
protein localization to membrane GO:0072657 160 0.015
regulation of response to dna damage stimulus GO:2001020 94 0.015
positive regulation of kinase activity GO:0033674 204 0.015
divalent metal ion transport GO:0070838 152 0.015
amine metabolic process GO:0009308 44 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
negative regulation of cell death GO:0060548 345 0.014
positive regulation of mapk cascade GO:0043410 190 0.014
protein maturation GO:0051604 233 0.014
engulfment of apoptotic cell GO:0043652 2 0.014
interspecies interaction between organisms GO:0044419 156 0.014
positive regulation of cell cycle process GO:0090068 106 0.014
negative regulation of transferase activity GO:0051348 124 0.014
regulation of multi organism process GO:0043900 157 0.014
organ morphogenesis GO:0009887 147 0.014
negative regulation of cytokine production GO:0001818 82 0.014
positive regulation of transferase activity GO:0051347 227 0.014
nuclear transport GO:0051169 179 0.014
divalent inorganic cation transport GO:0072511 158 0.014
cofactor metabolic process GO:0051186 87 0.014
regulation of cytokine production GO:0001817 232 0.014
cellular carbohydrate metabolic process GO:0044262 84 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
response to external biotic stimulus GO:0043207 261 0.014
ion transmembrane transport GO:0034220 338 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
hematopoietic or lymphoid organ development GO:0048534 186 0.014
response to bacterium GO:0009617 144 0.014
regulation of dna metabolic process GO:0051052 153 0.014
determination of adult lifespan GO:0008340 2 0.014
negative regulation of proteolysis GO:0045861 132 0.014
signal transduction by phosphorylation GO:0023014 297 0.013
maintenance of protein location in cell GO:0032507 56 0.013
negative regulation of protein processing GO:0010955 142 0.013
phospholipid metabolic process GO:0006644 99 0.013
regulation of cytoplasmic transport GO:1903649 149 0.013
chemical homeostasis GO:0048878 306 0.013
positive regulation of cellular amine metabolic process GO:0033240 7 0.013
ion homeostasis GO:0050801 230 0.013
regulation of cell motility GO:2000145 299 0.013
heart morphogenesis GO:0003007 48 0.013
blood vessel development GO:0001568 172 0.013
sleep GO:0030431 2 0.013
ossification GO:0001503 121 0.013
mapk cascade GO:0000165 288 0.013
long term memory GO:0007616 2 0.013
wound healing GO:0042060 115 0.013
morphogenesis of a polarized epithelium GO:0001738 3 0.013
regulation of osteoblast differentiation GO:0045667 38 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
immune effector process GO:0002252 159 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
regulation of protein import into nucleus GO:0042306 78 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
regulation of cell cycle process GO:0010564 266 0.013
adult locomotory behavior GO:0008344 1 0.013
ribonucleoprotein complex subunit organization GO:0071826 81 0.013
response to abiotic stimulus GO:0009628 336 0.013
cellular response to lipid GO:0071396 127 0.013
metencephalon development GO:0022037 2 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
regulation of protein localization to nucleus GO:1900180 85 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
negative regulation of organelle organization GO:0010639 126 0.013
regulation of chromosome organization GO:0033044 103 0.012
nucleoside catabolic process GO:0009164 408 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
lipid biosynthetic process GO:0008610 177 0.012
small molecule biosynthetic process GO:0044283 157 0.012
regulation of erk1 and erk2 cascade GO:0070372 99 0.012
stem cell development GO:0048864 69 0.012
response to fungus GO:0009620 4 0.012
dna repair GO:0006281 198 0.012
mesenchyme development GO:0060485 59 0.012
limbic system development GO:0021761 3 0.012
nuclear import GO:0051170 106 0.012
regulation of metal ion transport GO:0010959 120 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
regulation of canonical wnt signaling pathway GO:0060828 88 0.012
response to lithium ion GO:0010226 2 0.012
anatomical structure homeostasis GO:0060249 100 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
response to hormone GO:0009725 175 0.012
negative regulation of growth GO:0045926 97 0.012
polysaccharide metabolic process GO:0005976 33 0.012
positive regulation of protein complex assembly GO:0031334 86 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.012
multi organism cellular process GO:0044764 156 0.012
tissue regeneration GO:0042246 3 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
mitotic nuclear division GO:0007067 119 0.012
secretion by cell GO:0032940 226 0.012
regulation of dephosphorylation GO:0035303 96 0.012
heart valve formation GO:0003188 2 0.011
angiogenesis GO:0001525 147 0.011
stem cell division GO:0017145 2 0.011
cellular component disassembly GO:0022411 92 0.011
regulation of proteolysis GO:0030162 293 0.011
vesicle mediated transport GO:0016192 371 0.011
positive regulation of immune system process GO:0002684 283 0.011
negative regulation of non canonical wnt signaling pathway GO:2000051 1 0.011
apoptotic signaling pathway GO:0097190 268 0.011
wnt signaling pathway GO:0016055 156 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.011
hexose metabolic process GO:0019318 55 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
mitotic cell cycle GO:0000278 326 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
chromatin organization GO:0006325 351 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
cardiac ventricle development GO:0003231 23 0.011
autonomic nervous system development GO:0048483 1 0.011
regulation of nucleocytoplasmic transport GO:0046822 98 0.011
protein targeting GO:0006605 187 0.011
regulation of cellular component movement GO:0051270 334 0.011
regulation of fat cell differentiation GO:0045598 23 0.011
chromatin modification GO:0016568 298 0.011
cardiac chamber development GO:0003205 30 0.011
methylation GO:0032259 106 0.011
histone modification GO:0016570 251 0.011
nerve development GO:0021675 4 0.011
positive regulation of organelle organization GO:0010638 195 0.011
peptidyl threonine modification GO:0018210 45 0.011
mitochondrion organization GO:0007005 156 0.011
cell activation GO:0001775 213 0.011
regulation of vesicle mediated transport GO:0060627 130 0.011
regulation of protein catabolic process GO:0042176 155 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
urogenital system development GO:0001655 65 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
neuroblast division GO:0055057 1 0.011
single organism nuclear import GO:1902593 104 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
somatic stem cell maintenance GO:0035019 4 0.011
associative learning GO:0008306 1 0.010
protein homooligomerization GO:0051260 100 0.010
negative regulation of cell differentiation GO:0045596 171 0.010
neuroblast proliferation GO:0007405 4 0.010
mitotic cell cycle process GO:1903047 286 0.010
regulation of anatomical structure morphogenesis GO:0022603 286 0.010
alpha amino acid metabolic process GO:1901605 72 0.010
positive regulation of secretion GO:0051047 116 0.010
positive regulation of ras gtpase activity GO:0032320 117 0.010
growth GO:0040007 202 0.010
regulation of microtubule cytoskeleton organization GO:0070507 61 0.010
tube morphogenesis GO:0035239 95 0.010
positive regulation of programmed cell death GO:0043068 249 0.010
rho protein signal transduction GO:0007266 26 0.010
autophagy GO:0006914 88 0.010
regulation of phosphatase activity GO:0010921 81 0.010
regulation of locomotion GO:0040012 329 0.010

DEFA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.022
neurodegenerative disease DOID:1289 102 0.022
nervous system disease DOID:863 431 0.022
disease of metabolism DOID:0014667 295 0.017
cancer DOID:162 167 0.017
disease of cellular proliferation DOID:14566 174 0.017
organ system cancer DOID:0050686 164 0.017
sensory system disease DOID:0050155 203 0.012
brain disease DOID:936 73 0.012
inherited metabolic disorder DOID:655 242 0.011