Homo sapiens

202 known processes

CYLD

cylindromatosis (turban tumor syndrome)

(Aliases: SBS,CYLD1,TEM,USPL2,EAC,CDMT,MFT1,MFT,KIAA0849,FLJ31664,FLJ20180,CYLDI,FLJ78684)

CYLD biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of interferon beta production GO:0032728 17 0.989
interferon beta production GO:0032608 23 0.940
regulation of interferon alpha production GO:0032647 11 0.884
activation of innate immune response GO:0002218 55 0.737
positive regulation of interferon alpha production GO:0032727 11 0.720
optic nerve development GO:0021554 2 0.714
protein deubiquitination GO:0016579 79 0.701
protein modification by small protein conjugation GO:0032446 342 0.670
positive regulation of immune system process GO:0002684 283 0.660
positive regulation of interferon beta biosynthetic process GO:0045359 4 0.585
positive regulation of type i interferon production GO:0032481 20 0.568
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.552
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.531
regulation of protein localization GO:0032880 296 0.515
establishment of protein localization to organelle GO:0072594 172 0.506
peptidyl serine phosphorylation GO:0018105 101 0.480
positive regulation of immune response GO:0050778 159 0.480
regulation of locomotion GO:0040012 329 0.475
regulation of immune response GO:0050776 201 0.468
positive regulation of defense response GO:0031349 87 0.455
immune response regulating signaling pathway GO:0002764 97 0.448
regulation of interferon beta production GO:0032648 22 0.442
positive regulation of cytokine production GO:0001819 167 0.410
endocytic recycling GO:0032456 12 0.398
interferon beta biosynthetic process GO:0045350 4 0.389
interferon alpha production GO:0032607 11 0.356
pre mirna processing GO:0031054 8 0.348
negative regulation of response to biotic stimulus GO:0002832 18 0.340
innate immune response activating signal transduction GO:0002758 48 0.339
protein ubiquitination GO:0016567 314 0.335
regulation of immune effector process GO:0002697 91 0.333
positive regulation of cell death GO:0010942 263 0.319
cellular response to dna damage stimulus GO:0006974 379 0.316
cranial nerve morphogenesis GO:0021602 1 0.313
cranial nerve formation GO:0021603 1 0.298
immune response activating signal transduction GO:0002757 90 0.297
post embryonic development GO:0009791 2 0.287
golgi ribbon formation GO:0090161 3 0.287
response to other organism GO:0051707 261 0.282
Fly
regulation of type i interferon production GO:0032479 26 0.279
modulation of molecular function in other organism involved in symbiotic interaction GO:0052205 2 0.275
innate immune response GO:0045087 178 0.267
cellular response to oxidative stress GO:0034599 85 0.263
heart contraction GO:0060047 62 0.262
cell activation GO:0001775 213 0.262
Mouse
regulation of protein transport GO:0051223 213 0.261
negative regulation of multi organism process GO:0043901 92 0.258
cranial nerve development GO:0021545 4 0.257
regulation of cell migration GO:0030334 289 0.254
inorganic cation transmembrane transport GO:0098662 194 0.252
muscle system process GO:0003012 81 0.251
apoptotic signaling pathway GO:0097190 268 0.250
modification dependent macromolecule catabolic process GO:0043632 212 0.242
dsrna fragmentation GO:0031050 13 0.238
negative regulation of programmed cell death GO:0043069 321 0.238
cellular macromolecular complex assembly GO:0034622 324 0.236
immune response GO:0006955 307 0.235
neuron differentiation GO:0030182 138 0.228
cytokine production GO:0001816 247 0.222
regulation of cytokine production GO:0001817 232 0.221
protein import GO:0017038 130 0.220
positive regulation of innate immune response GO:0045089 79 0.220
single organism cellular localization GO:1902580 332 0.216
endosomal transport GO:0016197 129 0.214
cellular response to external stimulus GO:0071496 111 0.204
i kappab kinase nf kappab signaling GO:0007249 166 0.194
regulation of muscle system process GO:0090257 53 0.192
activation of immune response GO:0002253 114 0.191
type i interferon production GO:0032606 27 0.189
regulation of defense response GO:0031347 154 0.188
vesicle mediated transport GO:0016192 371 0.187
regulation of transcription factor import into nucleus GO:0042990 39 0.186
positive regulation of programmed cell death GO:0043068 249 0.183
negative regulation of immune system process GO:0002683 136 0.180
Mouse
negative regulation of cell death GO:0060548 345 0.179
chromatin organization GO:0006325 351 0.172
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.168
nervous system development GO:0007399 293 0.168
ion transmembrane transport GO:0034220 338 0.168
nerve development GO:0021675 4 0.164
response to organic cyclic compound GO:0014070 204 0.163
response to biotic stimulus GO:0009607 276 0.161
Fly
defense response to other organism GO:0098542 129 0.160
Fly
negative regulation of intracellular signal transduction GO:1902532 183 0.158
protein targeting to nucleus GO:0044744 104 0.158
positive regulation of intracellular transport GO:0032388 104 0.156
regulation of response to biotic stimulus GO:0002831 55 0.155
production of mirnas involved in gene silencing by mirna GO:0035196 12 0.153
nuclear transport GO:0051169 179 0.153
cellular response to organic cyclic compound GO:0071407 127 0.152
peptidyl serine modification GO:0018209 106 0.150
cytoplasmic transport GO:0016482 379 0.150
negative regulation of defense response GO:0031348 47 0.149
protein localization to organelle GO:0033365 280 0.149
single organism membrane organization GO:0044802 268 0.149
positive regulation of transport GO:0051050 336 0.145
response to cytokine GO:0034097 232 0.144
regulation of establishment of protein localization GO:0070201 242 0.140
microtubule cytoskeleton organization GO:0000226 176 0.137
positive regulation of developmental process GO:0051094 314 0.136
regulation of multi organism process GO:0043900 157 0.135
serine phosphorylation of stat protein GO:0042501 4 0.134
regulation of cell motility GO:2000145 299 0.134
production of small rna involved in gene silencing by rna GO:0070918 13 0.131
negative regulation of response to external stimulus GO:0032102 83 0.130
regulation of nucleocytoplasmic transport GO:0046822 98 0.128
cellular response to parathyroid hormone stimulus GO:0071374 2 0.127
leukocyte activation GO:0045321 164 0.123
Mouse
regulation of ion transmembrane transporter activity GO:0032412 72 0.123
negative regulation of immune effector process GO:0002698 38 0.121
positive regulation of defense response to virus by host GO:0002230 14 0.121
response to virus GO:0009615 126 0.121
lymphocyte proliferation GO:0046651 70 0.121
interaction with host GO:0051701 42 0.121
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.120
cellular response to dsrna GO:0071359 19 0.119
positive regulation of protein phosphorylation GO:0001934 313 0.115
regulation of cell differentiation GO:0045595 393 0.111
Mouse
fibroblast apoptotic process GO:0044346 8 0.110
response to external biotic stimulus GO:0043207 261 0.110
Fly
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.110
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.110
positive regulation of cellular component organization GO:0051130 376 0.105
regulation of intracellular protein transport GO:0033157 123 0.105
circulatory system process GO:0003013 113 0.104
gene silencing GO:0016458 49 0.104
regulation of response to external stimulus GO:0032101 222 0.103
negative regulation of apoptotic process GO:0043066 316 0.103
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.103
protein targeting GO:0006605 187 0.102
negative regulation of catalytic activity GO:0043086 335 0.101
cardiac muscle contraction GO:0060048 34 0.101
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.100
response to lipid GO:0033993 206 0.098
chromatin modification GO:0016568 298 0.097
cell projection organization GO:0030030 252 0.096
positive regulation of phosphorylation GO:0042327 394 0.096
regulation of innate immune response GO:0045088 97 0.096
intracellular protein transport GO:0006886 270 0.095
positive regulation of apoptotic process GO:0043065 246 0.095
sodium ion transmembrane transport GO:0035725 59 0.093
regulation of cysteine type endopeptidase activity GO:2000116 127 0.093
response to oxidative stress GO:0006979 121 0.092
Fly
extrinsic apoptotic signaling pathway GO:0097191 119 0.090
response to dsrna GO:0043331 25 0.090
mononuclear cell proliferation GO:0032943 71 0.090
positive regulation of hydrolase activity GO:0051345 331 0.089
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.088
muscle contraction GO:0006936 73 0.088
response to nitrogen compound GO:1901698 184 0.088
programmed necrotic cell death GO:0097300 18 0.088
Mouse
regulation of protein targeting GO:1903533 91 0.086
negative regulation of cytokine production GO:0001818 82 0.085
regulation of cellular ketone metabolic process GO:0010565 50 0.085
cardiac muscle hypertrophy GO:0003300 14 0.083
mating GO:0007618 1 0.082
regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway GO:0039531 7 0.082
regulation of cellular component movement GO:0051270 334 0.082
protein modification by small protein removal GO:0070646 92 0.081
early endosome to golgi transport GO:0034498 3 0.079
ribonucleoprotein complex assembly GO:0022618 78 0.079
modulation of molecular function in other organism GO:0044359 2 0.079
gtp catabolic process GO:0006184 237 0.075
defense response to bacterium GO:0042742 63 0.073
Fly
striated muscle contraction GO:0006941 52 0.072
cell development GO:0048468 328 0.071
neurogenesis GO:0022008 169 0.071
regulation of leukocyte differentiation GO:1902105 61 0.071
Mouse
rna interference GO:0016246 4 0.070
regulation of cellular amine metabolic process GO:0033238 11 0.070
negative regulation of transporter activity GO:0032410 25 0.070
defense response GO:0006952 315 0.069
Fly
anatomical structure formation involved in morphogenesis GO:0048646 284 0.069
cellular response to endogenous stimulus GO:0071495 336 0.068
determination of adult lifespan GO:0008340 2 0.067
Fly
sodium ion transport GO:0006814 61 0.067
posttranscriptional regulation of gene expression GO:0010608 213 0.067
response to growth factor GO:0070848 205 0.067
ncrna metabolic process GO:0034660 108 0.067
regulation of cytoskeleton organization GO:0051493 177 0.064
neuron projection development GO:0031175 106 0.064
protein import into nucleus GO:0006606 104 0.064
cellular component morphogenesis GO:0032989 314 0.063
lipid translocation GO:0034204 2 0.063
negative regulation of defense response to virus GO:0050687 10 0.061
response to endoplasmic reticulum stress GO:0034976 49 0.061
type i interferon signaling pathway GO:0060337 11 0.061
cell morphogenesis GO:0000902 296 0.061
regulation of microtubule based process GO:0032886 74 0.061
regulation of gene expression epigenetic GO:0040029 73 0.059
transmembrane transport GO:0055085 399 0.059
regulation of epithelial cell migration GO:0010632 93 0.059
negative regulation of cellular protein metabolic process GO:0032269 353 0.058
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.058
cellular response to nutrient levels GO:0031669 69 0.058
regulation of lymphocyte activation GO:0051249 103 0.058
Mouse
gene silencing by mirna GO:0035195 23 0.058
positive regulation of intracellular protein transport GO:0090316 76 0.057
positive regulation of cell motility GO:2000147 177 0.057
regulation of defense response to virus GO:0050688 33 0.056
lymphocyte activation GO:0046649 133 0.055
Mouse
rna processing GO:0006396 255 0.055
secretion by cell GO:0032940 226 0.055
reactive oxygen species metabolic process GO:0072593 75 0.055
defense response to virus GO:0051607 71 0.055
cardiovascular system development GO:0072358 262 0.054
rna phosphodiester bond hydrolysis GO:0090501 35 0.054
peptidyl threonine phosphorylation GO:0018107 41 0.054
ribonucleoprotein complex biogenesis GO:0022613 116 0.053
regulation of transporter activity GO:0032409 82 0.053
biological adhesion GO:0022610 331 0.052
cellular response to radiation GO:0071478 65 0.052
regulation of cytoplasmic transport GO:1903649 149 0.052
autophagy GO:0006914 88 0.052
regulation of interferon beta biosynthetic process GO:0045357 4 0.052
regulation of microtubule cytoskeleton organization GO:0070507 61 0.052
covalent chromatin modification GO:0016569 254 0.050
neurotransmitter secretion GO:0007269 4 0.049
targeting of mrna for destruction involved in rna interference GO:0030423 3 0.049
cellular response to biotic stimulus GO:0071216 71 0.049
positive regulation of protein complex assembly GO:0031334 86 0.049
purine ribonucleoside metabolic process GO:0046128 437 0.049
positive regulation of cellular catabolic process GO:0031331 284 0.049
cellular protein catabolic process GO:0044257 261 0.049
cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 8 0.048
microtubule polymerization or depolymerization GO:0031109 37 0.048
guanosine containing compound metabolic process GO:1901068 244 0.048
rab protein signal transduction GO:0032482 4 0.048
memory GO:0007613 3 0.048
ubiquitin dependent protein catabolic process GO:0006511 206 0.048
locomotory behavior GO:0007626 1 0.046
secretion GO:0046903 254 0.046
regulation of secretion GO:0051046 194 0.045
negative regulation of sodium ion transmembrane transporter activity GO:2000650 2 0.044
regulation of cell activation GO:0050865 125 0.044
Mouse
cellular response to misfolded protein GO:0071218 2 0.044
negative regulation of cellular component organization GO:0051129 235 0.044
regulation of relaxation of cardiac muscle GO:1901897 2 0.042
negative regulation of striated muscle contraction GO:0045988 2 0.042
head development GO:0060322 108 0.041
multi organism cellular process GO:0044764 156 0.041
cellular response to growth factor stimulus GO:0071363 197 0.041
modification dependent protein catabolic process GO:0019941 209 0.041
regulation of response to cytokine stimulus GO:0060759 46 0.041
ribonucleoprotein complex subunit organization GO:0071826 81 0.040
actin filament based process GO:0030029 224 0.040
muscle adaptation GO:0043500 12 0.040
positive regulation of protein transport GO:0051222 135 0.040
immune effector process GO:0002252 159 0.040
positive regulation of protein import into nucleus GO:0042307 46 0.040
immune system development GO:0002520 195 0.039
Mouse
cellular response to starvation GO:0009267 58 0.039
hemopoiesis GO:0030097 180 0.039
Mouse
protein catabolic process GO:0030163 325 0.039
cell cycle g1 s phase transition GO:0044843 80 0.039
establishment of protein localization to golgi GO:0072600 4 0.039
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 12 0.038
cellular macromolecule catabolic process GO:0044265 380 0.038
cellular response to nitrogen compound GO:1901699 144 0.038
multicellular organismal aging GO:0010259 3 0.038
Fly
cellular response to organonitrogen compound GO:0071417 124 0.038
positive regulation of secretion by cell GO:1903532 108 0.038
regulation of transmembrane transport GO:0034762 139 0.038
regulation of cellular response to stress GO:0080135 244 0.038
chemical homeostasis GO:0048878 306 0.038
Fly
small gtpase mediated signal transduction GO:0007264 78 0.037
regulation of cellular component biogenesis GO:0044087 281 0.037
negative regulation of phosphorus metabolic process GO:0010563 267 0.037
positive regulation of cell differentiation GO:0045597 211 0.037
positive regulation of protein localization to nucleus GO:1900182 48 0.036
regulation of protein import into nucleus GO:0042306 78 0.036
regulation of cell projection organization GO:0031344 107 0.035
generation of precursor metabolites and energy GO:0006091 68 0.035
protein polyubiquitination GO:0000209 110 0.035
positive regulation of cellular component movement GO:0051272 181 0.035
viral life cycle GO:0019058 132 0.035
regulation of defense response to virus by host GO:0050691 22 0.035
regulation of sodium ion transmembrane transporter activity GO:2000649 17 0.035
response to nutrient levels GO:0031667 81 0.034
regulation of cellular amino acid metabolic process GO:0006521 6 0.034
behavior GO:0007610 112 0.034
regulation of sodium ion transmembrane transport GO:1902305 23 0.034
leukocyte differentiation GO:0002521 98 0.034
Mouse
cellular response to abiotic stimulus GO:0071214 117 0.034
dna repair GO:0006281 198 0.033
regulation of leukocyte activation GO:0002694 115 0.033
Mouse
ribonucleotide catabolic process GO:0009261 405 0.032
energy derivation by oxidation of organic compounds GO:0015980 43 0.032
regulation of growth GO:0040008 165 0.032
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.032
positive regulation of transcription factor import into nucleus GO:0042993 25 0.031
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.031
glycosyl compound catabolic process GO:1901658 413 0.031
regulation of t cell activation GO:0050863 77 0.031
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.031
hippocampus development GO:0021766 1 0.031
positive regulation of muscle hypertrophy GO:0014742 6 0.031
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.031
macromolecular complex disassembly GO:0032984 60 0.030
cation transmembrane transport GO:0098655 238 0.030
regulation of proteolysis GO:0030162 293 0.030
blood circulation GO:0008015 113 0.030
ncrna processing GO:0034470 83 0.030
cell projection assembly GO:0030031 126 0.030
epithelial cell migration GO:0010631 119 0.030
calcium ion transport GO:0006816 147 0.030
neuron development GO:0048666 113 0.030
pattern recognition receptor signaling pathway GO:0002221 48 0.030
generation of neurons GO:0048699 152 0.030
negative regulation of the force of heart contraction by chemical signal GO:0003108 1 0.029
negative regulation of protein metabolic process GO:0051248 391 0.029
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.029
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.029
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.029
production of sirna involved in rna interference GO:0030422 3 0.029
regulation of protein localization to nucleus GO:1900180 85 0.029
histone modification GO:0016570 251 0.029
chromatin assembly GO:0031497 61 0.029
programmed cell death in response to reactive oxygen species GO:0097468 4 0.028
regulation of homeostatic process GO:0032844 121 0.028
protein oligomerization GO:0051259 173 0.028
regulation of mda 5 signaling pathway GO:0039533 4 0.028
cell adhesion GO:0007155 325 0.028
negative regulation of ion transmembrane transport GO:0034766 26 0.028
regulation of reactive oxygen species metabolic process GO:2000377 41 0.028
protein k63 linked ubiquitination GO:0070534 31 0.027
long term memory GO:0007616 2 0.027
limbic system development GO:0021761 3 0.027
chromatin assembly or disassembly GO:0006333 78 0.027
t cell activation GO:0042110 99 0.027
Mouse
cellular component disassembly GO:0022411 92 0.027
positive regulation of cell migration GO:0030335 172 0.027
regulation of ion transport GO:0043269 189 0.027
oxidation reduction process GO:0055114 396 0.026
response to exogenous dsrna GO:0043330 10 0.026
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.026
female gamete generation GO:0007292 2 0.026
peptidyl lysine modification GO:0018205 144 0.025
leukocyte migration GO:0050900 107 0.025
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.025
cilium assembly GO:0042384 63 0.025
cellular response to decreased oxygen levels GO:0036294 51 0.025
maintenance of location GO:0051235 112 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
regulation of ion transmembrane transport GO:0034765 132 0.025
inorganic ion transmembrane transport GO:0098660 231 0.024
mda 5 signaling pathway GO:0039530 4 0.024
nuclear import GO:0051170 106 0.024
regulation of purine nucleotide metabolic process GO:1900542 264 0.024
neuroblast proliferation GO:0007405 4 0.024
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.024
negative regulation of type i interferon production GO:0032480 5 0.024
negative regulation of viral process GO:0048525 66 0.024
regulation of oxidative stress induced cell death GO:1903201 24 0.024
tissue migration GO:0090130 119 0.024
nitrogen compound transport GO:0071705 191 0.024
cellular ketone metabolic process GO:0042180 80 0.024
regulation of meiosis GO:0040020 3 0.024
positive regulation of amine transport GO:0051954 2 0.024
regulation of transmembrane transporter activity GO:0022898 74 0.024
regulation of membrane potential GO:0042391 95 0.024
divalent inorganic cation transport GO:0072511 158 0.024
peptidyl serine autophosphorylation GO:0036289 2 0.024
protein maturation GO:0051604 233 0.023
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.023
regulation of glial cell differentiation GO:0045685 3 0.023
regulation of rhodopsin mediated signaling pathway GO:0022400 1 0.023
negative regulation of multicellular organismal process GO:0051241 317 0.023
Mouse
regulation of endopeptidase activity GO:0052548 170 0.023
gtp metabolic process GO:0046039 239 0.023
macropinocytosis GO:0044351 1 0.023
oxidative stress induced premature senescence GO:0090403 3 0.023
membrane organization GO:0061024 292 0.023
regulation of anatomical structure morphogenesis GO:0022603 286 0.023
regulation of cell cycle GO:0051726 393 0.023
regulation of fibroblast apoptotic process GO:2000269 8 0.023
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.023
neuron remodeling GO:0016322 2 0.022
negative regulation of apoptotic signaling pathway GO:2001234 97 0.022
neurological system process GO:0050877 163 0.022
response to molecule of bacterial origin GO:0002237 82 0.022
response to bacterium GO:0009617 144 0.022
Fly
misfolded protein transport GO:0070843 1 0.022
ribonucleoside triphosphate catabolic process GO:0009203 391 0.022
microtubule bundle formation GO:0001578 15 0.022
regulation of protein deubiquitination GO:0090085 4 0.022
positive regulation of peptidase activity GO:0010952 88 0.022
oocyte development GO:0048599 1 0.021
cellular homeostasis GO:0019725 196 0.021
muscle hypertrophy GO:0014896 14 0.021
regulation of protein maturation GO:1903317 150 0.021
lymphocyte mediated immunity GO:0002449 48 0.021
dephosphorylation GO:0016311 209 0.021
positive regulation of endopeptidase activity GO:0010950 84 0.021
response to inorganic substance GO:0010035 127 0.021
leukocyte proliferation GO:0070661 74 0.021
organelle fission GO:0048285 149 0.021
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.021
protein deacetylation GO:0006476 38 0.021
response to parathyroid hormone GO:0071107 3 0.021
nucleoside triphosphate metabolic process GO:0009141 422 0.021
positive regulation of response to external stimulus GO:0032103 88 0.020
protein sumoylation GO:0016925 25 0.020
regulation of gtp catabolic process GO:0033124 180 0.020
amine metabolic process GO:0009308 44 0.020
carbohydrate metabolic process GO:0005975 207 0.020
mapk cascade GO:0000165 288 0.020
retrograde transport endosome to golgi GO:0042147 45 0.020
ion homeostasis GO:0050801 230 0.020
regulation of rab protein signal transduction GO:0032483 39 0.020
nuclear export GO:0051168 69 0.020
response to oxygen containing compound GO:1901700 369 0.020
negative regulation of protein transport GO:0051224 75 0.020
regulation of ion homeostasis GO:2000021 73 0.020
positive regulation of rig i signaling pathway GO:1900246 4 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
cell cycle phase transition GO:0044770 173 0.020
ribonucleoside catabolic process GO:0042454 406 0.019
tricarboxylic acid cycle GO:0006099 4 0.019
regulation of peptidase activity GO:0052547 180 0.019
protein monoubiquitination GO:0006513 39 0.019
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.019
negative regulation of glycoprotein metabolic process GO:1903019 8 0.019
negative regulation of innate immune response GO:0045824 18 0.019
cell cell signaling GO:0007267 155 0.019
positive regulation of myeloid cell differentiation GO:0045639 39 0.019
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.019
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 17 0.019
lipid metabolic process GO:0006629 381 0.019
epithelium migration GO:0090132 119 0.019
single organism carbohydrate metabolic process GO:0044723 193 0.019
mrna catabolic process GO:0006402 56 0.019
divalent metal ion transport GO:0070838 152 0.019
protein localization to cell surface GO:0034394 28 0.018
regulation of cytokine biosynthetic process GO:0042035 35 0.018
nucleoside catabolic process GO:0009164 408 0.018
positive regulation of protein kinase activity GO:0045860 190 0.018
positive regulation of proteolysis GO:0045862 142 0.018
positive regulation of cell proliferation GO:0008284 301 0.018
regulation of lymphocyte proliferation GO:0050670 64 0.018
regulation of meiotic cell cycle GO:0051445 4 0.018
ripoptosome assembly GO:0097343 1 0.018
Mouse
retrograde transport vesicle recycling within golgi GO:0000301 3 0.018
adaptive immune response GO:0002250 49 0.018
macromolecule deacylation GO:0098732 41 0.018
inositol lipid mediated signaling GO:0048017 55 0.018
protein k63 linked deubiquitination GO:0070536 21 0.018
system process GO:0003008 349 0.018
purine nucleoside triphosphate metabolic process GO:0009144 412 0.018
negative regulation of protein complex disassembly GO:0043242 20 0.017
regulation of cell cycle g1 s phase transition GO:1902806 42 0.017
cellular carbohydrate metabolic process GO:0044262 84 0.017
positive regulation of secretion GO:0051047 116 0.017
neuromuscular junction development GO:0007528 3 0.017
positive regulation of catabolic process GO:0009896 310 0.017
cell death in response to hydrogen peroxide GO:0036474 10 0.017
regulation of neurotransmitter secretion GO:0046928 3 0.017
negative regulation of developmental process GO:0051093 247 0.017
Mouse
negative regulation of cell activation GO:0050866 33 0.017
Mouse
regulation of mapk cascade GO:0043408 262 0.017
positive regulation of locomotion GO:0040017 186 0.017
negative regulation of ion transport GO:0043271 39 0.017
chemotaxis GO:0006935 157 0.017
cytokine biosynthetic process GO:0042089 37 0.017
regulation of synaptic plasticity GO:0048167 3 0.017
growth GO:0040007 202 0.016
positive regulation of cell activation GO:0050867 81 0.016
cellular protein complex disassembly GO:0043624 36 0.016
regulation of protein processing GO:0070613 150 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
wound healing GO:0042060 115 0.016
negative regulation of molecular function in other organism GO:0044362 2 0.016
negative regulation of ion transmembrane transporter activity GO:0032413 19 0.016
phototransduction visible light GO:0007603 2 0.016
response to type i interferon GO:0034340 14 0.016
regulation of rab gtpase activity GO:0032313 39 0.016
protein autophosphorylation GO:0046777 123 0.016
regulation of intracellular transport GO:0032386 195 0.016
response to organonitrogen compound GO:0010243 156 0.016
cation transport GO:0006812 331 0.016
cellular response to type i interferon GO:0071357 12 0.016
regulation of rig i signaling pathway GO:0039535 6 0.016
g1 s transition of mitotic cell cycle GO:0000082 78 0.015

CYLD disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.421
nervous system disease DOID:863 431 0.421
glaucoma DOID:1686 8 0.407
retinal disease DOID:5679 118 0.407
retinal degeneration DOID:8466 89 0.407
sensory system disease DOID:0050155 203 0.407
eye and adnexa disease DOID:1492 150 0.407
eye disease DOID:5614 149 0.407
physical disorder DOID:0080015 41 0.068
congenital nervous system abnormality DOID:2490 21 0.068
neurodegenerative disease DOID:1289 102 0.028
synucleinopathy DOID:0050890 22 0.019