Homo sapiens

70 known processes

PPIA

peptidylprolyl isomerase A (cyclophilin A)

(Aliases: MGC23397,CYPH,CYPA,MGC12404,MGC117158)

PPIA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
glomerular mesangial cell development GO:0072144 1 0.889
multicellular organismal aging GO:0010259 3 0.598
cellular response to oxidative stress GO:0034599 85 0.550
positive regulation of developmental process GO:0051094 314 0.546
renal interstitial fibroblast development GO:0072141 1 0.375
cellular response to dna damage stimulus GO:0006974 379 0.350
organelle assembly GO:0070925 176 0.278
regulation of nucleotide metabolic process GO:0006140 269 0.261
nucleoside catabolic process GO:0009164 408 0.249
cytoplasmic transport GO:0016482 379 0.243
dna repair GO:0006281 198 0.236
ribonucleotide catabolic process GO:0009261 405 0.234
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.214
protein acylation GO:0043543 138 0.200
response to other organism GO:0051707 261 0.191
cellular response to cytokine stimulus GO:0071345 181 0.181
vesicle mediated transport GO:0016192 371 0.180
negative regulation of cell death GO:0060548 345 0.165
response to external biotic stimulus GO:0043207 261 0.162
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.159
nucleocytoplasmic transport GO:0006913 176 0.152
organelle inheritance GO:0048308 2 0.145
adult locomotory behavior GO:0008344 1 0.129
response to cytokine GO:0034097 232 0.128
post embryonic development GO:0009791 2 0.127
blood circulation GO:0008015 113 0.127
cellular homeostasis GO:0019725 196 0.125
positive regulation of transport GO:0051050 336 0.122
ribonucleoprotein complex assembly GO:0022618 78 0.122
immune effector process GO:0002252 159 0.122
anion transport GO:0006820 161 0.120
immune response GO:0006955 307 0.114
determination of adult lifespan GO:0008340 2 0.112
negative regulation of apoptotic process GO:0043066 316 0.107
positive regulation of binding GO:0051099 45 0.107
regulation of intracellular transport GO:0032386 195 0.104
intrinsic apoptotic signaling pathway GO:0097193 127 0.103
immune system development GO:0002520 195 0.098
response to acid chemical GO:0001101 66 0.096
anatomical structure homeostasis GO:0060249 100 0.089
somatic muscle development GO:0007525 1 0.085
ribonucleoprotein complex biogenesis GO:0022613 116 0.081
atp metabolic process GO:0046034 176 0.080
heart process GO:0003015 62 0.079
positive regulation of cell proliferation GO:0008284 301 0.076
purine nucleotide catabolic process GO:0006195 405 0.076
response to virus GO:0009615 126 0.076
ribonucleoside triphosphate metabolic process GO:0009199 412 0.074
apoptotic signaling pathway GO:0097190 268 0.073
endocytosis GO:0006897 159 0.073
nucleoside triphosphate metabolic process GO:0009141 422 0.073
nucleoside phosphate catabolic process GO:1901292 412 0.070
positive regulation of cellular amine metabolic process GO:0033240 7 0.070
ribonucleoside catabolic process GO:0042454 406 0.069
internal protein amino acid acetylation GO:0006475 101 0.069
purine ribonucleotide catabolic process GO:0009154 404 0.067
organophosphate catabolic process GO:0046434 430 0.065
response to oxidative stress GO:0006979 121 0.065
organonitrogen compound biosynthetic process GO:1901566 200 0.064
kidney interstitial fibroblast differentiation GO:0072071 2 0.062
microvillus assembly GO:0030033 2 0.062
cellular chemical homeostasis GO:0055082 180 0.062
positive regulation of growth GO:0045927 58 0.061
positive regulation of cellular catabolic process GO:0031331 284 0.060
rna transport GO:0050658 39 0.056
innate immune response GO:0045087 178 0.056
protein targeting GO:0006605 187 0.055
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.054
purine nucleoside triphosphate metabolic process GO:0009144 412 0.054
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.053
negative regulation of cellular protein metabolic process GO:0032269 353 0.052
regulation of establishment of protein localization GO:0070201 242 0.052
alcohol metabolic process GO:0006066 114 0.051
ribonucleoprotein complex subunit organization GO:0071826 81 0.050
posttranscriptional regulation of gene expression GO:0010608 213 0.050
nucleotide catabolic process GO:0009166 408 0.050
secretion GO:0046903 254 0.050
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.049
hematopoietic or lymphoid organ development GO:0048534 186 0.049
organelle fission GO:0048285 149 0.049
negative regulation of programmed cell death GO:0043069 321 0.048
cellular cation homeostasis GO:0030003 163 0.048
cellular response to acid chemical GO:0071229 44 0.048
tissue homeostasis GO:0001894 63 0.047
regulation of binding GO:0051098 111 0.047
meiotic chromosome segregation GO:0045132 4 0.047
nitrogen compound transport GO:0071705 191 0.046
positive regulation of nucleotide metabolic process GO:0045981 230 0.046
intracellular protein transport GO:0006886 270 0.044
covalent chromatin modification GO:0016569 254 0.044
response to interleukin 4 GO:0070670 7 0.042
positive regulation of cell death GO:0010942 263 0.042
ion homeostasis GO:0050801 230 0.041
regulation of cyclic nucleotide biosynthetic process GO:0030802 49 0.041
regulation of growth GO:0040008 165 0.040
internal peptidyl lysine acetylation GO:0018393 97 0.039
anatomical structure formation involved in morphogenesis GO:0048646 284 0.038
positive regulation of catabolic process GO:0009896 310 0.038
positive regulation of apoptotic process GO:0043065 246 0.038
cellular macromolecular complex assembly GO:0034622 324 0.037
carboxylic acid biosynthetic process GO:0046394 97 0.037
purine nucleoside catabolic process GO:0006152 398 0.037
microtubule organizing center organization GO:0031023 62 0.036
cellular macromolecule catabolic process GO:0044265 380 0.036
response to lipid GO:0033993 206 0.035
regulation of nucleotide biosynthetic process GO:0030808 50 0.035
regulation of apoptotic signaling pathway GO:2001233 175 0.035
cell aging GO:0007569 52 0.034
neuron differentiation GO:0030182 138 0.033
Mouse
single organism carbohydrate metabolic process GO:0044723 193 0.033
regulation of intracellular protein transport GO:0033157 123 0.033
rna interference GO:0016246 4 0.033
positive regulation of immune system process GO:0002684 283 0.032
defense response GO:0006952 315 0.031
nuclear transport GO:0051169 179 0.031
ribonucleoside triphosphate catabolic process GO:0009203 391 0.031
heart contraction GO:0060047 62 0.031
negative regulation of immune system process GO:0002683 136 0.031
response to oxygen containing compound GO:1901700 369 0.031
cellular response to oxygen containing compound GO:1901701 276 0.030
muscle cell cellular homeostasis GO:0046716 3 0.030
negative regulation of intracellular transport GO:0032387 60 0.030
cation homeostasis GO:0055080 189 0.030
regulation of purine nucleotide biosynthetic process GO:1900371 50 0.030
aging GO:0007568 66 0.030
positive regulation of hydrolase activity GO:0051345 331 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.029
myoblast fusion GO:0007520 1 0.029
cellular amide metabolic process GO:0043603 69 0.029
purine nucleoside triphosphate catabolic process GO:0009146 392 0.029
response to inorganic substance GO:0010035 127 0.029
locomotory behavior GO:0007626 1 0.029
microtubule based process GO:0007017 210 0.028
chemical homeostasis GO:0048878 306 0.028
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
reactive oxygen species metabolic process GO:0072593 75 0.028
translesion synthesis GO:0019985 8 0.028
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.028
mrna metabolic process GO:0016071 175 0.028
regulation of purine nucleotide metabolic process GO:1900542 264 0.028
neuromuscular junction development GO:0007528 3 0.027
single organism reproductive process GO:0044702 98 0.027
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.027
gtp metabolic process GO:0046039 239 0.027
cellular divalent inorganic cation homeostasis GO:0072503 128 0.027
signal transduction in response to dna damage GO:0042770 57 0.027
lipid biosynthetic process GO:0008610 177 0.026
actomyosin structure organization GO:0031032 59 0.026
positive regulation of programmed cell death GO:0043068 249 0.026
oogenesis GO:0048477 2 0.026
female gamete generation GO:0007292 2 0.026
myeloid cell differentiation GO:0030099 117 0.026
monocarboxylic acid metabolic process GO:0032787 185 0.026
response to bacterium GO:0009617 144 0.026
negative regulation of phosphate metabolic process GO:0045936 267 0.026
Rat
regulation of nucleocytoplasmic transport GO:0046822 98 0.026
carbohydrate metabolic process GO:0005975 207 0.026
oxidation reduction process GO:0055114 396 0.026
positive regulation of camp biosynthetic process GO:0030819 35 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
positive regulation of gtpase activity GO:0043547 166 0.025
nucleoside diphosphate metabolic process GO:0009132 16 0.025
circulatory system process GO:0003013 113 0.024
platelet activation GO:0030168 44 0.024
microtubule cytoskeleton organization GO:0000226 176 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.024
actin myosin filament sliding GO:0033275 6 0.024
secretion by cell GO:0032940 226 0.023
response to wounding GO:0009611 168 0.023
regulation of cellular response to stress GO:0080135 244 0.023
regulation of peptidase activity GO:0052547 180 0.023
cell growth GO:0016049 160 0.023
cellular response to endogenous stimulus GO:0071495 336 0.023
regulation of protein targeting GO:1903533 91 0.023
atp transport GO:0015867 4 0.023
negative regulation of transcription initiation from rna polymerase ii promoter GO:0060633 3 0.023
maintenance of location GO:0051235 112 0.022
regulation of membrane potential GO:0042391 95 0.022
regulation of cytoplasmic transport GO:1903649 149 0.022
double strand break repair GO:0006302 101 0.022
organic anion transport GO:0015711 103 0.022
negative regulation of apoptotic signaling pathway GO:2001234 97 0.022
glycosyl compound catabolic process GO:1901658 413 0.021
negative regulation of cell growth GO:0030308 83 0.021
response to biotic stimulus GO:0009607 276 0.021
protein targeting to nucleus GO:0044744 104 0.021
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.021
establishment or maintenance of cell polarity GO:0007163 31 0.021
regulation of gene expression epigenetic GO:0040029 73 0.021
muscle structure development GO:0061061 98 0.021
protein localization to nucleus GO:0034504 136 0.021
actin filament based process GO:0030029 224 0.021
system process GO:0003008 349 0.020
cellular ion homeostasis GO:0006873 168 0.020
positive regulation of mitochondrial membrane permeability GO:0035794 17 0.020
multicellular organismal homeostasis GO:0048871 67 0.020
cellular amine metabolic process GO:0044106 41 0.020
epithelial cell differentiation GO:0030855 141 0.020
replicative cell aging GO:0001302 3 0.020
negative regulation of neuron apoptotic process GO:0043524 23 0.019
response to abiotic stimulus GO:0009628 336 0.019
hemopoiesis GO:0030097 180 0.019
organelle localization GO:0051640 84 0.019
regulation of protein localization GO:0032880 296 0.019
regulation of innate immune response GO:0045088 97 0.019
receptor mediated endocytosis GO:0006898 84 0.019
regulation of protein processing GO:0070613 150 0.019
protein acetylation GO:0006473 116 0.019
morphogenesis of a polarized epithelium GO:0001738 3 0.019
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.019
histone acetylation GO:0016573 93 0.018
nervous system development GO:0007399 293 0.018
Mouse
establishment of protein localization to organelle GO:0072594 172 0.018
single organism membrane organization GO:0044802 268 0.018
membrane organization GO:0061024 292 0.018
oocyte development GO:0048599 1 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
cellular metal ion homeostasis GO:0006875 146 0.018
retina homeostasis GO:0001895 42 0.018
regulation of proteolysis GO:0030162 293 0.018
signal transduction by p53 class mediator GO:0072331 72 0.018
regulation of response to dna damage stimulus GO:2001020 94 0.018
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.018
response to metal ion GO:0010038 84 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.017
regulation of developmental growth GO:0048638 30 0.017
cellular ketone metabolic process GO:0042180 80 0.017
divalent inorganic cation homeostasis GO:0072507 136 0.017
cellular component morphogenesis GO:0032989 314 0.017
neuron cellular homeostasis GO:0070050 3 0.017
oocyte differentiation GO:0009994 2 0.017
negative regulation of cellular response to oxidative stress GO:1900408 18 0.017
positive regulation of developmental growth GO:0048639 16 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.017
camp biosynthetic process GO:0006171 47 0.017
calcium ion homeostasis GO:0055074 122 0.017
dna catabolic process endonucleolytic GO:0000737 37 0.017
growth GO:0040007 202 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
cell cycle checkpoint GO:0000075 117 0.016
mapk cascade GO:0000165 288 0.016
single organism cell adhesion GO:0098602 179 0.016
spermatid development GO:0007286 4 0.016
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.016
protein localization to organelle GO:0033365 280 0.016
epidermis development GO:0008544 59 0.016
regulation of cytokine production GO:0001817 232 0.016
single organism nuclear import GO:1902593 104 0.016
nuclear export GO:0051168 69 0.016
base excision repair GO:0006284 21 0.016
negative regulation of catalytic activity GO:0043086 335 0.016
Rat
protein homooligomerization GO:0051260 100 0.016
negative regulation of response to wounding GO:1903035 47 0.016
pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 1 0.016
regulation of actin filament depolymerization GO:0030834 10 0.015
regulation of rna splicing GO:0043484 62 0.015
protein import into nucleus GO:0006606 104 0.015
apoptotic mitochondrial changes GO:0008637 57 0.015
cytosolic calcium ion homeostasis GO:0051480 89 0.015
negative regulation of organelle organization GO:0010639 126 0.015
mitochondrial calcium ion homeostasis GO:0051560 11 0.015
ribonucleotide biosynthetic process GO:0009260 81 0.015
negative regulation of kinase activity GO:0033673 106 0.015
rna processing GO:0006396 255 0.015
positive regulation of synaptic transmission GO:0050806 4 0.015
negative regulation of protein processing GO:0010955 142 0.015
gtp catabolic process GO:0006184 237 0.015
neural crest cell development GO:0014032 3 0.015
organic acid biosynthetic process GO:0016053 97 0.015
translation GO:0006412 132 0.015
tissue regeneration GO:0042246 3 0.015
single organism cellular localization GO:1902580 332 0.015
generation of precursor metabolites and energy GO:0006091 68 0.015
nuclear import GO:0051170 106 0.014
cyclic nucleotide metabolic process GO:0009187 82 0.014
leukocyte mediated immunity GO:0002443 59 0.014
circulatory system development GO:0072359 262 0.014
regulation of reactive oxygen species metabolic process GO:2000377 41 0.014
regulation of protein localization to nucleus GO:1900180 85 0.014
cellular protein complex assembly GO:0043623 188 0.014
development of primary sexual characteristics GO:0045137 35 0.014
glomerulus vasculature development GO:0072012 6 0.014
peptidyl tyrosine phosphorylation GO:0018108 170 0.014
striated muscle myosin thick filament assembly GO:0071688 2 0.014
chromatin modification GO:0016568 298 0.014
detection of chemical stimulus GO:0009593 55 0.014
mesenchymal cell development GO:0014031 50 0.014
taxis GO:0042330 157 0.014
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.014
regulation of protein maturation GO:1903317 150 0.014
developmental process involved in reproduction GO:0003006 66 0.014
regulation of myeloid cell differentiation GO:0045637 81 0.014
response to hyperoxia GO:0055093 4 0.014
guanosine containing compound metabolic process GO:1901068 244 0.014
amine metabolic process GO:0009308 44 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
anterior posterior axis specification GO:0009948 2 0.014
epithelium development GO:0060429 227 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
cellular protein complex disassembly GO:0043624 36 0.013
pyrimidine ribonucleoside biosynthetic process GO:0046132 2 0.013
dna replication GO:0006260 116 0.013
phospholipid metabolic process GO:0006644 99 0.013
sex differentiation GO:0007548 45 0.013
interleukin 8 production GO:0032637 51 0.013
regulation of multicellular organism growth GO:0040014 8 0.013
purine containing compound catabolic process GO:0072523 411 0.013
purine ribonucleoside metabolic process GO:0046128 437 0.013
regulation of immune response GO:0050776 201 0.012
negative regulation of proteolysis GO:0045861 132 0.012
cell development GO:0048468 328 0.012
response to fatty acid GO:0070542 13 0.012
regulation of peptide transport GO:0090087 62 0.012
developmental growth GO:0048589 48 0.012
reproductive process GO:0022414 106 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
protein complex disassembly GO:0043241 52 0.012
cation transmembrane transport GO:0098655 238 0.012
positive regulation of secretion GO:0051047 116 0.012
regulation of camp metabolic process GO:0030814 52 0.012
regulation of protein transport GO:0051223 213 0.012
regulation of anatomical structure morphogenesis GO:0022603 286 0.012
regulation of necroptotic process GO:0060544 7 0.012
blastoderm segmentation GO:0007350 2 0.012
cellular response to reactive oxygen species GO:0034614 50 0.012
regulation of defense response GO:0031347 154 0.012
cofactor metabolic process GO:0051186 87 0.012
positive regulation of cytokine production GO:0001819 167 0.012
striated muscle cell differentiation GO:0051146 43 0.011
establishment of rna localization GO:0051236 39 0.011
negative regulation of oxidative stress induced cell death GO:1903202 17 0.011
purine nucleotide transport GO:0015865 6 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
cellular component disassembly GO:0022411 92 0.011
positive regulation of cyclic nucleotide metabolic process GO:0030801 49 0.011
segmentation GO:0035282 4 0.011
response to interferon gamma GO:0034341 39 0.011
lipid metabolic process GO:0006629 381 0.011
regulation of transporter activity GO:0032409 82 0.011
neural nucleus development GO:0048857 47 0.011
extrinsic apoptotic signaling pathway GO:0097191 119 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
positive regulation of immune response GO:0050778 159 0.011
reproductive system development GO:0061458 56 0.011
negative regulation of translation GO:0017148 37 0.011
reproductive structure development GO:0048608 55 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
Rat
epithelial cell proliferation GO:0050673 128 0.011
ribosomal subunit export from nucleus GO:0000054 4 0.011
regulation of cellular component movement GO:0051270 334 0.011
regulation of response to external stimulus GO:0032101 222 0.010
cell type specific apoptotic process GO:0097285 125 0.010
regulation of secretion GO:0051046 194 0.010
peptide transport GO:0015833 74 0.010
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.010
actin filament based movement GO:0030048 17 0.010
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 18 0.010
negative regulation of protein complex assembly GO:0031333 43 0.010
rna splicing GO:0008380 131 0.010
regulation of cell differentiation GO:0045595 393 0.010
pattern specification process GO:0007389 43 0.010
ribonucleoside biosynthetic process GO:0042455 25 0.010
regulation of mitochondrion organization GO:0010821 54 0.010
regulation of transcription factor import into nucleus GO:0042990 39 0.010
negative regulation of protein maturation GO:1903318 142 0.010
negative regulation of cytoplasmic transport GO:1903650 46 0.010
stem cell development GO:0048864 69 0.010
dna biosynthetic process GO:0071897 40 0.010
response to hormone GO:0009725 175 0.010

PPIA disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.048
nervous system disease DOID:863 431 0.048
auditory system disease DOID:2742 53 0.045
autosomal dominant nonsyndromic deafness DOID:0050564 23 0.045
nonsyndromic deafness DOID:0050563 50 0.045
sensory system disease DOID:0050155 203 0.045
neurodegenerative disease DOID:1289 102 0.034
cancer DOID:162 167 0.028
disease of cellular proliferation DOID:14566 174 0.028
organ system cancer DOID:0050686 164 0.028
disease of metabolism DOID:0014667 295 0.012