Homo sapiens

55 known processes

PPIB

peptidylprolyl isomerase B (cyclophilin B)

(Aliases: MGC2224,CYPB,CYP-S1,MGC14109,SCYLP,OI9)

PPIB biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to unfolded protein GO:0006986 24 0.751
chaperone mediated protein folding GO:0061077 13 0.604
4 hydroxyproline metabolic process GO:0019471 5 0.585
response to endoplasmic reticulum stress GO:0034976 49 0.491
er nucleus signaling pathway GO:0006984 23 0.459
endoplasmic reticulum unfolded protein response GO:0030968 16 0.455
modification dependent macromolecule catabolic process GO:0043632 212 0.376
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.347
regulation of wnt protein secretion GO:0061356 1 0.342
monocarboxylic acid metabolic process GO:0032787 185 0.310
cellular response to unfolded protein GO:0034620 16 0.310
glycoprotein biosynthetic process GO:0009101 91 0.241
regulation of cell migration GO:0030334 289 0.214
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.191
regulation of growth GO:0040008 165 0.178
ubiquitin dependent protein catabolic process GO:0006511 206 0.161
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.158
post embryonic development GO:0009791 2 0.151
cellular response to topologically incorrect protein GO:0035967 19 0.128
growth GO:0040007 202 0.126
glycoprotein metabolic process GO:0009100 110 0.122
positive regulation of blood pressure GO:0045777 3 0.110
regulation of behavior GO:0050795 82 0.097
positive regulation of developmental process GO:0051094 314 0.096
cellular modified amino acid metabolic process GO:0006575 64 0.087
protein n linked glycosylation GO:0006487 23 0.084
maintenance of location GO:0051235 112 0.077
apoptotic signaling pathway GO:0097190 268 0.076
regulation of cell motility GO:2000145 299 0.075
cellular macromolecule catabolic process GO:0044265 380 0.074
positive regulation of cellular component organization GO:0051130 376 0.072
cellular protein catabolic process GO:0044257 261 0.072
positive regulation of growth GO:0045927 58 0.072
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.070
protein glycosylation GO:0006486 62 0.069
response to topologically incorrect protein GO:0035966 29 0.062
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.061
regulation of proteolysis GO:0030162 293 0.060
intracellular protein transport GO:0006886 270 0.060
cytoplasmic transport GO:0016482 379 0.057
posttranscriptional regulation of gene expression GO:0010608 213 0.056
regulation of apoptotic signaling pathway GO:2001233 175 0.055
cell chemotaxis GO:0060326 112 0.052
determination of adult lifespan GO:0008340 2 0.051
negative regulation of apoptotic process GO:0043066 316 0.050
regulation of locomotion GO:0040012 329 0.049
cellular ketone metabolic process GO:0042180 80 0.049
single organism carbohydrate metabolic process GO:0044723 193 0.049
cellular amino acid metabolic process GO:0006520 116 0.047
response to oxygen containing compound GO:1901700 369 0.047
glycosylation GO:0070085 71 0.047
carbohydrate derivative biosynthetic process GO:1901137 207 0.047
carbohydrate metabolic process GO:0005975 207 0.046
response to organic cyclic compound GO:0014070 204 0.045
negative regulation of programmed cell death GO:0043069 321 0.043
single organism membrane organization GO:0044802 268 0.043
cellular response to endogenous stimulus GO:0071495 336 0.042
cellular amine metabolic process GO:0044106 41 0.041
oxidation reduction process GO:0055114 396 0.041
regulation of cell growth GO:0001558 135 0.041
positive regulation of phosphorylation GO:0042327 394 0.041
positive regulation of multicellular organism growth GO:0040018 6 0.041
regulation of cellular amino acid metabolic process GO:0006521 6 0.040
response to decreased oxygen levels GO:0036293 96 0.040
proteasomal protein catabolic process GO:0010498 176 0.039
regulation of leukocyte chemotaxis GO:0002688 46 0.039
positive regulation of protein phosphorylation GO:0001934 313 0.038
rna interference GO:0016246 4 0.036
protein folding GO:0006457 38 0.036
response to cytokine GO:0034097 232 0.035
regulation of cell adhesion GO:0030155 166 0.035
response to hypoxia GO:0001666 96 0.034
vesicle mediated transport GO:0016192 371 0.034
regulation of multi organism process GO:0043900 157 0.034
multicellular organismal aging GO:0010259 3 0.033
positive regulation of transport GO:0051050 336 0.033
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.033
lipid localization GO:0010876 106 0.031
single organism cell adhesion GO:0098602 179 0.030
negative regulation of hydrolase activity GO:0051346 182 0.030
leukocyte activation GO:0045321 164 0.030
establishment of protein localization to membrane GO:0090150 121 0.030
positive regulation of cell death GO:0010942 263 0.030
regulation of cysteine type endopeptidase activity GO:2000116 127 0.029
alpha amino acid metabolic process GO:1901605 72 0.029
male sex differentiation GO:0046661 25 0.027
cytokinesis GO:0000910 96 0.026
regulation of establishment of protein localization GO:0070201 242 0.025
hindbrain development GO:0030902 3 0.024
negative regulation of catalytic activity GO:0043086 335 0.024
cellular homeostasis GO:0019725 196 0.024
protein maturation GO:0051604 233 0.023
developmental growth GO:0048589 48 0.023
peptidyl glutamic acid modification GO:0018200 4 0.023
regulation of gtp catabolic process GO:0033124 180 0.023
vitamin metabolic process GO:0006766 26 0.023
cellular response to organonitrogen compound GO:0071417 124 0.023
purine nucleoside catabolic process GO:0006152 398 0.023
positive regulation of dna metabolic process GO:0051054 73 0.022
regulation of response to oxidative stress GO:1902882 26 0.022
embryo development GO:0009790 123 0.022
regulation of cell cycle process GO:0010564 266 0.022
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.021
male genitalia development GO:0030539 1 0.021
regulation of peptidase activity GO:0052547 180 0.021
regulation of membrane potential GO:0042391 95 0.021
positive regulation of programmed cell death GO:0043068 249 0.021
purine ribonucleotide catabolic process GO:0009154 404 0.021
lymphocyte activation GO:0046649 133 0.020
response to abiotic stimulus GO:0009628 336 0.020
peptidyl tyrosine modification GO:0018212 170 0.020
locomotory behavior GO:0007626 1 0.020
membrane organization GO:0061024 292 0.020
circulatory system process GO:0003013 113 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
protein catabolic process GO:0030163 325 0.019
protein localization to organelle GO:0033365 280 0.019
positive regulation of developmental growth GO:0048639 16 0.019
t cell activation GO:0042110 99 0.019
regulation of cell division GO:0051302 116 0.019
cellular response to external stimulus GO:0071496 111 0.019
cellular response to oxidative stress GO:0034599 85 0.019
regulation of cell cycle GO:0051726 393 0.019
regulation of cellular response to stress GO:0080135 244 0.018
regulation of protein kinase activity GO:0045859 289 0.018
wnt protein secretion GO:0061355 1 0.018
cell activation GO:0001775 213 0.018
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
chemotaxis GO:0006935 157 0.018
intrinsic apoptotic signaling pathway GO:0097193 127 0.018
reactive nitrogen species metabolic process GO:2001057 3 0.017
regulation of cellular component movement GO:0051270 334 0.017
extrinsic apoptotic signaling pathway GO:0097191 119 0.017
actin filament organization GO:0007015 128 0.017
negative regulation of cell death GO:0060548 345 0.017
establishment of protein localization to endoplasmic reticulum GO:0072599 11 0.017
response to inorganic substance GO:0010035 127 0.016
blood circulation GO:0008015 113 0.016
protein hydroxylation GO:0018126 9 0.016
response to starvation GO:0042594 59 0.016
cell death in response to oxidative stress GO:0036473 29 0.016
cellular response to organic cyclic compound GO:0071407 127 0.016
response to hormone GO:0009725 175 0.016
protein localization to nucleus GO:0034504 136 0.016
embryo development ending in birth or egg hatching GO:0009792 34 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
regulation of body fluid levels GO:0050878 99 0.016
synaptic vesicle recycling GO:0036465 3 0.016
regulation of endocytosis GO:0030100 72 0.015
regulation of cellular ketone metabolic process GO:0010565 50 0.015
negative regulation of protein processing GO:0010955 142 0.015
negative regulation of cell cycle GO:0045786 193 0.015
positive regulation of kinase activity GO:0033674 204 0.015
positive regulation of protein secretion GO:0050714 60 0.015
regulation of gene expression epigenetic GO:0040029 73 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
reproduction GO:0000003 63 0.015
Fly
macromolecule glycosylation GO:0043413 63 0.015
aging GO:0007568 66 0.015
regeneration GO:0031099 4 0.014
regulation of sequestering of calcium ion GO:0051282 41 0.014
nervous system development GO:0007399 293 0.014
negative regulation of multicellular organismal process GO:0051241 317 0.014
cytosolic calcium ion transport GO:0060401 48 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
negative regulation of apoptotic signaling pathway GO:2001234 97 0.014
negative regulation of catabolic process GO:0009895 104 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
positive regulation of secretion GO:0051047 116 0.014
regulation of protein processing GO:0070613 150 0.014
regulation of kinase activity GO:0043549 314 0.014
regulation of chemotaxis GO:0050920 74 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
peptidyl asparagine modification GO:0018196 11 0.014
regulation of protein secretion GO:0050708 86 0.014
cell division GO:0051301 168 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
embryonic placenta development GO:0001892 1 0.013
single organism cellular localization GO:1902580 332 0.013
system process GO:0003008 349 0.013
regulation of cellular amine metabolic process GO:0033238 11 0.013
peptidyl cysteine modification GO:0018198 9 0.013
response to toxic substance GO:0009636 37 0.013
receptor mediated endocytosis GO:0006898 84 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
neurogenesis GO:0022008 169 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
posttranslational protein targeting to membrane GO:0006620 5 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
fatty acid metabolic process GO:0006631 115 0.012
extracellular structure organization GO:0043062 41 0.012
heat acclimation GO:0010286 3 0.012
regulation of protein localization GO:0032880 296 0.012
response to transforming growth factor beta GO:0071559 94 0.012
cellular response to hormone stimulus GO:0032870 125 0.012
positive regulation of cellular component movement GO:0051272 181 0.012
cellular protein complex assembly GO:0043623 188 0.012
lipid storage GO:0019915 28 0.012
regulation of cellular protein catabolic process GO:1903362 96 0.012
positive regulation of transferase activity GO:0051347 227 0.012
mitotic cell cycle phase transition GO:0044772 162 0.012
positive regulation of immune system process GO:0002684 283 0.011
developmental process involved in reproduction GO:0003006 66 0.011
negative regulation of growth GO:0045926 97 0.011
regulation of proteasomal protein catabolic process GO:0061136 87 0.011
vesicle organization GO:0016050 62 0.011
peptide cross linking GO:0018149 12 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
primary neural tube formation GO:0014020 3 0.011
sequestering of calcium ion GO:0051208 17 0.011
protein export from nucleus GO:0006611 29 0.011
regulation of developmental growth GO:0048638 30 0.011
regulation of systemic arterial blood pressure GO:0003073 19 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
response to external biotic stimulus GO:0043207 261 0.011
neuron differentiation GO:0030182 138 0.011
negative regulation of synaptic transmission GO:0050805 2 0.010
reactive oxygen species biosynthetic process GO:1903409 4 0.010
positive regulation of mapk cascade GO:0043410 190 0.010
positive regulation of locomotion GO:0040017 186 0.010
protein targeting GO:0006605 187 0.010
glycoprotein catabolic process GO:0006516 7 0.010
regulation of purine nucleotide metabolic process GO:1900542 264 0.010
organic acid biosynthetic process GO:0016053 97 0.010
regulation of binding GO:0051098 111 0.010
regulation of dna replication GO:0006275 68 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.010
cytosolic calcium ion homeostasis GO:0051480 89 0.010
retina layer formation GO:0010842 3 0.010
regulation of meiosis GO:0040020 3 0.010

PPIB disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.029
disease of cellular proliferation DOID:14566 174 0.029
organ system cancer DOID:0050686 164 0.029
bone disease DOID:0080001 88 0.017
musculoskeletal system disease DOID:17 223 0.017
connective tissue disease DOID:65 109 0.017
myeloma DOID:0070004 7 0.013
immune system cancer DOID:0060083 36 0.013
hematologic cancer DOID:2531 36 0.013
bone marrow cancer DOID:4960 10 0.013
bone development disease DOID:0080006 55 0.001
osteochondrodysplasia DOID:2256 35 0.001
osteogenesis imperfecta DOID:12347 13 0.001