Homo sapiens

64 known processes

PPIE

peptidylprolyl isomerase E (cyclophilin E)

(Aliases: CYP-33,MGC3736,MGC111222,CYP33)

PPIE biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.451
cellular ketone metabolic process GO:0042180 80 0.264
post embryonic development GO:0009791 2 0.185
cellular response to dna damage stimulus GO:0006974 379 0.183
regulation of cellular amino acid metabolic process GO:0006521 6 0.173
regulation of meiotic cell cycle GO:0051445 4 0.170
dna repair GO:0006281 198 0.160
amine metabolic process GO:0009308 44 0.154
covalent chromatin modification GO:0016569 254 0.143
regulation of cellular amine metabolic process GO:0033238 11 0.136
nucleoside monophosphate metabolic process GO:0009123 191 0.133
cellular amine metabolic process GO:0044106 41 0.128
purine ribonucleoside metabolic process GO:0046128 437 0.128
positive regulation of hydrolase activity GO:0051345 331 0.110
dna replication GO:0006260 116 0.108
ribonucleoside triphosphate metabolic process GO:0009199 412 0.096
nucleotide excision repair GO:0006289 31 0.092
negative regulation of protein metabolic process GO:0051248 391 0.091
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.089
chromatin modification GO:0016568 298 0.086
regulation of cellular ketone metabolic process GO:0010565 50 0.084
cell development GO:0048468 328 0.082
protein processing GO:0016485 226 0.076
regulation of kinase activity GO:0043549 314 0.076
positive regulation of phosphorylation GO:0042327 394 0.073
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.071
ribonucleoside catabolic process GO:0042454 406 0.071
cellular macromolecule catabolic process GO:0044265 380 0.068
Worm
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.067
histone modification GO:0016570 251 0.066
purine nucleotide catabolic process GO:0006195 405 0.066
internal protein amino acid acetylation GO:0006475 101 0.064
glycosyl compound catabolic process GO:1901658 413 0.064
chromatin organization GO:0006325 351 0.062
purine ribonucleotide catabolic process GO:0009154 404 0.061
purine nucleoside triphosphate metabolic process GO:0009144 412 0.061
regulation of cell division GO:0051302 116 0.059
multicellular organismal aging GO:0010259 3 0.057
positive regulation of cellular amine metabolic process GO:0033240 7 0.057
ribonucleoside monophosphate metabolic process GO:0009161 187 0.057
negative regulation of cellular protein metabolic process GO:0032269 353 0.054
regulation of cell cycle GO:0051726 393 0.051
negative regulation of catalytic activity GO:0043086 335 0.049
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.049
regulation of purine nucleotide metabolic process GO:1900542 264 0.048
regulation of nucleoside metabolic process GO:0009118 209 0.047
protein maturation GO:0051604 233 0.047
nucleotide catabolic process GO:0009166 408 0.046
cellular lipid metabolic process GO:0044255 303 0.046
cellular macromolecular complex assembly GO:0034622 324 0.045
regulation of nucleotide metabolic process GO:0006140 269 0.044
cell division GO:0051301 168 0.043
response to cytokine GO:0034097 232 0.043
lipid metabolic process GO:0006629 381 0.040
methylation GO:0032259 106 0.040
purine nucleoside triphosphate catabolic process GO:0009146 392 0.039
regulation of cell differentiation GO:0045595 393 0.038
ribonucleotide catabolic process GO:0009261 405 0.038
cellular amino acid metabolic process GO:0006520 116 0.037
regulation of proteolysis GO:0030162 293 0.037
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.036
positive regulation of catabolic process GO:0009896 310 0.036
positive regulation of cellular catabolic process GO:0031331 284 0.036
atp catabolic process GO:0006200 157 0.036
carbohydrate derivative biosynthetic process GO:1901137 207 0.035
nucleoside triphosphate metabolic process GO:0009141 422 0.035
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.034
negative regulation of cellular component organization GO:0051129 235 0.034
histone h3 acetylation GO:0043966 45 0.034
purine ribonucleoside catabolic process GO:0046130 398 0.033
gtp metabolic process GO:0046039 239 0.032
peptidyl lysine dimethylation GO:0018027 3 0.032
regulation of cell cycle process GO:0010564 266 0.031
response to oxygen containing compound GO:1901700 369 0.031
positive regulation of nucleotide catabolic process GO:0030813 185 0.031
cell projection organization GO:0030030 252 0.030
embryo development GO:0009790 123 0.030
Worm
positive regulation of programmed cell death GO:0043068 249 0.030
positive regulation of protein phosphorylation GO:0001934 313 0.029
nucleoside phosphate catabolic process GO:1901292 412 0.029
negative regulation of multicellular organismal process GO:0051241 317 0.029
ribonucleoside triphosphate catabolic process GO:0009203 391 0.029
positive regulation of cellular component organization GO:0051130 376 0.028
cytoplasmic transport GO:0016482 379 0.028
cytokine production GO:0001816 247 0.028
regulation of peptidase activity GO:0052547 180 0.027
negative regulation of transferase activity GO:0051348 124 0.027
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.027
purine nucleoside monophosphate metabolic process GO:0009126 186 0.027
protein acetylation GO:0006473 116 0.027
transcription coupled nucleotide excision repair GO:0006283 8 0.026
posttranscriptional regulation of gene expression GO:0010608 213 0.026
protein stabilization GO:0050821 64 0.026
response to lipid GO:0033993 206 0.026
myeloid cell differentiation GO:0030099 117 0.026
positive regulation of nucleoside metabolic process GO:0045979 186 0.026
female gamete generation GO:0007292 2 0.025
mitotic cell cycle process GO:1903047 286 0.025
regulation of intracellular transport GO:0032386 195 0.025
negative regulation of developmental process GO:0051093 247 0.025
response to abiotic stimulus GO:0009628 336 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.024
regulation of transferase activity GO:0051338 355 0.024
mitotic cell cycle phase transition GO:0044772 162 0.023
positive regulation of gtp catabolic process GO:0033126 166 0.023
regulation of membrane potential GO:0042391 95 0.023
regulation of cellular component biogenesis GO:0044087 281 0.023
histone methylation GO:0016571 60 0.022
peptidyl lysine acetylation GO:0018394 101 0.022
negative regulation of protein modification process GO:0031400 200 0.022
negative regulation of cell proliferation GO:0008285 228 0.022
regulation of establishment of protein localization GO:0070201 242 0.022
regulation of nucleotide catabolic process GO:0030811 205 0.022
nervous system development GO:0007399 293 0.022
regulation of mitotic cell cycle GO:0007346 189 0.022
mapk cascade GO:0000165 288 0.022
regulation of cysteine type endopeptidase activity GO:2000116 127 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
positive regulation of transport GO:0051050 336 0.021
cellular response to cytokine stimulus GO:0071345 181 0.021
regulation of cellular response to stress GO:0080135 244 0.020
immune system development GO:0002520 195 0.020
positive regulation of organelle organization GO:0010638 195 0.020
protein alkylation GO:0008213 74 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
rna processing GO:0006396 255 0.020
negative regulation of intracellular signal transduction GO:1902532 183 0.020
atp metabolic process GO:0046034 176 0.020
negative regulation of phosphorylation GO:0042326 174 0.019
oogenesis GO:0048477 2 0.019
osteoblast differentiation GO:0001649 92 0.019
histone h4 k16 acetylation GO:0043984 14 0.019
purine containing compound catabolic process GO:0072523 411 0.019
regulation of protein kinase activity GO:0045859 289 0.019
microtubule cytoskeleton organization GO:0000226 176 0.019
nucleoside catabolic process GO:0009164 408 0.019
protein localization to organelle GO:0033365 280 0.019
guanosine containing compound catabolic process GO:1901069 239 0.019
purine containing compound biosynthetic process GO:0072522 88 0.019
apoptotic signaling pathway GO:0097190 268 0.019
neuromuscular junction development GO:0007528 3 0.018
dna damage checkpoint GO:0000077 68 0.018
small gtpase mediated signal transduction GO:0007264 78 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
regulation of purine nucleotide catabolic process GO:0033121 205 0.018
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
organonitrogen compound biosynthetic process GO:1901566 200 0.017
gtp catabolic process GO:0006184 237 0.017
organophosphate catabolic process GO:0046434 430 0.017
positive regulation of cell death GO:0010942 263 0.017
regulation of protein complex assembly GO:0043254 147 0.017
positive regulation of dna metabolic process GO:0051054 73 0.017
immune response GO:0006955 307 0.017
glycerolipid metabolic process GO:0046486 107 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.017
nuclear migration GO:0007097 1 0.016
secretion GO:0046903 254 0.016
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.016
histone h4 k8 acetylation GO:0043982 15 0.016
positive regulation of gtpase activity GO:0043547 166 0.016
mrna processing GO:0006397 133 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
protein acylation GO:0043543 138 0.016
positive regulation of transferase activity GO:0051347 227 0.016
cellular component morphogenesis GO:0032989 314 0.016
protein methylation GO:0006479 74 0.016
hemopoiesis GO:0030097 180 0.016
embryonic hemopoiesis GO:0035162 4 0.016
segmentation GO:0035282 4 0.016
interspecies interaction between organisms GO:0044419 156 0.016
tube development GO:0035295 125 0.016
negative regulation of kinase activity GO:0033673 106 0.016
peptidyl lysine modification GO:0018205 144 0.015
response to hormone GO:0009725 175 0.015
cell part morphogenesis GO:0032990 137 0.015
negative regulation of protein processing GO:0010955 142 0.015
locomotory behavior GO:0007626 1 0.015
nitrogen compound transport GO:0071705 191 0.015
glycerophospholipid metabolic process GO:0006650 84 0.015
organelle assembly GO:0070925 176 0.015
mitotic cell cycle GO:0000278 326 0.015
associative learning GO:0008306 1 0.015
organophosphate biosynthetic process GO:0090407 163 0.015
regulation of intracellular protein transport GO:0033157 123 0.015
cellular protein catabolic process GO:0044257 261 0.015
membrane organization GO:0061024 292 0.014
macromolecule methylation GO:0043414 97 0.014
anterior posterior axis specification GO:0009948 2 0.014
single organism membrane fusion GO:0044801 37 0.014
purine nucleoside catabolic process GO:0006152 398 0.014
viral process GO:0016032 146 0.014
microtubule based process GO:0007017 210 0.014
guanosine containing compound metabolic process GO:1901068 244 0.014
protein catabolic process GO:0030163 325 0.014
negative regulation of protein kinase activity GO:0006469 98 0.014
single organism cellular localization GO:1902580 332 0.014
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.014
internal peptidyl lysine acetylation GO:0018393 97 0.014
regulation of meiosis GO:0040020 3 0.014
regulation of protein localization GO:0032880 296 0.014
nucleoside phosphate biosynthetic process GO:1901293 109 0.014
ubiquitin dependent protein catabolic process GO:0006511 206 0.014
cellular protein complex assembly GO:0043623 188 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
regulation of gtpase activity GO:0043087 180 0.014
growth GO:0040007 202 0.014
regulation of gtp catabolic process GO:0033124 180 0.014
purine nucleoside monophosphate catabolic process GO:0009128 158 0.014
blastoderm segmentation GO:0007350 2 0.014
mitotic nuclear division GO:0007067 119 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.013
intracellular protein transport GO:0006886 270 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.013
Worm
single organism membrane organization GO:0044802 268 0.013
regeneration GO:0031099 4 0.013
sensory perception of smell GO:0007608 2 0.013
defense response GO:0006952 315 0.013
nuclear transport GO:0051169 179 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
nucleus localization GO:0051647 1 0.013
protein targeting GO:0006605 187 0.013
cell cycle phase transition GO:0044770 173 0.013
regulation of transporter activity GO:0032409 82 0.012
regulation of protein processing GO:0070613 150 0.012
protein ubiquitination GO:0016567 314 0.012
regulation of ras protein signal transduction GO:0046578 155 0.012
calcium ion transport GO:0006816 147 0.012
anatomical structure homeostasis GO:0060249 100 0.012
regulation of protein transport GO:0051223 213 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
regulation of mapk cascade GO:0043408 262 0.012
regulation of lipid metabolic process GO:0019216 96 0.012
nucleoside monophosphate catabolic process GO:0009125 159 0.012
establishment of nucleus localization GO:0040023 1 0.012
developmental process involved in reproduction GO:0003006 66 0.012
adult locomotory behavior GO:0008344 1 0.012
negative regulation of programmed cell death GO:0043069 321 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
negative regulation of cell differentiation GO:0045596 171 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
jak stat cascade GO:0007259 46 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
negative regulation of cell death GO:0060548 345 0.011
single organism reproductive process GO:0044702 98 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
cell cycle checkpoint GO:0000075 117 0.011
protein targeting to nucleus GO:0044744 104 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
mitochondrion organization GO:0007005 156 0.011
nucleotide biosynthetic process GO:0009165 109 0.011
system process GO:0003008 349 0.011
maintenance of location GO:0051235 112 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
signal transduction by phosphorylation GO:0023014 297 0.011
neurogenesis GO:0022008 169 0.011
translational initiation GO:0006413 48 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
cellular component disassembly GO:0022411 92 0.011
Worm
regulation of dna metabolic process GO:0051052 153 0.010
ras protein signal transduction GO:0007265 73 0.010
nuclear division GO:0000280 128 0.010
cell morphogenesis GO:0000902 296 0.010
negative regulation of proteolysis GO:0045861 132 0.010
determination of adult lifespan GO:0008340 2 0.010
intrinsic apoptotic signaling pathway GO:0097193 127 0.010
negative regulation of cell cycle phase transition GO:1901988 89 0.010
interleukin 2 production GO:0032623 20 0.010
regulation of immune response GO:0050776 201 0.010
response to organic cyclic compound GO:0014070 204 0.010
negative regulation of protein maturation GO:1903318 142 0.010
negative regulation of mitotic cell cycle GO:0045930 102 0.010

PPIE disease predictions

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 118 0.080
retinal degeneration DOID:8466 89 0.080
sensory system disease DOID:0050155 203 0.080
eye and adnexa disease DOID:1492 150 0.080
nervous system disease DOID:863 431 0.080
eye disease DOID:5614 149 0.080
disease of cellular proliferation DOID:14566 174 0.071
cancer DOID:162 167 0.039
organ system cancer DOID:0050686 164 0.023
disease of metabolism DOID:0014667 295 0.019
inherited metabolic disorder DOID:655 242 0.019
immune system disease DOID:2914 155 0.011