Homo sapiens

0 known processes

POLA2

polymerase (DNA directed), alpha 2 (70kD subunit)

(Aliases: FLJ37250,FLJ21662)

POLA2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna replication GO:0006260 116 0.867
Yeast Mouse
dna dependent dna replication GO:0006261 44 0.662
Yeast
determination of adult lifespan GO:0008340 2 0.607
dna replication initiation GO:0006270 6 0.567
Yeast
multicellular organismal aging GO:0010259 3 0.565
double strand break repair GO:0006302 101 0.443
establishment of nucleus localization GO:0040023 1 0.383
dna synthesis involved in dna repair GO:0000731 6 0.353
negative regulation of smooth muscle cell proliferation GO:0048662 14 0.336
embryo development GO:0009790 123 0.230
Worm
nuclear migration GO:0007097 1 0.229
nuclear division GO:0000280 128 0.225
nucleus localization GO:0051647 1 0.216
tube development GO:0035295 125 0.214
receptor mediated endocytosis GO:0006898 84 0.204
lagging strand elongation GO:0006273 3 0.193
response to oxygen containing compound GO:1901700 369 0.173
cellular response to endogenous stimulus GO:0071495 336 0.173
post embryonic development GO:0009791 2 0.170
Worm
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.170
purine ribonucleoside metabolic process GO:0046128 437 0.158
regulation of mapk cascade GO:0043408 262 0.156
negative regulation of cellular protein metabolic process GO:0032269 353 0.154
cellular amino acid metabolic process GO:0006520 116 0.151
purine containing compound catabolic process GO:0072523 411 0.148
regulation of cellular ketone metabolic process GO:0010565 50 0.144
regulation of smooth muscle cell migration GO:0014910 15 0.139
cellular response to oxygen containing compound GO:1901701 276 0.135
methylation GO:0032259 106 0.133
organ morphogenesis GO:0009887 147 0.127
regulation of kinase activity GO:0043549 314 0.120
regulation of protein serine threonine kinase activity GO:0071900 179 0.119
nucleoside monophosphate catabolic process GO:0009125 159 0.117
vesicle mediated transport GO:0016192 371 0.113
negative regulation of protein modification process GO:0031400 200 0.110
response to organic cyclic compound GO:0014070 204 0.110
covalent chromatin modification GO:0016569 254 0.103
single organism carbohydrate metabolic process GO:0044723 193 0.103
negative regulation of programmed cell death GO:0043069 321 0.101
histone methylation GO:0016571 60 0.101
cellular response to molecule of bacterial origin GO:0071219 62 0.099
negative regulation of multi organism process GO:0043901 92 0.097
meiosis i GO:0007127 4 0.092
atp catabolic process GO:0006200 157 0.091
ribonucleoside monophosphate metabolic process GO:0009161 187 0.090
endocytosis GO:0006897 159 0.090
histone modification GO:0016570 251 0.088
mitotic nuclear division GO:0007067 119 0.088
nucleoside triphosphate catabolic process GO:0009143 394 0.084
response to other organism GO:0051707 261 0.083
purine ribonucleoside catabolic process GO:0046130 398 0.083
negative regulation of protein phosphorylation GO:0001933 140 0.082
lung development GO:0030324 20 0.082
macromolecule methylation GO:0043414 97 0.080
muscle cell proliferation GO:0033002 35 0.079
organophosphate catabolic process GO:0046434 430 0.078
regulation of cellular amine metabolic process GO:0033238 11 0.077
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.076
sensory organ development GO:0007423 52 0.074
cell division GO:0051301 168 0.074
Worm
chromatin organization GO:0006325 351 0.073
negative regulation of smooth muscle cell migration GO:0014912 7 0.071
chromatin modification GO:0016568 298 0.070
oogenesis GO:0048477 2 0.070
response to drug GO:0042493 81 0.069
dna repair GO:0006281 198 0.069
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.068
protein targeting GO:0006605 187 0.067
Mouse
negative regulation of phosphate metabolic process GO:0045936 267 0.066
respiratory tube development GO:0030323 20 0.065
organelle fission GO:0048285 149 0.065
protein targeting to nucleus GO:0044744 104 0.064
Mouse
nucleoside phosphate catabolic process GO:1901292 412 0.063
eye development GO:0001654 42 0.063
engulfment of apoptotic cell GO:0043652 2 0.060
amine metabolic process GO:0009308 44 0.059
negative regulation of protein metabolic process GO:0051248 391 0.058
respiratory gaseous exchange GO:0007585 3 0.058
negative regulation of cell migration GO:0030336 102 0.058
purine nucleoside monophosphate metabolic process GO:0009126 186 0.057
cellular response to biotic stimulus GO:0071216 71 0.055
nucleotide catabolic process GO:0009166 408 0.052
regulation of multi organism process GO:0043900 157 0.052
negative regulation of multicellular organismal process GO:0051241 317 0.051
regulation of protein localization GO:0032880 296 0.050
regulation of histone modification GO:0031056 47 0.050
negative regulation of developmental process GO:0051093 247 0.049
response to molecule of bacterial origin GO:0002237 82 0.049
sex differentiation GO:0007548 45 0.049
purine nucleoside triphosphate catabolic process GO:0009146 392 0.049
rna splicing GO:0008380 131 0.048
single organism nuclear import GO:1902593 104 0.048
Mouse
cellular response to organic cyclic compound GO:0071407 127 0.047
negative regulation of catalytic activity GO:0043086 335 0.046
non recombinational repair GO:0000726 14 0.046
positive regulation of nucleotide catabolic process GO:0030813 185 0.046
regulation of cellular amino acid metabolic process GO:0006521 6 0.045
purine nucleotide catabolic process GO:0006195 405 0.045
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.045
response to external biotic stimulus GO:0043207 261 0.045
negative regulation of organelle organization GO:0010639 126 0.045
cellular response to organonitrogen compound GO:0071417 124 0.045
cellular response to growth factor stimulus GO:0071363 197 0.044
protein import into nucleus GO:0006606 104 0.044
Mouse
protein alkylation GO:0008213 74 0.043
membrane organization GO:0061024 292 0.043
response to biotic stimulus GO:0009607 276 0.043
dna strand elongation involved in dna replication GO:0006271 3 0.043
cellular ketone metabolic process GO:0042180 80 0.042
aging GO:0007568 66 0.042
negative regulation of cell motility GO:2000146 104 0.042
positive regulation of cellular catabolic process GO:0031331 284 0.042
apoptotic cell clearance GO:0043277 12 0.042
regulation of smooth muscle cell proliferation GO:0048660 28 0.041
cellular amide metabolic process GO:0043603 69 0.040
cellular macromolecular complex assembly GO:0034622 324 0.040
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.039
nucleoside catabolic process GO:0009164 408 0.039
reproductive process GO:0022414 106 0.036
single fertilization GO:0007338 11 0.036
negative regulation of protein kinase activity GO:0006469 98 0.036
positive regulation of cellular amine metabolic process GO:0033240 7 0.036
negative regulation of cell death GO:0060548 345 0.036
female gamete generation GO:0007292 2 0.036
mitotic cell cycle GO:0000278 326 0.035
reproductive system development GO:0061458 56 0.035
carbohydrate metabolic process GO:0005975 207 0.035
regulation of cytokine biosynthetic process GO:0042035 35 0.035
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.035
regeneration GO:0031099 4 0.034
mapk cascade GO:0000165 288 0.034
regulation of growth GO:0040008 165 0.034
negative regulation of apoptotic process GO:0043066 316 0.034
response to hydrogen peroxide GO:0042542 40 0.033
developmental process involved in reproduction GO:0003006 66 0.033
signal transduction by phosphorylation GO:0023014 297 0.033
response to reactive oxygen species GO:0000302 61 0.033
ribonucleoside catabolic process GO:0042454 406 0.033
lipid metabolic process GO:0006629 381 0.033
histone lysine methylation GO:0034968 50 0.032
protein localization to nucleus GO:0034504 136 0.032
Mouse
response to lipid GO:0033993 206 0.031
bradykinin catabolic process GO:0010815 4 0.031
alpha amino acid metabolic process GO:1901605 72 0.031
respiratory system process GO:0003016 3 0.030
regulation of establishment of protein localization GO:0070201 242 0.030
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.030
response to hormone GO:0009725 175 0.030
g1 s transition of mitotic cell cycle GO:0000082 78 0.029
negative regulation of cell proliferation GO:0008285 228 0.029
respiratory system development GO:0060541 22 0.029
double strand break repair via homologous recombination GO:0000724 50 0.028
response to decreased oxygen levels GO:0036293 96 0.028
single organism reproductive process GO:0044702 98 0.028
gtp metabolic process GO:0046039 239 0.028
phagocytosis engulfment GO:0006911 7 0.027
cellular response to lipid GO:0071396 127 0.027
response to bacterium GO:0009617 144 0.027
glycosyl compound catabolic process GO:1901658 413 0.027
negative regulation of phosphorylation GO:0042326 174 0.027
negative regulation of phosphorus metabolic process GO:0010563 267 0.026
lung alveolus development GO:0048286 4 0.026
guanosine containing compound catabolic process GO:1901069 239 0.025
mrna metabolic process GO:0016071 175 0.025
regulation of intracellular transport GO:0032386 195 0.025
fertilization GO:0009566 12 0.025
protein import GO:0017038 130 0.025
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 391 0.025
lipid biosynthetic process GO:0008610 177 0.025
protein methylation GO:0006479 74 0.025
response to abiotic stimulus GO:0009628 336 0.024
response to organonitrogen compound GO:0010243 156 0.024
regulation of peptidase activity GO:0052547 180 0.024
cellular amine metabolic process GO:0044106 41 0.024
regulation of response to external stimulus GO:0032101 222 0.024
response to fungus GO:0009620 4 0.024
apoptotic signaling pathway GO:0097190 268 0.024
rna dependent dna replication GO:0006278 16 0.024
stress activated mapk cascade GO:0051403 93 0.024
regulation of histone h3 k27 methylation GO:0061085 4 0.023
negative regulation of response to external stimulus GO:0032102 83 0.023
gonad development GO:0008406 34 0.022
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.022
stress activated protein kinase signaling cascade GO:0031098 94 0.022
neurogenesis GO:0022008 169 0.022
negative regulation of cell differentiation GO:0045596 171 0.022
negative regulation of mitotic cell cycle GO:0045930 102 0.021
peptide metabolic process GO:0006518 51 0.021
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.021
negative regulation of cell cycle GO:0045786 193 0.021
smooth muscle cell migration GO:0014909 18 0.021
cellular component morphogenesis GO:0032989 314 0.021
histone h3 k4 methylation GO:0051568 27 0.021
atp metabolic process GO:0046034 176 0.021
positive regulation of phosphorylation GO:0042327 394 0.021
regulation of cell differentiation GO:0045595 393 0.020
regulation of mrna metabolic process GO:1903311 53 0.020
response to cytokine GO:0034097 232 0.020
cell cycle g1 s phase transition GO:0044843 80 0.020
positive regulation of hydrolase activity GO:0051345 331 0.020
cytokine metabolic process GO:0042107 38 0.020
cardiovascular system development GO:0072358 262 0.020
mitotic cell cycle phase transition GO:0044772 162 0.019
regulation of protein kinase activity GO:0045859 289 0.019
nucleoside monophosphate metabolic process GO:0009123 191 0.019
dna biosynthetic process GO:0071897 40 0.019
Yeast
dephosphorylation GO:0016311 209 0.019
dna strand elongation GO:0022616 5 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
microtubule organizing center organization GO:0031023 62 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
nucleus organization GO:0006997 28 0.018
growth GO:0040007 202 0.018
cellular carbohydrate metabolic process GO:0044262 84 0.018
metencephalon development GO:0022037 2 0.018
negative regulation of retinoic acid receptor signaling pathway GO:0048387 4 0.018
regulation of locomotion GO:0040012 329 0.018
leading strand elongation GO:0006272 1 0.018
regulation of nucleocytoplasmic transport GO:0046822 98 0.018
positive regulation of neural precursor cell proliferation GO:2000179 2 0.018
intracellular protein transport GO:0006886 270 0.018
Mouse
ras protein signal transduction GO:0007265 73 0.018
response to inorganic substance GO:0010035 127 0.018
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.018
mrna processing GO:0006397 133 0.018
gtp catabolic process GO:0006184 237 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.018
regulation of protein targeting GO:1903533 91 0.018
cellular response to nitrogen compound GO:1901699 144 0.018
negative regulation of cellular component organization GO:0051129 235 0.017
regulation of transferase activity GO:0051338 355 0.017
generation of neurons GO:0048699 152 0.017
negative regulation of transferase activity GO:0051348 124 0.017
cell fate determination GO:0001709 3 0.017
autophagy GO:0006914 88 0.017
cellular response to hormone stimulus GO:0032870 125 0.017
hindbrain development GO:0030902 3 0.017
negative regulation of cellular component movement GO:0051271 106 0.017
response to oxidative stress GO:0006979 121 0.016
regulation of intracellular protein transport GO:0033157 123 0.016
regulation of gtp catabolic process GO:0033124 180 0.016
cation homeostasis GO:0055080 189 0.016
negative regulation of locomotion GO:0040013 118 0.016
positive regulation of cytoplasmic transport GO:1903651 82 0.016
cellular response to external stimulus GO:0071496 111 0.016
histone h3 k9 methylation GO:0051567 10 0.016
cellular glucan metabolic process GO:0006073 22 0.016
circulatory system development GO:0072359 262 0.016
response to activity GO:0014823 0 0.016
locomotory behavior GO:0007626 1 0.016
viral life cycle GO:0019058 132 0.015
negative regulation of gene expression epigenetic GO:0045814 19 0.015
negative regulation of cell cycle phase transition GO:1901988 89 0.015
purine nucleoside monophosphate catabolic process GO:0009128 158 0.015
cell projection morphogenesis GO:0048858 129 0.015
negative regulation of peptidase activity GO:0010466 91 0.015
reproduction GO:0000003 63 0.015
positive regulation of protein kinase activity GO:0045860 190 0.015
negative regulation of cell development GO:0010721 48 0.015
regulation of cell migration GO:0030334 289 0.015
response to alcohol GO:0097305 64 0.014
protein autophosphorylation GO:0046777 123 0.014
regulation of map kinase activity GO:0043405 108 0.014
regulation of dna metabolic process GO:0051052 153 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.014
Worm
segmentation GO:0035282 4 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
sister chromatid cohesion GO:0007062 24 0.014
positive regulation of histone modification GO:0031058 29 0.014
positive regulation of cell cycle process GO:0090068 106 0.014
blastocyst development GO:0001824 3 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
response to extracellular stimulus GO:0009991 85 0.014
positive regulation of catabolic process GO:0009896 310 0.014
protein complex localization GO:0031503 31 0.014
extrinsic apoptotic signaling pathway GO:0097191 119 0.014
maintenance of location GO:0051235 112 0.014
anatomical structure homeostasis GO:0060249 100 0.013
Yeast
neuromuscular junction development GO:0007528 3 0.013
chordate embryonic development GO:0043009 34 0.013
energy reserve metabolic process GO:0006112 22 0.013
skeletal system development GO:0001501 79 0.013
regulation of cell cycle process GO:0010564 266 0.013
peptidyl lysine modification GO:0018205 144 0.013
regulation of cell motility GO:2000145 299 0.013
regulation of cell division GO:0051302 116 0.013
cytoplasmic transport GO:0016482 379 0.013
Mouse
response to nitrogen compound GO:1901698 184 0.013
negative regulation of proteolysis GO:0045861 132 0.013
interleukin 10 biosynthetic process GO:0042091 2 0.013
ribonucleoside monophosphate catabolic process GO:0009158 158 0.013
regulation of dna replication GO:0006275 68 0.013
regulation of chromatin organization GO:1902275 56 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
positive regulation of gtp catabolic process GO:0033126 166 0.013
microtubule based process GO:0007017 210 0.013
positive regulation of cell differentiation GO:0045597 211 0.013
phagocytosis GO:0006909 42 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
positive regulation of developmental process GO:0051094 314 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.012
purine ribonucleoside biosynthetic process GO:0046129 23 0.012
meiotic chromosome separation GO:0051307 3 0.012
double strand break repair via nonhomologous end joining GO:0006303 10 0.012
reactive nitrogen species metabolic process GO:2001057 3 0.012
peptide catabolic process GO:0043171 10 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
neuron differentiation GO:0030182 138 0.012
protein dealkylation GO:0008214 17 0.012
response to toxic substance GO:0009636 37 0.012
cellular response to dna damage stimulus GO:0006974 379 0.012
cell cycle dna replication GO:0044786 11 0.012
nervous system development GO:0007399 293 0.012
positive regulation of gtpase activity GO:0043547 166 0.012
histone demethylation GO:0016577 15 0.011
regulation of response to biotic stimulus GO:0002831 55 0.011
negative regulation of epidermal cell differentiation GO:0045605 4 0.011
jnk cascade GO:0007254 80 0.011
cellular lipid catabolic process GO:0044242 65 0.011
carbohydrate derivative biosynthetic process GO:1901137 207 0.011
rna processing GO:0006396 255 0.011
cell part morphogenesis GO:0032990 137 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
central nervous system development GO:0007417 123 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
response to oxygen levels GO:0070482 100 0.011
mrna splicing via spliceosome GO:0000398 89 0.011
sexual reproduction GO:0019953 37 0.011
positive regulation of histone h3 k4 methylation GO:0051571 8 0.011
positive regulation of meiotic cell cycle GO:0051446 2 0.011
viral process GO:0016032 146 0.011
embryonic organ development GO:0048568 36 0.011
cellular response to hypoxia GO:0071456 51 0.011
positive regulation of cell death GO:0010942 263 0.011
protein modification by small protein conjugation GO:0032446 342 0.011
regulation of protein import into nucleus GO:0042306 78 0.011
reciprocal meiotic recombination GO:0007131 4 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
nucleoside triphosphate metabolic process GO:0009141 422 0.011
cell development GO:0048468 328 0.011
digestive system development GO:0055123 75 0.011
chemical homeostasis GO:0048878 306 0.011
sodium ion export from cell GO:0036376 6 0.011
positive regulation of mapk cascade GO:0043410 190 0.010
negative regulation of endopeptidase activity GO:0010951 84 0.010
bmp signaling pathway GO:0030509 49 0.010
regulation of growth rate GO:0040009 1 0.010
t cell activation GO:0042110 99 0.010
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.010
purine nucleoside catabolic process GO:0006152 398 0.010
regulation of viral genome replication GO:0045069 48 0.010
leukocyte activation GO:0045321 164 0.010

POLA2 disease predictions

Disease DO term ID Size Probability Func Analog Org
heart conduction disease DOID:10273 18 0.346
brugada syndrome DOID:0050451 8 0.346
cardiovascular system disease DOID:1287 106 0.346
disease of metabolism DOID:0014667 295 0.069
cancer DOID:162 167 0.044
disease of cellular proliferation DOID:14566 174 0.044
organ system cancer DOID:0050686 164 0.044
gastrointestinal system cancer DOID:3119 52 0.042
sensory system disease DOID:0050155 203 0.012
nervous system disease DOID:863 431 0.012
aicardi goutieres syndrome DOID:0050629 7 0.011
neuropathy DOID:870 52 0.011