Homo sapiens

97 known processes

RUNX2

runt-related transcription factor 2

(Aliases: OSF2,AML3,CBFA1,PEBP2A2,PEBP2A1,PEA2aA,PEBP2aA1,CCD,PEBP2aA,CCD1,OSF-2,MGC120023,MGC120022)

RUNX2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cell differentiation GO:0045595 393 0.784
Human Mouse Fly
cellular response to endogenous stimulus GO:0071495 336 0.651
Mouse Rat
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.634
Fly
positive regulation of cell differentiation GO:0045597 211 0.568
Human Mouse Fly
negative regulation of multicellular organismal process GO:0051241 317 0.476
Human
negative regulation of developmental process GO:0051093 247 0.460
Human
cell development GO:0048468 328 0.439
Mouse Fly
positive regulation of developmental process GO:0051094 314 0.411
Human Mouse Worm Fly
hematopoietic or lymphoid organ development GO:0048534 186 0.377
Human Mouse Fly
nervous system development GO:0007399 293 0.361
Fly
positive regulation of programmed cell death GO:0043068 249 0.344
Fly
positive regulation of cell proliferation GO:0008284 301 0.333
Mouse
negative regulation of cell proliferation GO:0008285 228 0.329
regulation of cell migration GO:0030334 289 0.326
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.321
cellular ketone metabolic process GO:0042180 80 0.318
regulation of locomotion GO:0040012 329 0.310
negative regulation of cell differentiation GO:0045596 171 0.293
Human
cytokine production GO:0001816 247 0.289
regulation of cellular ketone metabolic process GO:0010565 50 0.287
cell morphogenesis involved in differentiation GO:0000904 144 0.280
Fly
cellular amine metabolic process GO:0044106 41 0.271
response to growth factor GO:0070848 205 0.267
Mouse Rat
amine metabolic process GO:0009308 44 0.257
circulatory system development GO:0072359 262 0.256
regulation of cellular amine metabolic process GO:0033238 11 0.254
cellular component morphogenesis GO:0032989 314 0.253
Fly
negative regulation of cell death GO:0060548 345 0.250
cell morphogenesis GO:0000902 296 0.246
Fly
response to oxygen containing compound GO:1901700 369 0.244
positive regulation of cellular amine metabolic process GO:0033240 7 0.242
cellular amino acid metabolic process GO:0006520 116 0.239
cellular response to oxygen containing compound GO:1901701 276 0.238
regulation of cell motility GO:2000145 299 0.236
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.234
Mouse
regulation of cellular component movement GO:0051270 334 0.232
positive regulation of protein phosphorylation GO:0001934 313 0.228
response to abiotic stimulus GO:0009628 336 0.226
skeletal system development GO:0001501 79 0.225
Zebrafish Mouse
hemopoiesis GO:0030097 180 0.221
Human Mouse Fly
regulation of cytokine production GO:0001817 232 0.221
neuron projection development GO:0031175 106 0.217
Fly
regulation of secretion GO:0051046 194 0.216
chromatin organization GO:0006325 351 0.214
anatomical structure formation involved in morphogenesis GO:0048646 284 0.213
regulation of cell cycle GO:0051726 393 0.213
positive regulation of apoptotic process GO:0043065 246 0.213
positive regulation of cell death GO:0010942 263 0.206
Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.201
cellular response to growth factor stimulus GO:0071363 197 0.201
Mouse Rat
regulation of anatomical structure morphogenesis GO:0022603 286 0.199
Mouse Fly
positive regulation of cellular component organization GO:0051130 376 0.184
post embryonic development GO:0009791 2 0.184
enzyme linked receptor protein signaling pathway GO:0007167 303 0.183
Mouse
defense response GO:0006952 315 0.172
positive regulation of phosphorylation GO:0042327 394 0.167
epithelial cell differentiation GO:0030855 141 0.163
stem cell differentiation GO:0048863 93 0.162
Mouse
vasculature development GO:0001944 181 0.161
mapk cascade GO:0000165 288 0.161
locomotory behavior GO:0007626 1 0.160
regulation of secretion by cell GO:1903530 177 0.157
mesenchymal cell development GO:0014031 50 0.157
chromatin modification GO:0016568 298 0.156
g protein coupled receptor signaling pathway GO:0007186 207 0.155
covalent chromatin modification GO:0016569 254 0.155
behavior GO:0007610 112 0.152
cell projection organization GO:0030030 252 0.152
Fly
cardiovascular system development GO:0072358 262 0.151
negative regulation of apoptotic process GO:0043066 316 0.150
blood vessel morphogenesis GO:0048514 162 0.148
secretion by cell GO:0032940 226 0.142
regulation of cellular amino acid metabolic process GO:0006521 6 0.140
forelimb morphogenesis GO:0035136 4 0.140
Mouse
histone modification GO:0016570 251 0.140
cranial nerve development GO:0021545 4 0.138
stem cell development GO:0048864 69 0.136
regulation of ossification GO:0030278 58 0.135
Mouse Rat
blood vessel development GO:0001568 172 0.135
immune system development GO:0002520 195 0.134
Human Mouse Fly
organ morphogenesis GO:0009887 147 0.130
Mouse Fly
positive regulation of locomotion GO:0040017 186 0.128
ameboidal type cell migration GO:0001667 135 0.127
epithelium development GO:0060429 227 0.126
regulation of leukocyte differentiation GO:1902105 61 0.122
Human
negative regulation of locomotion GO:0040013 118 0.117
lipid metabolic process GO:0006629 381 0.116
response to cytokine GO:0034097 232 0.116
response to lipid GO:0033993 206 0.115
regulation of osteoblast differentiation GO:0045667 38 0.112
Mouse
response to organic cyclic compound GO:0014070 204 0.112
myeloid cell differentiation GO:0030099 117 0.111
Human
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.108
Mouse
negative regulation of immune system process GO:0002683 136 0.107
Human
negative regulation of cell migration GO:0030336 102 0.104
positive regulation of mapk cascade GO:0043410 190 0.103
mesenchymal cell differentiation GO:0048762 52 0.102
mesenchyme development GO:0060485 59 0.101
immune response GO:0006955 307 0.100
regulation of cellular component biogenesis GO:0044087 281 0.099
cellular response to organic cyclic compound GO:0071407 127 0.099
response to external biotic stimulus GO:0043207 261 0.098
positive regulation of transport GO:0051050 336 0.097
connective tissue development GO:0061448 39 0.096
Zebrafish Mouse
vesicle mediated transport GO:0016192 371 0.095
head development GO:0060322 108 0.094
tube development GO:0035295 125 0.092
Fly
generation of neurons GO:0048699 152 0.092
Fly
regulation of cell cycle process GO:0010564 266 0.092
response to biotic stimulus GO:0009607 276 0.092
brain development GO:0007420 97 0.091
signal transduction by phosphorylation GO:0023014 297 0.090
regulation of establishment of protein localization GO:0070201 242 0.090
neuron differentiation GO:0030182 138 0.089
Fly
nerve development GO:0021675 4 0.089
positive regulation of cell motility GO:2000147 177 0.088
taxis GO:0042330 157 0.087
Fly
peptidyl lysine modification GO:0018205 144 0.086
angiogenesis GO:0001525 147 0.084
chemotaxis GO:0006935 157 0.082
Fly
secretion GO:0046903 254 0.081
neurological system process GO:0050877 163 0.080
positive regulation of cell migration GO:0030335 172 0.079
regulation of epithelial cell migration GO:0010632 93 0.079
central nervous system development GO:0007417 123 0.079
positive regulation of cytokine production GO:0001819 167 0.078
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.078
cellular response to cytokine stimulus GO:0071345 181 0.078
cell projection morphogenesis GO:0048858 129 0.078
Fly
regulation of protein transport GO:0051223 213 0.078
cell adhesion GO:0007155 325 0.078
tissue morphogenesis GO:0048729 96 0.077
negative regulation of cellular component movement GO:0051271 106 0.077
metal ion transport GO:0030001 272 0.076
neurogenesis GO:0022008 169 0.076
Fly
negative regulation of cell motility GO:2000146 104 0.075
neuron development GO:0048666 113 0.075
Fly
regulation of myeloid cell differentiation GO:0045637 81 0.075
Human
regulation of mapk cascade GO:0043408 262 0.075
regulation of protein kinase activity GO:0045859 289 0.075
positive regulation of osteoblast differentiation GO:0045669 23 0.074
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.074
negative regulation of programmed cell death GO:0043069 321 0.074
apoptotic signaling pathway GO:0097190 268 0.073
osteoblast differentiation GO:0001649 92 0.073
regulation of protein localization GO:0032880 296 0.071
positive regulation of immune system process GO:0002684 283 0.071
Human
bmp signaling pathway GO:0030509 49 0.070
Mouse
ossification GO:0001503 121 0.070
regulation of response to external stimulus GO:0032101 222 0.068
positive regulation of leukocyte differentiation GO:1902107 37 0.068
Human
regulation of vasculature development GO:1901342 97 0.068
regulation of leukocyte activation GO:0002694 115 0.068
biological adhesion GO:0022610 331 0.068
response to transforming growth factor beta GO:0071559 94 0.067
cell activation GO:0001775 213 0.067
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.067
regulation of cell development GO:0060284 161 0.067
Fly
regulation of cell growth GO:0001558 135 0.066
negative regulation of protein metabolic process GO:0051248 391 0.065
system process GO:0003008 349 0.065
associative learning GO:0008306 1 0.064
cytoplasmic transport GO:0016482 379 0.064
regulation of protein serine threonine kinase activity GO:0071900 179 0.064
growth GO:0040007 202 0.064
Worm
regulation of purine nucleotide metabolic process GO:1900542 264 0.064
cell part morphogenesis GO:0032990 137 0.063
Fly
protein localization to organelle GO:0033365 280 0.063
purine ribonucleotide catabolic process GO:0009154 404 0.062
negative regulation of cellular component organization GO:0051129 235 0.062
epithelium migration GO:0090132 119 0.061
female gamete generation GO:0007292 2 0.061
intracellular protein transport GO:0006886 270 0.061
regulation of neuron differentiation GO:0045664 70 0.061
regulation of neurogenesis GO:0050767 82 0.061
positive regulation of cell development GO:0010720 92 0.061
Fly
mitotic cell cycle process GO:1903047 286 0.061
cell growth GO:0016049 160 0.060
protein acylation GO:0043543 138 0.060
epithelial cell migration GO:0010631 119 0.060
single organism cellular localization GO:1902580 332 0.060
positive regulation of cell cycle GO:0045787 140 0.059
regulation of angiogenesis GO:0045765 92 0.059
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.058
cellular response to dna damage stimulus GO:0006974 379 0.058
tissue migration GO:0090130 119 0.058
nucleoside phosphate catabolic process GO:1901292 412 0.058
leukocyte differentiation GO:0002521 98 0.058
Human Mouse
mitotic cell cycle GO:0000278 326 0.058
oogenesis GO:0048477 2 0.058
neuron fate commitment GO:0048663 2 0.057
single organism cell adhesion GO:0098602 179 0.057
leukocyte activation GO:0045321 164 0.057
Mouse
ion transmembrane transport GO:0034220 338 0.057
purine nucleoside triphosphate catabolic process GO:0009146 392 0.057
neural crest cell development GO:0014032 3 0.057
positive regulation of cellular component movement GO:0051272 181 0.057
endocrine system development GO:0035270 26 0.057
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.056
muscle structure development GO:0061061 98 0.056
embryonic forelimb morphogenesis GO:0035115 4 0.054
Mouse
lymphocyte activation GO:0046649 133 0.054
Mouse
regulation of cell adhesion GO:0030155 166 0.054
regeneration GO:0031099 4 0.054
response to hypoxia GO:0001666 96 0.053
regulation of defense response GO:0031347 154 0.053
muscle contraction GO:0006936 73 0.053
memory GO:0007613 3 0.052
regulation of kinase activity GO:0043549 314 0.052
regulation of apoptotic signaling pathway GO:2001233 175 0.052
organ formation GO:0048645 3 0.051
hindbrain development GO:0030902 3 0.051
response to oxygen levels GO:0070482 100 0.051
motor neuron axon guidance GO:0008045 2 0.051
ribonucleoside triphosphate metabolic process GO:0009199 412 0.051
nucleocytoplasmic transport GO:0006913 176 0.050
response to other organism GO:0051707 261 0.050
protein acetylation GO:0006473 116 0.050
immune effector process GO:0002252 159 0.050
cation transport GO:0006812 331 0.050
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.050
purine ribonucleoside metabolic process GO:0046128 437 0.049
regulation of cell morphogenesis GO:0022604 153 0.049
regulation of transferase activity GO:0051338 355 0.049
positive regulation of cell division GO:0051781 59 0.048
protein localization to nucleus GO:0034504 136 0.048
limbic system development GO:0021761 3 0.048
embryonic morphogenesis GO:0048598 85 0.048
Mouse Fly
digestive system development GO:0055123 75 0.048
Fly
cellular homeostasis GO:0019725 196 0.047
negative regulation of cellular protein metabolic process GO:0032269 353 0.047
positive regulation of protein kinase activity GO:0045860 190 0.047
negative regulation of phosphate metabolic process GO:0045936 267 0.046
cellular response to lipid GO:0071396 127 0.046
inorganic ion transmembrane transport GO:0098660 231 0.046
small gtpase mediated signal transduction GO:0007264 78 0.046
negative regulation of cell cycle GO:0045786 193 0.045
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.045
response to hormone GO:0009725 175 0.045
cellular macromolecule catabolic process GO:0044265 380 0.045
skeletal system morphogenesis GO:0048705 24 0.044
Mouse
embryo development GO:0009790 123 0.044
Mouse Worm Fly
cartilage development GO:0051216 31 0.044
Zebrafish Mouse
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.044
regulation of cellular response to stress GO:0080135 244 0.044
hindlimb morphogenesis GO:0035137 2 0.043
cell fate determination GO:0001709 3 0.043
segmentation GO:0035282 4 0.043
peptidyl tyrosine modification GO:0018212 170 0.043
positive regulation of cellular catabolic process GO:0031331 284 0.043
negative regulation of vasculature development GO:1901343 43 0.043
blastoderm segmentation GO:0007350 2 0.043
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.043
organophosphate catabolic process GO:0046434 430 0.043
response to wounding GO:0009611 168 0.042
Fly
ribonucleoside catabolic process GO:0042454 406 0.041
positive regulation of ossification GO:0045778 32 0.041
Mouse Rat
negative regulation of protein modification process GO:0031400 200 0.041
regulation of growth GO:0040008 165 0.041
Worm
neuromuscular junction development GO:0007528 3 0.041
neuroblast proliferation GO:0007405 4 0.040
protein targeting GO:0006605 187 0.040
leukocyte migration GO:0050900 107 0.040
regulation of immune response GO:0050776 201 0.040
ion homeostasis GO:0050801 230 0.040
regulation of ion transport GO:0043269 189 0.040
cell cell signaling GO:0007267 155 0.040
positive regulation of organelle organization GO:0010638 195 0.040
regulation of stem cell differentiation GO:2000736 56 0.040
regulation of binding GO:0051098 111 0.040
interspecies interaction between organisms GO:0044419 156 0.040
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.039
Fly
endothelial cell migration GO:0043542 86 0.039
nuclear transport GO:0051169 179 0.039
regulation of hormone levels GO:0010817 125 0.039
protein catabolic process GO:0030163 325 0.039
forebrain regionalization GO:0021871 3 0.038
multicellular organismal aging GO:0010259 3 0.038
cellular lipid metabolic process GO:0044255 303 0.038
regulation of proteolysis GO:0030162 293 0.038
regulation of cellular response to growth factor stimulus GO:0090287 76 0.038
Mouse
regulation of nervous system development GO:0051960 88 0.038
cellular response to abiotic stimulus GO:0071214 117 0.038
skin development GO:0043588 76 0.038
sex determination GO:0007530 3 0.038
regulation of cell projection organization GO:0031344 107 0.038
regulation of lymphocyte activation GO:0051249 103 0.038
negative regulation of phosphorus metabolic process GO:0010563 267 0.038
negative regulation of growth GO:0045926 97 0.038
endochondral bone morphogenesis GO:0060350 3 0.038
Mouse
purine nucleoside catabolic process GO:0006152 398 0.037
regulation of mitotic cell cycle GO:0007346 189 0.037
regulation of homeostatic process GO:0032844 121 0.037
cellular response to organonitrogen compound GO:0071417 124 0.037
positive regulation of kinase activity GO:0033674 204 0.037
regulation of acrosome reaction GO:0060046 4 0.037
response to decreased oxygen levels GO:0036293 96 0.036
nucleoside triphosphate metabolic process GO:0009141 422 0.036
regulation of vesicle mediated transport GO:0060627 130 0.036
regulation of cell activation GO:0050865 125 0.036
determination of adult lifespan GO:0008340 2 0.036
digestive tract development GO:0048565 75 0.035
Fly
inflammatory response GO:0006954 79 0.035
regulation of epithelial cell proliferation GO:0050678 113 0.035
regulation of mononuclear cell proliferation GO:0032944 65 0.035
forebrain generation of neurons GO:0021872 3 0.035
ribonucleotide catabolic process GO:0009261 405 0.035
positive regulation of angiogenesis GO:0045766 51 0.035
establishment of protein localization to organelle GO:0072594 172 0.035
regulation of lymphocyte proliferation GO:0050670 64 0.035
epithelial to mesenchymal transition GO:0001837 48 0.035
protein import GO:0017038 130 0.035
positive regulation of nucleotide metabolic process GO:0045981 230 0.034
regulation of intracellular transport GO:0032386 195 0.034
positive regulation of catabolic process GO:0009896 310 0.034
cellular ion homeostasis GO:0006873 168 0.034
negative regulation of cell growth GO:0030308 83 0.034
cell substrate adhesion GO:0031589 132 0.034
regulation of metal ion transport GO:0010959 120 0.034
rhythmic behavior GO:0007622 2 0.034
positive regulation of cell cycle process GO:0090068 106 0.034
positive regulation of neurogenesis GO:0050769 49 0.034
purine containing compound catabolic process GO:0072523 411 0.033
positive regulation of myeloid cell differentiation GO:0045639 39 0.033
Human
regulation of transmission of nerve impulse GO:0051969 2 0.033
morphogenesis of an epithelium GO:0002009 60 0.033
protein modification by small protein conjugation GO:0032446 342 0.033
divalent inorganic cation transport GO:0072511 158 0.033
regulation of reactive oxygen species metabolic process GO:2000377 41 0.033
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.033
cell division GO:0051301 168 0.033
bmp signaling pathway involved in heart development GO:0061312 3 0.033
gland development GO:0048732 48 0.033
response to alcohol GO:0097305 64 0.033
purine ribonucleoside catabolic process GO:0046130 398 0.032
negative regulation of protein phosphorylation GO:0001933 140 0.032
negative regulation of transport GO:0051051 176 0.032
regulation of myeloid leukocyte differentiation GO:0002761 39 0.032
Human
cellular response to hormone stimulus GO:0032870 125 0.032
gamma aminobutyric acid signaling pathway GO:0007214 3 0.032
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.032
t cell activation GO:0042110 99 0.032
Mouse
neuron projection morphogenesis GO:0048812 50 0.032
Fly
protein ubiquitination GO:0016567 314 0.032
nitrogen compound transport GO:0071705 191 0.032
leukocyte proliferation GO:0070661 74 0.031
cell type specific apoptotic process GO:0097285 125 0.031
response to drug GO:0042493 81 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.031
regulation of cytoplasmic transport GO:1903649 149 0.031
inner ear morphogenesis GO:0042472 4 0.031
cellular metal ion homeostasis GO:0006875 146 0.031
regulation of nucleotide metabolic process GO:0006140 269 0.031
receptor metabolic process GO:0043112 81 0.031
circadian behavior GO:0048512 2 0.031
mononuclear cell proliferation GO:0032943 71 0.031
negative regulation of catalytic activity GO:0043086 335 0.031
positive regulation of acrosome reaction GO:2000344 4 0.030
divalent metal ion transport GO:0070838 152 0.030
cell cycle phase transition GO:0044770 173 0.030
ras protein signal transduction GO:0007265 73 0.030
peptidyl lysine acetylation GO:0018394 101 0.030
immune response regulating signaling pathway GO:0002764 97 0.030
tube morphogenesis GO:0035239 95 0.030
Fly
cellular protein catabolic process GO:0044257 261 0.030
positive regulation of cellular component biogenesis GO:0044089 158 0.030
cellular response to nitrogen compound GO:1901699 144 0.030
transmembrane transport GO:0055085 399 0.030
positive regulation of axon extension GO:0045773 4 0.030
modification dependent protein catabolic process GO:0019941 209 0.030
response to nitrogen compound GO:1901698 184 0.030
peptidyl tyrosine phosphorylation GO:0018108 170 0.030
reproductive process GO:0022414 106 0.029
Worm Fly
response to virus GO:0009615 126 0.029
guanosine containing compound metabolic process GO:1901068 244 0.029
pattern specification process GO:0007389 43 0.029
Zebrafish
inorganic cation transmembrane transport GO:0098662 194 0.029
single organismal cell cell adhesion GO:0016337 148 0.029
protein maturation GO:0051604 233 0.029
organic hydroxy compound metabolic process GO:1901615 147 0.029
epithelial cell proliferation GO:0050673 128 0.029
regulation of meiotic cell cycle GO:0051445 4 0.029
regulation of dna metabolic process GO:0051052 153 0.029
embryonic hindlimb morphogenesis GO:0035116 2 0.029
nucleotide catabolic process GO:0009166 408 0.028
reactive oxygen species metabolic process GO:0072593 75 0.028
adult locomotory behavior GO:0008344 1 0.028
positive regulation of immune response GO:0050778 159 0.028
steroid metabolic process GO:0008202 94 0.028
purine nucleotide catabolic process GO:0006195 405 0.028
regulation of canonical wnt signaling pathway GO:0060828 88 0.028
lipid biosynthetic process GO:0008610 177 0.028
maintenance of location GO:0051235 112 0.028
regulation of erk1 and erk2 cascade GO:0070372 99 0.027
single organism nuclear import GO:1902593 104 0.027
calcium ion transport GO:0006816 147 0.027
regulation of multi organism process GO:0043900 157 0.027
single organism reproductive process GO:0044702 98 0.027
Fly
negative regulation of protein transport GO:0051224 75 0.027
mitotic cell cycle phase transition GO:0044772 162 0.027
sensory organ development GO:0007423 52 0.027
Fly
negative regulation of intracellular signal transduction GO:1902532 183 0.027
renal system development GO:0072001 63 0.027
nucleoside catabolic process GO:0009164 408 0.027
positive regulation of lymphocyte activation GO:0051251 73 0.026
bone mineralization GO:0030282 34 0.026
peptidyl serine modification GO:0018209 106 0.026
sensory perception GO:0007600 103 0.026
peripheral nervous system development GO:0007422 2 0.026
regulation of neuron projection development GO:0010975 57 0.026
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.026
protein targeting to nucleus GO:0044744 104 0.026
cellular macromolecular complex assembly GO:0034622 324 0.026
compound eye development GO:0048749 1 0.026
Fly
negative regulation of phosphorylation GO:0042326 174 0.025
response to oxidative stress GO:0006979 121 0.025
modification dependent macromolecule catabolic process GO:0043632 212 0.025
glial cell migration GO:0008347 4 0.025
intracellular receptor signaling pathway GO:0030522 104 0.025
positive regulation of proteolysis GO:0045862 142 0.025
protein autophosphorylation GO:0046777 123 0.025
positive regulation of leukocyte proliferation GO:0070665 48 0.025
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.025
glycosyl compound catabolic process GO:1901658 413 0.025
myeloid leukocyte differentiation GO:0002573 60 0.025
Human
positive regulation of leukocyte activation GO:0002696 80 0.025
positive regulation of stem cell differentiation GO:2000738 29 0.025
dna replication GO:0006260 116 0.025
regulation of wnt signaling pathway GO:0030111 123 0.025
cellular chemical homeostasis GO:0055082 180 0.025
small molecule biosynthetic process GO:0044283 157 0.025
regulation of endopeptidase activity GO:0052548 170 0.024
glycoprotein metabolic process GO:0009100 110 0.024
regulation of cell cell adhesion GO:0022407 57 0.024
response to steroid hormone GO:0048545 80 0.024
endothelial cell proliferation GO:0001935 65 0.024
kidney development GO:0001822 53 0.024
cellular response to external stimulus GO:0071496 111 0.024
regulation of male gonad development GO:2000018 4 0.024
regulation of cell division GO:0051302 116 0.024
canonical wnt signaling pathway GO:0060070 116 0.024
internal protein amino acid acetylation GO:0006475 101 0.024
negative regulation of response to external stimulus GO:0032102 83 0.024
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.024
positive regulation of intracellular transport GO:0032388 104 0.024
cell chemotaxis GO:0060326 112 0.024
endocytosis GO:0006897 159 0.024
regulation of biomineral tissue development GO:0070167 31 0.024
histone acetylation GO:0016573 93 0.023
regulation of protein catabolic process GO:0042176 155 0.023
ubiquitin dependent protein catabolic process GO:0006511 206 0.023
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.023
carbohydrate derivative biosynthetic process GO:1901137 207 0.023
actin filament based process GO:0030029 224 0.023
regulation of muscle cell differentiation GO:0051147 31 0.023
peptidyl serine phosphorylation GO:0018105 101 0.023
exocytosis GO:0006887 71 0.023
dendrite development GO:0016358 24 0.023
Fly
long term memory GO:0007616 2 0.023
stem cell division GO:0017145 2 0.023
posttranscriptional regulation of gene expression GO:0010608 213 0.023
reactive nitrogen species metabolic process GO:2001057 3 0.023
positive regulation of mononuclear cell proliferation GO:0032946 47 0.023
regulation of ras protein signal transduction GO:0046578 155 0.023
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 41 0.023
oocyte differentiation GO:0009994 2 0.023
detection of stimulus GO:0051606 85 0.023
positive regulation of cell activation GO:0050867 81 0.023
defense response to other organism GO:0098542 129 0.023
cellular cation homeostasis GO:0030003 163 0.023
negative regulation of cell cycle process GO:0010948 121 0.023
wound healing GO:0042060 115 0.023
Fly
wnt signaling pathway GO:0016055 156 0.022
positive regulation of secretion GO:0051047 116 0.022
response to axon injury GO:0048678 1 0.022
positive regulation of protein transport GO:0051222 135 0.022
negative regulation of cell adhesion GO:0007162 64 0.022
hair follicle morphogenesis GO:0031069 2 0.022
regulation of bone mineralization GO:0030500 29 0.022
multi organism cellular process GO:0044764 156 0.022
positive regulation of cytoplasmic transport GO:1903651 82 0.022
forebrain development GO:0030900 26 0.022

RUNX2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.085
bone disease DOID:0080001 88 0.052
musculoskeletal system disease DOID:17 223 0.052
connective tissue disease DOID:65 109 0.052
cancer DOID:162 167 0.041
Human
disease of cellular proliferation DOID:14566 174 0.041
Human
organ system cancer DOID:0050686 164 0.040
Human
central nervous system disease DOID:331 186 0.035
nervous system disease DOID:863 431 0.035
sensory system disease DOID:0050155 203 0.030
bone development disease DOID:0080006 55 0.029
eye and adnexa disease DOID:1492 150 0.024
eye disease DOID:5614 149 0.024