Homo sapiens

74 known processes

SHMT1

serine hydroxymethyltransferase 1 (soluble)

(Aliases: SHMT,CSHMT,MGC15229,MGC24556)

SHMT1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 116 0.206
post embryonic development GO:0009791 2 0.068
oxidation reduction process GO:0055114 396 0.066
small molecule catabolic process GO:0044282 92 0.063
cellular ketone metabolic process GO:0042180 80 0.060
cofactor metabolic process GO:0051186 87 0.059
organonitrogen compound biosynthetic process GO:1901566 200 0.053
cellular modified amino acid metabolic process GO:0006575 64 0.052
lipid metabolic process GO:0006629 381 0.052
amine metabolic process GO:0009308 44 0.048
cellular amine metabolic process GO:0044106 41 0.047
coenzyme metabolic process GO:0006732 65 0.046
cellular lipid metabolic process GO:0044255 303 0.043
response to oxygen containing compound GO:1901700 369 0.042
regulation of cellular ketone metabolic process GO:0010565 50 0.042
monocarboxylic acid metabolic process GO:0032787 185 0.041
regulation of cellular amino acid metabolic process GO:0006521 6 0.040
purine ribonucleoside metabolic process GO:0046128 437 0.038
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
regulation of cellular amine metabolic process GO:0033238 11 0.034
multicellular organismal aging GO:0010259 3 0.034
small molecule biosynthetic process GO:0044283 157 0.033
Rat
carboxylic acid biosynthetic process GO:0046394 97 0.033
Rat
chemical homeostasis GO:0048878 306 0.032
alpha amino acid metabolic process GO:1901605 72 0.032
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
carbohydrate metabolic process GO:0005975 207 0.032
single organism carbohydrate metabolic process GO:0044723 193 0.031
organophosphate biosynthetic process GO:0090407 163 0.031
determination of adult lifespan GO:0008340 2 0.030
protein oligomerization GO:0051259 173 0.030
positive regulation of cellular amine metabolic process GO:0033240 7 0.029
female gamete generation GO:0007292 2 0.029
positive regulation of hydrolase activity GO:0051345 331 0.027
mitotic cell cycle GO:0000278 326 0.027
organic acid biosynthetic process GO:0016053 97 0.027
Rat
organic hydroxy compound metabolic process GO:1901615 147 0.027
organophosphate catabolic process GO:0046434 430 0.027
mitotic cell cycle process GO:1903047 286 0.027
nucleoside triphosphate metabolic process GO:0009141 422 0.026
regulation of cell cycle GO:0051726 393 0.026
cellular response to dna damage stimulus GO:0006974 379 0.026
oogenesis GO:0048477 2 0.026
response to abiotic stimulus GO:0009628 336 0.025
purine containing compound catabolic process GO:0072523 411 0.025
organic acid catabolic process GO:0016054 71 0.024
ribonucleoside monophosphate metabolic process GO:0009161 187 0.024
negative regulation of catalytic activity GO:0043086 335 0.024
ribonucleotide catabolic process GO:0009261 405 0.024
mitochondrion organization GO:0007005 156 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.023
locomotory behavior GO:0007626 1 0.023
ras protein signal transduction GO:0007265 73 0.023
purine nucleoside catabolic process GO:0006152 398 0.023
chromatin organization GO:0006325 351 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.022
protein processing GO:0016485 226 0.022
single organism cellular localization GO:1902580 332 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
endocytosis GO:0006897 159 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
positive regulation of cellular component organization GO:0051130 376 0.021
regulation of hormone levels GO:0010817 125 0.020
mitotic nuclear division GO:0007067 119 0.020
glycosyl compound catabolic process GO:1901658 413 0.020
defense response GO:0006952 315 0.020
regulation of proteolysis GO:0030162 293 0.020
purine nucleoside triphosphate metabolic process GO:0009144 412 0.020
transmembrane transport GO:0055085 399 0.020
histone modification GO:0016570 251 0.020
nucleotide catabolic process GO:0009166 408 0.020
protein catabolic process GO:0030163 325 0.020
purine ribonucleotide catabolic process GO:0009154 404 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
apoptotic signaling pathway GO:0097190 268 0.020
nucleoside triphosphate catabolic process GO:0009143 394 0.020
purine nucleoside triphosphate catabolic process GO:0009146 392 0.020
nucleoside monophosphate metabolic process GO:0009123 191 0.020
secretion GO:0046903 254 0.020
alcohol metabolic process GO:0006066 114 0.020
maintenance of location GO:0051235 112 0.020
regulation of immune response GO:0050776 201 0.019
purine ribonucleoside catabolic process GO:0046130 398 0.019
nucleotide biosynthetic process GO:0009165 109 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
dna repair GO:0006281 198 0.019
cellular component morphogenesis GO:0032989 314 0.019
cellular amino acid catabolic process GO:0009063 31 0.018
immune response GO:0006955 307 0.018
membrane organization GO:0061024 292 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
ion homeostasis GO:0050801 230 0.018
nucleoside catabolic process GO:0009164 408 0.018
negative regulation of protein metabolic process GO:0051248 391 0.018
regeneration GO:0031099 4 0.018
purine nucleotide catabolic process GO:0006195 405 0.018
small gtpase mediated signal transduction GO:0007264 78 0.018
single organism membrane organization GO:0044802 268 0.018
cell projection organization GO:0030030 252 0.018
positive regulation of catabolic process GO:0009896 310 0.018
negative regulation of cellular protein metabolic process GO:0032269 353 0.017
response to biotic stimulus GO:0009607 276 0.017
chromosome segregation GO:0007059 114 0.017
cellular macromolecule catabolic process GO:0044265 380 0.017
fatty acid metabolic process GO:0006631 115 0.017
microtubule based process GO:0007017 210 0.017
hematopoietic or lymphoid organ development GO:0048534 186 0.017
vesicle mediated transport GO:0016192 371 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
nitrogen compound transport GO:0071705 191 0.017
carboxylic acid catabolic process GO:0046395 71 0.017
response to external biotic stimulus GO:0043207 261 0.016
cytoplasmic transport GO:0016482 379 0.016
regulation of protein localization GO:0032880 296 0.016
protein maturation GO:0051604 233 0.016
response to other organism GO:0051707 261 0.016
protein homooligomerization GO:0051260 100 0.016
Rat
secretion by cell GO:0032940 226 0.016
ribonucleoside catabolic process GO:0042454 406 0.016
neuromuscular junction development GO:0007528 3 0.016
negative regulation of programmed cell death GO:0043069 321 0.016
positive regulation of immune system process GO:0002684 283 0.016
hemopoiesis GO:0030097 180 0.016
epithelium development GO:0060429 227 0.016
meiotic chromosome segregation GO:0045132 4 0.016
regulation of protein kinase activity GO:0045859 289 0.016
lipid biosynthetic process GO:0008610 177 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
cellular homeostasis GO:0019725 196 0.015
regulation of transferase activity GO:0051338 355 0.015
regulation of cell cycle process GO:0010564 266 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
anion transport GO:0006820 161 0.015
response to nitrogen compound GO:1901698 184 0.015
cell morphogenesis GO:0000902 296 0.015
segmentation GO:0035282 4 0.014
peripheral nervous system development GO:0007422 2 0.014
immune system development GO:0002520 195 0.014
cellular carbohydrate metabolic process GO:0044262 84 0.014
mitotic cell cycle phase transition GO:0044772 162 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
organelle fission GO:0048285 149 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
microtubule cytoskeleton organization GO:0000226 176 0.014
dephosphorylation GO:0016311 209 0.014
ion transmembrane transport GO:0034220 338 0.014
actin filament based process GO:0030029 224 0.014
regulation of peptidase activity GO:0052547 180 0.014
positive regulation of protein phosphorylation GO:0001934 313 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
regulation of kinase activity GO:0043549 314 0.014
inorganic ion transmembrane transport GO:0098660 231 0.013
spermatid differentiation GO:0048515 4 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
cellular response to abiotic stimulus GO:0071214 117 0.013
regulation of cell differentiation GO:0045595 393 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
cell projection assembly GO:0030031 126 0.013
oocyte development GO:0048599 1 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
covalent chromatin modification GO:0016569 254 0.013
adult locomotory behavior GO:0008344 1 0.013
negative regulation of protein modification process GO:0031400 200 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
oocyte differentiation GO:0009994 2 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
intracellular protein transport GO:0006886 270 0.013
sister chromatid segregation GO:0000819 54 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
protein tetramerization GO:0051262 47 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
cellular protein complex assembly GO:0043623 188 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
atp metabolic process GO:0046034 176 0.012
positive regulation of immune response GO:0050778 159 0.012
response to lipid GO:0033993 206 0.012
cellular lipid catabolic process GO:0044242 65 0.012
regulation of secretion GO:0051046 194 0.012
memory GO:0007613 3 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
cellular chemical homeostasis GO:0055082 180 0.012
cell cycle phase transition GO:0044770 173 0.012
protein localization to organelle GO:0033365 280 0.012
response to fungus GO:0009620 4 0.012
innate immune response GO:0045087 178 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
cation homeostasis GO:0055080 189 0.012
response to inorganic substance GO:0010035 127 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
positive regulation of cell death GO:0010942 263 0.012
cell part morphogenesis GO:0032990 137 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
mapk cascade GO:0000165 288 0.012
nucleoside monophosphate catabolic process GO:0009125 159 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
positive regulation of transport GO:0051050 336 0.012
chromatin modification GO:0016568 298 0.012
regulation of cellular response to stress GO:0080135 244 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
endomembrane system organization GO:0010256 196 0.012
rho protein signal transduction GO:0007266 26 0.012
purine nucleoside monophosphate catabolic process GO:0009128 158 0.012
negative regulation of cell death GO:0060548 345 0.012
sulfur compound metabolic process GO:0006790 101 0.011
spermatid development GO:0007286 4 0.011
reproductive process GO:0022414 106 0.011
negative regulation of transport GO:0051051 176 0.011
regulation of intracellular transport GO:0032386 195 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
cellular protein catabolic process GO:0044257 261 0.011
mitotic sister chromatid segregation GO:0000070 53 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
organic anion transport GO:0015711 103 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
regulation of protein maturation GO:1903317 150 0.011
regulation of defense response GO:0031347 154 0.011
cilium organization GO:0044782 68 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
extrinsic apoptotic signaling pathway GO:0097191 119 0.011
protein targeting GO:0006605 187 0.011
methylation GO:0032259 106 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
positive regulation of developmental process GO:0051094 314 0.011
negative regulation of transferase activity GO:0051348 124 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
cellular component disassembly GO:0022411 92 0.011
cation transport GO:0006812 331 0.011
regulation of multi organism process GO:0043900 157 0.011
lipid catabolic process GO:0016042 84 0.011
system process GO:0003008 349 0.011
regulation of gtpase activity GO:0043087 180 0.011
myeloid cell differentiation GO:0030099 117 0.011
negative regulation of protein processing GO:0010955 142 0.011
cell projection morphogenesis GO:0048858 129 0.011
regulation of protein processing GO:0070613 150 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
regulation of protein transport GO:0051223 213 0.010
positive regulation of proteolysis GO:0045862 142 0.010
regulation of protein complex assembly GO:0043254 147 0.010
response to organic cyclic compound GO:0014070 204 0.010
regulation of neural precursor cell proliferation GO:2000177 4 0.010
posttranscriptional regulation of gene expression GO:0010608 213 0.010
organelle assembly GO:0070925 176 0.010
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010
growth GO:0040007 202 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.010
cellular response to oxygen containing compound GO:1901701 276 0.010
nuclear division GO:0000280 128 0.010
organic acid transport GO:0015849 65 0.010
peptide metabolic process GO:0006518 51 0.010
rna splicing GO:0008380 131 0.010
positive regulation of nucleoside metabolic process GO:0045979 186 0.010
response to hormone GO:0009725 175 0.010
regulation of hormone secretion GO:0046883 57 0.010
regulation of response to external stimulus GO:0032101 222 0.010
negative regulation of cell cycle GO:0045786 193 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
regulation of anatomical structure morphogenesis GO:0022603 286 0.010
central nervous system development GO:0007417 123 0.010
cellular amide metabolic process GO:0043603 69 0.010
gtp metabolic process GO:0046039 239 0.010

SHMT1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.234
inherited metabolic disorder DOID:655 242 0.234
amino acid metabolic disorder DOID:9252 50 0.058
disease of cellular proliferation DOID:14566 174 0.037
cancer DOID:162 167 0.035
organ system cancer DOID:0050686 164 0.031
immune system disease DOID:2914 155 0.021
carbohydrate metabolic disorder DOID:2978 55 0.019
glycogen storage disease DOID:2747 10 0.017
glycogen metabolism disorder DOID:0050728 10 0.017
central nervous system disease DOID:331 186 0.015
nervous system disease DOID:863 431 0.015
hematopoietic system disease DOID:74 100 0.014
musculoskeletal system disease DOID:17 223 0.014
sensory system disease DOID:0050155 203 0.014
eye and adnexa disease DOID:1492 150 0.010