Homo sapiens

68 known processes

EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3

(Aliases: PERK,PEK,WRS,DKFZp781H1925)

EIF2AK3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule catabolic process GO:0044265 380 0.193
modification dependent protein catabolic process GO:0019941 209 0.152
modification dependent macromolecule catabolic process GO:0043632 212 0.151
protein catabolic process GO:0030163 325 0.145
cellular protein catabolic process GO:0044257 261 0.132
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.124
ubiquitin dependent protein catabolic process GO:0006511 206 0.119
endoplasmic reticulum unfolded protein response GO:0030968 16 0.114
negative regulation of cell death GO:0060548 345 0.113
Mouse
determination of adult lifespan GO:0008340 2 0.109
Worm
post embryonic development GO:0009791 2 0.092
Worm
negative regulation of programmed cell death GO:0043069 321 0.090
Mouse
response to abiotic stimulus GO:0009628 336 0.089
cation transport GO:0006812 331 0.087
negative regulation of apoptotic process GO:0043066 316 0.081
Mouse
protein ubiquitination GO:0016567 314 0.077
multicellular organismal aging GO:0010259 3 0.077
Worm
vesicle mediated transport GO:0016192 371 0.074
response to oxygen containing compound GO:1901700 369 0.073
reactive oxygen species metabolic process GO:0072593 75 0.068
oogenesis GO:0048477 2 0.066
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.065
actin filament based process GO:0030029 224 0.065
dephosphorylation GO:0016311 209 0.065
maintenance of location GO:0051235 112 0.063
secretion GO:0046903 254 0.059
Mouse
female gamete generation GO:0007292 2 0.058
cellular response to endogenous stimulus GO:0071495 336 0.057
protein modification by small protein conjugation GO:0032446 342 0.056
cellular response to oxygen containing compound GO:1901701 276 0.055
proteasomal protein catabolic process GO:0010498 176 0.052
regulation of cellular amino acid metabolic process GO:0006521 6 0.051
segmentation GO:0035282 4 0.046
membrane organization GO:0061024 292 0.046
single organism cellular localization GO:1902580 332 0.046
regulation of cell differentiation GO:0045595 393 0.045
ribonucleotide catabolic process GO:0009261 405 0.044
oocyte differentiation GO:0009994 2 0.043
system process GO:0003008 349 0.043
Mouse
transmembrane transport GO:0055085 399 0.043
cellular response to organic cyclic compound GO:0071407 127 0.042
purine ribonucleoside catabolic process GO:0046130 398 0.042
pharynx development GO:0060465 1 0.041
ribonucleoside triphosphate catabolic process GO:0009203 391 0.041
nucleoside phosphate catabolic process GO:1901292 412 0.040
ribonucleoside catabolic process GO:0042454 406 0.040
regulation of reactive oxygen species metabolic process GO:2000377 41 0.040
carbohydrate derivative biosynthetic process GO:1901137 207 0.040
purine ribonucleotide catabolic process GO:0009154 404 0.040
blastoderm segmentation GO:0007350 2 0.039
anterior posterior axis specification embryo GO:0008595 2 0.039
amine metabolic process GO:0009308 44 0.039
regulation of cellular amine metabolic process GO:0033238 11 0.039
response to decreased oxygen levels GO:0036293 96 0.038
actin cytoskeleton organization GO:0030036 207 0.038
organophosphate catabolic process GO:0046434 430 0.037
regulation of apoptotic signaling pathway GO:2001233 175 0.037
Mouse
secretion by cell GO:0032940 226 0.037
regulation of cellular response to stress GO:0080135 244 0.036
Mouse
glycosyl compound catabolic process GO:1901658 413 0.036
regulation of cell cycle GO:0051726 393 0.036
Fly
oocyte development GO:0048599 1 0.036
purine containing compound catabolic process GO:0072523 411 0.036
response to hypoxia GO:0001666 96 0.036
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.035
purine ribonucleoside metabolic process GO:0046128 437 0.035
response to disaccharide GO:0034285 1 0.035
purine nucleotide catabolic process GO:0006195 405 0.034
regulation of cellular component biogenesis GO:0044087 281 0.034
cellular amine metabolic process GO:0044106 41 0.034
positive regulation of hydrolase activity GO:0051345 331 0.034
Mouse
response to organonitrogen compound GO:0010243 156 0.033
regulation of nucleotide metabolic process GO:0006140 269 0.033
nervous system development GO:0007399 293 0.033
Mouse
tripartite regional subdivision GO:0007351 2 0.033
regulation of purine nucleotide catabolic process GO:0033121 205 0.033
response to organic cyclic compound GO:0014070 204 0.033
negative regulation of intracellular signal transduction GO:1902532 183 0.033
nucleoside triphosphate metabolic process GO:0009141 422 0.033
nucleotide catabolic process GO:0009166 408 0.032
regulation of cellular ketone metabolic process GO:0010565 50 0.032
Mouse
hindbrain development GO:0030902 3 0.031
positive regulation of nucleotide metabolic process GO:0045981 230 0.031
guanosine containing compound catabolic process GO:1901069 239 0.031
response to wounding GO:0009611 168 0.031
ribonucleoside triphosphate metabolic process GO:0009199 412 0.031
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.031
cellular amino acid metabolic process GO:0006520 116 0.030
response to unfolded protein GO:0006986 24 0.029
gtp metabolic process GO:0046039 239 0.029
positive regulation of transferase activity GO:0051347 227 0.029
purine nucleoside triphosphate catabolic process GO:0009146 392 0.028
cell cycle phase transition GO:0044770 173 0.028
Fly
cellular ketone metabolic process GO:0042180 80 0.028
Mouse
response to nitrogen compound GO:1901698 184 0.027
microtubule based process GO:0007017 210 0.027
positive regulation of transport GO:0051050 336 0.027
metal ion transport GO:0030001 272 0.027
cell projection organization GO:0030030 252 0.027
response to oxygen levels GO:0070482 100 0.027
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.027
regulation of blood coagulation GO:0030193 42 0.027
positive regulation of cellular amine metabolic process GO:0033240 7 0.026
cellular component morphogenesis GO:0032989 314 0.026
protein localization to organelle GO:0033365 280 0.026
regulation of nucleoside metabolic process GO:0009118 209 0.026
regeneration GO:0031099 4 0.026
mitotic cell cycle process GO:1903047 286 0.026
Fly
cellular response to cytokine stimulus GO:0071345 181 0.026
metencephalon development GO:0022037 2 0.026
regulation of dephosphorylation GO:0035303 96 0.026
positive regulation of immune system process GO:0002684 283 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
anterior posterior axis specification GO:0009948 2 0.025
regulation of transferase activity GO:0051338 355 0.025
nucleoside catabolic process GO:0009164 408 0.025
intracellular mrna localization GO:0008298 1 0.025
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
positive regulation of catabolic process GO:0009896 310 0.024
Fly
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.024
lipid metabolic process GO:0006629 381 0.024
Mouse
positive regulation of cellular component organization GO:0051130 376 0.024
positive regulation of phosphorylation GO:0042327 394 0.024
positive regulation of nucleoside metabolic process GO:0045979 186 0.024
cellular response to organonitrogen compound GO:0071417 124 0.023
microtubule cytoskeleton organization GO:0000226 176 0.023
ion transmembrane transport GO:0034220 338 0.023
negative regulation of phosphorus metabolic process GO:0010563 267 0.023
positive regulation of gtp catabolic process GO:0033126 166 0.023
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.023
ras protein signal transduction GO:0007265 73 0.023
negative regulation of apoptotic signaling pathway GO:2001234 97 0.022
regulation of protein localization GO:0032880 296 0.022
positive regulation of cellular catabolic process GO:0031331 284 0.022
Fly
regulation of cell activation GO:0050865 125 0.022
rho protein signal transduction GO:0007266 26 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
cytoplasmic transport GO:0016482 379 0.022
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.022
positive regulation of developmental process GO:0051094 314 0.022
cerebellum development GO:0021549 2 0.022
locomotory behavior GO:0007626 1 0.022
response to fungus GO:0009620 4 0.022
lipid biosynthetic process GO:0008610 177 0.021
rna interference GO:0016246 4 0.021
protein targeting GO:0006605 187 0.021
regulation of cellular component movement GO:0051270 334 0.021
immune response GO:0006955 307 0.021
regulation of gtpase activity GO:0043087 180 0.021
cellular lipid metabolic process GO:0044255 303 0.021
Mouse
regulation of protein kinase activity GO:0045859 289 0.021
cellular response to dna damage stimulus GO:0006974 379 0.021
intracellular protein transport GO:0006886 270 0.021
purine nucleoside catabolic process GO:0006152 398 0.021
wound healing GO:0042060 115 0.021
regulation of proteolysis GO:0030162 293 0.021
Mouse
response to endoplasmic reticulum stress GO:0034976 49 0.021
regulation of cell motility GO:2000145 299 0.020
regulation of purine nucleotide metabolic process GO:1900542 264 0.020
neurological system process GO:0050877 163 0.020
Mouse
cell development GO:0048468 328 0.020
Mouse
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.020
lipid localization GO:0010876 106 0.020
inorganic ion transmembrane transport GO:0098660 231 0.020
regulation of phosphatase activity GO:0010921 81 0.020
regulation of cytokine production GO:0001817 232 0.019
coagulation GO:0050817 78 0.019
negative regulation of multicellular organismal process GO:0051241 317 0.019
Mouse
regulation of kinase activity GO:0043549 314 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
Mouse Rat
regulation of gtp catabolic process GO:0033124 180 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
defense response GO:0006952 315 0.019
gtp catabolic process GO:0006184 237 0.019
cytokine production GO:0001816 247 0.019
cellular response to nitrogen compound GO:1901699 144 0.019
positive regulation of kinase activity GO:0033674 204 0.019
mitotic cell cycle phase transition GO:0044772 162 0.019
Fly
positive regulation of nucleotide catabolic process GO:0030813 185 0.019
regulation of locomotion GO:0040012 329 0.019
ribonucleoside monophosphate metabolic process GO:0009161 187 0.019
chemical homeostasis GO:0048878 306 0.019
regulation of nucleotide catabolic process GO:0030811 205 0.018
cellular response to biotic stimulus GO:0071216 71 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
regulation of hemostasis GO:1900046 42 0.018
protein oligomerization GO:0051259 173 0.018
cellular macromolecular complex assembly GO:0034622 324 0.018
actin filament organization GO:0007015 128 0.018
cellular response to superoxide GO:0071451 6 0.018
memory GO:0007613 3 0.018
cation transmembrane transport GO:0098655 238 0.018
cellular response to oxidative stress GO:0034599 85 0.018
negative regulation of protein modification process GO:0031400 200 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
establishment of protein localization to organelle GO:0072594 172 0.017
positive regulation of blood coagulation GO:0030194 11 0.017
apoptotic signaling pathway GO:0097190 268 0.017
Mouse
positive regulation of protein kinase activity GO:0045860 190 0.017
glycerolipid metabolic process GO:0046486 107 0.017
mitotic cell cycle GO:0000278 326 0.017
Fly
response to other organism GO:0051707 261 0.017
response to hormone GO:0009725 175 0.017
blood coagulation GO:0007596 76 0.017
positive regulation of protein phosphorylation GO:0001934 313 0.017
cellular response to hydrogen peroxide GO:0070301 37 0.017
negative regulation of catalytic activity GO:0043086 335 0.017
positive regulation of gtpase activity GO:0043547 166 0.017
regulation of multi organism process GO:0043900 157 0.017
regulation of growth GO:0040008 165 0.017
Worm
regulation of establishment of protein localization GO:0070201 242 0.017
response to organophosphorus GO:0046683 41 0.017
regulation of response to external stimulus GO:0032101 222 0.017
regulation of immune response GO:0050776 201 0.016
cell morphogenesis GO:0000902 296 0.016
monovalent inorganic cation transport GO:0015672 128 0.016
endocytosis GO:0006897 159 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
Mouse Rat
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.016
Mouse
response to external biotic stimulus GO:0043207 261 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
regulation of coagulation GO:0050818 44 0.016
regulation of wound healing GO:0061041 56 0.016
negative regulation of protein metabolic process GO:0051248 391 0.016
Mouse Rat
biological adhesion GO:0022610 331 0.016
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.016
regulation of protein catabolic process GO:0042176 155 0.016
single organism membrane organization GO:0044802 268 0.016
cellular response to fluid shear stress GO:0071498 7 0.016
morphogenesis of embryonic epithelium GO:0016331 4 0.015
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.015
regulation of cell migration GO:0030334 289 0.015
spermatid development GO:0007286 4 0.015
small molecule biosynthetic process GO:0044283 157 0.015
regulation of cell maturation GO:1903429 3 0.015
regulation of neural precursor cell proliferation GO:2000177 4 0.015
regulation of cell cycle process GO:0010564 266 0.015
Fly
hemostasis GO:0007599 76 0.015
inorganic cation transmembrane transport GO:0098662 194 0.015
small gtpase mediated signal transduction GO:0007264 78 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
mononuclear cell proliferation GO:0032943 71 0.015
positive regulation of cellular component movement GO:0051272 181 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
purine nucleoside monophosphate catabolic process GO:0009128 158 0.015
neurogenesis GO:0022008 169 0.015
regulation of cell development GO:0060284 161 0.015
positive regulation of cell migration GO:0030335 172 0.015
innate immune response GO:0045087 178 0.014
response to sucrose GO:0009744 1 0.014
regulation of leukocyte activation GO:0002694 115 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
rna processing GO:0006396 255 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
protein localization to membrane GO:0072657 160 0.014
cation homeostasis GO:0055080 189 0.014
response to cytokine GO:0034097 232 0.014
negative regulation of phosphorylation GO:0042326 174 0.014
peripheral nervous system development GO:0007422 2 0.014
embryo development GO:0009790 123 0.014
growth GO:0040007 202 0.014
Worm
positive regulation of immune response GO:0050778 159 0.014
phospholipid metabolic process GO:0006644 99 0.014
spermatid differentiation GO:0048515 4 0.014
adult locomotory behavior GO:0008344 1 0.014
lymphocyte activation GO:0046649 133 0.014
regulation of oocyte development GO:0060281 1 0.014
nitrogen compound transport GO:0071705 191 0.014
cell projection morphogenesis GO:0048858 129 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
cellular response to reactive oxygen species GO:0034614 50 0.014
response to oxidative stress GO:0006979 121 0.013
positive regulation of hemostasis GO:1900048 11 0.013
oxidation reduction process GO:0055114 396 0.013
cell adhesion GO:0007155 325 0.013
cellular metal ion homeostasis GO:0006875 146 0.013
leukocyte activation GO:0045321 164 0.013
protein k33 linked ubiquitination GO:1990390 1 0.013
negative regulation of developmental process GO:0051093 247 0.013
Mouse
neuron differentiation GO:0030182 138 0.013
neurotransmitter secretion GO:0007269 4 0.013
epithelial cell differentiation GO:0030855 141 0.013
primary neural tube formation GO:0014020 3 0.013
neuromuscular junction development GO:0007528 3 0.013
regulation of transcription involved in g2 m transition of mitotic cell cycle GO:0000117 1 0.013
regulation of secretion by cell GO:1903530 177 0.013
positive regulation of organelle organization GO:0010638 195 0.013
positive regulation of response to wounding GO:1903036 28 0.013
hemopoiesis GO:0030097 180 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
maintenance of protein location GO:0045185 57 0.013
cellular response to tumor necrosis factor GO:0071356 63 0.013
golgi vesicle transport GO:0048193 80 0.013
toxin transport GO:1901998 4 0.013
negative regulation of immune system process GO:0002683 136 0.013
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.013
regulation of secretion GO:0051046 194 0.012
generation of neurons GO:0048699 152 0.012
ion homeostasis GO:0050801 230 0.012
inner ear morphogenesis GO:0042472 4 0.012
regulation of protein transport GO:0051223 213 0.012
positive regulation of cytokine production GO:0001819 167 0.012
protein import GO:0017038 130 0.012
tissue regeneration GO:0042246 3 0.012
associative learning GO:0008306 1 0.012
regulation of protein ubiquitination GO:0031396 95 0.012
regulation of intracellular transport GO:0032386 195 0.012
activation of immune response GO:0002253 114 0.012
positive regulation of cellular component biogenesis GO:0044089 158 0.012
sodium ion transport GO:0006814 61 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
response to inorganic substance GO:0010035 127 0.012
neural tube closure GO:0001843 3 0.012
regulation of ion transport GO:0043269 189 0.012
cellular protein complex assembly GO:0043623 188 0.012
vesicle targeting rough er to cis golgi GO:0048207 2 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
response to tumor necrosis factor GO:0034612 76 0.012
nucleoside monophosphate metabolic process GO:0009123 191 0.012
circadian behavior GO:0048512 2 0.011
negative regulation of oxidative stress induced cell death GO:1903202 17 0.011
response to purine containing compound GO:0014074 40 0.011
positive regulation of cell motility GO:2000147 177 0.011
response to transforming growth factor beta GO:0071559 94 0.011
histone modification GO:0016570 251 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
head development GO:0060322 108 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
cellular homeostasis GO:0019725 196 0.011
cell projection assembly GO:0030031 126 0.011
atp catabolic process GO:0006200 157 0.011
protein localization to nucleus GO:0034504 136 0.011
regulation of cellular response to growth factor stimulus GO:0090287 76 0.011
cell type specific apoptotic process GO:0097285 125 0.011
mapk cascade GO:0000165 288 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
g2 m transition of mitotic cell cycle GO:0000086 41 0.011
Fly
covalent chromatin modification GO:0016569 254 0.011
single organism cell adhesion GO:0098602 179 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
positive regulation of wound healing GO:0090303 20 0.011
mating GO:0007618 1 0.011
organophosphate biosynthetic process GO:0090407 163 0.011
positive regulation of locomotion GO:0040017 186 0.011
rhythmic behavior GO:0007622 2 0.011
g1 s transition of mitotic cell cycle GO:0000082 78 0.011
nucleoside monophosphate catabolic process GO:0009125 159 0.011
nerve development GO:0021675 4 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
Mouse
monosaccharide metabolic process GO:0005996 74 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
chromatin modification GO:0016568 298 0.011
cellular ion homeostasis GO:0006873 168 0.011
cell cycle g2 m phase transition GO:0044839 43 0.011
Fly
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
carbohydrate metabolic process GO:0005975 207 0.011
regulation of mononuclear cell proliferation GO:0032944 65 0.011
atp metabolic process GO:0046034 176 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010
reproductive process GO:0022414 106 0.010
peptidyl serine phosphorylation GO:0018105 101 0.010
Worm
tube closure GO:0060606 3 0.010
regulation of cellular response to oxidative stress GO:1900407 26 0.010
negative regulation of glycogen metabolic process GO:0070874 4 0.010
cell death in response to oxidative stress GO:0036473 29 0.010
positive regulation of protein transport GO:0051222 135 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.010
sex determination GO:0007530 3 0.010
cellular response to lipid GO:0071396 127 0.010
ossification GO:0001503 121 0.010
immune effector process GO:0002252 159 0.010
organic acid biosynthetic process GO:0016053 97 0.010
compound eye development GO:0048749 1 0.010
ribonucleoside monophosphate catabolic process GO:0009158 158 0.010
regulation of dna metabolic process GO:0051052 153 0.010
protein homooligomerization GO:0051260 100 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.010
cellular chemical homeostasis GO:0055082 180 0.010
cellular response to oxygen levels GO:0071453 55 0.010
regulation of cell division GO:0051302 116 0.010

EIF2AK3 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.033
nervous system disease DOID:863 431 0.033
musculoskeletal system disease DOID:17 223 0.020
sensory system disease DOID:0050155 203 0.016
eye and adnexa disease DOID:1492 150 0.016
eye disease DOID:5614 149 0.016
disease of metabolism DOID:0014667 295 0.014
cancer DOID:162 167 0.013
disease of cellular proliferation DOID:14566 174 0.013
organ system cancer DOID:0050686 164 0.013
connective tissue disease DOID:65 109 0.012
retinal disease DOID:5679 118 0.012
retinal degeneration DOID:8466 89 0.010
bone disease DOID:0080001 88 0.010
brain disease DOID:936 73 0.010